NCBI Conserved Domain Search

fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410489 Cd Length: 105 Bit Score: 207.26 E-value: 2.01e-62

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720379787 1022 LTDFSSEMPCLAEYADGLWYRAKIISIKEFNPLSVLVLFVDYGCTEKLTINRLRQIPVQLMQYPAQAIKVLLAGFKPPLS 1101
Cdd:cd20418      1 LTDFRPEMPCLAEYSDGKWYRAKLLSILEFNPVKILVRHVDYGSTAALPTSRLRQIPAELMQYPCQAIKVKLAGFKPPLN 80

                           90       100
                   ....*....|....*....|....*
gi 1720379787 1102 DSGKTRIPYCPKWSMEALWTMIDCL 1126
Cdd:cd20418     81 DSETERIPYCPEWSMKALWAMIDLL 105

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410486 Cd Length: 96 Bit Score: 172.23 E-value: 3.10e-50

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720379787  256 FLSLLKTIEEFYKGEDGENLEILCPLQNQACVAKFEDGIWYRAKVIGLPGHREVEVKYVDFGNTAKITLKDMRKIKDEFL 335
Cdd:cd20415      1 FLILTKKIQEFYKEGDDGGLEILCPVQGQACVALFEDGAWYRARIIGLPGHREVEVKYVDFGNTATVTIKHVRKIKDDFL 80

                           90
                   ....*....|....*.
gi 1720379787  336 EPPEKAIKCKLAYVEP 351
Cdd:cd20415     81 SLPEKARECRLAFIEP 96

fourth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410488 Cd Length: 68 Bit Score: 141.80 E-value: 5.66e-40

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720379787  775 WKKGEPCAVRGSDTLWYRGKVMEVVGGTIRVQYLDHGFTEKIPQCHLYPILLYPDTPQFCIPCQLYQT 842
Cdd:cd20417      1 WKKGEGCVVRGSDTLWYRGKVLEVIGGMVRVQYVDQGYIEKIPQCHLYPMVLYPDIPQFCIPCQLYGT 68

third Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410487 Cd Length: 82 Bit Score: 136.46 E-value: 6.36e-38

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720379787  496 LEEKMVAAYEHSEWKPVKWECDMHCAVKVPAKNQWRRGQILRMVTDKLVEVLLYDVGVELVVNIHCLRELQENLKTMGRL 575
Cdd:cd20416      1 LQEKMIAEYENSKPEPVKWENDMHCAVQIQDKKQWRRGQIIRVVSDTLVEVFLYDFGNKEVVNIDCLRKLEENLKTIGKL 80


                   ..
gi 1720379787  576 SL 577
Cdd:cd20416     81 AL 82

first Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410485 Cd Length: 77 Bit Score: 114.61 E-value: 2.98e-30

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720379787   18 ELGARIFVNSIKNRMWCRGIITEIIPSKTKNIRKPCSPTKFSVCEISLIQIFMVDFGNSEVLIITGVGDTHEGPEH 93
Cdd:cd20414      1 ELGERIAVKSKKNGMWCRGTITELIPLENKNKGKPCGPTRYKIHDVAVMQVFLLDYGHSEVFVVTGVGVLVVRPED 76

Tudor domain;

Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 95.50 E-value: 4.20e-23

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720379787  727 SSFEAIVTCIGDDGTIFVVPKLSEFELIKMMDEIQSNLKCLGLLEPYSWKKGEPCAVRGSDTLWYRGKVMEVV-GGTIRV 805
Cdd:pfam00567    1 STIDVVVSHIESPSTFYIQPKSDSKKLEKLTEELQEYYASKPPESLPPAVGDGCVAAFSEDGKWYRAKITESLdDGLVEV 80

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1720379787  806 QYLDHGFTEKIPQCHLYPILLYPD-TPQFCIPCQLY 840
Cdd:pfam00567   81 LFIDYGNTETVPLSDLRPLPPELEsLPPQAIKCQLA 116

Tudor domain;

Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 87.02 E-value: 3.72e-20

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720379787  234 SVMVCHINSPTDFYLQLMENL-DFLSLLKTIEEFYKgEDGENLEILCPLQNQACVAKfEDGIWYRAKVIGLPGHREVEVK 312
Cdd:pfam00567    4 DVVVSHIESPSTFYIQPKSDSkKLEKLTEELQEYYA-SKPPESLPPAVGDGCVAAFS-EDGKWYRAKITESLDDGLVEVL 81

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1720379787  313 YVDFGNTAKITLKDMRKIKDEFLEPPEKAIKCKLA 347
Cdd:pfam00567   82 FIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLA 116

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410510 Cd Length: 125 Bit Score: 84.85 E-value: 3.23e-19

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720379787  233 VSVMVCHINSPTDFYLQLMENL-DFLSLLKTIEEFYK--GEDGENLEIlcplqnqACVAKF-EDGIWYRAKVIGLPGHRE 308
Cdd:cd20439     12 VDVKCSYVNSPGDFWCQLQTKSsELKSLMKQIQSYYLihNDPYKHGQI-------ACVAKYsKDGKWYRAAVLKQVSAKE 84

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1720379787  309 VEVKYVDFGNTAKITLKDMRKIKDEFLEPPEKAIKCKL 346
Cdd:cd20439     85 VDVIFVDYGNQERVLISDLRAIKPQFLLLEGQAFRCSL 122

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410511 Cd Length: 127 Bit Score: 77.50 E-value: 1.11e-16

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720379787  231 TEVSVMVCHINSPTDFYLQLMENLDFLS-LLKTIEEFYKGEDGEnleILCPLQNQACVAK-FEDGIWYRAKVIGLPGHRE 308
Cdd:cd20440     10 SEEEVYITHVYSPAKFYCQLDRNTEILEaLMEKIAEISKLFNSQ---ILDNCKTRLCLAKyFEDGQWYRALAHPVESSSH 86

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1720379787  309 VEVKYVDFGNTAKITLKDMRKIKDEFLE---PPEKAIKCKL 346
Cdd:cd20440     87 LSVYFVDYGNKQIVEKNEVLPIPDTAVDlllTPMQAIKCCL 127

second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410506 Cd Length: 134 Bit Score: 70.74 E-value: 3.48e-14

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720379787  987 HHGDTDDSGVSWESESENLEEALQRFNKNvetfpPLTDFSSEMP-----CLAEYADGLWYRAKIISIKEFN----PLSVL 1057
Cdd:cd20435     12 HRSSDGEVTKSMSSTYLKLSMKLNMYYSD-----PSNRILHGKVkvgdlCAVEDENNLYHRVKVLEITEKDdktkPREVL 86

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1720379787 1058 VLFVDYGCTEKLTINRLRQIPVQLMQYPAQAIKVLLAGFKPP 1099
Cdd:cd20435     87 VKFIDEGRVETVVVSQLLELPEELKSLPPQAVEVFLCNVKPV 128

Tudor domain;

Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 67.76 E-value: 1.98e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720379787 1003 ENLEEALQRFNKNVEtfPPLTDFSSEMPCLAEYA-DGLWYRAKIISIKEfNPLsVLVLFVDYGCTEKLTINRLRQIPVQL 1081
Cdd:pfam00567   28 EKLTEELQEYYASKP--PESLPPAVGDGCVAAFSeDGKWYRAKITESLD-DGL-VEVLFIDYGNTETVPLSDLRPLPPEL 103

                           90
                   ....*....|....
gi 1720379787 1082 MQYPAQAIKVLLAG 1095
Cdd:pfam00567  104 ESLPPQAIKCQLAG 117

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410479 Cd Length: 130 Bit Score: 68.17 E-value: 2.50e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720379787  235 VMVCHINSPTDFYLQLM--ENLDFLSLLKT-IEEFYKGEDGENLEIlcPLQNQACVAKF-EDGIWYRAKVIGL-PGHREV 309
Cdd:cd20408      1 GTVTEFKNPGEFYIQIYtlEVLESLVKLTSqLKKTYASVNNHKEYI--PEVGEVCVAKYsEDQNWYRALVQTVdVQQKKA 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1720379787  310 EVKYVDFGNTAKITLKDMRKIKDEFLEPPEKAIKCKLAYVEPSKKSqWS 358
Cdd:cd20408     79 GVFYIDYGNEETVPLNRIQPLKKDIELFPPCAIKCCLANVKPPSGS-WS 126

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410493 Cd Length: 135 Bit Score: 67.92 E-value: 3.32e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720379787  235 VMVCHINSPTDFYLQLMEN-LDFLSLLKTIEEFYKGEDGENLEILCPLQNQACVAKFEDGIWYRAKVIGLPGhREVEVKY 313
Cdd:cd20422      4 AQVEFVKDPSEFWIRLGEHaVPFSKLMRSMTAFYSQASKLDGVVLKPQPGQLCCAKWKEDRYYRAIVTAVKG-KMVEVFL 82

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1720379787  314 VDFGNTAKITLKDMRKIKDEFLEPPEKAIKCKLAYVEPSKKSqWS 358
Cdd:cd20422     83 VDRGNTEMVDWYDVKKLLPQFRELPALALKCCLADICPLGER-WS 126

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410496 Cd Length: 115 Bit Score: 67.10 E-value: 3.58e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720379787  233 VSVMVCHINSPTDFYLQLMENLDFLSLLKTIEEFYKGEDGENLEILCPLQNQACVAKFEDGIWYRAKVIGLPGHREVEVK 312
Cdd:cd20425      2 TEVYVSHVNSPSDFYVQLAQDEDELSMISEKLNASKANDEEVECESLQLGDLICAEYPEDGLWYRAVVKEKIPNNLVSVQ 81

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1720379787  313 YVDFGNTAKITLKDMRKIKDEFLEPPEKAIKCKL 346
Cdd:cd20425     82 FIDYGNTSVVQPSKIHRLPKELLSIPALSIHCFL 115

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410450 Cd Length: 50 Bit Score: 64.07 E-value: 7.03e-13

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1720379787  283 NQACVAKFE-DGIWYRAKVIGLPGHREVEVKYVDFGNTAKITLKDMRKI 330
Cdd:cd20379      2 GDLCAAKYEeDGKWYRARVLEVLSNDKVEVFFVDYGNTETVPLSDLRPL 50

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).

Pssm-ID: 197660 Cd Length: 57 Bit Score: 61.91 E-value: 4.33e-12

                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 1720379787   283 NQACVAKFEDGIWYRAKVIGLPGHREVEVKYVDFGNTAKITLKDMRKIKDEF 334
Cdd:smart00333    6 GDKVAARWEDGEWYRARIVKVDGEQLYEVFFIDYGNEEVVPPSDLRQLPEEL 57

Tudor domain;

Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 63.91 E-value: 4.64e-12

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720379787  471 VNICNVISPEKIYVQWLLTENLLNSLEEKMVAAYEHSEWKPVKWECDMHCAVKVPAKNQWRRGQILRMVTDKLVEVLLYD 550
Cdd:pfam00567    5 VVVSHIESPSTFYIQPKSDSKKLEKLTEELQEYYASKPPESLPPAVGDGCVAAFSEDGKWYRAKITESLDDGLVEVLFID 84

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1720379787  551 VGVELVVNIHCLRELQENLKTMGRLSLECSL 581
Cdd:pfam00567   85 YGNTETVPLSDLRPLPPELESLPPQAIKCQL 115

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410482 Cd Length: 116 Bit Score: 62.85 E-value: 9.87e-12

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720379787  280 PLQNQACVAKFE-DGIWYRAKVIGLpGHREVEVKYVDFGNTAKITLKDMRKIKDEFLEPPEKAIKCKLA 347
Cdd:cd20411     48 PRIGDACCARFTgDKNWYRAVVLET-SDSEVKVLYADYGNTETLPLSRILPITKSHLELPFQIIRCSLA 115

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410495 Cd Length: 126 Bit Score: 62.52 E-value: 1.72e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720379787  232 EVSVMVCHINSPTDFYLQLMENLDFLSLLK-TIEEFYKgedgENLEILCPLQ-NQACVAKFEDGIWYRAKVIGLPghREV 309
Cdd:cd20424     13 EEEVYITYVNDPWTFYCQLARNAGVLDQLAsAISRLSS----EIRKLELSVNpGTLCLAKYSDQHWYRGIIITNK--NST 86

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1720379787  310 EVKYVDFGNTAKITLKDMRKIKD---EFLEPPEKAIKCKL 346
Cdd:cd20424     87 EVFFVDYGNTEKVEKEDMLPIPSdayELLLLPMQAIKCSL 126

Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope, where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. It contains a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410478 Cd Length: 76 Bit Score: 60.68 E-value: 2.21e-11

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720379787  286 CVAKFEDGiWYRAKVIG-LPGHREVEVKYVDFGNTAKITLKDMRKIKDEFLEPPEKAIKCKLAYVEP 351
Cdd:cd20407     11 CAAPVMNA-WYRAQVVGvFEETDEVEIKYLDYGGYERVPVDDLRQIRSDFMTLPFQATECYLANIEP 76

fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410489 Cd Length: 105 Bit Score: 61.27 E-value: 2.71e-11

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720379787  286 CVAKFEDGIWYRAKVIGLPGHREVE--VKYVDFGNTAKITLKDMRKIKDEFLEPPEKAIKCKLAYVEP 351
Cdd:cd20418     10 CLAEYSDGKWYRAKLLSILEFNPVKilVRHVDYGSTAALPTSRLRQIPAELMQYPCQAIKVKLAGFKP 77

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410511 Cd Length: 127 Bit Score: 60.55 E-value: 9.30e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720379787  961 VQVKHIVSPDEMYICLDSEdsytqfnhhgdtddsgvsweseSENLEEALQRFNKNVETFP-PLTDFSSEMPCLAEY-ADG 1038
Cdd:cd20440     14 VYITHVYSPAKFYCQLDRN----------------------TEILEALMEKIAEISKLFNsQILDNCKTRLCLAKYfEDG 71

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1720379787 1039 LWYRAKIISIKefNPLSVLVLFVDYGCTEKLTINRLRQIP---VQLMQYPAQAIKVLL 1093
Cdd:cd20440     72 QWYRALAHPVE--SSSHLSVYFVDYGNKQIVEKNEVLPIPdtaVDLLLTPMQAIKCCL 127

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410494 Cd Length: 80 Bit Score: 58.65 E-value: 1.17e-10

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720379787  281 LQNQACVAKF-EDGIWYRAKVIGLPGHRE-VEVKYVDFGNTAKITLKDMRKIKDEFLEPPEKAIKCKL 346
Cdd:cd20423      4 LPNPVCLAKYsEDGKWCRALIDNVYEPVEmVEVTYVDYGNKELVSLKNLRSISEEFLKLKAQAFRCSL 71

sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410512 Cd Length: 108 Bit Score: 59.75 E-value: 1.24e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720379787  242 SPTDFYLQLMENLDflSLLKTIEEFYKG--EDGENLEILCpLQNQACVAKF-EDGIWYRAKVIGLPGHREVEVKYVDFGN 318
Cdd:cd20441      1 SPSRFFIQLSEDEK--VILQLAEELNETseKSRENAAVKL-KVGDLVAAEYdEDLALYRAVITAVLPGKSFKVEFIDYGN 77

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1720379787  319 TAKITLKDMRKIKDEFLEPPEKAIKCKLAYV 349
Cdd:cd20441     78 TAVVDKSNIYTLQEKFLSLPRLSIPCSLSGV 108

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410494 Cd Length: 80 Bit Score: 57.11 E-value: 4.56e-10

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720379787 1029 MPCLAEYA-DGLWYRAKIISIKEfNPLSVLVLFVDYGCTEKLTINRLRQIPVQLMQYPAQAIKVLLAGFKPP 1099
Cdd:cd20423      7 PVCLAKYSeDGKWCRALIDNVYE-PVEMVEVTYVDYGNKELVSLKNLRSISEEFLKLKAQAFRCSLYNLIQP 77

Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope, where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. It contains a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410478 Cd Length: 76 Bit Score: 56.83 E-value: 4.57e-10

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720379787 1031 CLAeYADGLWYRAKIISIKEfNPLSVLVLFVDYGCTEKLTINRLRQIPVQLMQYPAQAIKVLLAGFKP 1098
Cdd:cd20407     11 CAA-PVMNAWYRAQVVGVFE-ETDEVEIKYLDYGGYERVPVDDLRQIRSDFMTLPFQATECYLANIEP 76

Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor 2 (AtTudor2), and similar proteins; The family includes AtTudor1 (also called Tudor-SN protein 1) and AtTudor2 (also called Tudor-SN protein 2 or 100 kDa coactivator-like protein). They are cytoprotective ribonucleases (RNases) required for resistance to abiotic stresses, acting as positive regulators of mRNA decapping during stress. Members of this family contain one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410514 [Multi-domain] Cd Length: 117 Bit Score: 57.86 E-value: 5.95e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720379787  246 FYLQLMENLDFLSLLKTIEEfYKGEDGENLE-ILCPLQNQACVAKFE-DGIWYRAKVIGLP------GHREVEVKYVDFG 317
Cdd:cd20443      4 FYVQVVSDQRLSSIQQQLEG-LSLKDKANPPgGFNPKKGELVLAQFSaDNSWNRAMVVNAPrqgtqsPKDEYEVFYIDYG 82

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1720379787  318 NTAKITLKDMRKIKDEFLEPPEKAIKCKLAYVEP 351
Cdd:cd20443     83 NQETVPLSALRPLDPSVSSAPGLAQLCSLAHIKV 116

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410508 Cd Length: 120 Bit Score: 57.81 E-value: 6.26e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720379787  231 TEVSVMVCHINSPTDFYLQLME-NLDFLSLLKTIEEFYKGEDGENLEilcPLQN--QACVAKFEDGIWYRAKVIGLPGHR 307
Cdd:cd20437      3 TTEKVKITAAVSPSKFYCQLLSwEPELSKLTTQMTLHYESVSKELNP---SCENfgLLCAAKGKDGQWHRGFLQQLLPPS 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1720379787  308 EVEVKYVDFGNTAKITLKDMRKIKDEFLEPPEKAIKCKLA 347
Cdd:cd20437     80 QVKVWFIDYGNSEAVSSHSVLKLPPDFFSLPLMSFPCSLS 119

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410480 Cd Length: 82 Bit Score: 56.31 E-value: 7.99e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720379787 1003 ENLEEALQRFNKNVETFPPLTDFSSEM--PCLAEY-ADGLWYRAKIISIKefNPLSVLVLFVDYGCTEKLTINRLRQIPV 1079
Cdd:cd20409      2 RQLAELQESLSAYCKVAPASSDFSPAVgeVCCAQFtEDNQWYRASVLAYS--SEDSVLVGYIDFGNSEEVALSRLRPIPP 79


                   ...
gi 1720379787 1080 QLM 1082
Cdd:cd20409     80 SLL 82

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410486 Cd Length: 96 Bit Score: 56.67 E-value: 8.47e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720379787 1006 EEALQRFNKNVETFPPLTDfsseMPCLAEYADGLWYRAKIISIKEFNplSVLVLFVDYGCTEKLTINRLRQIPVQLMQYP 1085
Cdd:cd20415     10 EFYKEGDDGGLEILCPVQG----QACVALFEDGAWYRARIIGLPGHR--EVEVKYVDFGNTATVTIKHVRKIKDDFLSLP 83

                           90
                   ....*....|...
gi 1720379787 1086 AQAIKVLLAGFKP 1098
Cdd:cd20415     84 EKARECRLAFIEP 96

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410450 Cd Length: 50 Bit Score: 55.21 E-value: 9.36e-10

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1720379787 1029 MPCLAEY-ADGLWYRAKIISIKEFNplSVLVLFVDYGCTEKLTINRLRQI 1077
Cdd:cd20379      3 DLCAAKYeEDGKWYRARVLEVLSND--KVEVFFVDYGNTETVPLSDLRPL 50

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410497 Cd Length: 140 Bit Score: 57.89 E-value: 1.23e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720379787  240 INSPTDFYLQL-MENLDFLSllKTIEEFYKGEDGENLEILCPLQNQACVAKF-EDGIWYRAKVIGLPGHReVEVKYVDFG 317
Cdd:cd20426      8 VDSPEYFWCQFaTEKIQCLA--VKVQEAGEQVADRGNFIPSIYVGDPCIVKYsEDNHWYRALVTKINDNL-VSVRFVDYG 84

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1720379787  318 NTAKITLKDMRKIKDEFLEPPEKAIKCKLAYVEPSKKSqWS 358
Cdd:cd20426     85 NEEDVVREQVRALPSELLKIPVQAFPCCLSGFNLSEGL-WS 124

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410504 [Multi-domain] Cd Length: 84 Bit Score: 55.77 E-value: 1.43e-09

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1720379787  286 CVAKF-EDGIWYRAKVIGLPGHREVEVKYVDFGNTAKITLKDMRKIKDEF 334
Cdd:cd20433     34 CAAKFvEDGEWYRAKVEKVEGDKKVHVLYIDYGNREVLPSTRLAALPPAF 83

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410450 Cd Length: 50 Bit Score: 54.44 E-value: 1.72e-09

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1720379787  777 KGEPCAVRGSDT-LWYRGKVMEVV-GGTIRVQYLDHGFTEKIPQCHLYPI 824
Cdd:cd20379      1 VGDLCAAKYEEDgKWYRARVLEVLsNDKVEVFFVDYGNTETVPLSDLRPL 50

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410509 Cd Length: 141 Bit Score: 57.10 E-value: 1.94e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720379787  237 VCHINSPTDFYLQLME-NLDFLSLLKTIEEFYKGEDGENLEILCPLQNQACVAKF-EDGIWYRAKVIGLPGHrEVEVKYV 314
Cdd:cd20438     11 VEYVLNPSNFWIRTDEyNNEFQALMKNIADIYNLCGNDEELLKKPEPGLLCCARYsKDRHYYRAVITEVLDL-KVSVYFL 89

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1720379787  315 DFGNTAKITLKDMRKIKDEFLEPPEKAIKCKLAYVEP 351
Cdd:cd20438     90 DFGNTDTVPFYDVKTLLPEFSELPALAMCCSLAHVFP 126

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410492 Cd Length: 130 Bit Score: 55.51 E-value: 5.41e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720379787  221 YHPPILPEEMTEvSVMVCHINSPTDFYLQLM---ENLDFLSLlkTIEEFYKGEDGENLEILCPLQNQACVAKFEDGIWYR 297
Cdd:cd20421      2 YFYPQLQVGVTE-TVVVTEVTDPHRIFCQLRslsQELKRLSE--SMHQYYEGRVGSGYETRPEKLGSPCAARGSDGRWYR 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1720379787  298 AKVIG-LPGHREVEVKYVDFGNTAKITLKDMRKIKDEFLEPPEKAIKCKL 346
Cdd:cd20421     79 AVLQQvFSANRVVEVLHVDYGRKEVVSVSNLRYLAPEYFRMPVVTYPCAL 128

Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, also called Tudor and KH domain-containing protein (TDRKH), participates in the primary piwi-interacting RNA (piRNA) biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. The family also includes the TDRD2 homolog found in Drosophila melanogaster (dTDRKH), which is also called partner of PIWIs protein, or PAPI, and is involved in Zucchini-mediated piRNA 3'-end maturation. TDRD2 contains two KH domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410483 Cd Length: 95 Bit Score: 54.22 E-value: 5.96e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720379787  254 LDflSLLKTIEEFYkgEDGENLEILCPLQ-NQACVAKFE-DGIWYRAKVIGLPGHREVEVKYVDFGNTAKITLKDMRKIK 331
Cdd:cd20412      6 LD--KLVQEMTQYY--ESEENRHTLLTVQvGDIVAAPFRhDGSWYRARVLGFLENGNLDLYFVDYGDSGYVPLEDLRALR 81

                           90
                   ....*....|...
gi 1720379787  332 DEFLEPPEKAIKC 344
Cdd:cd20412     82 SDFLSLPFQAIEC 94

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).

Pssm-ID: 197660 Cd Length: 57 Bit Score: 52.66 E-value: 7.99e-09

                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1720379787   773 YSWKKGEPCAVRGSDTLWYRGKVMEVVG-GTIRVQYLDHGFTEKIPQCHLYPI 824
Cdd:smart00333    1 PTFKVGDKVAARWEDGEWYRARIVKVDGeQLYEVFFIDYGNEEVVPPSDLRQL 53

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410480 Cd Length: 82 Bit Score: 53.23 E-value: 1.22e-08

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1720379787  279 CPLQNQACVAKF-EDGIWYRAKVIGLPGHREVEVKYVDFGNTAKITLKDMRKIKDEFL 335
Cdd:cd20409     25 SPAVGEVCCAQFtEDNQWYRASVLAYSSEDSVLVGYIDFGNSEEVALSRLRPIPPSLL 82

Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is an ATP-dependent DEAD-like RNA helicase required during spermatogenesis. It is involved in the biosynthesis of PIWI-interacting RNAs (piRNAs). A recessive deleterious mutation mutation in TDRD9 causes non-obstructive azoospermia in infertile men. TDRD9 contains an N-terminal HrpA-like RNA helicase module and a Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410502 Cd Length: 101 Bit Score: 53.55 E-value: 1.22e-08

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720379787 1020 PPLTDFSSEMPCLAEYADGL---WYRAKIISIkefNPLSVLVLFVDYGCTEKLTINRLRQIPVQLMQYP 1085
Cdd:cd20431     36 PLTTKPVPNLLCLAPFTDADmkkYYRAKILYV---SGSSAEVFFVDYGNTSQVPSSLLREIPETLLTLP 101

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410450 Cd Length: 50 Bit Score: 51.75 E-value: 1.29e-08

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1720379787  517 DMHCAVKVPAKNQWRRGQILRMVTDKLVEVLLYDVGVELVVNIHCLREL 565
Cdd:cd20379      2 GDLCAAKYEEDGKWYRARVLEVLSNDKVEVFFVDYGNTETVPLSDLRPL 50

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410497 Cd Length: 140 Bit Score: 54.81 E-value: 1.44e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720379787 1000 SESENLEEALQRFNKNVETfppLTDFSSEM----PCLAEYA-DGLWYRAKIISIKEfNPLSVLvlFVDYGCTEKLTINRL 1074
Cdd:cd20426     21 EKIQCLAVKVQEAGEQVAD---RGNFIPSIyvgdPCIVKYSeDNHWYRALVTKIND-NLVSVR--FVDYGNEEDVVREQV 94

                           90       100
                   ....*....|....*....|..
gi 1720379787 1075 RQIPVQLMQYPAQAIKVLLAGF 1096
Cdd:cd20426     95 RALPSELLKIPVQAFPCCLSGF 116

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410504 [Multi-domain] Cd Length: 84 Bit Score: 52.69 E-value: 1.86e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720379787 1003 ENLEEALQRFNknvETFPPLT--------DFssempCLAEY-ADGLWYRAKIISIKefNPLSVLVLFVDYGCTEKLTINR 1073
Cdd:cd20433      6 EKLMEKLRFEI---ASNPPLPgsytprkgDL-----CAAKFvEDGEWYRAKVEKVE--GDKKVHVLYIDYGNREVLPSTR 75


                   ....*
gi 1720379787 1074 LRQIP 1078
Cdd:cd20433     76 LAALP 80

Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is an ATP-dependent DEAD-like RNA helicase required during spermatogenesis. It is involved in the biosynthesis of PIWI-interacting RNAs (piRNAs). A recessive deleterious mutation mutation in TDRD9 causes non-obstructive azoospermia in infertile men. TDRD9 contains an N-terminal HrpA-like RNA helicase module and a Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410502 Cd Length: 101 Bit Score: 52.78 E-value: 2.30e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720379787  271 DGENLEILCPL-----QNQ------------ACVAKFEDGI---WYRAKVIGLPGHrEVEVKYVDFGNTAKITLKDMRKI 330
Cdd:cd20431     15 DENSSEILQQLtaeinQRQlvplttkpvpnlLCLAPFTDADmkkYYRAKILYVSGS-SAEVFFVDYGNTSQVPSSLLREI 93


                   ....*...
gi 1720379787  331 KDEFLEPP 338
Cdd:cd20431     94 PETLLTLP 101

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410495 Cd Length: 126 Bit Score: 53.66 E-value: 2.36e-08

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720379787 1031 CLAEYADGLWYRAKIISIKEfnplSVLVLFVDYGCTEKLTINRLRQIP---VQLMQYPAQAIKVLL 1093
Cdd:cd20424     65 CLAKYSDQHWYRGIIITNKN----STEVFFVDYGNTEKVEKEDMLPIPsdaYELLLLPMQAIKCSL 126

first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410498 Cd Length: 98 Bit Score: 52.43 E-value: 2.74e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720379787 1003 ENLEEALQRFNKNVETFPPLTDFSSEMPCLAEYADGLWYRAKIISIKEfnpLSVLVLFVDYGCTEKLTINRLRQIPVQLM 1082
Cdd:cd20427      1 EQMEDEMKEFYSKSSTAMCLRSPSVGQLVAVKAEEDAWLRAQVIEVEE---DKVKVYYVDHGFSEVVERSKLFKLNKQFY 77

                           90
                   ....*....|....*.
gi 1720379787 1083 QYPAQAIKVLLAGFKP 1098
Cdd:cd20427     78 SLPFQATKCKLAGLEP 93

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410490 Cd Length: 118 Bit Score: 53.22 E-value: 3.05e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720379787  237 VCHINSPTDFYLQLMENLD---FLSLLKTIEEFYKGEDGENLEIL---CPLQNQACVAKF-EDGIWYRAKVIGLPGHREV 309
Cdd:cd20419      2 VEYIESPSQFYVRFYSKDTsemLEDMMIEMRRCYSNEHVSERYVMpeaFIQPGQVCCVRIpEDVWWYRVIIHQVLNKQEV 81

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1720379787  310 EVKYVDFGNTAKITLKDMRKIKDEFLEPPEKAIKCKL 346
Cdd:cd20419     82 EVFYPDFGDIGTVQKSRLRFLKCCYSKLPAQAIPASL 118

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410481 [Multi-domain] Cd Length: 59 Bit Score: 51.19 E-value: 3.10e-08

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720379787  280 PLQNQACVAKF-EDGIWYRAKVIGLPGHREVEVKYVDFGNTAKITLKDMRKIKDEFL 335
Cdd:cd20410      3 PIVGEPCCAFFsGDGNWYRAMVKEILPGGAVKVHFVDYGNVEEVTLDKLRKITSTFL 59

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410479 Cd Length: 130 Bit Score: 52.76 E-value: 5.34e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720379787 1005 LEEALQRFNKNVETFPPLTDFSSEMpCLAEYA-DGLWYRAKIisiKEFNPL--SVLVLFVDYGCTEKLTINRLRQIPVQL 1081
Cdd:cd20408     28 LTSQLKKTYASVNNHKEYIPEVGEV-CVAKYSeDQNWYRALV---QTVDVQqkKAGVFYIDYGNEETVPLNRIQPLKKDI 103

                           90
                   ....*....|....*...
gi 1720379787 1082 MQYPAQAIKVLLAGFKPP 1099
Cdd:cd20408    104 ELFPPCAIKCCLANVKPP 121

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).

Pssm-ID: 197660 Cd Length: 57 Bit Score: 49.58 E-value: 9.43e-08

                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 1720379787  1029 MPCLAEYADGLWYRAKIISIKEFNplSVLVLFVDYGCTEKLTINRLRQIP 1078
Cdd:smart00333    7 DKVAARWEDGEWYRARIVKVDGEQ--LYEVFFIDYGNEEVVPPSDLRQLP 54

first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410498 Cd Length: 98 Bit Score: 50.89 E-value: 1.04e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720379787  263 IEEFYKgEDGENLEILCPLQNQACVAKFEDGIWYRAKVIGLPGHReVEVKYVDFGNTAKITLKDMRKIKDEFLEPPEKAI 342
Cdd:cd20427      7 MKEFYS-KSSTAMCLRSPSVGQLVAVKAEEDAWLRAQVIEVEEDK-VKVYYVDHGFSEVVERSKLFKLNKQFYSLPFQAT 84


                   ....*....
gi 1720379787  343 KCKLAYVEP 351
Cdd:cd20427     85 KCKLAGLEP 93

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410481 [Multi-domain] Cd Length: 59 Bit Score: 48.49 E-value: 3.07e-07

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720379787  776 KKGEPC-AVRGSDTLWYRGKVMEVV-GGTIRVQYLDHGFTEKIPQCHLYPIllypdTPQF 833
Cdd:cd20410      4 IVGEPCcAFFSGDGNWYRAMVKEILpGGAVKVHFVDYGNVEEVTLDKLRKI-----TSTF 58

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410508 Cd Length: 120 Bit Score: 50.11 E-value: 4.06e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720379787  471 VNICNVISPEKIYVQWLLTENLLNSLEEKMVAAYE--HSEWKPVKWECDMHCAVKvPAKNQWRRGQILRMVTDKLVEVLL 548
Cdd:cd20437      7 VKITAAVSPSKFYCQLLSWEPELSKLTTQMTLHYEsvSKELNPSCENFGLLCAAK-GKDGQWHRGFLQQLLPPSQVKVWF 85

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1720379787  549 YDVGVELVVNIHCLRELQENLKTMGRLSLECSL 581
Cdd:cd20437     86 IDYGNSEAVSSHSVLKLPPDFFSLPLMSFPCSL 118

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410481 [Multi-domain] Cd Length: 59 Bit Score: 47.72 E-value: 5.53e-07

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1720379787 1030 PCLAEYA-DGLWYRAKIISIkeFNPLSVLVLFVDYGCTEKLTINRLRQIPVQLM 1082
Cdd:cd20410      8 PCCAFFSgDGNWYRAMVKEI--LPGGAVKVHFVDYGNVEEVTLDKLRKITSTFL 59

second Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410516 Cd Length: 56 Bit Score: 47.03 E-value: 8.29e-07

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720379787  283 NQACVAKFEDGiWYRAKVIGLPGHREVEVKYVDFGNTAKITLKDMRKIKDEFLEPP 338
Cdd:cd20445      2 NELCIAKYMDK-WYRAVCLESVGDGRPTVLFCDYGNILMARLTDIRPFPPTFATEP 56

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410504 [Multi-domain] Cd Length: 84 Bit Score: 47.68 E-value: 1.03e-06

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720379787  752 ELIKMMD----EIQSNLKCLGllePYSWKKGEPCAVRGS-DTLWYRGKVMEVVG-GTIRVQYLDHGFTEKIPQCHLYPI 824
Cdd:cd20433      4 QLEKLMEklrfEIASNPPLPG---SYTPRKGDLCAAKFVeDGEWYRAKVEKVEGdKKVHVLYIDYGNREVLPSTRLAAL 79

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410479 Cd Length: 130 Bit Score: 48.91 E-value: 1.22e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720379787  744 VVPKLSEFELikMMDEIQSNLKCLgllEPYSWKKGEPCAVRGS-DTLWYRGKVMEV--VGGTIRVQYLDHGFTEKIPQCH 820
Cdd:cd20408     21 VLESLVKLTS--QLKKTYASVNNH---KEYIPEVGEVCVAKYSeDQNWYRALVQTVdvQQKKAGVFYIDYGNEETVPLNR 95

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1720379787  821 LYPilLYPDTPQFC---IPCQLYQTLPVGNTWQPDAI 854
Cdd:cd20408     96 IQP--LKKDIELFPpcaIKCCLANVKPPSGSWSEECI 130

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410493 Cd Length: 135 Bit Score: 47.89 E-value: 3.10e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720379787 1031 CLAEYADGLWYRAKIISIKEfnpLSVLVLFVDYGCTEKLTINRLRQIPVQLMQYPAQAIKVLLAgfkpplsDSGktriPY 1110
Cdd:cd20422     56 CCAKWKEDRYYRAIVTAVKG---KMVEVFLVDRGNTEMVDWYDVKKLLPQFRELPALALKCCLA-------DIC----PL 121


                   ....*....
gi 1720379787 1111 CPKWSMEAL 1119
Cdd:cd20422    122 GERWSPEAI 130

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410482 Cd Length: 116 Bit Score: 47.06 E-value: 3.75e-06

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720379787 1031 CLAEYA-DGLWYRAKIISIKEfnpLSVLVLFVDYGCTEKLTINRLRQIPVQLMQYPAQAIKVLLAG 1095
Cdd:cd20411     54 CCARFTgDKNWYRAVVLETSD---SEVKVLYADYGNTETLPLSRILPITKSHLELPFQIIRCSLAG 116

second Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410499 Cd Length: 140 Bit Score: 47.44 E-value: 3.96e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720379787  235 VMVCHINSPTDFYLQL-MENLDFLS-LLKTIEEFYKGED-GENLEILCPLQNQACVAKFEdGIWYRAKVIGLPGHREVEV 311
Cdd:cd20428      4 VRVTNVCSDGTLYCQVpSKGLSKLNeILDKIEYYFHSRQmTSEYFVSLPFCGKICLARYK-GKWARVEITNVHSSRALDV 82

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1720379787  312 KYVDFGNTAKITLKDMRKIKDEFLEP----PEKAIKCKLA 347
Cdd:cd20428     83 HFLDTGTVASVKVSELREIPPPFLRElisiPPQALKCCLA 122

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410496 Cd Length: 115 Bit Score: 46.30 E-value: 7.10e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720379787  961 VQVKHIVSPDEMYICLDSEDSytQFNHHGDTDDSGvsWESESENLEEALQRfnknvetfppltdfsSEMPClAEYA-DGL 1039
Cdd:cd20425      4 VYVSHVNSPSDFYVQLAQDED--ELSMISEKLNAS--KANDEEVECESLQL---------------GDLIC-AEYPeDGL 63

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1720379787 1040 WYRAkIISIKEFNPLsVLVLFVDYGCTEKLTINRLRQIPVQLMQYPAQAI 1089
Cdd:cd20425     64 WYRA-VVKEKIPNNL-VSVQFIDYGNTSVVQPSKIHRLPKELLSIPALSI 111

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410510 Cd Length: 125 Bit Score: 45.94 E-value: 9.82e-06

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720379787 1031 CLAEYA-DGLWYRAKIIsiKEFNPLSVLVLFVDYGCTEKLTINRLRQIPVQLMQYPAQAIKVLLAGF 1096
Cdd:cd20439     61 CVAKYSkDGKWYRAAVL--KQVSAKEVDVIFVDYGNQERVLISDLRAIKPQFLLLEGQAFRCSLNNF 125

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410509 Cd Length: 141 Bit Score: 45.93 E-value: 1.35e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720379787  776 KKGEP----CAVRGSDTLWYRGKVMEVVGGTIRVQYLDHGFTEKIPQCHLYPIL-LYPDTPQFCIPCQLYQTLPVGNTWQ 850
Cdd:cd20438     53 KKPEPgllcCARYSKDRHYYRAVITEVLDLKVSVYFLDFGNTDTVPFYDVKTLLpEFSELPALAMCCSLAHVFPVEEVWT 132


                   ....*....
gi 1720379787  851 PDAIELLQE 859
Cdd:cd20438    133 KNANDFFKK 141

second Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410499 Cd Length: 140 Bit Score: 45.90 E-value: 1.50e-05

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720379787 1031 CLAEYAdGLWYRAKIISIKEFNPLSVLvlFVDYGCTEKLTINRLRQIPVQ----LMQYPAQAIKVLLAGFKP 1098
Cdd:cd20428     58 CLARYK-GKWARVEITNVHSSRALDVH--FLDTGTVASVKVSELREIPPPflreLISIPPQALKCCLADLPL 126

Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor 2 (AtTudor2), and similar proteins; The family includes AtTudor1 (also called Tudor-SN protein 1) and AtTudor2 (also called Tudor-SN protein 2 or 100 kDa coactivator-like protein). They are cytoprotective ribonucleases (RNases) required for resistance to abiotic stresses, acting as positive regulators of mRNA decapping during stress. Members of this family contain one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410514 [Multi-domain] Cd Length: 117 Bit Score: 45.15 E-value: 1.56e-05

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720379787 1032 LAEY-ADGLWYRAKIIS---------IKEFNplsvlVLFVDYGCTEKLTINRLRQIPVQLMQYPAQAIKVLLAGFKPP 1099
Cdd:cd20443     45 LAQFsADNSWNRAMVVNaprqgtqspKDEYE-----VFYIDYGNQETVPLSALRPLDPSVSSAPGLAQLCSLAHIKVP 117

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410492 Cd Length: 130 Bit Score: 44.72 E-value: 3.49e-05

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720379787  776 KKGEPCAVRGSDTLWYRGKVMEVVGG--TIRVQYLDHGFTEKIPQCHLYPILL-YPDTPQFCIPCQLY 840
Cdd:cd20421     62 KLGSPCAARGSDGRWYRAVLQQVFSAnrVVEVLHVDYGRKEVVSVSNLRYLAPeYFRMPVVTYPCALF 129

Tudor domain found in zinc finger CCCH-type with G patch domain-containing protein (ZGPAT) and similar proteins; ZGPAT, also called ZIP, G patch domain-containing protein 6 (GPATC6), GPATCH6, zinc finger CCCH domain-containing protein 9 (ZC3HDC9), ZC3H9, or zinc finger and G patch domain-containing protein, is a transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. It represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. It contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410455 Cd Length: 55 Bit Score: 41.83 E-value: 5.67e-05

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1720379787  286 CVAKFEDGIWYRAKVIGLPGHREVEVKYVDFGNTAKITLKD 326
Cdd:cd20384     11 CLAKYDDGLWYPATVTDIDEDGKYTVKFDSYGEVAVVELDD 51

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410493 Cd Length: 135 Bit Score: 44.04 E-value: 6.28e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720379787  515 ECDMHCAVKVpAKNQWRRGQILRmVTDKLVEVLLYDVGVELVVNIHCLRELQENLKTMGRLSLECSLVDIRPTGgsDKWT 594
Cdd:cd20422     51 QPGQLCCAKW-KEDRYYRAIVTA-VKGKMVEVFLVDRGNTEMVDWYDVKKLLPQFRELPALALKCCLADICPLG--ERWS 126


                   ....*.
gi 1720379787  595 ATACDC 600
Cdd:cd20422    127 PEAISA 132

Tudor domain found in zinc finger CCCH-type with G patch domain-containing protein (ZGPAT) and similar proteins; ZGPAT, also called ZIP, G patch domain-containing protein 6 (GPATC6), GPATCH6, zinc finger CCCH domain-containing protein 9 (ZC3HDC9), ZC3H9, or zinc finger and G patch domain-containing protein, is a transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. It represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. It contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410455 Cd Length: 55 Bit Score: 41.83 E-value: 6.38e-05

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1720379787 1024 DFSS---EMPCLAEYADGLWYRAKIISIKEFNPLSV 1056
Cdd:cd20384      1 DFSSlkeGSRCLAKYDDGLWYPATVTDIDEDGKYTV 36

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410486 Cd Length: 96 Bit Score: 42.81 E-value: 6.52e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720379787  753 LIKMMDEI--QSNLKCLGLLEPYswkKGEPCAVRGSDTLWYRGKVMEVVGG-TIRVQYLDHGFTEKIPQCHLYPIllyPD 829
Cdd:cd20415      4 LTKKIQEFykEGDDGGLEILCPV---QGQACVALFEDGAWYRARIIGLPGHrEVEVKYVDFGNTATVTIKHVRKI---KD 77

                           90
                   ....*....|....
gi 1720379787  830 T----PQFCIPCQL 839
Cdd:cd20415     78 DflslPEKARECRL 91

second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410506 Cd Length: 134 Bit Score: 43.39 E-value: 9.66e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720379787  242 SPTDFYLQLME------------NLDFLSLLKTIEEFYKgeDGENLEILCPLQ-NQACVAKFEDGIWYRAKVIGLP---- 304
Cdd:cd20435      1 DATHYSARILEhrssdgevtksmSSTYLKLSMKLNMYYS--DPSNRILHGKVKvGDLCAVEDENNLYHRVKVLEITekdd 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1720379787  305 --GHREVEVKYVDFGNTAKITLKDMRKIKDEFLEPPEKAI 342
Cdd:cd20435     79 ktKPREVLVKFIDEGRVETVVVSQLLELPEELKSLPPQAV 118

first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410507 Cd Length: 147 Bit Score: 43.56 E-value: 9.84e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720379787  473 ICNVISPEKIYVQWlltENLLNSLEEKMVAAYE----HSEWKPVKWECDMHCAVKVPAKNQWRRGQILRmVTDKLVEVLL 548
Cdd:cd20436      5 THRVCHPKEVLVKF---QGQYNSICELDYHILQneiqNATKSKSSWGVGEFCLVEDTTSGEWYRGRVLE-KIDEKYEVFL 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1720379787  549 YDVGVELVVNIHCLRELQENLKTMGRLSLECSLVDIRPTGGsdKWTATACDCLS 602
Cdd:cd20436     81 IDRGEVLNVHATNMASASGELFQLPPKAVCGIFANILPIGE--KWSSTAVNYFS 132

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410496 Cd Length: 115 Bit Score: 42.83 E-value: 1.09e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720379787  471 VNICNVISPEKIYVQWLLTENLLNSLEEKMVAAYEHSEW--KPVKWECDMHCAVkVPAKNQWRRGQILRMVTDKLVEVLL 548
Cdd:cd20425      4 VYVSHVNSPSDFYVQLAQDEDELSMISEKLNASKANDEEveCESLQLGDLICAE-YPEDGLWYRAVVKEKIPNNLVSVQF 82

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1720379787  549 YDVGVELVVNIHCLRELQENLKTMGRLSLECSL 581
Cdd:cd20425     83 IDYGNTSVVQPSKIHRLPKELLSIPALSIHCFL 115

Tudor domain found in survival motor neuron protein (SMN), motor neuron-related-splicing factor 30 (SPF30), and similar proteins; This group contains SMN, SPF30, Tudor domain-containing protein 3 (TDRD3), DNA excision repair protein ERCC-6-like 2 (ERCC6L2), and similar proteins. SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. ERCC6L2, also called DNA repair and recombination protein RAD26-like (RAD26L), may be involved in early DNA damage response. It regulates RNA Pol II-mediated transcription via its interaction with DNA-dependent protein kinase (DNA-PK) to resolve R loops and minimize transcription-associated genome instability. Members of this group contain a single Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410549 Cd Length: 50 Bit Score: 40.70 E-value: 1.26e-04

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1720379787 1029 MPCLAEYA-DGLWYRAKIISIKEfNPLSVLVLFVDYGCTEKLTINRLRQI 1077
Cdd:cd21182      2 DKCLAPYSdDGKYYEATIEEITE-ESDTATVVFDGYGNSEEVPLSDLKPL 50

Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins; TDRD8, also called serine/threonine-protein kinase (EC 2.7.11.1) 31 (STK31), serine/threonine-protein kinase NYD-SPK, or Sugen kinase 396 (SgK396), is a germ cell-specific factor expressed in embryonic gonocytes of both sexes, and in postnatal spermatocytes and round spermatids in males. It acts as a cell-cycle regulated protein that contributes to the tumorigenicity of epithelial cancer cells. TDRD8 contains a Tudor domain and a serine/threonine kinase domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410501 [Multi-domain] Cd Length: 75 Bit Score: 41.12 E-value: 1.78e-04

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1720379787  288 AKF-EDGIWYRAKVIGLPGHREVEVKYVDFGNTAKITLKDMRKIKDEF 334
Cdd:cd20430     27 GKFsEDNCWYRCKVKSILSDEKCTVQYIDYGNTETVSRSSIVELPPDL 74

second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410506 Cd Length: 134 Bit Score: 42.62 E-value: 1.87e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720379787  725 NTSSFEA-IVTCIGDDGTIFVVPKLSEFELIKMMDEI---QSNLKCLGLLepyswKKGEPCAVRGSDTLWYRGKVMEVVG 800
Cdd:cd20435      1 DATHYSArILEHRSSDGEVTKSMSSTYLKLSMKLNMYysdPSNRILHGKV-----KVGDLCAVEDENNLYHRVKVLEITE 75

                           90       100
                   ....*....|....*....|....*....
gi 1720379787  801 -------GTIRVQYLDHGFTEKIPQCHLY 822
Cdd:cd20435     76 kddktkpREVLVKFIDEGRVETVVVSQLL 104

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410479 Cd Length: 130 Bit Score: 42.36 E-value: 1.94e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720379787  478 SPEKIYVQWLLTENL--LNSLEEKMVAAY----EHSEWKPVKWECdmhCAVKVPAKNQWRRGQIL-RMVTDKLVEVLLYD 550
Cdd:cd20408      8 NPGEFYIQIYTLEVLesLVKLTSQLKKTYasvnNHKEYIPEVGEV---CVAKYSEDQNWYRALVQtVDVQQKKAGVFYID 84

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1720379787  551 VGVELVVNIHCLRELQENLKTMGRLSLECSLVDIRPTGGSdkWTATAC 598
Cdd:cd20408     85 YGNEETVPLNRIQPLKKDIELFPPCAIKCCLANVKPPSGS--WSEECI 130

seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410513 Cd Length: 160 Bit Score: 43.10 E-value: 1.94e-04

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720379787  286 CVAKFEDGI-WYRAKVIGL-PGHREVEVKYVDFGNTAKITLKDMRKIKDEFLEPPEKAIKCKLAYVEPSKKS 355
Cdd:cd20442     56 CLAKSKKNLkWYRAVVEHLyPETEKMLVFFVDHGITEVVSMGNIKQLSNDLLQIPRQAVLCRWNWPESSKEL 127

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410482 Cd Length: 116 Bit Score: 41.66 E-value: 2.90e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720379787  731 AIVTCIGDDGTIFVVPK---LSEFELIKMMDEIQSNLKCLGLLEPYSWKKGEPCAVR-GSDTLWYRGKVMEVVGGTIRVQ 806
Cdd:cd20411      1 ALVLEVISPDLFYALPKtgqVNVEKLKALMTELAEYCSKQSVPQQFRPRIGDACCARfTGDKNWYRAVVLETSDSEVKVL 80

                           90
                   ....*....|....*...
gi 1720379787  807 YLDHGFTEKIPQCHLYPI 824
Cdd:cd20411     81 YADYGNTETLPLSRILPI 98

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410492 Cd Length: 130 Bit Score: 41.64 E-value: 4.30e-04

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720379787 1030 PCLAEYADGLWYRAKIISIKEFNPLsVLVLFVDYGCTEKLTINRLRQIPVQLMQYP 1085
Cdd:cd20421     66 PCAARGSDGRWYRAVLQQVFSANRV-VEVLHVDYGRKEVVSVSNLRYLAPEYFRMP 120

seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410513 Cd Length: 160 Bit Score: 41.95 E-value: 5.70e-04

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720379787 1029 MPCLAEYADGL-WYRAKIISIKEfNPLSVLVLFVDYGCTEKLTINRLRQIPVQLMQYPAQAI 1089
Cdd:cd20442     54 LECLAKSKKNLkWYRAVVEHLYP-ETEKMLVFFVDHGITEVVSMGNIKQLSNDLLQIPRQAV 114

seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410513 Cd Length: 160 Bit Score: 41.56 E-value: 6.26e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720379787  471 VNICNVISPEKIYVQWLLTENLLNSLEEKMV-AAYEHSEWKPVKWECDMHCAVKVPAKNQWRRGQILRMVTDKL-VEVLL 548
Cdd:cd20442      6 GTLLSVSKNGTFYVRLLRNSEQLTDLESLIAkEAKKCKFVPVEDIKEGLECLAKSKKNLKWYRAVVEHLYPETEkMLVFF 85

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1720379787  549 YDVGVELVVNIHCLRELQENLKTMGRLSLEC 579
Cdd:cd20442     86 VDHGITEVVSMGNIKQLSNDLLQIPRQAVLC 116

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410493 Cd Length: 135 Bit Score: 40.96 E-value: 6.72e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720379787  769 LLEPyswKKGEPCAVRGSDTLWYRGKVMEVVGGTIRVQYLDHGFTEKIPQCHLYPILL-YPDTPQFCIPCQLYQTLPVGN 847
Cdd:cd20422     47 VLKP---QPGQLCCAKWKEDRYYRAIVTAVKGKMVEVFLVDRGNTEMVDWYDVKKLLPqFRELPALALKCCLADICPLGE 123


                   ....*..
gi 1720379787  848 TWQPDAI 854
Cdd:cd20422    124 RWSPEAI 130

third Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410500 Cd Length: 91 Bit Score: 39.78 E-value: 7.06e-04

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720379787  493 LNSLEEKMVAAYEHSEWKPVKWECDMHCAVKVpaKNQWRRGQILRMVTDKLVEVLLYDVGVELVVNIHCLRELQE 567
Cdd:cd20429      9 LEVLMEEMILYYNKTEERPVAIEKNKVYAAKI--ENNWYRVLVKGILTNGLVSVYELDYGKHELVSIRKVQPLIE 81

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410496 Cd Length: 115 Bit Score: 40.52 E-value: 7.35e-04

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720379787  781 CAVRGSDTLWYRGKVME-VVGGTIRVQYLDHGFTEKIPQCHLY---PILLypDTPQFCIPCQL 839
Cdd:cd20425     55 CAEYPEDGLWYRAVVKEkIPNNLVSVQFIDYGNTSVVQPSKIHrlpKELL--SIPALSIHCFL 115

Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, also called Tudor and KH domain-containing protein (TDRKH), participates in the primary piwi-interacting RNA (piRNA) biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. The family also includes the TDRD2 homolog found in Drosophila melanogaster (dTDRKH), which is also called partner of PIWIs protein, or PAPI, and is involved in Zucchini-mediated piRNA 3'-end maturation. TDRD2 contains two KH domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410483 Cd Length: 95 Bit Score: 39.59 E-value: 8.52e-04

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1720379787 1037 DGLWYRAKIISIKEfnPLSVLVLFVDYGCTEKLTINRLRQIPVQLMQYPAQAI 1089
Cdd:cd20412     42 DGSWYRARVLGFLE--NGNLDLYFVDYGDSGYVPLEDLRALRSDFLSLPFQAI 92

second Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410516 Cd Length: 56 Bit Score: 38.56 E-value: 9.05e-04

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1720379787 1031 CLAEYADGlWYRAkiISIKEFNPLSVLVLFVDYGCTEKLTINRLRQIPVQLMQYP 1085
Cdd:cd20445      5 CIAKYMDK-WYRA--VCLESVGDGRPTVLFCDYGNILMARLTDIRPFPPTFATEP 56

Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally identified in the Tudor protein of Drosophila, that adopts a beta-barrel-like core structure containing four short beta-strands followed by an alpha-helical region. It binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Tudor domain-containing proteins may mediate protein-protein interactions required for various DNA-templated biological processes, such as RNA metabolism, as well as histone modification and the DNA damage response. Members of this superfamily contain one or more copies of the Tudor domain.

Pssm-ID: 410449 [Multi-domain] Cd Length: 47 Bit Score: 37.57 E-value: 1.37e-03

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1720379787  283 NQACVAKF-EDGIWYRAKVIGLPGHREVEVKYVDfGNTAKITLKDMR 328
Cdd:cd04508      1 GDRVEAKWsDDGQWYPATVVAVNDDGKYTVLFDD-GNEEEVSEDDIR 46

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410490 Cd Length: 118 Bit Score: 39.74 E-value: 1.53e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720379787  475 NVISPEKIYVQWL--LTENLLNSLEEKMVAAYE---HSEWKPVKwECDMH----CAVKVPAKNQWRRGQILRMVTDKLVE 545
Cdd:cd20419      4 YIESPSQFYVRFYskDTSEMLEDMMIEMRRCYSnehVSERYVMP-EAFIQpgqvCCVRIPEDVWWYRVIIHQVLNKQEVE 82

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1720379787  546 VLLYDVGVELVVNIHCLRELQENLKTMGRLSLECSL 581
Cdd:cd20419     83 VFYPDFGDIGTVQKSRLRFLKCCYSKLPAQAIPASL 118

sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410512 Cd Length: 108 Bit Score: 39.34 E-value: 1.60e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720379787  747 KLSEFE--LIKMMDEIQSNLKCLGLLEPYSWKKGEPCAVRGS-DTLWYRGKVMEVVGG-TIRVQYLDHGFTEKIPQCHLY 822
Cdd:cd20441      8 QLSEDEkvILQLAEELNETSEKSRENAAVKLKVGDLVAAEYDeDLALYRAVITAVLPGkSFKVEFIDYGNTAVVDKSNIY 87

                           90       100
                   ....*....|....*....|.
gi 1720379787  823 PIllyPDT----PQFCIPCQL 839
Cdd:cd20441     88 TL---QEKflslPRLSIPCSL 105

first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410507 Cd Length: 147 Bit Score: 40.10 E-value: 1.88e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720379787  750 EFELIKMMDEIQSNLKclgllEPYSWKKGEPCAVRGSDT-LWYRGKVMEVVGGTIRVQYLDHGFTEKIPQCHLYPIllyP 828
Cdd:cd20436     27 ELDYHILQNEIQNATK-----SKSSWGVGEFCLVEDTTSgEWYRGRVLEKIDEKYEVFLIDRGEVLNVHATNMASA---S 98

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1720379787  829 DT----PQFCIPCQLYQTLPVGNTWQPDAIELLQELLSKR 864
Cdd:cd20436     99 GElfqlPPKAVCGIFANILPIGEKWSSTAVNYFSSLIGSQ 138

first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410498 Cd Length: 98 Bit Score: 38.95 E-value: 1.98e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720379787  755 KMMDEIQSNLKCLGLLEPyswKKGEPCAVRGSDTLWYRGKVMEVVGGTIRVQYLDHGFTEKIPQCHLYPIllypdTPQFC 834
Cdd:cd20427      6 EMKEFYSKSSTAMCLRSP---SVGQLVAVKAEEDAWLRAQVIEVEEDKVKVYYVDHGFSEVVERSKLFKL-----NKQFY 77

Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally identified in the Tudor protein of Drosophila, that adopts a beta-barrel-like core structure containing four short beta-strands followed by an alpha-helical region. It binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Tudor domain-containing proteins may mediate protein-protein interactions required for various DNA-templated biological processes, such as RNA metabolism, as well as histone modification and the DNA damage response. Members of this superfamily contain one or more copies of the Tudor domain.

Pssm-ID: 410449 [Multi-domain] Cd Length: 47 Bit Score: 37.18 E-value: 2.26e-03

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1720379787 1031 CLAEY-ADGLWYRAKIISIKEFNplSVLVLFvDYGCTEKLTINRLR 1075
Cdd:cd04508      4 VEAKWsDDGQWYPATVVAVNDDG--KYTVLF-DDGNEEEVSEDDIR 46

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410508 Cd Length: 120 Bit Score: 38.94 E-value: 2.96e-03

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720379787  778 GEPCAVRGSDTLWYRGKVMEV-VGGTIRVQYLDHGFTEKIPQCHLYPilLYPD---TPQFCIPCQL 839
Cdd:cd20437     55 GLLCAAKGKDGQWHRGFLQQLlPPSQVKVWFIDYGNSEAVSSHSVLK--LPPDffsLPLMSFPCSL 118

first Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410515 Cd Length: 55 Bit Score: 36.90 E-value: 3.45e-03

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720379787  280 PLQNQACVAKFeDGIWYRAKVIGlPGHREVE--VKYVDFGNTAKITLKDMRKIKDEF 334
Cdd:cd20444      1 PTPGQMVIAKF-DGNHYRAIVLR-VLNPDLKilVRFVDFGNVEVMKLENLYECPEYL 55

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410508 Cd Length: 120 Bit Score: 38.55 E-value: 3.56e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720379787  996 VSWESESENLEEALQRF--NKNVETFPPLTDFSseMPCLAEYADGLWYRAKIISIkeFNPLSVLVLFVDYGCTEKLTINR 1073
Cdd:cd20437     23 LSWEPELSKLTTQMTLHyeSVSKELNPSCENFG--LLCAAKGKDGQWHRGFLQQL--LPPSQVKVWFIDYGNSEAVSSHS 98

                           90       100
                   ....*....|....*....|.
gi 1720379787 1074 LRQIPVQLMQYPAQAIKVLLA 1094
Cdd:cd20437     99 VLKLPPDFFSLPLMSFPCSLS 119

fourth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410488 Cd Length: 68 Bit Score: 36.64 E-value: 4.93e-03

                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1720379787  284 QACVAKFEDGIWYRAKVIGLPGHrEVEVKYVDFGNTAKI 322
Cdd:cd20417      5 EGCVVRGSDTLWYRGKVLEVIGG-MVRVQYVDQGYIEKI 42

first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410507 Cd Length: 147 Bit Score: 38.56 E-value: 5.35e-03

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720379787  293 GIWYRAKVIglpghREVEVKY----VDFGNTAKITLKDMRKIKDEFLEPPEKAIKCKLAYVEPSkKSQWS 358
Cdd:cd20436     61 GEWYRGRVL-----EKIDEKYevflIDRGEVLNVHATNMASASGELFQLPPKAVCGIFANILPI-GEKWS 124

Tudor domain found in Schizosaccharomyces pombe splicing factor spf30 (SpSPF30) and similar proteins; SpSPF30, also called survival of motor neuron-related-splicing factor 30, is necessary for spliceosome assembly. It contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410517 Cd Length: 56 Bit Score: 35.93 E-value: 6.46e-03

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1720379787 1031 CLAEY--ADGLWYRAKIISIKEF--NPLsVLVLFVDYGCTEKLTINRLRQI 1077
Cdd:cd20446      7 VMARWksGDGKFYPARITSITGSsiNPI-YTVKFLDYGEIDTVYLKDIRPL 56

Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins; TDRD8, also called serine/threonine-protein kinase (EC 2.7.11.1) 31 (STK31), serine/threonine-protein kinase NYD-SPK, or Sugen kinase 396 (SgK396), is a germ cell-specific factor expressed in embryonic gonocytes of both sexes, and in postnatal spermatocytes and round spermatids in males. It acts as a cell-cycle regulated protein that contributes to the tumorigenicity of epithelial cancer cells. TDRD8 contains a Tudor domain and a serine/threonine kinase domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410501 [Multi-domain] Cd Length: 75 Bit Score: 36.12 E-value: 8.79e-03

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1720379787 1037 DGLWYRAKIISIKEFNplSVLVLFVDYGCTEKLTINRLRQIPVQL 1081
Cdd:cd20430     32 DNCWYRCKVKSILSDE--KCTVQYIDYGNTETVSRSSIVELPPDL 74