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Conserved domains on  [gi|1720384927|ref|XP_030104586|]
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LETM1 domain-containing protein 1 isoform X4 [Mus musculus]

Protein Classification

LETM1/MDM38 family protein( domain architecture ID 2987)

LETM1/MDM38 family protein similar to Homo sapiens LETM1 domain-containing protein 1 that plays an essential role for mitochondrial structure and function, as well as thermogenesis of brown adipocytes

Gene Ontology:  GO:0005743|GO:0005739
TCDB:  2.A.97.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LETM1_RBD super family cl06685
LETM1-like, RBD; Members of this entry are inner mitochondrial membrane proteins which play a ...
 116-249 3.62e-38

LETM1-like, RBD; Members of this entry are inner mitochondrial membrane proteins which play a role in potassium and hydrogen ion exchange. Deletion of LETM1 is thought to be involved in the development of Wolf-Hirschhorn syndrome in humans. This entry represents the ribosome-binding domain (RBD) of LETM1/MDM38 proteins.


The actual alignment was detected with superfamily member pfam07766:

Pssm-ID: 462258 [Multi-domain]  Cd Length: 229  Bit Score: 133.38  E-value: 3.62e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720384927 116 LFANVQSGTHPAA-QDVLALRDCFSTyPLGFSQLQASQMRALSQAMLLTPYLPPPLLRQRLKSHTTVIHQLDRALAKLGI 194
Cdd:pfam07766  96 FFKKVRSGGEPPSnEEILKVAKLFKD-DLTLDNLSRPQLVALCKYMNLTPFGTDNLLRYRLRHKLLEIKRDDRAIAREGV 174

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1720384927 195 GQLTAQEVKSACYLRGLNSTHIADDRCRAWLGEWLHISCSLKEPELSLLLHNVVL 249
Cdd:pfam07766 175 DSLSLEELQSACYSRGIRPLGLSEERLREWLQQWLDLSLNLKVPSSLLLLSRAVL 229
 
Name Accession Description Interval E-value
LETM1_RBD pfam07766
LETM1-like, RBD; Members of this entry are inner mitochondrial membrane proteins which play a ...
 116-249 3.62e-38

LETM1-like, RBD; Members of this entry are inner mitochondrial membrane proteins which play a role in potassium and hydrogen ion exchange. Deletion of LETM1 is thought to be involved in the development of Wolf-Hirschhorn syndrome in humans. This entry represents the ribosome-binding domain (RBD) of LETM1/MDM38 proteins.


Pssm-ID: 462258 [Multi-domain]  Cd Length: 229  Bit Score: 133.38  E-value: 3.62e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720384927 116 LFANVQSGTHPAA-QDVLALRDCFSTyPLGFSQLQASQMRALSQAMLLTPYLPPPLLRQRLKSHTTVIHQLDRALAKLGI 194
Cdd:pfam07766  96 FFKKVRSGGEPPSnEEILKVAKLFKD-DLTLDNLSRPQLVALCKYMNLTPFGTDNLLRYRLRHKLLEIKRDDRAIAREGV 174

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1720384927 195 GQLTAQEVKSACYLRGLNSTHIADDRCRAWLGEWLHISCSLKEPELSLLLHNVVL 249
Cdd:pfam07766 175 DSLSLEELQSACYSRGIRPLGLSEERLREWLQQWLDLSLNLKVPSSLLLLSRAVL 229
 
Name Accession Description Interval E-value
LETM1_RBD pfam07766
LETM1-like, RBD; Members of this entry are inner mitochondrial membrane proteins which play a ...
 116-249 3.62e-38

LETM1-like, RBD; Members of this entry are inner mitochondrial membrane proteins which play a role in potassium and hydrogen ion exchange. Deletion of LETM1 is thought to be involved in the development of Wolf-Hirschhorn syndrome in humans. This entry represents the ribosome-binding domain (RBD) of LETM1/MDM38 proteins.


Pssm-ID: 462258 [Multi-domain]  Cd Length: 229  Bit Score: 133.38  E-value: 3.62e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720384927 116 LFANVQSGTHPAA-QDVLALRDCFSTyPLGFSQLQASQMRALSQAMLLTPYLPPPLLRQRLKSHTTVIHQLDRALAKLGI 194
Cdd:pfam07766  96 FFKKVRSGGEPPSnEEILKVAKLFKD-DLTLDNLSRPQLVALCKYMNLTPFGTDNLLRYRLRHKLLEIKRDDRAIAREGV 174

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1720384927 195 GQLTAQEVKSACYLRGLNSTHIADDRCRAWLGEWLHISCSLKEPELSLLLHNVVL 249
Cdd:pfam07766 175 DSLSLEELQSACYSRGIRPLGLSEERLREWLQQWLDLSLNLKVPSSLLLLSRAVL 229
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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