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Conserved domains on  [gi|1720389494|ref|XP_030105480|]
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KRAB-zinc finger protein isoform X2 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 12-52 2.71e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 86.76  E-value: 2.71e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1720389494  12 LLAFKDVAVEFSQEEWGCLDSAQRSLYINVMLENYNNLVSV 52
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
183-600 1.80e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.56  E-value: 1.80e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389494 183 KPHQCGKCGKCFSTSSNLTVHQRIHTGEKPYKCNL--CDKSFSQSTTLKTHQRLHTGEKPYkcRECGMSFPYLSSLKVHQ 260
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSD--LNSKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389494 261 NLHPGAKPYKCKECDksftikSTLIKHQRNHtgekPYTCNVCDRSFRQCANLKTHQRlhtgekpykckecgKAFTQSSSL 340
Cdd:COG5048   110 LSSSSSNSNDNNLLS------SHSLPPSSRD----PQLPDLLSISNLRNNPLPGNNS--------------SSVNTPQSN 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389494 341 KKHLNLHTgkkpykcEECDKSFTEKSTLTTHKRIHTGKKPYKCNICGKSFNSCTNLKTHQTLHTGEKPYKCKECGKAFPY 420
Cdd:COG5048   166 SLHPPLPA-------NSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPK 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389494 421 MSSLKIHQNLHPGEKPYKCKECDKSFTLKSSLRTHQIIHTGE-------KPYKCNICGKSFNQCTNLKTHQR--LHTGE- 490
Cdd:COG5048   239 SLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEs 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389494 491 -KPYKCKE--CGKSFHYWSSLKSHQNLHSGEKPYKCK--ECDKSFTEKST------LIKHQRIHTGKKLYKC-NICDKSF 558
Cdd:COG5048   319 lKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNneppqsLQQYKDLKNDKKSETLsNSCIRNF 398

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 1720389494 559 TWCASLKTHKKFHTGEKP--YKCRKCGKSFPQLSTLKRHQKIHE 600
Cdd:COG5048   399 KRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHT 442
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 12-52 2.71e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 86.76  E-value: 2.71e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1720389494  12 LLAFKDVAVEFSQEEWGCLDSAQRSLYINVMLENYNNLVSV 52
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
13-53 3.67e-21

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 87.26  E-value: 3.67e-21
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1720389494   13 LAFKDVAVEFSQEEWGCLDSAQRSLYINVMLENYNNLVSVE 53
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 13-51 8.55e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 76.82  E-value: 8.55e-18
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1720389494  13 LAFKDVAVEFSQEEWGCLDSAQRSLYINVMLENYNNLVS 51
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
183-600 1.80e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.56  E-value: 1.80e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389494 183 KPHQCGKCGKCFSTSSNLTVHQRIHTGEKPYKCNL--CDKSFSQSTTLKTHQRLHTGEKPYkcRECGMSFPYLSSLKVHQ 260
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSD--LNSKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389494 261 NLHPGAKPYKCKECDksftikSTLIKHQRNHtgekPYTCNVCDRSFRQCANLKTHQRlhtgekpykckecgKAFTQSSSL 340
Cdd:COG5048   110 LSSSSSNSNDNNLLS------SHSLPPSSRD----PQLPDLLSISNLRNNPLPGNNS--------------SSVNTPQSN 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389494 341 KKHLNLHTgkkpykcEECDKSFTEKSTLTTHKRIHTGKKPYKCNICGKSFNSCTNLKTHQTLHTGEKPYKCKECGKAFPY 420
Cdd:COG5048   166 SLHPPLPA-------NSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPK 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389494 421 MSSLKIHQNLHPGEKPYKCKECDKSFTLKSSLRTHQIIHTGE-------KPYKCNICGKSFNQCTNLKTHQR--LHTGE- 490
Cdd:COG5048   239 SLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEs 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389494 491 -KPYKCKE--CGKSFHYWSSLKSHQNLHSGEKPYKCK--ECDKSFTEKST------LIKHQRIHTGKKLYKC-NICDKSF 558
Cdd:COG5048   319 lKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNneppqsLQQYKDLKNDKKSETLsNSCIRNF 398

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 1720389494 559 TWCASLKTHKKFHTGEKP--YKCRKCGKSFPQLSTLKRHQKIHE 600
Cdd:COG5048   399 KRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHT 442
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 351-403 2.34e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 40.23  E-value: 2.34e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1720389494 351 KPYkCEECDKSFTEKSTLTTHKRIHTgkkpYKCNICGKSFNSCTNLKTH-QTLH 403
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
zf-H2C2_2 pfam13465
Zinc-finger double domain;
311-336 3.28e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.28e-04
                          10        20
                  ....*....|....*....|....*.
gi 1720389494 311 NLKTHQRLHTGEKPYKCKECGKAFTQ 336
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 12-52 2.71e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 86.76  E-value: 2.71e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1720389494  12 LLAFKDVAVEFSQEEWGCLDSAQRSLYINVMLENYNNLVSV 52
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
13-53 3.67e-21

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 87.26  E-value: 3.67e-21
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1720389494   13 LAFKDVAVEFSQEEWGCLDSAQRSLYINVMLENYNNLVSVE 53
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 13-51 8.55e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 76.82  E-value: 8.55e-18
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1720389494  13 LAFKDVAVEFSQEEWGCLDSAQRSLYINVMLENYNNLVS 51
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
183-600 1.80e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.56  E-value: 1.80e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389494 183 KPHQCGKCGKCFSTSSNLTVHQRIHTGEKPYKCNL--CDKSFSQSTTLKTHQRLHTGEKPYkcRECGMSFPYLSSLKVHQ 260
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSD--LNSKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389494 261 NLHPGAKPYKCKECDksftikSTLIKHQRNHtgekPYTCNVCDRSFRQCANLKTHQRlhtgekpykckecgKAFTQSSSL 340
Cdd:COG5048   110 LSSSSSNSNDNNLLS------SHSLPPSSRD----PQLPDLLSISNLRNNPLPGNNS--------------SSVNTPQSN 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389494 341 KKHLNLHTgkkpykcEECDKSFTEKSTLTTHKRIHTGKKPYKCNICGKSFNSCTNLKTHQTLHTGEKPYKCKECGKAFPY 420
Cdd:COG5048   166 SLHPPLPA-------NSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPK 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389494 421 MSSLKIHQNLHPGEKPYKCKECDKSFTLKSSLRTHQIIHTGE-------KPYKCNICGKSFNQCTNLKTHQR--LHTGE- 490
Cdd:COG5048   239 SLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEs 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389494 491 -KPYKCKE--CGKSFHYWSSLKSHQNLHSGEKPYKCK--ECDKSFTEKST------LIKHQRIHTGKKLYKC-NICDKSF 558
Cdd:COG5048   319 lKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNneppqsLQQYKDLKNDKKSETLsNSCIRNF 398

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 1720389494 559 TWCASLKTHKKFHTGEKP--YKCRKCGKSFPQLSTLKRHQKIHE 600
Cdd:COG5048   399 KRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
119-511 5.58e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.94  E-value: 5.58e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389494 119 RHRSTHTGEEPYESKHCEKTFSLRSNISQDQRLYTAKKEHRQEEydehfSSTHRLMQQINYIGEKPHQCGKCGKCFSTSS 198
Cdd:COG5048    51 RHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLN-----SKSLPLSNSKASSSSLSSSSSNSNDNNLLSS 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389494 199 NLTVHQRIHTGEKP--YKCNLCDKSFSQSTTLKTHQRLHTGEK-PYKCRECGMSFPYLSSLKVHQNLHPGAKPYKCKECD 275
Cdd:COG5048   126 HSLPPSSRDPQLPDllSISNLRNNPLPGNNSSSVNTPQSNSLHpPLPANSLSKDPSSNLSLLISSNVSTSIPSSSENSPL 205

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389494 276 KSFTIKSTLIKHQRNHTGEKPYTCNVCDRSFRQCANLKTHQRLHTGEKPYKCKECGKAFTQSSSLKKHLNLHTG------ 349
Cdd:COG5048   206 SSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDsssekg 285

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389494 350 -KKPYKCEECDKSFTEKSTLTTHKR--IHTGK--KPYKC--NICGKSFNSCTNLKTHQTLHTGEKPYKCKECGKAFPYMS 422
Cdd:COG5048   286 fSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSP 365

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389494 423 SLKI----HQNLHPGEKPYKCKECDKSFTLKSSLRTH-------QIIHTGEKPYKCNICGKSFNQCTNLKTHQRLHTGEK 491
Cdd:COG5048   366 LLNNeppqSLQQYKDLKNDKKSETLSNSCIRNFKRDSnlslhiiTHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHA 445

                         410       420
                  ....*....|....*....|
gi 1720389494 492 PYKCkECGKSFHYWSSLKSH 511
Cdd:COG5048   446 PLLC-SILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
267-634 1.72e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.40  E-value: 1.72e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389494 267 KPYKCKECDKSFTIKSTLIKHQRNHTGEKPYTCNV--CDRSFRQCANLKTHQRLHTGEKPYKC-KECGKAFTQSSSLKKH 343
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389494 344 LNLHTGKKPYKCEECDKSFTEKSTLT--THKRIHTGKKPYKCNICGKSFNSCTNLKTHQTLHTGEKPYKCKEcgkafpym 421
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLpdLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSN-------- 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389494 422 SSLKIHQNLHPGEKPYKCKECDKSFTLKSSLRTHQIIHTGEKPYKCNICGKSFNQCTNLKTHQRLHTGEKPYKCKECGKS 501
Cdd:COG5048   184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRS 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389494 502 FHYWSSLKSHQNLHSGE-------KPYKCKECDKSFTEKSTLIKHQR--IHTGKKLYKC----NICDKSFTWCASLKTHK 568
Cdd:COG5048   264 SLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGESLKPFscpySLCGKLFSRNDALKRHI 343

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389494 569 KFHTGEKPYKC--RKCGKSFPQLSTLKRHQKIHEDKGHTGEKL--------------------------------YKCND 614
Cdd:COG5048   344 LLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQQYKDLKNDKKsetlsnscirnfkrdsnlslhiithlsfrpynCKNPP 423

                         410       420
                  ....*....|....*....|
gi 1720389494 615 CDRSYSYHSSFRRHQKIHSS 634
Cdd:COG5048   424 CSKSFNRHYNLIPHKKIHTN 443
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 321-401 4.61e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.25  E-value: 4.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389494 321 GEKPYKCK--ECGKAFTQSSSLKKHLnLHTgkkpykceECDKSFTEKSTLTTHKRIHTGKKPYKCNICGKSFNSCTNLKT 398
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM-LHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ...
gi 1720389494 399 HQT 401
Cdd:COG5189   417 HRK 419
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 517-597 4.78e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.25  E-value: 4.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389494 517 GEKPYKCK--ECDKSFTEKSTLiKHQRIHTGkklykcniCDKSFTWCASLKTHKKFHTGEKPYKCRKCGKSFPQLSTLKR 594
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGL-KYHMLHGH--------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ...
gi 1720389494 595 HQK 597
Cdd:COG5189   417 HRK 419
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 405-483 1.76e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.32  E-value: 1.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389494 405 GEKPYKCK--ECGKAFPYMSSLKIHQnLHpgekpykcKECDKSFTLKSSLRTHQIIHTGEKPYKCNICGKSFNQCTNLKT 482
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM-LH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  .
gi 1720389494 483 H 483
Cdd:COG5189   417 H 417
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 351-403 2.34e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 40.23  E-value: 2.34e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1720389494 351 KPYkCEECDKSFTEKSTLTTHKRIHTgkkpYKCNICGKSFNSCTNLKTH-QTLH 403
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 519-567 2.61e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.85  E-value: 2.61e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1720389494 519 KPYkCKECDKSFTEKSTLIKHQRIHTgkklYKCNICDKSFTWCASLKTH 567
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
zf-H2C2_2 pfam13465
Zinc-finger double domain;
311-336 3.28e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.28e-04
                          10        20
                  ....*....|....*....|....*.
gi 1720389494 311 NLKTHQRLHTGEKPYKCKECGKAFTQ 336
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
479-502 7.40e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.40e-04
                          10        20
                  ....*....|....*....|....
gi 1720389494 479 NLKTHQRLHTGEKPYKCKECGKSF 502
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
350-634 7.69e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.38  E-value: 7.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389494 350 KKPYKCEECDKSFTEKSTLTTHKRIHTGKKPYKCN--ICGKSFNSCTNLKTHQTLHTGEKPYKCK--------------- 412
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsnskassssl 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389494 413 -ECGKAFPYMSSL--------KIHQNLHPGEKPYKCKECDKSFTLKSSLRTHQIIHTgEKPYKCNICGKSFNQCTNLKTH 483
Cdd:COG5048   111 sSSSSNSNDNNLLsshslppsSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSL-HPPLPANSLSKDPSSNLSLLIS 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389494 484 QRLHTGEKPYKCKECGKSFHYWSSLKSHQNLHSGEKPYKCKECDKSFTEKSTLIKHQRIHTGKKLYKCNICDKSFTWCAS 563
Cdd:COG5048   190 SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTAS 269

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720389494 564 LKTHKKFHTGE-------KPYKCRKCGKSFPQLSTLKRHQKIHEDKGHTGEKLYKC-NDCDRSYSYHSSFRRHQKIHSS 634
Cdd:COG5048   270 SQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSVNHSGESLKPFSCPySLCGKLFSRNDALKRHILLHTS 348
zf-H2C2_2 pfam13465
Zinc-finger double domain;
199-224 1.01e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.01e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720389494 199 NLTVHQRIHTGEKPYKCNLCDKSFSQ 224
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 349-427 1.72e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 1.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389494 349 GKKPYKCE--ECDKSFTEKSTLTTHKrihtgkkpyKCNICGKSFNSCTNLKTHQTLHTGEKPYKCKECGKAFPYMSSLKI 426
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  .
gi 1720389494 427 H 427
Cdd:COG5189   417 H 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
451-476 2.14e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.14e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720389494 451 SLRTHQIIHTGEKPYKCNICGKSFNQ 476
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 209-292 2.16e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 2.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389494 209 GEKPYKCNL--CDKSFSQSTTLKTHqRLHtGEKPYKCRECGMSFPylsslkvHQNLHPGAKPYKCKECDKSFTIKSTLiK 286
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYH-MLH-GHQNQKLHENPSPEK-------MNIFSAKDKPYRCEVCDKRYKNLNGL-K 415


                  ....*.
gi 1720389494 287 HQRNHT 292
Cdd:COG5189   416 YHRKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
563-586 2.55e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.55e-03
                          10        20
                  ....*....|....*....|....
gi 1720389494 563 SLKTHKKFHTGEKPYKCRKCGKSF 586
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
368-392 3.26e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.26e-03
                          10        20
                  ....*....|....*....|....*
gi 1720389494 368 LTTHKRIHTGKKPYKCNICGKSFNS 392
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 489-572 3.66e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 3.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389494 489 GEKPYKCK--ECGKSFHYWSSLKSHQnLHSgekpykckECDKSFTEKSTLIKHQRIHTGKKLYKCNICDKSFTWCASLKT 566
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM-LHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1720389494 567 HKKFHT 572
Cdd:COG5189   417 HRKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
395-418 4.34e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.34e-03
                          10        20
                  ....*....|....*....|....
gi 1720389494 395 NLKTHQTLHTGEKPYKCKECGKAF 418
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
339-363 6.24e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.24e-03
                          10        20
                  ....*....|....*....|....*
gi 1720389494 339 SLKKHLNLHTGKKPYKCEECDKSFT 363
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 435-487 6.30e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.00  E-value: 6.30e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1720389494 435 KPYkCKECDKSFTLKSSLrthqIIHTGEKPYKCNICGKSFNQCTNLKTH-QRLH 487
Cdd:cd20908     1 KPW-CYYCDREFDDEKIL----IQHQKAKHFKCHICHKKLYTAGGLAVHcLQVH 49
zf-H2C2_2 pfam13465
Zinc-finger double domain;
228-250 7.16e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.16e-03
                          10        20
                  ....*....|....*....|...
gi 1720389494 228 LKTHQRLHTGEKPYKCRECGMSF 250
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
507-531 8.80e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 8.80e-03
                          10        20
                  ....*....|....*....|....*
gi 1720389494 507 SLKSHQNLHSGEKPYKCKECDKSFT 531
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 433-511 9.84e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 38.93  E-value: 9.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389494 433 GEKPYKCK--ECDKSFTLKSSLRTHQiihtgekpyKCNICGKSFNQCTNLKTHQRLHTGEKPYKCKECGKSFHYWSSLKS 510
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  .
gi 1720389494 511 H 511
Cdd:COG5189   417 H 417
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 265-343 9.93e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 38.93  E-value: 9.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389494 265 GAKPYKCK--ECDKSFTIKSTLiKHQRNHTGEKPYTCNVCDRsfrqcanlKTHQRLHTGEKPYKCKECGKAFTQSSSLKK 342
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGL-KYHMLHGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  .
gi 1720389494 343 H 343
Cdd:COG5189   417 H 417
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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