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Conserved domains on  [gi|1720392703|ref|XP_030106228|]
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sal-like protein 3 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 294-376 3.08e-20

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


:

Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 86.07  E-value: 3.08e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720392703  294 KHKCRFCAKVFGSDSALQIHLRSHTgerpFKCNICGNRFSTKGNLKVHF-QRHKEKYPHIqMNPYPVPEYLD-NVPTCSG 371
Cdd:cd20908      1 KPWCYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHClQVHKETLTKV-PNALPGRDDPEiEIFGMEG 75


                   ....*
gi 1720392703  372 IPYGM 376
Cdd:cd20908     76 IPEGD 80
zf-H2C2_2 pfam13465
Zinc-finger double domain;
574-599 4.11e-07

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 46.98  E-value: 4.11e-07
                           10        20
                   ....*....|....*....|....*.
gi 1720392703  574 ALKMHYRTHTGERPFKCKICGRAFTT 599
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like super family cl41227
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 1003-1048 7.69e-07

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


The actual alignment was detected with superfamily member cd20908:

Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 47.94  E-value: 7.69e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1720392703 1003 CQSCGKTFSSASALQIHERTHTgekpFGCTICGRAFTTKGNLKVHM 1048
Cdd:cd20908      4 CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHC 45
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
586-1036 8.43e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 8.43e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720392703  586 RPFKCKICGRAFTTKGNLKTHFGVHRAKPPlrvqHSC--PICQKKFTNAVVLQQHIRMHMGGQIPNTPLPEGLQEAmdaD 663
Cdd:COG5048     32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKP----SQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNS---K 104

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720392703  664 LPFDEKNAETLSSFDDDIDENSMEEDSELKDTASDSSKPLLSYSGSCPPSPPSVISSIAALENQMKMIdsvmncqqlANL 743
Cdd:COG5048    105 ASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLP---------ANS 175

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720392703  744 KSVENGSGESDRLSNDSSSAVGDLESRSAGSPALSESSSSQALSPAHSNGESFRSKSPGLGHQEDPQEIPLKTERLDSPP 823
Cdd:COG5048    176 LSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSS 255

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720392703  824 PGPGNGGALDLTAGHPGrplikeeAPFSLLFLSRERGKCASTVCGVCGKPFACKSALEIHYRS--HTKE--RPFVCTV-- 897
Cdd:COG5048    256 SASESPRSSLPTASSQS-------SSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYsl 328

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720392703  898 CRRGCSTMGNLKQHLLTHklkelPSQVFDPNFTLGPSHSTPSLASSPAPTMIKMEVNGHSKAIALGEGPALPAGvqvptg 977
Cdd:COG5048    329 CGKLFSRNDALKRHILLH-----TSISPAKEKLLNSSSKFSPLLNNEPPQSLQQYKDLKNDKKSETLSNSCIRN------ 397

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1720392703  978 pqTVMSPGLAPMLAPPPRRTPKQHNCQSCGKTFSSASALQIHERTHTGEKPFGCTICGR 1036
Cdd:COG5048    398 --FKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 110-252 7.52e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.16  E-value: 7.52e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720392703  110 PGPPLKPSASAPGTASVQLQGLTPHAALQLSAGPATASAGSGstlPAAfdGPQHLSQPASGTSTPCSTSAAP--PDSGAH 187
Cdd:PHA03247  2733 PALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAA---PAA--GPPRRLTRPAVASLSESRESLPspWDPADP 2807

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720392703  188 PACSTGPAPGAVAAASSTVGNAVQPQNASTPPALGPGPLLSS---------------------------------ASNLP 234
Cdd:PHA03247  2808 PAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSlplggsvapggdvrrrppsrspaakpaaparppVRRLA 2887

                          170
                   ....*....|....*...
gi 1720392703  235 NPLLPQTSSSSVIFPNPL 252
Cdd:PHA03247  2888 RPAVSRSTESFALPPDQP 2905
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
287-595 1.72e-03

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.38  E-value: 1.72e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720392703  287 SAEDPFFKHKCRFCAKVFGSDSALQIHLRSHTGERPFKCN--ICGNRFSTKGNLKVHFQRHKEKYPH-----IQMNPYPV 359
Cdd:COG5048     26 SLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDlnsksLPLSNSKA 105

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720392703  360 PEYLDNVPTCSG----IPYGMSLPPEKPVttWLDSKPVLPTV------------------PTSVGLQLPPTVPGTHNYTD 417
Cdd:COG5048    106 SSSSLSSSSSNSndnnLLSSHSLPPSSRD--PQLPDLLSISNlrnnplpgnnsssvntpqSNSLHPPLPANSLSKDPSSN 183

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720392703  418 SPSITPVSRSPQRPSPASSECTSLSPGLNNTESGITVRPESP-----QPLLGGPSLTKAEPVSLPCTSTRTGDAPVVGGQ 492
Cdd:COG5048    184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSslpltTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRS 263

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720392703  493 VSGLPTSAATAVTDSACTSLGSPGLPAVSDQFKAQFpfgglldSMQTSETSKLQQLVENIDKKMTDPNQCVICHRVLSCQ 572
Cdd:COG5048    264 SLPTASSQSSSPNESDSSSEKGFSLPIKSKQCNISF-------SRSSPLTRHLRSVNHSGESLKPFSCPYSLCGKLFSRN 336

                          330       340
                   ....*....|....*....|...
gi 1720392703  573 SALKMHYRTHTGERPFKCKICGR 595
Cdd:COG5048    337 DALKRHILLHTSISPAKEKLLNS 359
 
Name Accession Description Interval E-value
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 294-376 3.08e-20

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 86.07  E-value: 3.08e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720392703  294 KHKCRFCAKVFGSDSALQIHLRSHTgerpFKCNICGNRFSTKGNLKVHF-QRHKEKYPHIqMNPYPVPEYLD-NVPTCSG 371
Cdd:cd20908      1 KPWCYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHClQVHKETLTKV-PNALPGRDDPEiEIFGMEG 75


                   ....*
gi 1720392703  372 IPYGM 376
Cdd:cd20908     76 IPEGD 80
zf-H2C2_2 pfam13465
Zinc-finger double domain;
574-599 4.11e-07

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 46.98  E-value: 4.11e-07
                           10        20
                   ....*....|....*....|....*.
gi 1720392703  574 ALKMHYRTHTGERPFKCKICGRAFTT 599
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 1003-1048 7.69e-07

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 47.94  E-value: 7.69e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1720392703 1003 CQSCGKTFSSASALQIHERTHTgekpFGCTICGRAFTTKGNLKVHM 1048
Cdd:cd20908      4 CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHC 45
zf-H2C2_2 pfam13465
Zinc-finger double domain;
309-334 2.72e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 44.67  E-value: 2.72e-06
                           10        20
                   ....*....|....*....|....*.
gi 1720392703  309 ALQIHLRSHTGERPFKCNICGNRFST 334
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
586-1036 8.43e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 8.43e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720392703  586 RPFKCKICGRAFTTKGNLKTHFGVHRAKPPlrvqHSC--PICQKKFTNAVVLQQHIRMHMGGQIPNTPLPEGLQEAmdaD 663
Cdd:COG5048     32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKP----SQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNS---K 104

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720392703  664 LPFDEKNAETLSSFDDDIDENSMEEDSELKDTASDSSKPLLSYSGSCPPSPPSVISSIAALENQMKMIdsvmncqqlANL 743
Cdd:COG5048    105 ASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLP---------ANS 175

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720392703  744 KSVENGSGESDRLSNDSSSAVGDLESRSAGSPALSESSSSQALSPAHSNGESFRSKSPGLGHQEDPQEIPLKTERLDSPP 823
Cdd:COG5048    176 LSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSS 255

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720392703  824 PGPGNGGALDLTAGHPGrplikeeAPFSLLFLSRERGKCASTVCGVCGKPFACKSALEIHYRS--HTKE--RPFVCTV-- 897
Cdd:COG5048    256 SASESPRSSLPTASSQS-------SSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYsl 328

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720392703  898 CRRGCSTMGNLKQHLLTHklkelPSQVFDPNFTLGPSHSTPSLASSPAPTMIKMEVNGHSKAIALGEGPALPAGvqvptg 977
Cdd:COG5048    329 CGKLFSRNDALKRHILLH-----TSISPAKEKLLNSSSKFSPLLNNEPPQSLQQYKDLKNDKKSETLSNSCIRN------ 397

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1720392703  978 pqTVMSPGLAPMLAPPPRRTPKQHNCQSCGKTFSSASALQIHERTHTGEKPFGCTICGR 1036
Cdd:COG5048    398 --FKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 562-624 8.93e-05

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 42.16  E-value: 8.93e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720392703  562 CVICHRVLSCQSALKMHYRTHTgerpFKCKICGRAFTTKGNLKTHF-GVHRAKPPlRVQHSCPI 624
Cdd:cd20908      4 CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHClQVHKETLT-KVPNALPG 62
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 1031-1051 1.29e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 39.98  E-value: 1.29e-04
                           10        20
                   ....*....|....*....|.
gi 1720392703 1031 CTICGRAFTTKGNLKVHMGTH 1051
Cdd:pfam00096    3 CPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 620-642 5.60e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.05  E-value: 5.60e-04
                           10        20
                   ....*....|....*....|...
gi 1720392703  620 HSCPICQKKFTNAVVLQQHIRMH 642
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
PHA03247 PHA03247
large tegument protein UL36; Provisional
 110-252 7.52e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.16  E-value: 7.52e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720392703  110 PGPPLKPSASAPGTASVQLQGLTPHAALQLSAGPATASAGSGstlPAAfdGPQHLSQPASGTSTPCSTSAAP--PDSGAH 187
Cdd:PHA03247  2733 PALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAA---PAA--GPPRRLTRPAVASLSESRESLPspWDPADP 2807

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720392703  188 PACSTGPAPGAVAAASSTVGNAVQPQNASTPPALGPGPLLSS---------------------------------ASNLP 234
Cdd:PHA03247  2808 PAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSlplggsvapggdvrrrppsrspaakpaaparppVRRLA 2887

                          170
                   ....*....|....*...
gi 1720392703  235 NPLLPQTSSSSVIFPNPL 252
Cdd:PHA03247  2888 RPAVSRSTESFALPPDQP 2905
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
287-595 1.72e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.38  E-value: 1.72e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720392703  287 SAEDPFFKHKCRFCAKVFGSDSALQIHLRSHTGERPFKCN--ICGNRFSTKGNLKVHFQRHKEKYPH-----IQMNPYPV 359
Cdd:COG5048     26 SLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDlnsksLPLSNSKA 105

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720392703  360 PEYLDNVPTCSG----IPYGMSLPPEKPVttWLDSKPVLPTV------------------PTSVGLQLPPTVPGTHNYTD 417
Cdd:COG5048    106 SSSSLSSSSSNSndnnLLSSHSLPPSSRD--PQLPDLLSISNlrnnplpgnnsssvntpqSNSLHPPLPANSLSKDPSSN 183

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720392703  418 SPSITPVSRSPQRPSPASSECTSLSPGLNNTESGITVRPESP-----QPLLGGPSLTKAEPVSLPCTSTRTGDAPVVGGQ 492
Cdd:COG5048    184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSslpltTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRS 263

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720392703  493 VSGLPTSAATAVTDSACTSLGSPGLPAVSDQFKAQFpfgglldSMQTSETSKLQQLVENIDKKMTDPNQCVICHRVLSCQ 572
Cdd:COG5048    264 SLPTASSQSSSPNESDSSSEKGFSLPIKSKQCNISF-------SRSSPLTRHLRSVNHSGESLKPFSCPYSLCGKLFSRN 336

                          330       340
                   ....*....|....*....|...
gi 1720392703  573 SALKMHYRTHTGERPFKCKICGR 595
Cdd:COG5048    337 DALKRHILLHTSISPAKEKLLNS 359
ZnF_C2H2 smart00355
zinc finger;
620-642 1.84e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 36.67  E-value: 1.84e-03
                            10        20
                    ....*....|....*....|...
gi 1720392703   620 HSCPICQKKFTNAVVLQQHIRMH 642
Cdd:smart00355    1 YRCPECGKVFKSKSALREHMRTH 23
ZnF_C2H2 smart00355
zinc finger;
295-317 6.10e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 35.13  E-value: 6.10e-03
                            10        20
                    ....*....|....*....|...
gi 1720392703   295 HKCRFCAKVFGSDSALQIHLRSH 317
Cdd:smart00355    1 YRCPECGKVFKSKSALREHMRTH 23
ZnF_C2H2 smart00355
zinc finger;
1001-1023 8.27e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 34.75  E-value: 8.27e-03
                            10        20
                    ....*....|....*....|...
gi 1720392703  1001 HNCQSCGKTFSSASALQIHERTH 1023
Cdd:smart00355    1 YRCPECGKVFKSKSALREHMRTH 23
 
Name Accession Description Interval E-value
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 294-376 3.08e-20

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 86.07  E-value: 3.08e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720392703  294 KHKCRFCAKVFGSDSALQIHLRSHTgerpFKCNICGNRFSTKGNLKVHF-QRHKEKYPHIqMNPYPVPEYLD-NVPTCSG 371
Cdd:cd20908      1 KPWCYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHClQVHKETLTKV-PNALPGRDDPEiEIFGMEG 75


                   ....*
gi 1720392703  372 IPYGM 376
Cdd:cd20908     76 IPEGD 80
zf-H2C2_2 pfam13465
Zinc-finger double domain;
574-599 4.11e-07

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 46.98  E-value: 4.11e-07
                           10        20
                   ....*....|....*....|....*.
gi 1720392703  574 ALKMHYRTHTGERPFKCKICGRAFTT 599
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 1003-1048 7.69e-07

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 47.94  E-value: 7.69e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1720392703 1003 CQSCGKTFSSASALQIHERTHTgekpFGCTICGRAFTTKGNLKVHM 1048
Cdd:cd20908      4 CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHC 45
zf-H2C2_2 pfam13465
Zinc-finger double domain;
309-334 2.72e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 44.67  E-value: 2.72e-06
                           10        20
                   ....*....|....*....|....*.
gi 1720392703  309 ALQIHLRSHTGERPFKCNICGNRFST 334
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
586-1036 8.43e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 8.43e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720392703  586 RPFKCKICGRAFTTKGNLKTHFGVHRAKPPlrvqHSC--PICQKKFTNAVVLQQHIRMHMGGQIPNTPLPEGLQEAmdaD 663
Cdd:COG5048     32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKP----SQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNS---K 104

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720392703  664 LPFDEKNAETLSSFDDDIDENSMEEDSELKDTASDSSKPLLSYSGSCPPSPPSVISSIAALENQMKMIdsvmncqqlANL 743
Cdd:COG5048    105 ASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLP---------ANS 175

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720392703  744 KSVENGSGESDRLSNDSSSAVGDLESRSAGSPALSESSSSQALSPAHSNGESFRSKSPGLGHQEDPQEIPLKTERLDSPP 823
Cdd:COG5048    176 LSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSS 255

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720392703  824 PGPGNGGALDLTAGHPGrplikeeAPFSLLFLSRERGKCASTVCGVCGKPFACKSALEIHYRS--HTKE--RPFVCTV-- 897
Cdd:COG5048    256 SASESPRSSLPTASSQS-------SSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYsl 328

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720392703  898 CRRGCSTMGNLKQHLLTHklkelPSQVFDPNFTLGPSHSTPSLASSPAPTMIKMEVNGHSKAIALGEGPALPAGvqvptg 977
Cdd:COG5048    329 CGKLFSRNDALKRHILLH-----TSISPAKEKLLNSSSKFSPLLNNEPPQSLQQYKDLKNDKKSETLSNSCIRN------ 397

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1720392703  978 pqTVMSPGLAPMLAPPPRRTPKQHNCQSCGKTFSSASALQIHERTHTGEKPFGCTICGR 1036
Cdd:COG5048    398 --FKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 562-624 8.93e-05

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 42.16  E-value: 8.93e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720392703  562 CVICHRVLSCQSALKMHYRTHTgerpFKCKICGRAFTTKGNLKTHF-GVHRAKPPlRVQHSCPI 624
Cdd:cd20908      4 CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHClQVHKETLT-KVPNALPG 62
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 1031-1051 1.29e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 39.98  E-value: 1.29e-04
                           10        20
                   ....*....|....*....|.
gi 1720392703 1031 CTICGRAFTTKGNLKVHMGTH 1051
Cdd:pfam00096    3 CPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 588-610 1.30e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 39.98  E-value: 1.30e-04
                           10        20
                   ....*....|....*....|...
gi 1720392703  588 FKCKICGRAFTTKGNLKTHFGVH 610
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 323-345 2.25e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 39.21  E-value: 2.25e-04
                           10        20
                   ....*....|....*....|...
gi 1720392703  323 FKCNICGNRFSTKGNLKVHFQRH 345
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 1001-1023 4.61e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.44  E-value: 4.61e-04
                           10        20
                   ....*....|....*....|...
gi 1720392703 1001 HNCQSCGKTFSSASALQIHERTH 1023
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 620-642 5.60e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.05  E-value: 5.60e-04
                           10        20
                   ....*....|....*....|...
gi 1720392703  620 HSCPICQKKFTNAVVLQQHIRMH 642
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
PHA03247 PHA03247
large tegument protein UL36; Provisional
 110-252 7.52e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.16  E-value: 7.52e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720392703  110 PGPPLKPSASAPGTASVQLQGLTPHAALQLSAGPATASAGSGstlPAAfdGPQHLSQPASGTSTPCSTSAAP--PDSGAH 187
Cdd:PHA03247  2733 PALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAA---PAA--GPPRRLTRPAVASLSESRESLPspWDPADP 2807

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720392703  188 PACSTGPAPGAVAAASSTVGNAVQPQNASTPPALGPGPLLSS---------------------------------ASNLP 234
Cdd:PHA03247  2808 PAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSlplggsvapggdvrrrppsrspaakpaaparppVRRLA 2887

                          170
                   ....*....|....*...
gi 1720392703  235 NPLLPQTSSSSVIFPNPL 252
Cdd:PHA03247  2888 RPAVSRSTESFALPPDQP 2905
PHA03247 PHA03247
large tegument protein UL36; Provisional
 110-524 1.60e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.00  E-value: 1.60e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720392703  110 PGPPLKPSASAPGTAsvqlQGLTPHAALQLSAGPATASAGSGSTLPAAFDGPQHLSQPASGTSTPCSTSAAPPDSGA--- 186
Cdd:PHA03247  2551 PPPPLPPAAPPAAPD----RSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHApdp 2626

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720392703  187 HPACSTGPAPGAVAAASSTVGNAVQPQNASTPPALGPGPLLSSASNLPNPLLPQTSSSSVIFPNPLVSIAATANALDPls 266
Cdd:PHA03247  2627 PPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPP-- 2704

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720392703  267 almkhrkGKPPnvsvfEPKASAEDPffkhkcrfcakvfgsdsALQIHLRSHTGERPFkcnicgnrfstkgnlkvhfqrhk 346
Cdd:PHA03247  2705 -------PPTP-----EPAPHALVS-----------------ATPLPPGPAAARQAS----------------------- 2732

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720392703  347 ekyPHIQMNPYPVPeyldnVPTCSGIPYGMSLPPEKPVTtwldSKPVLPTVPTSVGLQLPPTVPGTHNYTDSPSiTPVSR 426
Cdd:PHA03247  2733 ---PALPAAPAPPA-----VPAGPATPGGPARPARPPTT----AGPPAPAPPAAPAAGPPRRLTRPAVASLSES-RESLP 2799

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720392703  427 SPQRPSPASSECTSLSPGLNNTESGITVRPESPQPLLGGPSLTKAEPVslpcTSTRTGDAPVVGGQVSGLPTSAATAVTD 506
Cdd:PHA03247  2800 SPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPP----PSLPLGGSVAPGGDVRRRPPSRSPAAKP 2875

                          410       420
                   ....*....|....*....|...
gi 1720392703  507 SACT-----SLGSPGLPAVSDQF 524
Cdd:PHA03247  2876 AAPArppvrRLARPAVSRSTESF 2898
zf-C2HE pfam16278
C2HE / C2H2 / C2HC zinc-binding finger; zf-C2HE is an unusual zinc-binding domain found in ...
 889-915 1.63e-03

C2HE / C2H2 / C2HC zinc-binding finger; zf-C2HE is an unusual zinc-binding domain found in fungi, plants and metazoa. It is often found at the C-terminus of HIT-domain-containing proteins, pfam01230. In fungi the fourth ligand is a Glu, in plants it is Cys and in metazoans it is usually a His. The fourth ligand is often mutated in neurogenerative disease-states.


Pssm-ID: 465082  Cd Length: 60  Bit Score: 38.04  E-value: 1.63e-03
                           10        20
                   ....*....|....*....|....*..
gi 1720392703  889 KERPFVCTVCRRGCSTMGNLKQHLLTH 915
Cdd:pfam16278   31 LKTPLKCHRCGNFGNNFPKLKAHLEEH 57
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
287-595 1.72e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.38  E-value: 1.72e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720392703  287 SAEDPFFKHKCRFCAKVFGSDSALQIHLRSHTGERPFKCN--ICGNRFSTKGNLKVHFQRHKEKYPH-----IQMNPYPV 359
Cdd:COG5048     26 SLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDlnsksLPLSNSKA 105

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720392703  360 PEYLDNVPTCSG----IPYGMSLPPEKPVttWLDSKPVLPTV------------------PTSVGLQLPPTVPGTHNYTD 417
Cdd:COG5048    106 SSSSLSSSSSNSndnnLLSSHSLPPSSRD--PQLPDLLSISNlrnnplpgnnsssvntpqSNSLHPPLPANSLSKDPSSN 183

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720392703  418 SPSITPVSRSPQRPSPASSECTSLSPGLNNTESGITVRPESP-----QPLLGGPSLTKAEPVSLPCTSTRTGDAPVVGGQ 492
Cdd:COG5048    184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSslpltTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRS 263

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720392703  493 VSGLPTSAATAVTDSACTSLGSPGLPAVSDQFKAQFpfgglldSMQTSETSKLQQLVENIDKKMTDPNQCVICHRVLSCQ 572
Cdd:COG5048    264 SLPTASSQSSSPNESDSSSEKGFSLPIKSKQCNISF-------SRSSPLTRHLRSVNHSGESLKPFSCPYSLCGKLFSRN 336

                          330       340
                   ....*....|....*....|...
gi 1720392703  573 SALKMHYRTHTGERPFKCKICGR 595
Cdd:COG5048    337 DALKRHILLHTSISPAKEKLLNS 359
ZnF_C2H2 smart00355
zinc finger;
620-642 1.84e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 36.67  E-value: 1.84e-03
                            10        20
                    ....*....|....*....|...
gi 1720392703   620 HSCPICQKKFTNAVVLQQHIRMH 642
Cdd:smart00355    1 YRCPECGKVFKSKSALREHMRTH 23
zf-C2H2_4 pfam13894
C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.
 323-345 2.12e-03

C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.


Pssm-ID: 464025  Cd Length: 24  Bit Score: 36.47  E-value: 2.12e-03
                           10        20
                   ....*....|....*....|...
gi 1720392703  323 FKCNICGNRFSTKGNLKVHFQRH 345
Cdd:pfam13894    1 FKCPICGKSFSSKKSLKRHLKTH 23
PHA03247 PHA03247
large tegument protein UL36; Provisional
 108-519 3.04e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 3.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720392703  108 RQPGPPLKPSASAPGTASVQLQGLTPHAALQLSAGPATASAGSGSTL---PAAFDGPQHLSQPASGTSTPCSTSAAPPDS 184
Cdd:PHA03247  2576 RPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHapdPPPPSPSPAANEPDPHPPPTVPPPERPRDD 2655

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720392703  185 GAHPACSTGPAPGAVAAASStvgnAVQPQNASTPPALGP--GPLLSSASNLP---------------NPLLPQTSSSSVI 247
Cdd:PHA03247  2656 PAPGRVSRPRRARRLGRAAQ----ASSPPQRPRRRAARPtvGSLTSLADPPPppptpepaphalvsaTPLPPGPAAARQA 2731

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720392703  248 FPNPLVSIAATANALDPLSALMKHRKGKPPNVSVFEPKASAEDPFFKHKCRFCAKVFGSDSALQIHLRSHTGERPFKCNI 327
Cdd:PHA03247  2732 SPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAV 2811

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720392703  328 CGNRFSTkgnlkvhfqrhkekyPHIQMNPYPVPEYLDNVPTCSGIPYGMSLPPEKPVTTWLDSKPVLPTVPTsvglQLPP 407
Cdd:PHA03247  2812 LAPAAAL---------------PPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPS----RSPA 2872

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720392703  408 TVPGThnytdsPSITPVSRSPQRPSPASSECTSLSpglnntesgitvrPESPQPLLGGPSLTKAEPVSLPCTSTRTGDAP 487
Cdd:PHA03247  2873 AKPAA------PARPPVRRLARPAVSRSTESFALP-------------PDQPERPPQPQAPPPPQPQPQPPPPPQPQPPP 2933

                          410       420       430
                   ....*....|....*....|....*....|..
gi 1720392703  488 vvggQVSGLPTSAATAVTDSACTSLGSPGLPA 519
Cdd:PHA03247  2934 ----PPPPRPQPPLAPTTDPAGAGEPSGAVPQ 2961
zf-C2H2_jaz pfam12171
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ...
 1000-1023 5.31e-03

Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.


Pssm-ID: 432381 [Multi-domain]  Cd Length: 27  Bit Score: 35.61  E-value: 5.31e-03
                           10        20
                   ....*....|....*....|....
gi 1720392703 1000 QHNCQSCGKTFSSASALQIHERTH 1023
Cdd:pfam12171    1 QFYCVLCDKYFKSENALQNHLKSK 24
zf-C2H2_4 pfam13894
C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.
 588-610 5.40e-03

C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.


Pssm-ID: 464025  Cd Length: 24  Bit Score: 35.31  E-value: 5.40e-03
                           10        20
                   ....*....|....*....|...
gi 1720392703  588 FKCKICGRAFTTKGNLKTHFGVH 610
Cdd:pfam13894    1 FKCPICGKSFSSKKSLKRHLKTH 23
ZnF_C2H2 smart00355
zinc finger;
295-317 6.10e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 35.13  E-value: 6.10e-03
                            10        20
                    ....*....|....*....|...
gi 1720392703   295 HKCRFCAKVFGSDSALQIHLRSH 317
Cdd:smart00355    1 YRCPECGKVFKSKSALREHMRTH 23
ZnF_C2H2 smart00355
zinc finger;
323-345 7.79e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 35.13  E-value: 7.79e-03
                            10        20
                    ....*....|....*....|...
gi 1720392703   323 FKCNICGNRFSTKGNLKVHFQRH 345
Cdd:smart00355    1 YRCPECGKVFKSKSALREHMRTH 23
ZnF_C2H2 smart00355
zinc finger;
1001-1023 8.27e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 34.75  E-value: 8.27e-03
                            10        20
                    ....*....|....*....|...
gi 1720392703  1001 HNCQSCGKTFSSASALQIHERTH 1023
Cdd:smart00355    1 YRCPECGKVFKSKSALREHMRTH 23
zf-C2H2_jaz pfam12171
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ...
 619-640 8.69e-03

Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.


Pssm-ID: 432381 [Multi-domain]  Cd Length: 27  Bit Score: 34.84  E-value: 8.69e-03
                           10        20
                   ....*....|....*....|..
gi 1720392703  619 QHSCPICQKKFTNAVVLQQHIR 640
Cdd:pfam12171    1 QFYCVLCDKYFKSENALQNHLK 22
zf-C2H2_4 pfam13894
C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.
 1029-1051 8.82e-03

C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.


Pssm-ID: 464025  Cd Length: 24  Bit Score: 34.93  E-value: 8.82e-03
                           10        20
                   ....*....|....*....|...
gi 1720392703 1029 FGCTICGRAFTTKGNLKVHMGTH 1051
Cdd:pfam13894    1 FKCPICGKSFSSKKSLKRHLKTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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