putative Polycomb group protein ASXL3 isoform X4 [Mus musculus]
ASXH and PHD_3 domain-containing protein( domain architecture ID 10621621)
ASXH and PHD_3 domain-containing protein
List of domain hits
Name | Accession | Description | Interval | E-value | |||
ASXH | pfam13919 | Asx homology domain; A conserved alpha helical domain with a characteriztic LXXLL motif. The ... |
179-304 | 4.55e-39 | |||
Asx homology domain; A conserved alpha helical domain with a characteriztic LXXLL motif. The LXXLL motif is detected in diverse transcription factors, coactivators and corepressors and is implicated in mediating interactions between them. The ASXH domain is found in animals, fungi and plants and is predicted to play a role in mediating contact between transcription factors and chromatin-associated complexes. In Drosophila Asx and Human ASXL1, the ASXH domain is predicted to mediate interactions with the Calypso and BAP1 deubiquitinases (DUBs) which further belong to the UCHL5/UCH37 clade of DUBs. : Pssm-ID: 464041 Cd Length: 129 Bit Score: 142.43 E-value: 4.55e-39
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PHD_3 super family | cl16478 | PHD domain of transcriptional enhancer, Asx; This is the DNA-binding domain on the additional ... |
2147-2202 | 1.92e-19 | |||
PHD domain of transcriptional enhancer, Asx; This is the DNA-binding domain on the additional sex combs-like 1 proteins. The Asx protein acts as an enhancer of trithorax and polycomb in displaying bidirectional homoeotic phenotypes in Drosophila, suggesting that it is required for maintenance of both activation and silencing of Hox genes. Asx is required for normal adult haematopoiesis and its function depends on its cellular context. The actual alignment was detected with superfamily member pfam13922: Pssm-ID: 316444 Cd Length: 68 Bit Score: 84.18 E-value: 1.92e-19
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Name | Accession | Description | Interval | E-value | |||
ASXH | pfam13919 | Asx homology domain; A conserved alpha helical domain with a characteriztic LXXLL motif. The ... |
179-304 | 4.55e-39 | |||
Asx homology domain; A conserved alpha helical domain with a characteriztic LXXLL motif. The LXXLL motif is detected in diverse transcription factors, coactivators and corepressors and is implicated in mediating interactions between them. The ASXH domain is found in animals, fungi and plants and is predicted to play a role in mediating contact between transcription factors and chromatin-associated complexes. In Drosophila Asx and Human ASXL1, the ASXH domain is predicted to mediate interactions with the Calypso and BAP1 deubiquitinases (DUBs) which further belong to the UCHL5/UCH37 clade of DUBs. Pssm-ID: 464041 Cd Length: 129 Bit Score: 142.43 E-value: 4.55e-39
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PHD_3 | pfam13922 | PHD domain of transcriptional enhancer, Asx; This is the DNA-binding domain on the additional ... |
2147-2202 | 1.92e-19 | |||
PHD domain of transcriptional enhancer, Asx; This is the DNA-binding domain on the additional sex combs-like 1 proteins. The Asx protein acts as an enhancer of trithorax and polycomb in displaying bidirectional homoeotic phenotypes in Drosophila, suggesting that it is required for maintenance of both activation and silencing of Hox genes. Asx is required for normal adult haematopoiesis and its function depends on its cellular context. Pssm-ID: 316444 Cd Length: 68 Bit Score: 84.18 E-value: 1.92e-19
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Name | Accession | Description | Interval | E-value | |||
ASXH | pfam13919 | Asx homology domain; A conserved alpha helical domain with a characteriztic LXXLL motif. The ... |
179-304 | 4.55e-39 | |||
Asx homology domain; A conserved alpha helical domain with a characteriztic LXXLL motif. The LXXLL motif is detected in diverse transcription factors, coactivators and corepressors and is implicated in mediating interactions between them. The ASXH domain is found in animals, fungi and plants and is predicted to play a role in mediating contact between transcription factors and chromatin-associated complexes. In Drosophila Asx and Human ASXL1, the ASXH domain is predicted to mediate interactions with the Calypso and BAP1 deubiquitinases (DUBs) which further belong to the UCHL5/UCH37 clade of DUBs. Pssm-ID: 464041 Cd Length: 129 Bit Score: 142.43 E-value: 4.55e-39
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PHD_3 | pfam13922 | PHD domain of transcriptional enhancer, Asx; This is the DNA-binding domain on the additional ... |
2147-2202 | 1.92e-19 | |||
PHD domain of transcriptional enhancer, Asx; This is the DNA-binding domain on the additional sex combs-like 1 proteins. The Asx protein acts as an enhancer of trithorax and polycomb in displaying bidirectional homoeotic phenotypes in Drosophila, suggesting that it is required for maintenance of both activation and silencing of Hox genes. Asx is required for normal adult haematopoiesis and its function depends on its cellular context. Pssm-ID: 316444 Cd Length: 68 Bit Score: 84.18 E-value: 1.92e-19
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Blast search parameters | ||||
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