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Conserved domains on  [gi|1720399599|ref|XP_030107629|]
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ankyrin repeat domain-containing protein 16 isoform X4 [Mus musculus]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1-154 3.34e-27

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 103.88  E-value: 3.34e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399599   1 MHGCLEAVQVLLERcHYEPDCRDNCGVTPFMDAIQCGHVSIAKLLLEqHKACSSAADSMGAQALHRAAVTGQDEAIRFLV 80
Cdd:COG0666    96 RNGDLEIVKLLLEA-GADVNARDKDGETPLHLAAYNGNLEIVKLLLE-AGADVNAQDNDGNTPLHLAAANGNLEIVKLLL 173

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720399599  81 cGLGIDVDVRAKSSQlTALHYAAKEGQTNTVQTLLSLGADINSTDERNRSVLHLACAGQHVACTRLLLQSGLKD 154
Cdd:COG0666   174 -EAGADVNARDNDGE-TPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADL 245
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1-154 3.34e-27

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 103.88  E-value: 3.34e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399599   1 MHGCLEAVQVLLERcHYEPDCRDNCGVTPFMDAIQCGHVSIAKLLLEqHKACSSAADSMGAQALHRAAVTGQDEAIRFLV 80
Cdd:COG0666    96 RNGDLEIVKLLLEA-GADVNARDKDGETPLHLAAYNGNLEIVKLLLE-AGADVNAQDNDGNTPLHLAAANGNLEIVKLLL 173

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720399599  81 cGLGIDVDVRAKSSQlTALHYAAKEGQTNTVQTLLSLGADINSTDERNRSVLHLACAGQHVACTRLLLQSGLKD 154
Cdd:COG0666   174 -EAGADVNARDNDGE-TPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADL 245
Ank_2 pfam12796
Ankyrin repeats (3 copies);
30-125 1.92e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 73.23  E-value: 1.92e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399599  30 FMDAIQCGHVSIAKLLLEQHKACSSAaDSMGAQALHRAAVTGQDEAIRFLVCGlgidVDVRAKSSQLTALHYAAKEGQTN 109
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQ-DKNGRTALHLAAKNGHLEIVKLLLEH----ADVNLKDNGRTALHYAARSGHLE 75

                          90
                  ....*....|....*.
gi 1720399599 110 TVQTLLSLGADINSTD 125
Cdd:pfam12796  76 IVKLLLEKGADINVKD 91
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 3-151 8.11e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 53.81  E-value: 8.11e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399599   3 GCLEAVQVLLERchyepdcRDNC-------GVTPFMDAIQCGHVSIAKLLLeQHKACSSAADSMGAQALHRAAVTGQDEA 75
Cdd:PHA02874   12 GDIEAIEKIIKN-------KGNCinisvdeTTTPLIDAIRSGDAKIVELFI-KHGADINHINTKIPHPLLTAIKIGAHDI 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399599  76 IRFL----------------------VCGLGIDVDVRAKSSQlTALHYAAKEGQTNTVQTLLSLGADINSTDERNRSVLH 133
Cdd:PHA02874   84 IKLLidngvdtsilpipciekdmiktILDCGIDVNIKDAELK-TFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIH 162

                         170
                  ....*....|....*...
gi 1720399599 134 LACAGQHVACTRLLLQSG 151
Cdd:PHA02874  163 IAIKHNFFDIIKLLLEKG 180
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 97-122 2.70e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.80  E-value: 2.70e-04
                           10        20
                   ....*....|....*....|....*.
gi 1720399599   97 TALHYAAKEGQTNTVQTLLSLGADIN 122
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADIN 29
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 28-151 3.53e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 40.38  E-value: 3.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399599  28 TPFMDAIQCGHVSIAKLLLEQHKACSSAADSMGAQALHRAAVTGQDEAIRFLvcglgIDVDVR----AKSSQL----TAL 99
Cdd:cd22192    19 SPLLLAAKENDVQAIKKLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVL-----MEAAPElvnePMTSDLyqgeTAL 93

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720399599 100 HYAAKEGQTNTVQTLLSLGADINST-------DERNRSVLHLacaGQHV----ACT------RLLLQSG 151
Cdd:cd22192    94 HIAVVNQNLNLVRELIARGADVVSPratgtffRPGPKNLIYY---GEHPlsfaACVgneeivRLLIEHG 159
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1-154 3.34e-27

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 103.88  E-value: 3.34e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399599   1 MHGCLEAVQVLLERcHYEPDCRDNCGVTPFMDAIQCGHVSIAKLLLEqHKACSSAADSMGAQALHRAAVTGQDEAIRFLV 80
Cdd:COG0666    96 RNGDLEIVKLLLEA-GADVNARDKDGETPLHLAAYNGNLEIVKLLLE-AGADVNAQDNDGNTPLHLAAANGNLEIVKLLL 173

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720399599  81 cGLGIDVDVRAKSSQlTALHYAAKEGQTNTVQTLLSLGADINSTDERNRSVLHLACAGQHVACTRLLLQSGLKD 154
Cdd:COG0666   174 -EAGADVNARDNDGE-TPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADL 245
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
5-159 2.47e-25

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 98.87  E-value: 2.47e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399599   5 LEAVQVLLERCHYEPDCRDNCGVTPFMDAIQCGHVSIAKLLLEqHKACSSAADSMGAQALHRAAVTGQDEAIRFLVcGLG 84
Cdd:COG0666    66 DLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLE-AGADVNARDKDGETPLHLAAYNGNLEIVKLLL-EAG 143

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720399599  85 IDVDVRAKSSQlTALHYAAKEGQTNTVQTLLSLGADINSTDERNRSVLHLACAGQHVACTRLLLQSG----LKDSEDLT 159
Cdd:COG0666   144 ADVNAQDNDGN-TPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGadvnAKDNDGKT 221
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1-158 4.13e-22

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 90.40  E-value: 4.13e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399599   1 MHGCLEAVQVLLERcHYEPDCRDNCGVTPFMDAIQCGHVSIAKLLLEqHKACSSAADSMGAQALHRAAVTGQDEAIRFLV 80
Cdd:COG0666   129 YNGNLEIVKLLLEA-GADVNAQDNDGNTPLHLAAANGNLEIVKLLLE-AGADVNARDNDGETPLHLAAENGHLEIVKLLL 206

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720399599  81 cGLGIDVDVRAKSsQLTALHYAAKEGQTNTVQTLLSLGADINSTDERNRSVLHLACAGQHVACTRLLLQSGLKDSEDL 158
Cdd:COG0666   207 -EAGADVNAKDND-GKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAAL 282
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
28-151 5.04e-20

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 84.62  E-value: 5.04e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399599  28 TPFMDAIQCGHVSIAKLLLEQHKACSSAADSMGAQALHRAAVTGQDEAIRFLVcGLGIDVDVRAKSSQlTALHYAAKEGQ 107
Cdd:COG0666    55 ALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLL-EAGADVNARDKDGE-TPLHLAAYNGN 132

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1720399599 108 TNTVQTLLSLGADINSTDERNRSVLHLACAGQHVACTRLLLQSG 151
Cdd:COG0666   133 LEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAG 176
Ank_2 pfam12796
Ankyrin repeats (3 copies);
30-125 1.92e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 73.23  E-value: 1.92e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399599  30 FMDAIQCGHVSIAKLLLEQHKACSSAaDSMGAQALHRAAVTGQDEAIRFLVCGlgidVDVRAKSSQLTALHYAAKEGQTN 109
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQ-DKNGRTALHLAAKNGHLEIVKLLLEH----ADVNLKDNGRTALHYAARSGHLE 75

                          90
                  ....*....|....*.
gi 1720399599 110 TVQTLLSLGADINSTD 125
Cdd:pfam12796  76 IVKLLLEKGADINVKD 91
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
41-151 6.36e-13

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 65.36  E-value: 6.36e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399599  41 IAKLLLEQHKACSSAADSMGAQALHRAAVTGQDEAIRFLVCGLGIDVDVRAKSsQLTALHYAAKEGQTNTVQTLLSLGAD 120
Cdd:COG0666    34 LLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDG-GNTLLHAAARNGDLEIVKLLLEAGAD 112

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1720399599 121 INSTDERNRSVLHLACAGQHVACTRLLLQSG 151
Cdd:COG0666   113 VNARDKDGETPLHLAAYNGNLEIVKLLLEAG 143
Ank_2 pfam12796
Ankyrin repeats (3 copies);
64-151 1.44e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 57.82  E-value: 1.44e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399599  64 LHRAAVTGQDEAIRFLVcGLGIDVDVRAKSSQlTALHYAAKEGQTNTVQTLLSlGADINSTDErNRSVLHLACAGQHVAC 143
Cdd:pfam12796   1 LHLAAKNGNLELVKLLL-ENGADANLQDKNGR-TALHLAAKNGHLEIVKLLLE-HADVNLKDN-GRTALHYAARSGHLEI 76


                  ....*...
gi 1720399599 144 TRLLLQSG 151
Cdd:pfam12796  77 VKLLLEKG 84
Ank_2 pfam12796
Ankyrin repeats (3 copies);
99-161 3.64e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 56.66  E-value: 3.64e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720399599  99 LHYAAKEGQTNTVQTLLSLGADINSTDERNRSVLHLACAGQHVACTRLLLQSGLKDSEDLTGT 161
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDNGRT 63
Ank_4 pfam13637
Ankyrin repeats (many copies);
95-148 1.19e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 51.89  E-value: 1.19e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1720399599  95 QLTALHYAAKEGQTNTVQTLLSLGADINSTDERNRSVLHLACAGQHVACTRLLL 148
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 3-151 8.11e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 53.81  E-value: 8.11e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399599   3 GCLEAVQVLLERchyepdcRDNC-------GVTPFMDAIQCGHVSIAKLLLeQHKACSSAADSMGAQALHRAAVTGQDEA 75
Cdd:PHA02874   12 GDIEAIEKIIKN-------KGNCinisvdeTTTPLIDAIRSGDAKIVELFI-KHGADINHINTKIPHPLLTAIKIGAHDI 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399599  76 IRFL----------------------VCGLGIDVDVRAKSSQlTALHYAAKEGQTNTVQTLLSLGADINSTDERNRSVLH 133
Cdd:PHA02874   84 IKLLidngvdtsilpipciekdmiktILDCGIDVNIKDAELK-TFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIH 162

                         170
                  ....*....|....*...
gi 1720399599 134 LACAGQHVACTRLLLQSG 151
Cdd:PHA02874  163 IAIKHNFFDIIKLLLEKG 180
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 5-151 2.82e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 49.28  E-value: 2.82e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399599   5 LEAVQVLLERCHYePDCRDNCGVTPFMDAIQC--GHVSIAKLLLeQHKACSSAADSMGAQALHRAAVTGQD--EAIRFLV 80
Cdd:PHA03100   86 KEIVKLLLEYGAN-VNAPDNNGITPLLYAISKksNSYSIVEYLL-DNGANVNIKNSDGENLLHLYLESNKIdlKILKLLI 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399599  81 CGlGIDVDVRAKSSQL---------------TALHYAAKEGQTNTVQTLLSLGADINSTDERNRSVLHLACAGQHVACTR 145
Cdd:PHA03100  164 DK-GVDINAKNRVNYLlsygvpinikdvygfTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFK 242


                  ....*.
gi 1720399599 146 LLLQSG 151
Cdd:PHA03100  243 LLLNNG 248
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 23-151 7.69e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 48.14  E-value: 7.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399599  23 DNCGVTPFMDAIQCGHVS--IAKLLleQHKACSSAADSMGAQALHRAAVTGQD-EAIRFLVCgLGIDVDVrAKSSQLTAL 99
Cdd:PHA02876  270 DDCKNTPLHHASQAPSLSrlVPKLL--ERGADVNAKNIKGETPLYLMAKNGYDtENIRTLIM-LGADVNA-ADRLYITPL 345

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1720399599 100 HYAAK-EGQTNTVQTLLSLGADINSTDERNRSVLHLACAGQHVACTRLLLQSG 151
Cdd:PHA02876  346 HQASTlDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYG 398
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 5-122 1.15e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 47.68  E-value: 1.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399599   5 LEAVQVLLERcHYEPDCRDNCGVTPFMDAIQCGHVSIAKLLLEqHKACSSAADSMGAQALHRAAVTGQDEAIRFLVCGlG 84
Cdd:PHA02875  115 LDIMKLLIAR-GADPDIPNTDKFSPLHLAVMMGDIKGIELLID-HKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDS-G 191

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1720399599  85 IDVDVRAKSSQLTALHYAAKEGQTNTVQTLLSLGADIN 122
Cdd:PHA02875  192 ANIDYFGKNGCVAALCYAIENNKIDIVRLFIKRGADCN 229
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 54-138 1.54e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 47.37  E-value: 1.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399599  54 SAADSMGAQALHRAAVTGQDEAIRFLVCGLGIDVDVRAKSSQlTALHYAAKEGQTNTVQTLLSLGADINSTDERNRSVLH 133
Cdd:PHA02876  335 NAADRLYITPLHQASTLDRNKDIVITLLELGANVNARDYCDK-TPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALH 413


                  ....*
gi 1720399599 134 LACAG 138
Cdd:PHA02876  414 FALCG 418
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 73-161 5.39e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 45.64  E-value: 5.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399599  73 DEAIRFLVCGLGIDVDVRAKSSQLTALHYAAKEGQTNTVQTLLSLGADINSTDERNRSVLHLACAGQHVACTRLLLQSGL 152
Cdd:PHA02878  146 EAEITKLLLSYGADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGA 225

                          90
                  ....*....|
gi 1720399599 153 K-DSEDLTGT 161
Cdd:PHA02878  226 StDARDKCGN 235
PHA03095 PHA03095
ankyrin-like protein; Provisional
 54-148 7.81e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 45.02  E-value: 7.81e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399599  54 SAADSMGAQALHRAAVTGQDEA--IRFLVCGlGIDVDVRAKSSQlTALHYAAKEGQTNTVQTLLSLGADINSTDERNRSV 131
Cdd:PHA03095  216 AATDMLGNTPLHSMATGSSCKRslVLPLLIA-GISINARNRYGQ-TPLHYAAVFNNPRACRRLIALGADINAVSSDGNTP 293

                          90
                  ....*....|....*..
gi 1720399599 132 LHLACAGQHVACTRLLL 148
Cdd:PHA03095  294 LSLMVRNNNGRAVRAAL 310
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 103-159 8.27e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 45.27  E-value: 8.27e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720399599 103 AKEGQTNTVQTLLSLGADINSTDERNRSVLHLACAGQHVACTRLLLQSG----LKDSEDLT 159
Cdd:PTZ00322   90 AASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGadptLLDKDGKT 150
Ank_4 pfam13637
Ankyrin repeats (many copies);
63-115 2.44e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 40.34  E-value: 2.44e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1720399599  63 ALHRAAVTGQDEAIRFLVCgLGIDVDVRAKSSQlTALHYAAKEGQTNTVQTLL 115
Cdd:pfam13637   4 ALHAAAASGHLELLRLLLE-KGADINAVDGNGE-TALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
1-46 2.91e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.95  E-value: 2.91e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1720399599   1 MHGCLEAVQVLLERcHYEPDCRDNCGVTPFMDAIQCGHVSIAKLLL 46
Cdd:pfam13637  10 ASGHLELLRLLLEK-GADINAVDGNGETALHFAASNGNVEVLKLLL 54
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 6-126 4.59e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 42.93  E-value: 4.59e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399599   6 EAVQVLLER-CHYepDCRDNCGVTPFMDAIQCGHVSIAKLLLEqhkaCSSAADS-MGAQALHRAAVTGQDEAIRFLVcGL 83
Cdd:PLN03192  572 DCVLVLLKHaCNV--HIRDANGNTALWNAISAKHHKIFRILYH----FASISDPhAAGDLLCTAAKRNDLTAMKELL-KQ 644

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1720399599  84 GIDVDVRAKSSqLTALHYAAKEGQTNTVQTLLSLGADIN--STDE 126
Cdd:PLN03192  645 GLNVDSEDHQG-ATALQVAMAEDHVDMVRLLIMNGADVDkaNTDD 688
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 6-151 9.53e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 41.90  E-value: 9.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399599   6 EAVQVLLERCHYePDCRDNCGVTPFMDAIQCGHVSIAKLLLEQHKACSSAADSMGAQALHRAAVTGQDEAIRFLVcGLGI 85
Cdd:PHA02875   49 EAIKLLMKHGAI-PDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLI-ARGA 126

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720399599  86 DVDVrAKSSQLTALHYAAKEGQTNTVQTLLSLGADINSTDERNRSVLHLACAGQHVACTRLLLQSG 151
Cdd:PHA02875  127 DPDI-PNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSG 191
Ank_5 pfam13857
Ankyrin repeats (many copies);
11-67 9.82e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.48  E-value: 9.82e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720399599  11 LLERCHYEPDCRDNCGVTPFMDAIQCGHVSIAKLLLEQHKACsSAADSMGAQALHRA 67
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDL-NLKDEEGLTALDLA 56
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 18-125 1.06e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 41.79  E-value: 1.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399599  18 EPDCRDNCGVTPFMDAIQCGHVSIAKLLLeQHKACSSAADSMGAQALHRAAVTGQDEAIRFLVCGLGIDVDVRAKSSQLT 97
Cdd:PHA02878  193 NVNIPDKTNNSPLHHAVKHYNKPIVHILL-ENGASTDARDKCGNTPLHISVGYCKDYDILKLLLEHGVDVNAKSYILGLT 271

                          90       100
                  ....*....|....*....|....*...
gi 1720399599  98 ALHYAAKEGQtnTVQTLLSLGADINSTD 125
Cdd:PHA02878  272 ALHSSIKSER--KLKLLLEYGADINSLN 297
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 20-182 1.36e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 41.59  E-value: 1.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399599  20 DCRDNCGVTPFMDAIQCGHVSIAKLLLEQHKACSSAADSMGAqALHRAAV-TGQDEAIRFLVcGLGIDVDVRAKSSQlTA 98
Cdd:PHA02876  369 NARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGT-ALHFALCgTNPYMSVKTLI-DRGANVNSKNKDLS-TP 445

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399599  99 LHYAAKEG-QTNTVQTLLSLGADINSTDERNRSVLHLACAGQHVACTRLLLQSGLKDSEDLTGTLAQQLTRSVDI----- 172
Cdd:PHA02876  446 LHYACKKNcKLDVIEMLLDNGADVNAINIQNQYPLLIALEYHGIVNILLHYGAELRDSRVLHKSLNDNMFSFRYIiahic 525

                         170
                  ....*....|.
gi 1720399599 173 LQDF-DHDVKS 182
Cdd:PHA02876  526 IQDFiRHDIRN 536
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 16-160 1.44e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 41.52  E-value: 1.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399599  16 HYEPDCRDNCGVTPFMDAIQCGHVSIAKLLLeQHKACSSAADSMGAQALHRAAVTGQDEAIR-FLVCGLGIDvDVRAKSS 94
Cdd:PHA02875   25 GINPNFEIYDGISPIKLAMKFRDSEAIKLLM-KHGAIPDVKYPDIESELHDAVEEGDVKAVEeLLDLGKFAD-DVFYKDG 102

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720399599  95 qLTALHYAAKEGQTNTVQTLLSLGA--DINSTDErnRSVLHLACAGQHVACTRLLLQ-SGLKDSEDLTG 160
Cdd:PHA02875  103 -MTPLHLATILKKLDIMKLLIARGAdpDIPNTDK--FSPLHLAVMMGDIKGIELLIDhKACLDIEDCCG 168
PHA03095 PHA03095
ankyrin-like protein; Provisional
 74-172 1.55e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 41.16  E-value: 1.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399599  74 EAIRFLVcGLGIDVDVRAKSSqLTALHYAAKEGQT-NTVQTLLSLGADINSTDERNRSVLHLACAGQ--HVACTRLLLQS 150
Cdd:PHA03095   64 DIVRLLL-EAGADVNAPERCG-FTPLHLYLYNATTlDVIKLLIKAGADVNAKDKVGRTPLHVYLSGFniNPKVIRLLLRK 141

                          90       100
                  ....*....|....*....|....
gi 1720399599 151 G--LKDSEDLTGTLAQQLTRSVDI 172
Cdd:PHA03095  142 GadVNALDLYGMTPLAVLLKSRNA 165
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 97-122 2.70e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.80  E-value: 2.70e-04
                           10        20
                   ....*....|....*....|....*.
gi 1720399599   97 TALHYAAKEGQTNTVQTLLSLGADIN 122
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADIN 29
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 28-151 3.53e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 40.38  E-value: 3.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399599  28 TPFMDAIQCGHVSIAKLLLEQHKACSSAADSMGAQALHRAAVTGQDEAIRFLvcglgIDVDVR----AKSSQL----TAL 99
Cdd:cd22192    19 SPLLLAAKENDVQAIKKLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVL-----MEAAPElvnePMTSDLyqgeTAL 93

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720399599 100 HYAAKEGQTNTVQTLLSLGADINST-------DERNRSVLHLacaGQHV----ACT------RLLLQSG 151
Cdd:cd22192    94 HIAVVNQNLNLVRELIARGADVVSPratgtffRPGPKNLIYY---GEHPlsfaACVgneeivRLLIEHG 159
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 84-141 3.72e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 40.43  E-value: 3.72e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1720399599  84 GIDVDVRAKSSqLTALHYAAKEGQTNTVQTLLSLGADINSTDERNRSVLHLACAGQHV 141
Cdd:PHA02876  168 GADVNAKDIYC-ITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNI 224
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 97-126 5.12e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 36.11  E-value: 5.12e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1720399599  97 TALHYAA-KEGQTNTVQTLLSLGADINSTDE 126
Cdd:pfam00023   4 TPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 2-135 5.97e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 39.56  E-value: 5.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399599   2 HGCLEAVQVLLERCHYePDCRDNCGVTPFMDAIQCGHVSIAKLLLEQHKACSSAADSmGAQALHRAAVTGQdEAIRFLVC 81
Cdd:PHA02874  167 HNFFDIIKLLLEKGAY-ANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKN-GFTPLHNAIIHNR-SAIELLIN 243

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720399599  82 GLGIDV-DVRAKssqlTALHYAAK-EGQTNTVQTLLSLGADINSTDERNRSVLHLA 135
Cdd:PHA02874  244 NASINDqDIDGS----TPLHHAINpPCDIDIIDILLYHKADISIKDNKGENPIDTA 295
Ank_5 pfam13857
Ankyrin repeats (many copies);
97-135 6.09e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.56  E-value: 6.09e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1720399599  97 TALHYAAKEGQTNTVQTLLSLGADINSTDERNRSVLHLA 135
Cdd:pfam13857  18 TPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
42-151 6.24e-04

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 39.17  E-value: 6.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399599  42 AKLLLEQHKACSSAADSMGAQALHRAAVTGQDEAIRFLVCGLGIDVDVRAKSSQLTALHYAAKEGQTNTVQTLLSLGADI 121
Cdd:COG0666     1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 1720399599 122 NSTDERNRSVLHLACAGQHVACTRLLLQSG 151
Cdd:COG0666    81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAG 110
PHA03095 PHA03095
ankyrin-like protein; Provisional
 4-133 8.29e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 36.16  E-value: 8.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399599   4 CLEAVQVLLERCHYePDCRDNCGVTPFMDAIQCGHV-SIAKLLLEqHKACSSAADSMGAQALHrAAVTGQD---EAIRFL 79
Cdd:PHA03095   62 VKDIVRLLLEAGAD-VNAPERCGFTPLHLYLYNATTlDVIKLLIK-AGADVNAKDKVGRTPLH-VYLSGFNinpKVIRLL 138

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720399599  80 VcGLGIDVDVRaKSSQLTALHYAAKEGQTN--TVQTLLSLGADINSTDERNRSVLH 133
Cdd:PHA03095  139 L-RKGADVNAL-DLYGMTPLAVLLKSRNANveLLRLLIDAGADVYAVDDRFRSLLH 192
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 18-97 8.59e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 36.03  E-value: 8.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399599  18 EPDCRDNCGVTPFMDAIQCGHVSIAKLLLEqHKACSSAADSMGAQALHRAAVTGQDEAIRFLV--CGLGIDVDVRAKSSQ 95
Cdd:PTZ00322  107 DPNCRDYDGRTPLHIACANGHVQVVRVLLE-FGADPTLLDKDGKTPLELAEENGFREVVQLLSrhSQCHFELGANAKPDS 185


                  ..
gi 1720399599  96 LT 97
Cdd:PTZ00322  186 FT 187
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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