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Conserved domains on  [gi|1720399713|ref|XP_030107667|]
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zinc finger protein 335 isoform X2 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 12143211)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation; similar to Homo sapiens DNA-binding protein Ikaros, a transcription regulator of hematopoietic cell differentiation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1089-1114 4.70e-06

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 44.28  E-value: 4.70e-06
                           10        20
                   ....*....|....*....|....*.
gi 1720399713 1089 DLRRHMLTHTNEKPFSCHVCGQRFNR 1114
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
1075-1099 8.92e-06

C2H2-type zinc-finger domain;


:

Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 43.31  E-value: 8.92e-06
                           10        20
                   ....*....|....*....|....*
gi 1720399713 1075 HQCNQCSFASKNKKDLRRHMLTHTN 1099
Cdd:pfam13909    1 YKCSQCDYSTAWKSNLKRHLRKHTG 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
577-602 4.14e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 4.14e-05
                           10        20
                   ....*....|....*....|....*.
gi 1720399713  577 RLTQHMKTHSTEKPHMCDKCGKSFKK 602
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
524-547 4.08e-04

C2H2-type zinc-finger domain;


:

Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 38.69  E-value: 4.08e-04
                           10        20
                   ....*....|....*....|....
gi 1720399713  524 YKCDECSYTSVYRKDVIRHAAVHS 547
Cdd:pfam13909    1 YKCSQCDYSTAWKSNLKRHLRKHT 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
510-535 5.05e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 5.05e-04
                           10        20
                   ....*....|....*....|....*.
gi 1720399713  510 SLKEHMFNHVGSKPYKCDECSYTSVY 535
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 1026-1126 6.13e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 6.13e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399713 1026 EAFPSRAEMESHKRAHAGPAAFKCPdcpfsarqwpevrAHMAQHSSLRPHQCN--QCSFASKNKKDLRRHML-------T 1096
Cdd:COG5189    314 RKLPCTNSSSNGKLAHGGERNIDTP-------------SRMLKVKDGKPYKCPveGCNKKYKNQNGLKYHMLhghqnqkL 380

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1720399713 1097 HTN------------EKPFSCHVCGQRFNRNGHLKFHIQRLH 1126
Cdd:COG5189    381 HENpspekmnifsakDKPYRCEVCDKRYKNLNGLKYHRKHSH 422
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1089-1114 4.70e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 44.28  E-value: 4.70e-06
                           10        20
                   ....*....|....*....|....*.
gi 1720399713 1089 DLRRHMLTHTNEKPFSCHVCGQRFNR 1114
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
1075-1099 8.92e-06

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 43.31  E-value: 8.92e-06
                           10        20
                   ....*....|....*....|....*
gi 1720399713 1075 HQCNQCSFASKNKKDLRRHMLTHTN 1099
Cdd:pfam13909    1 YKCSQCDYSTAWKSNLKRHLRKHTG 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
577-602 4.14e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 4.14e-05
                           10        20
                   ....*....|....*....|....*.
gi 1720399713  577 RLTQHMKTHSTEKPHMCDKCGKSFKK 602
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
524-547 4.08e-04

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 38.69  E-value: 4.08e-04
                           10        20
                   ....*....|....*....|....
gi 1720399713  524 YKCDECSYTSVYRKDVIRHAAVHS 547
Cdd:pfam13909    1 YKCSQCDYSTAWKSNLKRHLRKHT 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
510-535 5.05e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 5.05e-04
                           10        20
                   ....*....|....*....|....*.
gi 1720399713  510 SLKEHMFNHVGSKPYKCDECSYTSVY 535
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 1026-1126 6.13e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 6.13e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399713 1026 EAFPSRAEMESHKRAHAGPAAFKCPdcpfsarqwpevrAHMAQHSSLRPHQCN--QCSFASKNKKDLRRHML-------T 1096
Cdd:COG5189    314 RKLPCTNSSSNGKLAHGGERNIDTP-------------SRMLKVKDGKPYKCPveGCNKKYKNQNGLKYHMLhghqnqkL 380

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1720399713 1097 HTN------------EKPFSCHVCGQRFNRNGHLKFHIQRLH 1126
Cdd:COG5189    381 HENpspekmnifsakDKPYRCEVCDKRYKNLNGLKYHRKHSH 422
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1089-1114 4.70e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 44.28  E-value: 4.70e-06
                           10        20
                   ....*....|....*....|....*.
gi 1720399713 1089 DLRRHMLTHTNEKPFSCHVCGQRFNR 1114
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
1075-1099 8.92e-06

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 43.31  E-value: 8.92e-06
                           10        20
                   ....*....|....*....|....*
gi 1720399713 1075 HQCNQCSFASKNKKDLRRHMLTHTN 1099
Cdd:pfam13909    1 YKCSQCDYSTAWKSNLKRHLRKHTG 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
577-602 4.14e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 4.14e-05
                           10        20
                   ....*....|....*....|....*.
gi 1720399713  577 RLTQHMKTHSTEKPHMCDKCGKSFKK 602
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
524-547 4.08e-04

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 38.69  E-value: 4.08e-04
                           10        20
                   ....*....|....*....|....
gi 1720399713  524 YKCDECSYTSVYRKDVIRHAAVHS 547
Cdd:pfam13909    1 YKCSQCDYSTAWKSNLKRHLRKHT 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
510-535 5.05e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 5.05e-04
                           10        20
                   ....*....|....*....|....*.
gi 1720399713  510 SLKEHMFNHVGSKPYKCDECSYTSVY 535
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 591-613 1.85e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 1.85e-03
                           10        20
                   ....*....|....*....|...
gi 1720399713  591 HMCDKCGKSFKKRYTFKMHLLTH 613
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 1026-1126 6.13e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 6.13e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399713 1026 EAFPSRAEMESHKRAHAGPAAFKCPdcpfsarqwpevrAHMAQHSSLRPHQCN--QCSFASKNKKDLRRHML-------T 1096
Cdd:COG5189    314 RKLPCTNSSSNGKLAHGGERNIDTP-------------SRMLKVKDGKPYKCPveGCNKKYKNQNGLKYHMLhghqnqkL 380

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1720399713 1097 HTN------------EKPFSCHVCGQRFNRNGHLKFHIQRLH 1126
Cdd:COG5189    381 HENpspekmnifsakDKPYRCEVCDKRYKNLNGLKYHRKHSH 422
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
967-1133 7.51e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 7.51e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399713  967 PPRDGSEVLSPTKTHHMGGSQGSSTPPPAASHTLGLVVPQSPPSAAASSTKKFS------CKVCSEAFPSRAEMESHKRA 1040
Cdd:COG5048    169 PPLPANSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENsssslpLTTNSQLSPKSLLSQSPSSL 248

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399713 1041 HAGPAAFKCPDCPFSARQ-WPEVRAHMAQHSSLR------PHQCNQCSFASKNKKDLRRHMLT--HTNE--KPFSCHV-- 1107
Cdd:COG5048    249 SSSDSSSSASESPRSSLPtASSQSSSPNESDSSSekgfslPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYsl 328

                          170       180
                   ....*....|....*....|....*.
gi 1720399713 1108 CGQRFNRNGHLKFHIQRLHSIDGRKT 1133
Cdd:COG5048    329 CGKLFSRNDALKRHILLHTSISPAKE 354
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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