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Conserved domains on  [gi|1907179537|ref|XP_036008820|]
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CCR4-NOT transcription complex subunit 3 isoform X7 [Mus musculus]

Protein Classification

CNOT2/3/5 family protein( domain architecture ID 13694845)

CNOT2/3/5 family protein is a component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Not3 pfam04065
Not1 N-terminal domain, CCR4-Not complex component;
3-230 2.54e-130

Not1 N-terminal domain, CCR4-Not complex component;


:

Pssm-ID: 461155 [Multi-domain]  Cd Length: 228  Bit Score: 385.75  E-value: 2.54e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537   3 DKRKLQGEIDRCLKKVSEGVEQFEDIWQKLHNAANANQKEKYEADLKKEIKKLQRLRDQIKTWVASNEIKDKRQLIENRK 82
Cdd:pfam04065   1 AARKLQQEIDRTLKKVAEGLEEFDDIYEKLESATNSSQKEKLEADLKKEIKKLQRLRDQIKTWLSSNDIKDKKKLLENRK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537  83 LIETQMERFKVVERETKTKAYSKEGLGLAQ--KVDPAQKEKEEVGQWLTNTIDTLNMQVDQFESEVESLSVQTRkkKGDK 160
Cdd:pfam04065  81 LIEEAMERFKAVEKESKTKAFSKEGLSLAAasKLDPKEKEKAEARDWLSDSIDELNRQIEALEAEIESLQAQKK--KKKK 158

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537 161 DQKQDRIEGLKRHIEKHRYHVRMLETILRMLDNDSILVDAIRKIKDDVEYYVDSSQDPDFEENEFLYDDL 230
Cdd:pfam04065 159 DSEKARLEELEKLIERHKFHIEKLELILRLLENGELDPEQVDDIKEDIEYYVESNQDPDFVEDEDIYDDL 228
NOT2_3_5 pfam04153
NOT2 / NOT3 / NOT5 family; NOT1, NOT2, NOT3, NOT4 and NOT5 form a nuclear complex that ...
 619-744 1.04e-56

NOT2 / NOT3 / NOT5 family; NOT1, NOT2, NOT3, NOT4 and NOT5 form a nuclear complex that negatively regulates the basal and activated transcription of many genes. This family includes NOT2, NOT3 and NOT5.


:

Pssm-ID: 461199  Cd Length: 121  Bit Score: 188.96  E-value: 1.04e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537 619 AAWHHMPHPSDSERIRQYLPRNPCPTPpyhhQMPPPHSDTVEFYQRLSTETLFFIFYYLEGTKAQYLAAKALKKQSWRFH 698
Cdd:pfam04153   1 YSTFNSPWPLDAERPYEPDFRNPACYP----QEPLPRLESPEKFSKFDDETLFYIFYSMPGDYAQYLAAKELKKRSWRYH 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1907179537 699 TKYMMWFQRHEEPKTITDEFEQGTYIYFDYeKWGQRKKEGFTFEYR 744
Cdd:pfam04153  77 KKLRTWFTRDEEPKVITNEYERGTYIYFDY-TWEQRRKKDFTLDYE 121
Herpes_BLLF1 super family cl37540
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 298-565 2.57e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


The actual alignment was detected with superfamily member pfam05109:

Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 47.99  E-value: 2.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537 298 SQSPAKNGSKPVHSNQHPQSPAVPPTYPSGPPPTTSALSSTPgnNGASTPAAPTSALGPKASPAPSHNSGTPapyAQAVA 377
Cdd:pfam05109 491 SPSPRDNGTESKAPDMTSPTSAVTTPTPNATSPTPAVTTPTP--NATSPTLGKTSPTSAVTTPTPNATSPTP---AVTTP 565

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537 378 PPNASGPSNAQPRPPSAqpSGGSGGGSGGSSSNSNSGTGGGAGKQNGATSYSSVVADSPAEVTLSSS------GGSSASS 451
Cdd:pfam05109 566 TPNATIPTLGKTSPTSA--VTTPTPNATSPTVGETSPQANTTNHTLGGTSSTPVVTSPPKNATSAVTtgqhniTSSSTSS 643

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537 452 QALGPTSGPHNPAPSTSKESSTAAPsgagnvASGSGNNSGGPSLLVPLPVNPPSSPTPSFSEAKAAGTL--LNGPPQFST 529
Cdd:pfam05109 644 MSLRPSSISETLSPSTSDNSTSHMP------LLTSAHPTGGENITQVTPASTSTHHVSTSSPAPRPGTTsqASGPGNSST 717

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1907179537 530 TPEikaPEPLSSLKSMAERAAIS----SGIEDPVPTLHLT 565
Cdd:pfam05109 718 STK---PGEVNVTKGTPPKNATSpqapSGQKTAVPTVTST 754
 
Name Accession Description Interval E-value
Not3 pfam04065
Not1 N-terminal domain, CCR4-Not complex component;
3-230 2.54e-130

Not1 N-terminal domain, CCR4-Not complex component;


Pssm-ID: 461155 [Multi-domain]  Cd Length: 228  Bit Score: 385.75  E-value: 2.54e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537   3 DKRKLQGEIDRCLKKVSEGVEQFEDIWQKLHNAANANQKEKYEADLKKEIKKLQRLRDQIKTWVASNEIKDKRQLIENRK 82
Cdd:pfam04065   1 AARKLQQEIDRTLKKVAEGLEEFDDIYEKLESATNSSQKEKLEADLKKEIKKLQRLRDQIKTWLSSNDIKDKKKLLENRK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537  83 LIETQMERFKVVERETKTKAYSKEGLGLAQ--KVDPAQKEKEEVGQWLTNTIDTLNMQVDQFESEVESLSVQTRkkKGDK 160
Cdd:pfam04065  81 LIEEAMERFKAVEKESKTKAFSKEGLSLAAasKLDPKEKEKAEARDWLSDSIDELNRQIEALEAEIESLQAQKK--KKKK 158

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537 161 DQKQDRIEGLKRHIEKHRYHVRMLETILRMLDNDSILVDAIRKIKDDVEYYVDSSQDPDFEENEFLYDDL 230
Cdd:pfam04065 159 DSEKARLEELEKLIERHKFHIEKLELILRLLENGELDPEQVDDIKEDIEYYVESNQDPDFVEDEDIYDDL 228
NOT2_3_5 pfam04153
NOT2 / NOT3 / NOT5 family; NOT1, NOT2, NOT3, NOT4 and NOT5 form a nuclear complex that ...
 619-744 1.04e-56

NOT2 / NOT3 / NOT5 family; NOT1, NOT2, NOT3, NOT4 and NOT5 form a nuclear complex that negatively regulates the basal and activated transcription of many genes. This family includes NOT2, NOT3 and NOT5.


Pssm-ID: 461199  Cd Length: 121  Bit Score: 188.96  E-value: 1.04e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537 619 AAWHHMPHPSDSERIRQYLPRNPCPTPpyhhQMPPPHSDTVEFYQRLSTETLFFIFYYLEGTKAQYLAAKALKKQSWRFH 698
Cdd:pfam04153   1 YSTFNSPWPLDAERPYEPDFRNPACYP----QEPLPRLESPEKFSKFDDETLFYIFYSMPGDYAQYLAAKELKKRSWRYH 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1907179537 699 TKYMMWFQRHEEPKTITDEFEQGTYIYFDYeKWGQRKKEGFTFEYR 744
Cdd:pfam04153  77 KKLRTWFTRDEEPKVITNEYERGTYIYFDY-TWEQRRKKDFTLDYE 121
CDC36 COG5601
General negative regulator of transcription subunit [Transcription];
644-747 4.17e-14

General negative regulator of transcription subunit [Transcription];


Pssm-ID: 227888  Cd Length: 172  Bit Score: 70.78  E-value: 4.17e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537 644 TPPYHHQMPPPHSDTVEFYQR----LSTETLFFIFYYLEGTKAQYLAAKALKKQSWRFHTKYMMW--FQRHEEPKTITDE 717
Cdd:COG5601    64 LPNCYPNAPNPPIFKVNIEDMkmdnFHDETLFYIFYSFPNDVLQEKAYDELLKRNWRFHKMLKCWltFNPGMSPATADHV 143

                          90       100       110
                  ....*....|....*....|....*....|
gi 1907179537 718 FEQGTYIYFDYEKWGQRKKEgFTFEYRYLE 747
Cdd:COG5601   144 KERGSYVFFDPFSWSKVSLD-FLLDYKAVR 172
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
8-217 2.41e-05

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 47.75  E-value: 2.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537   8 QGEID----------RCLKKVSeGVEQFEDIWQKLhnaananqkekyeADLKKEIK-KLQRLRDQIKtwvASNEIKDkrq 76
Cdd:PRK03918  134 QGEIDailesdesreKVVRQIL-GLDDYENAYKNL-------------GEVIKEIKrRIERLEKFIK---RTENIEE--- 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537  77 lienrkLIETQMERFKVVERETKTKaySKEGLGLAQKVDPAQKEKEEVGQwLTNTIDTLNMQVDQFESEVESLsvqtrkk 156
Cdd:PRK03918  194 ------LIKEKEKELEEVLREINEI--SSELPELREELEKLEKEVKELEE-LKEEIEELEKELESLEGSKRKL------- 257

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907179537 157 kgdkdqkQDRIEGLKRHIEKHRYHVRMLETILRMLDNDSILVDAIRKIKDDVEYYVDSSQD 217
Cdd:PRK03918  258 -------EEKIRELEERIEELKKEIEELEEKVKELKELKEKAEEYIKLSEFYEEYLDELRE 311
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 298-565 2.57e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 47.99  E-value: 2.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537 298 SQSPAKNGSKPVHSNQHPQSPAVPPTYPSGPPPTTSALSSTPgnNGASTPAAPTSALGPKASPAPSHNSGTPapyAQAVA 377
Cdd:pfam05109 491 SPSPRDNGTESKAPDMTSPTSAVTTPTPNATSPTPAVTTPTP--NATSPTLGKTSPTSAVTTPTPNATSPTP---AVTTP 565

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537 378 PPNASGPSNAQPRPPSAqpSGGSGGGSGGSSSNSNSGTGGGAGKQNGATSYSSVVADSPAEVTLSSS------GGSSASS 451
Cdd:pfam05109 566 TPNATIPTLGKTSPTSA--VTTPTPNATSPTVGETSPQANTTNHTLGGTSSTPVVTSPPKNATSAVTtgqhniTSSSTSS 643

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537 452 QALGPTSGPHNPAPSTSKESSTAAPsgagnvASGSGNNSGGPSLLVPLPVNPPSSPTPSFSEAKAAGTL--LNGPPQFST 529
Cdd:pfam05109 644 MSLRPSSISETLSPSTSDNSTSHMP------LLTSAHPTGGENITQVTPASTSTHHVSTSSPAPRPGTTsqASGPGNSST 717

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1907179537 530 TPEikaPEPLSSLKSMAERAAIS----SGIEDPVPTLHLT 565
Cdd:pfam05109 718 STK---PGEVNVTKGTPPKNATSpqapSGQKTAVPTVTST 754
PHA03247 PHA03247
large tegument protein UL36; Provisional
 315-658 2.11e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 2.11e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537  315 PQSPAVPPTYPSGPPPTTSALSSTPGNNGASTPAAPTSALGPKASPAPSHNSGTPAPYA------------------QAV 376
Cdd:PHA03247  2577 PSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAAnepdphppptvppperprDDP 2656

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537  377 APPNASGPSNAQ--------------PRPPSA---------------QPSGGSGGGSGGSSSNSNSGTGGGAGKQNGATS 427
Cdd:PHA03247  2657 APGRVSRPRRARrlgraaqassppqrPRRRAArptvgsltsladpppPPPTPEPAPHALVSATPLPPGPAAARQASPALP 2736

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537  428 YSSVVADSPAEVTLSSSGGSSASSQAlgpTSGPHNPAPSTSKESSTAAPSGAGNVASGSGNNSGGPSLLVPLPVNPPSSP 507
Cdd:PHA03247  2737 AAPAPPAVPAGPATPGGPARPARPPT---TAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLA 2813

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537  508 TPSFSEAKAAGTLLNGPPQFST-TPEIKAPEPLSSLKSM----------AERAAISSGIEDPVPTLHLTDRDIilsstsa 576
Cdd:PHA03247  2814 PAAALPPAASPAGPLPPPTSAQpTAPPPPPGPPPPSLPLggsvapggdvRRRPPSRSPAAKPAAPARPPVRRL------- 2886

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537  577 pptsSQPPLQLSEVNIPLSlgvcPLGPVSLTKEQLYQQAMEEAAWHHMPhpsdserirqyLPRNPCPTPPYHHQMPPPHS 656
Cdd:PHA03247  2887 ----ARPAVSRSTESFALP----PDQPERPPQPQAPPPPQPQPQPPPPP-----------QPQPPPPPPPRPQPPLAPTT 2947


                   ..
gi 1907179537  657 DT 658
Cdd:PHA03247  2948 DP 2949
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1-185 4.86e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 40.44  E-value: 4.86e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537    1 MADKRKLQGEIDRCLKKVSEGVEQFEDIwqklhnAANANQKEKYEADLKKEIKKLQRLRDQIktwvaSNEIKDKRQ-LIE 79
Cdd:TIGR02169  694 QSELRRIENRLDELSQELSDASRKIGEI------EKEIEQLEQEEEKLKERLEELEEDLSSL-----EQEIENVKSeLKE 762

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537   80 NRKLIEtQMERFKVVERETKTKAYSKEGL-GLAQKVDPAQKEKEEVGQWLTNTIDT------LNMQVDQFESEVESLSVQ 152
Cdd:TIGR02169  763 LEARIE-ELEEDLHKLEEALNDLEARLSHsRIPEIQAELSKLEEEVSRIEARLREIeqklnrLTLEKEYLEKEIQELQEQ 841

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 1907179537  153 TRKKKGDKDQKQDRIEGLK-------RHIEKHRYHVRMLE 185
Cdd:TIGR02169  842 RIDLKEQIKSIEKEIENLNgkkeeleEELEELEAALRDLE 881
SPT5 COG5164
Transcription elongation factor SPT5 [Transcription];
339-492 6.59e-03

Transcription elongation factor SPT5 [Transcription];


Pssm-ID: 444063 [Multi-domain]  Cd Length: 495  Bit Score: 39.63  E-value: 6.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537 339 PGNNGASTPAAPTSALGpkasPAPSHNSGTPAPYAQAVAPPNASGPSnaqpRPPSAQPSGGSGGGSGGSSSNSNSGTGGG 418
Cdd:COG5164    48 AQNQGSTTPAGNTGGTR----PAGNQGATGPAQNQGGTTPAQNQGGT----RPAGNTGGTTPAGDGGATGPPDDGGATGP 119

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907179537 419 AGKqNGATSYSSVVADSPAEVTlsssGGSSASSQALGPT--SGPHNPAPSTSKESSTAAPSGAGNVASGSGNNSGG 492
Cdd:COG5164   120 PDD-GGSTTPPSGGSTTPPGDG----GSTPPGPGSTGPGgsTTPPGDGGSTTPPGPGGSTTPPDDGGSTTPPNKGE 190
 
Name Accession Description Interval E-value
Not3 pfam04065
Not1 N-terminal domain, CCR4-Not complex component;
3-230 2.54e-130

Not1 N-terminal domain, CCR4-Not complex component;


Pssm-ID: 461155 [Multi-domain]  Cd Length: 228  Bit Score: 385.75  E-value: 2.54e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537   3 DKRKLQGEIDRCLKKVSEGVEQFEDIWQKLHNAANANQKEKYEADLKKEIKKLQRLRDQIKTWVASNEIKDKRQLIENRK 82
Cdd:pfam04065   1 AARKLQQEIDRTLKKVAEGLEEFDDIYEKLESATNSSQKEKLEADLKKEIKKLQRLRDQIKTWLSSNDIKDKKKLLENRK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537  83 LIETQMERFKVVERETKTKAYSKEGLGLAQ--KVDPAQKEKEEVGQWLTNTIDTLNMQVDQFESEVESLSVQTRkkKGDK 160
Cdd:pfam04065  81 LIEEAMERFKAVEKESKTKAFSKEGLSLAAasKLDPKEKEKAEARDWLSDSIDELNRQIEALEAEIESLQAQKK--KKKK 158

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537 161 DQKQDRIEGLKRHIEKHRYHVRMLETILRMLDNDSILVDAIRKIKDDVEYYVDSSQDPDFEENEFLYDDL 230
Cdd:pfam04065 159 DSEKARLEELEKLIERHKFHIEKLELILRLLENGELDPEQVDDIKEDIEYYVESNQDPDFVEDEDIYDDL 228
NOT2_3_5 pfam04153
NOT2 / NOT3 / NOT5 family; NOT1, NOT2, NOT3, NOT4 and NOT5 form a nuclear complex that ...
 619-744 1.04e-56

NOT2 / NOT3 / NOT5 family; NOT1, NOT2, NOT3, NOT4 and NOT5 form a nuclear complex that negatively regulates the basal and activated transcription of many genes. This family includes NOT2, NOT3 and NOT5.


Pssm-ID: 461199  Cd Length: 121  Bit Score: 188.96  E-value: 1.04e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537 619 AAWHHMPHPSDSERIRQYLPRNPCPTPpyhhQMPPPHSDTVEFYQRLSTETLFFIFYYLEGTKAQYLAAKALKKQSWRFH 698
Cdd:pfam04153   1 YSTFNSPWPLDAERPYEPDFRNPACYP----QEPLPRLESPEKFSKFDDETLFYIFYSMPGDYAQYLAAKELKKRSWRYH 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1907179537 699 TKYMMWFQRHEEPKTITDEFEQGTYIYFDYeKWGQRKKEGFTFEYR 744
Cdd:pfam04153  77 KKLRTWFTRDEEPKVITNEYERGTYIYFDY-TWEQRRKKDFTLDYE 121
CDC36 COG5601
General negative regulator of transcription subunit [Transcription];
644-747 4.17e-14

General negative regulator of transcription subunit [Transcription];


Pssm-ID: 227888  Cd Length: 172  Bit Score: 70.78  E-value: 4.17e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537 644 TPPYHHQMPPPHSDTVEFYQR----LSTETLFFIFYYLEGTKAQYLAAKALKKQSWRFHTKYMMW--FQRHEEPKTITDE 717
Cdd:COG5601    64 LPNCYPNAPNPPIFKVNIEDMkmdnFHDETLFYIFYSFPNDVLQEKAYDELLKRNWRFHKMLKCWltFNPGMSPATADHV 143

                          90       100       110
                  ....*....|....*....|....*....|
gi 1907179537 718 FEQGTYIYFDYEKWGQRKKEgFTFEYRYLE 747
Cdd:COG5601   144 KERGSYVFFDPFSWSKVSLD-FLLDYKAVR 172
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
8-217 2.41e-05

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 47.75  E-value: 2.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537   8 QGEID----------RCLKKVSeGVEQFEDIWQKLhnaananqkekyeADLKKEIK-KLQRLRDQIKtwvASNEIKDkrq 76
Cdd:PRK03918  134 QGEIDailesdesreKVVRQIL-GLDDYENAYKNL-------------GEVIKEIKrRIERLEKFIK---RTENIEE--- 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537  77 lienrkLIETQMERFKVVERETKTKaySKEGLGLAQKVDPAQKEKEEVGQwLTNTIDTLNMQVDQFESEVESLsvqtrkk 156
Cdd:PRK03918  194 ------LIKEKEKELEEVLREINEI--SSELPELREELEKLEKEVKELEE-LKEEIEELEKELESLEGSKRKL------- 257

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907179537 157 kgdkdqkQDRIEGLKRHIEKHRYHVRMLETILRMLDNDSILVDAIRKIKDDVEYYVDSSQD 217
Cdd:PRK03918  258 -------EEKIRELEERIEELKKEIEELEEKVKELKELKEKAEEYIKLSEFYEEYLDELRE 311
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 298-565 2.57e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 47.99  E-value: 2.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537 298 SQSPAKNGSKPVHSNQHPQSPAVPPTYPSGPPPTTSALSSTPgnNGASTPAAPTSALGPKASPAPSHNSGTPapyAQAVA 377
Cdd:pfam05109 491 SPSPRDNGTESKAPDMTSPTSAVTTPTPNATSPTPAVTTPTP--NATSPTLGKTSPTSAVTTPTPNATSPTP---AVTTP 565

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537 378 PPNASGPSNAQPRPPSAqpSGGSGGGSGGSSSNSNSGTGGGAGKQNGATSYSSVVADSPAEVTLSSS------GGSSASS 451
Cdd:pfam05109 566 TPNATIPTLGKTSPTSA--VTTPTPNATSPTVGETSPQANTTNHTLGGTSSTPVVTSPPKNATSAVTtgqhniTSSSTSS 643

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537 452 QALGPTSGPHNPAPSTSKESSTAAPsgagnvASGSGNNSGGPSLLVPLPVNPPSSPTPSFSEAKAAGTL--LNGPPQFST 529
Cdd:pfam05109 644 MSLRPSSISETLSPSTSDNSTSHMP------LLTSAHPTGGENITQVTPASTSTHHVSTSSPAPRPGTTsqASGPGNSST 717

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1907179537 530 TPEikaPEPLSSLKSMAERAAIS----SGIEDPVPTLHLT 565
Cdd:pfam05109 718 STK---PGEVNVTKGTPPKNATSpqapSGQKTAVPTVTST 754
PHA03247 PHA03247
large tegument protein UL36; Provisional
 315-658 2.11e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 2.11e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537  315 PQSPAVPPTYPSGPPPTTSALSSTPGNNGASTPAAPTSALGPKASPAPSHNSGTPAPYA------------------QAV 376
Cdd:PHA03247  2577 PSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAAnepdphppptvppperprDDP 2656

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537  377 APPNASGPSNAQ--------------PRPPSA---------------QPSGGSGGGSGGSSSNSNSGTGGGAGKQNGATS 427
Cdd:PHA03247  2657 APGRVSRPRRARrlgraaqassppqrPRRRAArptvgsltsladpppPPPTPEPAPHALVSATPLPPGPAAARQASPALP 2736

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537  428 YSSVVADSPAEVTLSSSGGSSASSQAlgpTSGPHNPAPSTSKESSTAAPSGAGNVASGSGNNSGGPSLLVPLPVNPPSSP 507
Cdd:PHA03247  2737 AAPAPPAVPAGPATPGGPARPARPPT---TAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLA 2813

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537  508 TPSFSEAKAAGTLLNGPPQFST-TPEIKAPEPLSSLKSM----------AERAAISSGIEDPVPTLHLTDRDIilsstsa 576
Cdd:PHA03247  2814 PAAALPPAASPAGPLPPPTSAQpTAPPPPPGPPPPSLPLggsvapggdvRRRPPSRSPAAKPAAPARPPVRRL------- 2886

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537  577 pptsSQPPLQLSEVNIPLSlgvcPLGPVSLTKEQLYQQAMEEAAWHHMPhpsdserirqyLPRNPCPTPPYHHQMPPPHS 656
Cdd:PHA03247  2887 ----ARPAVSRSTESFALP----PDQPERPPQPQAPPPPQPQPQPPPPP-----------QPQPPPPPPPRPQPPLAPTT 2947


                   ..
gi 1907179537  657 DT 658
Cdd:PHA03247  2948 DP 2949
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 343-484 2.30e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 44.59  E-value: 2.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537 343 GASTPAAPTSALGPKASPAPSHNSGTPAPYAQAVAPPNASGPSNAQPRPPSAQPSGGSGGGSGGSSSNSnsgtgggagkQ 422
Cdd:PRK07764  389 GGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPP----------P 458

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907179537 423 NGATSYSSVVADSPAEvtlsssggsSASSQALGPTSGPHNPAPSTSKESSTAAPSGAGNVAS 484
Cdd:PRK07764  459 AAAPSAQPAPAPAAAP---------EPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDAAT 511
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 213-494 2.78e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 44.39  E-value: 2.78e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537  213 DSSQDPDFEEN-EFLYDDLDLEDIPQALVATS----------PPSHSHMEDEIFNQSSSTPTSTTSSSPIPPSPANCTTE 281
Cdd:PHA03307    30 DAADDLLSGSQgQLVSDSAELAAVTVVAGAAAcdrfepptgpPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPP 109

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537  282 NSEDDKKRGRSTDsevsqsPAKNGSKPVHSNQHPQSPAVPPTYPSGPPPTTSALSSTPGNNGASTP--AAPTSALGPKAS 359
Cdd:PHA03307   110 GPSSPDPPPPTPP------PASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSrqAALPLSSPEETA 183

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537  360 PAPSHNSGTPAPYAQAVAPPNASGP--SNAQPRPPSAQPSGGSGGGSGGSSSNSNSGTGGGAGKQNGATSYSSVvaDSPA 437
Cdd:PHA03307   184 RAPSSPPAEPPPSTPPAAASPRPPRrsSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPL--PRPA 261

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907179537  438 EVTLSSSGGSSASSQALGPTSGP---------HNPAPSTSKESSTAAPSGAGNVASGSGNNSGGPS 494
Cdd:PHA03307   262 PITLPTRIWEASGWNGPSSRPGPassssspreRSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSS 327
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 333-646 3.13e-04

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 44.18  E-value: 3.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537 333 SALSSTPGNNGASTPAA----PTSALGPKASPAPShnsgTPAPYAQAVAPPNASGPSNAQPRPPSAqpsggsgggsggss 408
Cdd:pfam17823 117 AAASSSPSSAAQSLPAAiaalPSEAFSAPRAAACR----ANASAAPRAAIAAASAPHAASPAPRTA-------------- 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537 409 snsnsGTGGGAGKQNGATSYSSVVADSPAEVTLSssggssassqalgPTSGPHNPAPSTSKESSTAAPSGAGNVASGSGN 488
Cdd:pfam17823 179 -----ASSTTAASSTTAASSAPTTAASSAPATLT-------------PARGISTAATATGHPAAGTALAAVGNSSPAAGT 240

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537 489 NSGGPSLLVPLPVNPPSSPTPSFseAKAAGTLLNGPPQfSTTPeikAPEPLSSLKSMAERAAISSGIEDPVPTLHLT-DR 567
Cdd:pfam17823 241 VTAAVGTVTPAALATLAAAAGTV--ASAAGTINMGDPH-ARRL---SPAKHMPSDTMARNPAAPMGAQAQGPIIQVStDQ 314

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537 568 DIIlssTSAPPTSSQPPLQLSEVNIPLSLGVCPLGPVSLTKEQLYQQAmeeAAWHHMPHPSDSERIRQYLP-RNPCPTPP 646
Cdd:pfam17823 315 PVH---NTAGEPTPSPSNTTLEPNTPKSVASTNLAVVTTTKAQAKEPS---ASPVPVLHTSMIPEVEATSPtTQPSPLLP 388
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 339-557 1.35e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.28  E-value: 1.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537 339 PGNNGASTPAAPTSALGPKASPAPSHNSGTPAPyAQAVAPPNASGPSNAQPRPPSAQPSGGSGGGSGGSSSNSNSGTGGG 418
Cdd:PRK07764  592 PGAAGGEGPPAPASSGPPEEAARPAAPAAPAAP-AAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWP 670

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537 419 AGKQNGATSYSSVVADSPAevtlsssggsSASSQALGPTSGPHNPAPSTSKESSTAAPSGAGNVASGSGNNSGGPSLLVP 498
Cdd:PRK07764  671 AKAGGAAPAAPPPAPAPAA----------PAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVP 740

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907179537 499 LPVNPPSSPTPSFSEAKAAGTLLNGPPQFSTTPeiKAPEPLSSLKSMAERAAISSGIED 557
Cdd:PRK07764  741 LPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAA--PPPSPPSEEEEMAEDDAPSMDDED 797
PHA03247 PHA03247
large tegument protein UL36; Provisional
 308-667 1.44e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 1.44e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537  308 PVHSNQHPQSPavpPTYPSGPPPTTSALSSTPGNNGASTPAAPTSALGPkASPAPSHNSGTPAPYAQAVAPPNASGPsnA 387
Cdd:PHA03247  2694 SLTSLADPPPP---PPTPEPAPHALVSATPLPPGPAAARQASPALPAAP-APPAVPAGPATPGGPARPARPPTTAGP--P 2767

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537  388 QPRPPSAQPSGGSGGGSGGSSSNSNSGTGGGAGKQNGATSYSSVVADSPAEVTLSSSGGSSASSQALGPTSGPHNPAPST 467
Cdd:PHA03247  2768 APAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPP 2847

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537  468 SKESStaapsgAGNVASGSGNNSGGPSLLVPLPVNPPSSPTpsfseakaAGTLLNGPPQFSTTPEIKAPEPLsslksmaE 547
Cdd:PHA03247  2848 PSLPL------GGSVAPGGDVRRRPPSRSPAAKPAAPARPP--------VRRLARPAVSRSTESFALPPDQP-------E 2906

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537  548 RAAISSGIEDPVPTlhltdrdiilsSTSAPPTSSQPPLQlsevniPLSLGVCPLGPVSLTKEQLYQQAMEEAAWHHMPHP 627
Cdd:PHA03247  2907 RPPQPQAPPPPQPQ-----------PQPPPPPQPQPPPP------PPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVP 2969

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|
gi 1907179537  628 SDSERIRQylpRNPCPTPPYHHQMPPPHSDTVEFYQRLST 667
Cdd:PHA03247  2970 GRVAVPRF---RVPQPAPSREAPASSTPPLTGHSLSRVSS 3006
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
5-149 2.18e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 41.59  E-value: 2.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537   5 RKLQGEIDRCLKKVSEGVEQFEDIWQKLHNA----ANANQKEKYEADLKKEIKKLQRLRDQIKTWVasneikdkrQLIEN 80
Cdd:PRK03918  296 IKLSEFYEEYLDELREIEKRLSRLEEEINGIeeriKELEEKEERLEELKKKLKELEKRLEELEERH---------ELYEE 366

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907179537  81 RKLIETQMERFKvvereTKTKAYSKEglGLAQKVDPAQKEKEEVgqwlTNTIDTLNMQVDQFESEVESL 149
Cdd:PRK03918  367 AKAKKEELERLK-----KRLTGLTPE--KLEKELEELEKAKEEI----EEEISKITARIGELKKEIKEL 424
PHA03247 PHA03247
large tegument protein UL36; Provisional
 315-654 2.94e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 2.94e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537  315 PQSPAVpptypsgppPTTSALSSTPGNNGA---STPAAPTSALGPKASP------APSHNSGTPApyaqAVAPPNASGPS 385
Cdd:PHA03247  2554 PLPPAA---------PPAAPDRSVPPPRPAprpSEPAVTSRARRPDAPPqsarprAPVDDRGDPR----GPAPPSPLPPD 2620

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537  386 NAQPRPPSAQPSGGSGGGSGGSSSNSNSGTGGGAGKQNGATSYSSvVADSPAEVTLSSSGGSSASSQALGPTSG------ 459
Cdd:PHA03247  2621 THAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPR-RARRLGRAAQASSPPQRPRRRAARPTVGsltsla 2699

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537  460 -PHNPAPSTSKESSTAAPSGAGNVASGSGNNSGGPSLLVPLPVNPPSSPTPSFSEAKAAGTLLNGPPQFSTTPEIKAPEP 538
Cdd:PHA03247  2700 dPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGP 2779

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537  539 ---------------LSSLKSMAERAAISSGIEDPVPTLHLTDRDIILSSTSAPPTSSQPPLQLSEVNIPLSLG--VCPL 601
Cdd:PHA03247  2780 prrltrpavaslsesRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGgsVAPG 2859

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1907179537  602 GPVSltKEQLYQQAMEEAAwhHMPHPSDSERIRQYLPRN--PCPTPPYHHQMPPP 654
Cdd:PHA03247  2860 GDVR--RRPPSRSPAAKPA--APARPPVRRLARPAVSRSteSFALPPDQPERPPQ 2910
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 300-479 3.97e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.74  E-value: 3.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537 300 SPAKNGSKPVHSNQHPQSPAVPPTYPSGPPPTTSALSSTPGNNGASTPAAPTSALGPKASPAPS-------HNSGTPAPY 372
Cdd:PRK07764  600 PPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASdggdgwpAKAGGAAPA 679

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537 373 AQAVAPPNASGPSNAQPRPPSAQPsggsgggSGGSSSNSNSGTGGGAGKQNGATSYSSVVADSPAEVTLSSSGGSSAssq 452
Cdd:PRK07764  680 APPPAPAPAAPAAPAGAAPAQPAP-------APAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPP--- 749

                         170       180
                  ....*....|....*....|....*..
gi 1907179537 453 ALGPTSGPHNPAPSTSKESSTAAPSGA 479
Cdd:PRK07764  750 DPAGAPAQPPPPPAPAPAAAPAAAPPP 776
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
335-518 4.11e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 40.60  E-value: 4.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537 335 LSSTPGNNGASTPAAPTSALGPKASPAPSHNSGTPAPYAQAVAPPNASGPSNAQPRPPSAQPSGGSGGGSGGSSSNSNSG 414
Cdd:PRK07003  356 LAFEPAVTGGGAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPAT 435

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537 415 TGGgAGKQNGATSYSSVVADSPAEVTLSSSGGSSASSQALGPTSGPHNPAPSTSKE----------SSTAAPSGAGNVAS 484
Cdd:PRK07003  436 ADR-GDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFepapraaapsAATPAAVPDARAPA 514

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1907179537 485 GSGNNSGGPSLLVPLPVNPPSSPTPSFSEAKAAG 518
Cdd:PRK07003  515 AASREDAPAAAAPPAPEARPPTPAAAAPAARAGG 548
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1-185 4.86e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 40.44  E-value: 4.86e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537    1 MADKRKLQGEIDRCLKKVSEGVEQFEDIwqklhnAANANQKEKYEADLKKEIKKLQRLRDQIktwvaSNEIKDKRQ-LIE 79
Cdd:TIGR02169  694 QSELRRIENRLDELSQELSDASRKIGEI------EKEIEQLEQEEEKLKERLEELEEDLSSL-----EQEIENVKSeLKE 762

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537   80 NRKLIEtQMERFKVVERETKTKAYSKEGL-GLAQKVDPAQKEKEEVGQWLTNTIDT------LNMQVDQFESEVESLSVQ 152
Cdd:TIGR02169  763 LEARIE-ELEEDLHKLEEALNDLEARLSHsRIPEIQAELSKLEEEVSRIEARLREIeqklnrLTLEKEYLEKEIQELQEQ 841

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 1907179537  153 TRKKKGDKDQKQDRIEGLK-------RHIEKHRYHVRMLE 185
Cdd:TIGR02169  842 RIDLKEQIKSIEKEIENLNgkkeeleEELEELEAALRDLE 881
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
315-494 5.22e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 40.22  E-value: 5.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537 315 PQSPAVPPTYPSGPPPTTSALSSTPGNNGASTPAAPTSALGPKASPAP--SHNSGTPAPYAQAVAPPNASGPS--NAQPR 390
Cdd:PRK07003  385 ARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPpaTADRGDDAADGDAPVPAKANARAsaDSRCD 464

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537 391 PPSAQPSGGSGGGSGGSSSNSNSGTGGGAGKQNGATSYSSVVADSPAEVTLSSSGGSSASSQALGPTSGPHNPAPSTSKE 470
Cdd:PRK07003  465 ERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPAAAAPPAPEARPPTPAAAAPAA 544

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1907179537 471 SSTAAPSG------AG-NVASGSGNNSGGPS 494
Cdd:PRK07003  545 RAGGAAAAldvlrnAGmRVSSDRGARAAAAA 575
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
340-550 5.50e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 40.24  E-value: 5.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537 340 GNNGASTPAAPTSALGPKASPAPSHNSGTPAPYAQAVAPPNASGPSNAQPRPPSAQPsggsgggsggsSSNSNSGTGGGA 419
Cdd:PRK12323  367 QSGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAP-----------ARRSPAPEALAA 435

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537 420 GKQNGATSYSSVVADSPAEVTLSSSGGSSASSQALGPTSgPHNPAPSTSKESSTAAPSGAGNVASgsgnNSGGPSLLVPL 499
Cdd:PRK12323  436 ARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAA-AAAAAPARAAPAAAPAPADDDPPPW----EELPPEFASPA 510

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1907179537 500 PVNPPSSPTPSFSEAKAAGTLLNGPPQFSTTPEIKAPEPLSSLKSMAERAA 550
Cdd:PRK12323  511 PAQPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVV 561
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 2-192 5.81e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 40.05  E-value: 5.81e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537    2 ADKRKLQGEIDRcLKKVSEGVE-QFEDIWQKLHnaananQKEKYEADLKKEIKKLQRLRD-QIKTWVASNEIkDKRQLIE 79
Cdd:TIGR02169  237 RQKEAIERQLAS-LEEELEKLTeEISELEKRLE------EIEQLLEELNKKIKDLGEEEQlRVKEKIGELEA-EIASLER 308

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537   80 NRKLIETQMERFKvvERETKTKA----YSKEGLGLAQKVDPAQKEKEEvgqwLTNTIDTLNMQVDQFESEVESLSVQTRK 155
Cdd:TIGR02169  309 SIAEKERELEDAE--ERLAKLEAeidkLLAEIEELEREIEEERKRRDK----LTEEYAELKEELEDLRAELEEVDKEFAE 382

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 1907179537  156 KKGDKDQKQDRIEGLKRHIEKHRYHVRMLETILRMLD 192
Cdd:TIGR02169  383 TRDELKDYREKLEKLKREINELKRELDRLQEELQRLS 419
SPT5 COG5164
Transcription elongation factor SPT5 [Transcription];
339-492 6.59e-03

Transcription elongation factor SPT5 [Transcription];


Pssm-ID: 444063 [Multi-domain]  Cd Length: 495  Bit Score: 39.63  E-value: 6.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537 339 PGNNGASTPAAPTSALGpkasPAPSHNSGTPAPYAQAVAPPNASGPSnaqpRPPSAQPSGGSGGGSGGSSSNSNSGTGGG 418
Cdd:COG5164    48 AQNQGSTTPAGNTGGTR----PAGNQGATGPAQNQGGTTPAQNQGGT----RPAGNTGGTTPAGDGGATGPPDDGGATGP 119

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907179537 419 AGKqNGATSYSSVVADSPAEVTlsssGGSSASSQALGPT--SGPHNPAPSTSKESSTAAPSGAGNVASGSGNNSGG 492
Cdd:COG5164   120 PDD-GGSTTPPSGGSTTPPGDG----GSTPPGPGSTGPGgsTTPPGDGGSTTPPGPGGSTTPPDDGGSTTPPNKGE 190
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
296-394 9.41e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 39.37  E-value: 9.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907179537 296 EVSQSPAKNGSKPvhSNQHPQSP---AVPPTYPSGPPPTTSALSSTPGNNG-ASTPAAPTSALGPKASPAP-SHNSGTPA 370
Cdd:PRK14971  358 QLAQLTQKGDDAS--GGRGPKQHikpVFTQPAAAPQPSAAAAASPSPSQSSaAAQPSAPQSATQPAGTPPTvSVDPPAAV 435

                          90       100
                  ....*....|....*....|....
gi 1907179537 371 PYAQAVAPPNASGPSNAQPRPPSA 394
Cdd:PRK14971  436 PVNPPSTAPQAVRPAQFKEEKKIP 459
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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