histone-lysine N-methyltransferase KMT5C isoform X2 [Mus musculus]
List of domain hits
Name | Accession | Description | Interval | E-value | ||||
SET_KMT5C | cd19185 | SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5C (KMT5C) ... |
102-274 | 7.48e-108 | ||||
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5C (KMT5C) and similar proteins; KMT5C (also termed lysine N-methyltransferase 5C, lysine-specific methyltransferase 5C, suppressor of variegation 4-20 homolog 2, Su(var)4-20 homolog 2 or Suv4-20h2) is a histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4 (H4K20me3). It plays a central role in the establishment of constitutive heterochromatin in pericentric heterochromatin regions. : Pssm-ID: 380962 Cd Length: 142 Bit Score: 316.98 E-value: 7.48e-108
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PHA02682 super family | cl31817 | ORF080 virion core protein; Provisional |
276-397 | 1.03e-04 | ||||
ORF080 virion core protein; Provisional The actual alignment was detected with superfamily member PHA02682: Pssm-ID: 177464 [Multi-domain] Cd Length: 280 Bit Score: 44.08 E-value: 1.03e-04
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Name | Accession | Description | Interval | E-value | ||||
SET_KMT5C | cd19185 | SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5C (KMT5C) ... |
102-274 | 7.48e-108 | ||||
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5C (KMT5C) and similar proteins; KMT5C (also termed lysine N-methyltransferase 5C, lysine-specific methyltransferase 5C, suppressor of variegation 4-20 homolog 2, Su(var)4-20 homolog 2 or Suv4-20h2) is a histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4 (H4K20me3). It plays a central role in the establishment of constitutive heterochromatin in pericentric heterochromatin regions. Pssm-ID: 380962 Cd Length: 142 Bit Score: 316.98 E-value: 7.48e-108
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SET | smart00317 | SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ... |
120-255 | 1.69e-13 | ||||
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues Pssm-ID: 214614 [Multi-domain] Cd Length: 124 Bit Score: 66.97 E-value: 1.69e-13
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SET | pfam00856 | SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ... |
123-249 | 8.73e-10 | ||||
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure. Pssm-ID: 459965 [Multi-domain] Cd Length: 115 Bit Score: 56.38 E-value: 8.73e-10
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PHA02682 | PHA02682 | ORF080 virion core protein; Provisional |
276-397 | 1.03e-04 | ||||
ORF080 virion core protein; Provisional Pssm-ID: 177464 [Multi-domain] Cd Length: 280 Bit Score: 44.08 E-value: 1.03e-04
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Name | Accession | Description | Interval | E-value | ||||
SET_KMT5C | cd19185 | SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5C (KMT5C) ... |
102-274 | 7.48e-108 | ||||
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5C (KMT5C) and similar proteins; KMT5C (also termed lysine N-methyltransferase 5C, lysine-specific methyltransferase 5C, suppressor of variegation 4-20 homolog 2, Su(var)4-20 homolog 2 or Suv4-20h2) is a histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4 (H4K20me3). It plays a central role in the establishment of constitutive heterochromatin in pericentric heterochromatin regions. Pssm-ID: 380962 Cd Length: 142 Bit Score: 316.98 E-value: 7.48e-108
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SET_Suv4-20-like | cd10524 | SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of ... |
104-273 | 8.06e-76 | ||||
SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of variegation 4-20 (Suv4-20) and similar proteins; Suv4-20 (also termed Su(var)4-20) is a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-20' of histone H4. It acts as a dominant suppressor of position-effect variegation. The family also includes Suv4-20 homologs, lysine N-methyltransferase 5B (KMT5B) and lysine N-methyltransferase 5C (KMT5C). Both KMT5B (also termed lysine-specific methyltransferase 5B, or suppressor of variegation 4-20 homolog 1, or Su(var)4-20 homolog 1, or Suv4-20h1) and KMT5C (also termed lysine-specific methyltransferase 5C, or suppressor of variegation 4-20 homolog 2, or Su(var)4-20 homolog 2, or Suv4-20h2) are histone methyltransferases that specifically trimethylate 'Lys-20' of histone H4 (H4K20me3). They play central roles in the establishment of constitutive heterochromatin in pericentric heterochromatin regions. Pssm-ID: 380922 [Multi-domain] Cd Length: 141 Bit Score: 234.87 E-value: 8.06e-76
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SET_Suv4-20 | cd19186 | SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of ... |
103-273 | 5.40e-74 | ||||
SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of variegation 4-20 (Suv4-20) and similar proteins; Suv4-20 (also termed Su(var)4-20) is a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-20' of histone H4. It acts as a dominant suppressor of position-effect variegation. Pssm-ID: 380963 Cd Length: 142 Bit Score: 230.03 E-value: 5.40e-74
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SET_KMT5B | cd19184 | SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5B (KMT5B) ... |
103-274 | 2.93e-70 | ||||
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5B (KMT5B) and similar proteins; KMT5B (also termed lysine N-methyltransferase 5B, lysine-specific methyltransferase 5B, suppressor of variegation 4-20 homolog 1, Su(var)4-20 homolog 1 or Suv4-20h1) is a histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4 (H4K20me3). It plays a central role in the establishment of constitutive heterochromatin in pericentric heterochromatin regions. Pssm-ID: 380961 Cd Length: 144 Bit Score: 220.68 E-value: 2.93e-70
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SET | smart00317 | SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ... |
120-255 | 1.69e-13 | ||||
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues Pssm-ID: 214614 [Multi-domain] Cd Length: 124 Bit Score: 66.97 E-value: 1.69e-13
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SET | pfam00856 | SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ... |
123-249 | 8.73e-10 | ||||
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure. Pssm-ID: 459965 [Multi-domain] Cd Length: 115 Bit Score: 56.38 E-value: 8.73e-10
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SET | cd08161 | SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ... |
174-249 | 1.00e-07 | ||||
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site. Pssm-ID: 380914 [Multi-domain] Cd Length: 72 Bit Score: 49.17 E-value: 1.00e-07
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SET_SMYD | cd20071 | SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing ... |
113-262 | 5.54e-05 | ||||
SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1-SYMD5. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions. Pssm-ID: 380997 [Multi-domain] Cd Length: 122 Bit Score: 42.75 E-value: 5.54e-05
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PHA02682 | PHA02682 | ORF080 virion core protein; Provisional |
276-397 | 1.03e-04 | ||||
ORF080 virion core protein; Provisional Pssm-ID: 177464 [Multi-domain] Cd Length: 280 Bit Score: 44.08 E-value: 1.03e-04
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SET_NSD2 | cd19211 | SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) ... |
120-194 | 9.31e-04 | ||||
SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins; NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-36' (H3K36me) methyltransferase activity. NSD2 has been shown to mediate di- and trimethylation of H3K36 and dimethylation of H4K20 in different systems, and has been characterized as a transcriptional repressor interacting with histone deacetylase HDAC1 and histone demethylase LSD1. NSD2 mediates constitutive NF-kappaB signaling for cancer cell proliferation, survival and tumor growth. It is highly overexpressed in several types of human cancers, including small-cell lung cancers, neuroblastoma, carcinomas of stomach and colon, and bladder cancers, and its overexpression tends to be associated with tumor aggressiveness. WHSC1 is frequently deleted in Wolf-Hirschhorn syndrome (WHS). Pssm-ID: 380988 [Multi-domain] Cd Length: 142 Bit Score: 39.59 E-value: 9.31e-04
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SET_SETMAR | cd10544 | SET domain (including pre-SET and post-SET domains) found in SET domain and mariner ... |
180-269 | 3.23e-03 | ||||
SET domain (including pre-SET and post-SET domains) found in SET domain and mariner transposase fusion protein (SETMAR) and similar proteins; SETMAR (also termed metnase) is a DNA-binding protein that is indirectly recruited to sites of DNA damage through protein-protein interactions. It has a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity. SETMAR also acts as a histone-lysine N-methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3. It specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining. Pssm-ID: 380942 [Multi-domain] Cd Length: 254 Bit Score: 39.20 E-value: 3.23e-03
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Blast search parameters | ||||
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