NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1907189116|ref|XP_036009918|]
View 

WD repeat-containing protein 17 isoform X4 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 13235444)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 258-594 1.34e-43

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 160.58  E-value: 1.34e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189116  258 CITTFNLPSAAVSvqCLAWVPSaPGMFITGdSQVGVLRIWNVSRTTPIDNFKLKKtgfhcfhvvnsppKKKFSVQSPNKN 337
Cdd:cd00200      1 LRRTLKGHTGGVT--CVAFSPD-GKLLATG-SGDGTIKVWDLETGELLRTLKGHT-------------GPVRDVAASADG 63

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189116  338 HYIsstseavpppnltqnqafslppghvVCCFLDGGVGLYDMGAKKwdFLRELHG-KNGIFYIAWSHkDSKRIATCSGDG 416
Cdd:cd00200     64 TYL-------------------------ASGSSDKTIRLWDLETGE--CVRTLTGhTSYVSSVAFSP-DGRILSSSSRDK 115

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189116  417 FCII-RTVDGKLLHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIRVFyvATSSNQPLKVFSGHTARVFHVKWSPlREGI 494
Cdd:cd00200    116 TIKVwDVETGKCLTTLRgHTDWVNSVAFSPDGT-FVASSSQDGTIKLW--DLRTGKCVATLTGHTGEVNSVAFSP-DGEK 191

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189116  495 LCSGSDDGSVRIWDYTQDACVSTLNGHTAPVRGLMWNTEiPYLLISGSWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCH 574
Cdd:cd00200    192 LLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPD-GYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWS 270

                          330       340
                   ....*....|....*....|
gi 1907189116  575 PSRPfTMASCSRDSTVRLWS 594
Cdd:cd00200    271 PDGK-RLASGSADGTIRIWD 289
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 74-298 3.35e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 62.74  E-value: 3.35e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189116   74 KLHAIMSEHKKTITAISWCPHNPdLFASSSTDNLVIIWNVAEQKVIAKLDNIKETPACLGWCWnTHDAVAFVSQKGPLLI 153
Cdd:cd00200     84 ECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP-DGTFVASSSQDGTIKL 161

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189116  154 WTISgpdSGVSVHK-EAHSfaSDICIFRWHTqKKGKVAFGHIDGSISIFQPGSKNQKHVLRPDslegtdeEDPVTALEWD 232
Cdd:cd00200    162 WDLR---TGKCVATlTGHT--GEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKCLGTLRGH-------ENGVNSVAFS 228

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907189116  233 PlSTDYLLVANLHFGIRLLDSESLYCITTFNLPSAavSVQCLAWVPSAPgMFITGdSQVGVLRIWN 298
Cdd:cd00200    229 P-DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTN--SVTSLAWSPDGK-RLASG-SADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 258-594 1.34e-43

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 160.58  E-value: 1.34e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189116  258 CITTFNLPSAAVSvqCLAWVPSaPGMFITGdSQVGVLRIWNVSRTTPIDNFKLKKtgfhcfhvvnsppKKKFSVQSPNKN 337
Cdd:cd00200      1 LRRTLKGHTGGVT--CVAFSPD-GKLLATG-SGDGTIKVWDLETGELLRTLKGHT-------------GPVRDVAASADG 63

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189116  338 HYIsstseavpppnltqnqafslppghvVCCFLDGGVGLYDMGAKKwdFLRELHG-KNGIFYIAWSHkDSKRIATCSGDG 416
Cdd:cd00200     64 TYL-------------------------ASGSSDKTIRLWDLETGE--CVRTLTGhTSYVSSVAFSP-DGRILSSSSRDK 115

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189116  417 FCII-RTVDGKLLHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIRVFyvATSSNQPLKVFSGHTARVFHVKWSPlREGI 494
Cdd:cd00200    116 TIKVwDVETGKCLTTLRgHTDWVNSVAFSPDGT-FVASSSQDGTIKLW--DLRTGKCVATLTGHTGEVNSVAFSP-DGEK 191

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189116  495 LCSGSDDGSVRIWDYTQDACVSTLNGHTAPVRGLMWNTEiPYLLISGSWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCH 574
Cdd:cd00200    192 LLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPD-GYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWS 270

                          330       340
                   ....*....|....*....|
gi 1907189116  575 PSRPfTMASCSRDSTVRLWS 594
Cdd:cd00200    271 PDGK-RLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
224-595 5.11e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 162.39  E-value: 5.11e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189116  224 DPVTALEWDPLSTdYLLVANLHFGIRLLDSESLYCITTFNLPSAAVSvqCLAWVPSApGMFITGdSQVGVLRIWNVSRTT 303
Cdd:COG2319     79 AAVLSVAFSPDGR-LLASASADGTVRLWDLATGLLLRTLTGHTGAVR--SVAFSPDG-KTLASG-SADGTVRLWDLATGK 153

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189116  304 PIDNFKLKKTGFHCFHVvnsppkkkfsvqSPNkNHYISSTSEavpppnltqnqafslppghvvccflDGGVGLYDMGAKK 383
Cdd:COG2319    154 LLRTLTGHSGAVTSVAF------------SPD-GKLLASGSD-------------------------DGTVRLWDLATGK 195

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189116  384 WdfLRELHG-KNGIFYIAWSHkDSKRIATCSGDGFCIIRTVD-GKLLHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIR 460
Cdd:COG2319    196 L--LRTLTGhTGAVRSVAFSP-DGKLLASGSADGTVRLWDLAtGKLLRTLTgHSGSVRSVAFSPDGR-LLASGSADGTVR 271

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189116  461 VFYVATssNQPLKVFSGHTARVFHVKWSPlrEG-ILCSGSDDGSVRIWDYTQDACVSTLNGHTAPVRGLMWNteiPY--L 537
Cdd:COG2319    272 LWDLAT--GELLRTLTGHSGGVNSVAFSP--DGkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS---PDgkT 344

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1907189116  538 LISGSWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHPSRPfTMASCSRDSTVRLWSL 595
Cdd:COG2319    345 LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGR-TLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 74-298 3.35e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 62.74  E-value: 3.35e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189116   74 KLHAIMSEHKKTITAISWCPHNPdLFASSSTDNLVIIWNVAEQKVIAKLDNIKETPACLGWCWnTHDAVAFVSQKGPLLI 153
Cdd:cd00200     84 ECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP-DGTFVASSSQDGTIKL 161

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189116  154 WTISgpdSGVSVHK-EAHSfaSDICIFRWHTqKKGKVAFGHIDGSISIFQPGSKNQKHVLRPDslegtdeEDPVTALEWD 232
Cdd:cd00200    162 WDLR---TGKCVATlTGHT--GEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKCLGTLRGH-------ENGVNSVAFS 228

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907189116  233 PlSTDYLLVANLHFGIRLLDSESLYCITTFNLPSAavSVQCLAWVPSAPgMFITGdSQVGVLRIWN 298
Cdd:cd00200    229 P-DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTN--SVTSLAWSPDGK-RLASG-SADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 468-508 1.80e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.16  E-value: 1.80e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1907189116   468 SNQPLKVFSGHTARVFHVKWSPlREGILCSGSDDGSVRIWD 508
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
74-300 3.34e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 57.23  E-value: 3.34e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189116   74 KLHAIMSEHKKTITAISWCPHNpDLFASSSTDNLVIIWNVAEQKVIAKLDNIKETPACLGWcwnTHD--AVAFVSQKGPL 151
Cdd:COG2319    195 KLLRTLTGHTGAVRSVAFSPDG-KLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAF---SPDgrLLASGSADGTV 270

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189116  152 LIW---------TISGPDSGVSvhkeAHSFASDicifrwhtqkkGK-VAFGHIDGSISIFQPGSKNQKHVLrpdslegTD 221
Cdd:COG2319    271 RLWdlatgellrTLTGHSGGVN----SVAFSPD-----------GKlLASGSDDGTVRLWDLATGKLLRTL-------TG 328

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907189116  222 EEDPVTALEWDPLSTdYLLVANLHFGIRLLDSESLYCITTFNLPSAAVSvqCLAWVPSAPgMFITGDSQvGVLRIWNVS 300
Cdd:COG2319    329 HTGAVRSVAFSPDGK-TLASGSDDGTVRLWDLATGELLRTLTGHTGAVT--SVAFSPDGR-TLASGSAD-GTVRLWDLA 402
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 442-595 1.10e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 56.25  E-value: 1.10e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189116  442 WSQNNKDMIATGCEDKNIRVFYVAtsSNQPLKVFSGHTARVFHVKWSPLREGILCSGSDDGSVRIWDYTQDACVSTLNGh 521
Cdd:PLN00181   540 WNSYIKSQVASSNFEGVVQVWDVA--RSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKT- 616

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907189116  522 TAPVRGLMWNTEIPYLLISGSWDYTIKVWDTRG-GVCLDTVYDHGADVYGLTCHPSRpfTMASCSRDSTVRLWSL 595
Cdd:PLN00181   617 KANICCVQFPSESGRSLAFGSADHKVYYYDLRNpKLPLCTMIGHSKTVSYVRFVDSS--TLVSSSTDNTLKLWDL 689
WD40 pfam00400
WD domain, G-beta repeat;
469-508 6.22e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.95  E-value: 6.22e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1907189116  469 NQPLKVFSGHTARVFHVKWSPlREGILCSGSDDGSVRIWD 508
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 73-112 1.36e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 1.36e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1907189116    73 FKLHAIMSEHKKTITAISWCPHNpDLFASSSTDNLVIIWN 112
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
PTZ00420 PTZ00420
coronin; Provisional
 59-117 2.53e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 41.86  E-value: 2.53e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907189116   59 LAIYIYQLDHR---YNEFK-LHAIMSEHKKTITAISWCPHNPDLFASSSTDNLVIIWNVAEQK 117
Cdd:PTZ00420    97 LTIRVWEIPHNdesVKEIKdPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEK 159
WD40 pfam00400
WD domain, G-beta repeat;
73-112 3.17e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 3.17e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1907189116   73 FKLHAIMSEHKKTITAISWCPHNpDLFASSSTDNLVIIWN 112
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDG-KLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 258-594 1.34e-43

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 160.58  E-value: 1.34e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189116  258 CITTFNLPSAAVSvqCLAWVPSaPGMFITGdSQVGVLRIWNVSRTTPIDNFKLKKtgfhcfhvvnsppKKKFSVQSPNKN 337
Cdd:cd00200      1 LRRTLKGHTGGVT--CVAFSPD-GKLLATG-SGDGTIKVWDLETGELLRTLKGHT-------------GPVRDVAASADG 63

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189116  338 HYIsstseavpppnltqnqafslppghvVCCFLDGGVGLYDMGAKKwdFLRELHG-KNGIFYIAWSHkDSKRIATCSGDG 416
Cdd:cd00200     64 TYL-------------------------ASGSSDKTIRLWDLETGE--CVRTLTGhTSYVSSVAFSP-DGRILSSSSRDK 115

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189116  417 FCII-RTVDGKLLHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIRVFyvATSSNQPLKVFSGHTARVFHVKWSPlREGI 494
Cdd:cd00200    116 TIKVwDVETGKCLTTLRgHTDWVNSVAFSPDGT-FVASSSQDGTIKLW--DLRTGKCVATLTGHTGEVNSVAFSP-DGEK 191

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189116  495 LCSGSDDGSVRIWDYTQDACVSTLNGHTAPVRGLMWNTEiPYLLISGSWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCH 574
Cdd:cd00200    192 LLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPD-GYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWS 270

                          330       340
                   ....*....|....*....|
gi 1907189116  575 PSRPfTMASCSRDSTVRLWS 594
Cdd:cd00200    271 PDGK-RLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
224-595 5.11e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 162.39  E-value: 5.11e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189116  224 DPVTALEWDPLSTdYLLVANLHFGIRLLDSESLYCITTFNLPSAAVSvqCLAWVPSApGMFITGdSQVGVLRIWNVSRTT 303
Cdd:COG2319     79 AAVLSVAFSPDGR-LLASASADGTVRLWDLATGLLLRTLTGHTGAVR--SVAFSPDG-KTLASG-SADGTVRLWDLATGK 153

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189116  304 PIDNFKLKKTGFHCFHVvnsppkkkfsvqSPNkNHYISSTSEavpppnltqnqafslppghvvccflDGGVGLYDMGAKK 383
Cdd:COG2319    154 LLRTLTGHSGAVTSVAF------------SPD-GKLLASGSD-------------------------DGTVRLWDLATGK 195

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189116  384 WdfLRELHG-KNGIFYIAWSHkDSKRIATCSGDGFCIIRTVD-GKLLHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIR 460
Cdd:COG2319    196 L--LRTLTGhTGAVRSVAFSP-DGKLLASGSADGTVRLWDLAtGKLLRTLTgHSGSVRSVAFSPDGR-LLASGSADGTVR 271

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189116  461 VFYVATssNQPLKVFSGHTARVFHVKWSPlrEG-ILCSGSDDGSVRIWDYTQDACVSTLNGHTAPVRGLMWNteiPY--L 537
Cdd:COG2319    272 LWDLAT--GELLRTLTGHSGGVNSVAFSP--DGkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS---PDgkT 344

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1907189116  538 LISGSWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHPSRPfTMASCSRDSTVRLWSL 595
Cdd:COG2319    345 LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGR-TLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 366-595 1.28e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 149.02  E-value: 1.28e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189116  366 VCCFLDGG----VGLYDMGAKKWDF-----LRELHG-KNGIFYIAWSHkDSKRIATCSGDGFCII-RTVDGKLLHKYK-H 433
Cdd:cd00200     14 CVAFSPDGkllaTGSGDGTIKVWDLetgelLRTLKGhTGPVRDVAASA-DGTYLASGSSDKTIRLwDLETGECVRTLTgH 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189116  434 PAAVFGCDWSQNNKdMIATGCEDKNIRVFYVATssNQPLKVFSGHTARVFHVKWSPlREGILCSGSDDGSVRIWDYTQDA 513
Cdd:cd00200     93 TSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVET--GKCLTTLRGHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLRTGK 168

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189116  514 CVSTLNGHTAPVRGLMWnTEIPYLLISGSWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHPSRPFtMASCSRDSTVRLW 593
Cdd:cd00200    169 CVATLTGHTGEVNSVAF-SPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYL-LASGSEDGTIRVW 246


                   ..
gi 1907189116  594 SL 595
Cdd:cd00200    247 DL 248
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 393-595 1.05e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 146.33  E-value: 1.05e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189116  393 KNGIFYIAWsHKDSKRIATCSGDGFCII-RTVDGKLLHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIRVFyvATSSNQ 470
Cdd:cd00200      9 TGGVTCVAF-SPDGKLLATGSGDGTIKVwDLETGELLRTLKgHTGPVRDVAASADGT-YLASGSSDKTIRLW--DLETGE 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189116  471 PLKVFSGHTARVFHVKWSPLREgILCSGSDDGSVRIWDYTQDACVSTLNGHTAPVRGLMWNTEiPYLLISGSWDYTIKVW 550
Cdd:cd00200     85 CVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD-GTFVASSSQDGTIKLW 162

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 1907189116  551 DTRGGVCLDTVYDHGADVYGLTCHPSRpFTMASCSRDSTVRLWSL 595
Cdd:cd00200    163 DLRTGKCVATLTGHTGEVNSVAFSPDG-EKLLSSSSDGTIKLWDL 206
WD40 COG2319
WD40 repeat [General function prediction only];
189-554 1.98e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 143.13  E-value: 1.98e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189116  189 VAFGHIDGSISIFQPGSKNQKHVLRPDSlegtdeeDPVTALEWDPlSTDYLLVANLHFGIRLLDSESLYCITTFNLPSAA 268
Cdd:COG2319     93 LASASADGTVRLWDLATGLLLRTLTGHT-------GAVRSVAFSP-DGKTLASGSADGTVRLWDLATGKLLRTLTGHSGA 164

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189116  269 VSvqCLAWvpSAPG-MFITGDSQvGVLRIWNVSRTTPIDNFKLKKTGFHCFHVvnsppkkkfsvqSPNkNHYISSTSEav 347
Cdd:COG2319    165 VT--SVAF--SPDGkLLASGSDD-GTVRLWDLATGKLLRTLTGHTGAVRSVAF------------SPD-GKLLASGSA-- 224

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189116  348 pppnltqnqafslppghvvccflDGGVGLYDMGAKKWdfLRELHGKNG-IFYIAWSHkDSKRIATCSGDG-FCIIRTVDG 425
Cdd:COG2319    225 -----------------------DGTVRLWDLATGKL--LRTLTGHSGsVRSVAFSP-DGRLLASGSADGtVRLWDLATG 278

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189116  426 KLLHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIRVFYVATssNQPLKVFSGHTARVFHVKWSPLREgILCSGSDDGSV 504
Cdd:COG2319    279 ELLRTLTgHSGGVNSVAFSPDGK-LLASGSDDGTVRLWDLAT--GKLLRTLTGHTGAVRSVAFSPDGK-TLASGSDDGTV 354

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|
gi 1907189116  505 RIWDYTQDACVSTLNGHTAPVRGLMWNTEIPYLlISGSWDYTIKVWDTRG 554
Cdd:COG2319    355 RLWDLATGELLRTLTGHTGAVTSVAFSPDGRTL-ASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 433-595 2.70e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 133.61  E-value: 2.70e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189116  433 HPAAVFGCDWSQNNKdMIATGCEDKNIRVFyvATSSNQPLKVFSGHTARVFHVKWSPLREGILcSGSDDGSVRIWDYTQD 512
Cdd:cd00200      8 HTGGVTCVAFSPDGK-LLATGSGDGTIKVW--DLETGELLRTLKGHTGPVRDVAASADGTYLA-SGSSDKTIRLWDLETG 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189116  513 ACVSTLNGHTAPVRGLMWNTEIPYLLiSGSWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHPSRPFTmASCSRDSTVRL 592
Cdd:cd00200     84 ECVRTLTGHTSYVSSVAFSPDGRILS-SSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFV-ASSSQDGTIKL 161


                   ...
gi 1907189116  593 WSL 595
Cdd:cd00200    162 WDL 164
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 223-551 2.47e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 125.14  E-value: 2.47e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189116  223 EDPVTALEWDPLStDYLLVANLHFGIRLLDSESLYCITTfnLPSAAVSVQCLAWVPSAPGMFITG-DSQVgvlRIWNVSR 301
Cdd:cd00200      9 TGGVTCVAFSPDG-KLLATGSGDGTIKVWDLETGELLRT--LKGHTGPVRDVAASADGTYLASGSsDKTI---RLWDLET 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189116  302 TTPIDNFklkkTGfHCFHVvnsppkkkFSVQSPNKNHYISSTSEavpppnltqnqafslppghvvccflDGGVGLYDMGA 381
Cdd:cd00200     83 GECVRTL----TG-HTSYV--------SSVAFSPDGRILSSSSR-------------------------DKTIKVWDVET 124

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189116  382 KKwdFLRELHGKNG-IFYIAWSHkDSKRIATCSGDGFCII-RTVDGKLLHKYK-HPAAVFGCDWSQNNKDMIATGCeDKN 458
Cdd:cd00200    125 GK--CLTTLRGHTDwVNSVAFSP-DGTFVASSSQDGTIKLwDLRTGKCVATLTgHTGEVNSVAFSPDGEKLLSSSS-DGT 200

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189116  459 IRVFYVATSsnQPLKVFSGHTARVFHVKWSPLREgILCSGSDDGSVRIWDYTQDACVSTLNGHTAPVRGLMWNTEIPYlL 538
Cdd:cd00200    201 IKLWDLSTG--KCLGTLRGHENGVNSVAFSPDGY-LLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKR-L 276

                          330
                   ....*....|...
gi 1907189116  539 ISGSWDYTIKVWD 551
Cdd:cd00200    277 ASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 471-596 2.50e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 118.98  E-value: 2.50e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189116  471 PLKVFSGHTARVFHVKWSPLREgILCSGSDDGSVRIWDYTQDACVSTLNGHTAPVRGLMWnteIPY--LLISGSWDYTIK 548
Cdd:cd00200      1 LRRTLKGHTGGVTCVAFSPDGK-LLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAA---SADgtYLASGSSDKTIR 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1907189116  549 VWDTRGGVCLDTVYDHGADVYGLTCHPSRPFtMASCSRDSTVRLWSLI 596
Cdd:cd00200     77 LWDLETGECVRTLTGHTSYVSSVAFSPDGRI-LSSSSRDKTIKVWDVE 123
WD40 COG2319
WD40 repeat [General function prediction only];
387-595 3.63e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 121.56  E-value: 3.63e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189116  387 LRELHGKNGIFYIAWSHKDSKRIATCSGDGFCIIRTVDGKLLHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIRVFYVA 465
Cdd:COG2319     30 LLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLgHTAAVLSVAFSPDGR-LLASASADGTVRLWDLA 108

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189116  466 TSsnQPLKVFSGHTARVFHVKWSPLREGILcSGSDDGSVRIWDYTQDACVSTLNGHTAPVRGLMWNteiP--YLLISGSW 543
Cdd:COG2319    109 TG--LLLRTLTGHTGAVRSVAFSPDGKTLA-SGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFS---PdgKLLASGSD 182

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1907189116  544 DYTIKVWDTRGGVCLDTVYDHGADVYGLTCHP-SRpfTMASCSRDSTVRLWSL 595
Cdd:COG2319    183 DGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPdGK--LLASGSADGTVRLWDL 233
WD40 COG2319
WD40 repeat [General function prediction only];
465-595 4.31e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 72.64  E-value: 4.31e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189116  465 ATSSNQPLKVFSGHTARVFHVKWSPLREGILcSGSDDGSVRIWDYTQDACVSTLNGHTAPVRGLMWNTEIPYLLiSGSWD 544
Cdd:COG2319     22 AAALGALLLLLLGLAAAVASLAASPDGARLA-AGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLA-SASAD 99

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1907189116  545 YTIKVWDTRGGVCLDTVYDHGADVYGLTCHPSRPfTMASCSRDSTVRLWSL 595
Cdd:COG2319    100 GTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGK-TLASGSADGTVRLWDL 149
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 74-298 3.35e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 62.74  E-value: 3.35e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189116   74 KLHAIMSEHKKTITAISWCPHNPdLFASSSTDNLVIIWNVAEQKVIAKLDNIKETPACLGWCWnTHDAVAFVSQKGPLLI 153
Cdd:cd00200     84 ECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP-DGTFVASSSQDGTIKL 161

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189116  154 WTISgpdSGVSVHK-EAHSfaSDICIFRWHTqKKGKVAFGHIDGSISIFQPGSKNQKHVLRPDslegtdeEDPVTALEWD 232
Cdd:cd00200    162 WDLR---TGKCVATlTGHT--GEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKCLGTLRGH-------ENGVNSVAFS 228

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907189116  233 PlSTDYLLVANLHFGIRLLDSESLYCITTFNLPSAavSVQCLAWVPSAPgMFITGdSQVGVLRIWN 298
Cdd:cd00200    229 P-DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTN--SVTSLAWSPDGK-RLASG-SADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 468-508 1.80e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.16  E-value: 1.80e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1907189116   468 SNQPLKVFSGHTARVFHVKWSPlREGILCSGSDDGSVRIWD 508
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
74-300 3.34e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 57.23  E-value: 3.34e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189116   74 KLHAIMSEHKKTITAISWCPHNpDLFASSSTDNLVIIWNVAEQKVIAKLDNIKETPACLGWcwnTHD--AVAFVSQKGPL 151
Cdd:COG2319    195 KLLRTLTGHTGAVRSVAFSPDG-KLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAF---SPDgrLLASGSADGTV 270

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189116  152 LIW---------TISGPDSGVSvhkeAHSFASDicifrwhtqkkGK-VAFGHIDGSISIFQPGSKNQKHVLrpdslegTD 221
Cdd:COG2319    271 RLWdlatgellrTLTGHSGGVN----SVAFSPD-----------GKlLASGSDDGTVRLWDLATGKLLRTL-------TG 328

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907189116  222 EEDPVTALEWDPLSTdYLLVANLHFGIRLLDSESLYCITTFNLPSAAVSvqCLAWVPSAPgMFITGDSQvGVLRIWNVS 300
Cdd:COG2319    329 HTGAVRSVAFSPDGK-TLASGSDDGTVRLWDLATGELLRTLTGHTGAVT--SVAFSPDGR-TLASGSAD-GTVRLWDLA 402
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 442-595 1.10e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 56.25  E-value: 1.10e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189116  442 WSQNNKDMIATGCEDKNIRVFYVAtsSNQPLKVFSGHTARVFHVKWSPLREGILCSGSDDGSVRIWDYTQDACVSTLNGh 521
Cdd:PLN00181   540 WNSYIKSQVASSNFEGVVQVWDVA--RSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKT- 616

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907189116  522 TAPVRGLMWNTEIPYLLISGSWDYTIKVWDTRG-GVCLDTVYDHGADVYGLTCHPSRpfTMASCSRDSTVRLWSL 595
Cdd:PLN00181   617 KANICCVQFPSESGRSLAFGSADHKVYYYDLRNpKLPLCTMIGHSKTVSYVRFVDSS--TLVSSSTDNTLKLWDL 689
PTZ00420 PTZ00420
coronin; Provisional
 469-551 1.99e-07

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 55.34  E-value: 1.99e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189116  469 NQPLKVFSGHTARVFHVKWSPLREGILCSGSDDGSVRIWDYTQD----------ACVstLNGHTAPVRGLMWNTEIPYLL 538
Cdd:PTZ00420    64 KPPVIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPHNdesvkeikdpQCI--LKGHKKKISIIDWNPMNYYIM 141

                           90
                   ....*....|...
gi 1907189116  539 ISGSWDYTIKVWD 551
Cdd:PTZ00420   142 CSSGFDSFVNIWD 154
WD40 pfam00400
WD domain, G-beta repeat;
469-508 6.22e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.95  E-value: 6.22e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1907189116  469 NQPLKVFSGHTARVFHVKWSPlREGILCSGSDDGSVRIWD 508
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 514-551 1.27e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 1.27e-06
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1907189116   514 CVSTLNGHTAPVRGLMWNTEIPYLlISGSWDYTIKVWD 551
Cdd:smart00320    4 LLKTLKGHTGPVTSVAFSPDGKYL-ASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
514-551 7.89e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 7.89e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1907189116  514 CVSTLNGHTAPVRGLMWNTEIPYLlISGSWDYTIKVWD 551
Cdd:pfam00400    3 LLKTLEGHTGSVTSLAFSPDGKLL-ASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 448-508 5.37e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 47.25  E-value: 5.37e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907189116  448 DMIATGCEDKNIRVFYVATSSNQ------PLKVFSGHTARVFHVKWSPLREGILCSGSDDGSVRIWD 508
Cdd:PTZ00420    88 EILASGSEDLTIRVWEIPHNDESvkeikdPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWD 154
PTZ00420 PTZ00420
coronin; Provisional
 502-618 5.74e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 47.25  E-value: 5.74e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189116  502 GSVRIWDYTQDACVSTLNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTR-GGVCLDTVYD-------HGADVYGLTC 573
Cdd:PTZ00420    54 GAIRLENQMRKPPVIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPhNDESVKEIKDpqcilkgHKKKISIIDW 133

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1907189116  574 HPSRPFTMASCSRDSTVRLWSLIPLITPLQINI---LADRSWDeVIGN 618
Cdd:PTZ00420   134 NPMNYYIMCSSGFDSFVNIWDIENEKRAFQINMpkkLSSLKWN-IKGN 180
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 73-112 1.36e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 1.36e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1907189116    73 FKLHAIMSEHKKTITAISWCPHNpDLFASSSTDNLVIIWN 112
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 467-564 1.94e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 45.65  E-value: 1.94e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189116  467 SSNQPLKVFSGHTARVFHVKWSPLREGILCSGSDDGSVRIWDYTQDACVSTLNGHTAPVRGLMWNTEiPYLLISGSWDYT 546
Cdd:PTZ00421   113 NISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLD-GSLLCTTSKDKK 191

                           90
                   ....*....|....*...
gi 1907189116  547 IKVWDTRGGVCLDTVYDH 564
Cdd:PTZ00421   192 LNIIDPRDGTIVSSVEAH 209
WD40 pfam00400
WD domain, G-beta repeat;
555-594 3.08e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 3.08e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1907189116  555 GVCLDTVYDHGADVYGLTCHPSRPFtMASCSRDSTVRLWS 594
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 555-594 4.00e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 4.00e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1907189116   555 GVCLDTVYDHGADVYGLTCHPSRPFtMASCSRDSTVRLWS 594
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 467-592 4.54e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 44.11  E-value: 4.54e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189116  467 SSNQPLKVfsGHTARVFHVKWSPLREGILCSGSDDGSVRIWDYTQDACVST-------LNGHTAPVRGLMWNTEIPYLLI 539
Cdd:PTZ00421    65 ASNPPILL--GQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNisdpivhLQGHTKKVGIVSFHPSAMNVLA 142

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1907189116  540 SGSWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHpSRPFTMASCSRDSTVRL 592
Cdd:PTZ00421   143 SAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWN-LDGSLLCTTSKDKKLNI 194
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 42-122 1.43e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 41.94  E-value: 1.43e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189116   42 NKDVCAANGDRFaycatlaIYIYQLDhrynEFKLHAIMSEHKKTITAISWCPHNpDLFASSSTDNLVIIWNVAEQKVIAK 121
Cdd:cd00200    189 GEKLLSSSSDGT-------IKLWDLS----TGKCLGTLRGHENGVNSVAFSPDG-YLLASGSEDGTIRVWDLRTGECVQT 256


                   .
gi 1907189116  122 L 122
Cdd:cd00200    257 L 257
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 424-462 1.56e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 1.56e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1907189116   424 DGKLLHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIRVF 462
Cdd:smart00320    1 SGELLKTLKgHTGPVTSVAFSPDGK-YLASGSDDGTIKLW 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 527-595 2.45e-03

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 42.00  E-value: 2.45e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907189116  527 GLMWNTEIPYLLISGSWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLWSL 595
Cdd:PLN00181   537 GICWNSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSI 605
PTZ00420 PTZ00420
coronin; Provisional
 59-117 2.53e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 41.86  E-value: 2.53e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907189116   59 LAIYIYQLDHR---YNEFK-LHAIMSEHKKTITAISWCPHNPDLFASSSTDNLVIIWNVAEQK 117
Cdd:PTZ00420    97 LTIRVWEIPHNdesVKEIKdPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEK 159
WD40 pfam00400
WD domain, G-beta repeat;
73-112 3.17e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 3.17e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1907189116   73 FKLHAIMSEHKKTITAISWCPHNpDLFASSSTDNLVIIWN 112
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDG-KLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH