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Conserved domains on  [gi|1907195611|ref|XP_036010590|]
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serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit delta isoform X4 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP2R3A_B-like cd21504
serine/threonine protein phosphatase 2A regulatory subunit B" alpha and beta subunits, and ...
 157-395 1.15e-160

serine/threonine protein phosphatase 2A regulatory subunit B" alpha and beta subunits, and similar proteins; Heterotrimeric serine/threonine protein phosphatase 2A (PP2A) consists of scaffolding (A), catalytic (C), and variable (B, B', and B") subunits. The variable subunits dictate subcellular localization and substrate specificity of the PP2A holoenzyme. These B-family regulatory subunits play various roles including regulation of cytoskeletal assembly, neuronal differentiation, mitogen-activated protein kinase signaling, and apoptosis. This subfamily includes protein phosphatase 2A regulatory subunit B'' subunits alpha and beta, encoded by PPP2R3A and PPP2R3B. It also includes subunit delta encoded by PPP2R3D in mouse. They contain two-domain elongated structures with two calcium EF-hands which mediate Ca2+-dependent changes in phosphatase activity.


:

Pssm-ID: 410337  Cd Length: 274  Bit Score: 455.08  E-value: 1.15e-160
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195611 157 QDVVNSHPGLAFLRAAKDFHSRYITTVIQRIFYTVNRSWSGMISREELRRSSFLQAVSQLEVEPDINRMTSFFSYEHFYV 236
Cdd:cd21504    37 QDLLDTHPGLEFLQDTPEFQERYAETVIYRIFYSVNRSWSGRITLRELRRSNLLQALLLLDEEEDINKVLRYFSYEHFYV 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195611 237 IYCKFWELDLDRDLTIDRSDLARHGDGAISSRMIDRIFSGAVTRARLpRKVGKLSYADFVWFLLSEEDKTTPTSTEYWFR 316
Cdd:cd21504   117 IYCKFWELDTDHDLLIDKDDLLRYGDHALSPRIVDRIFSGAVRRFKS-GKEGKMSYEDFVWFILSEEDKTSPTSIEYWFR 195

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907195611 317 CMDLDGDGALSMFELEFFYEEQAQRMAARGVEPLPFHDLARQVLDLVAPRCPGRITLRDLKQCGLAGEFFDAFFNVDKY 395
Cdd:cd21504   196 CMDLDGDGVLSMYEMEYFYEEQLQRMECLGIEPVPFEDILCQMLDMIKPENEGKITLRDLKRCKLAGNFFNTLFNLNKF 274
 
Name Accession Description Interval E-value
PPP2R3A_B-like cd21504
serine/threonine protein phosphatase 2A regulatory subunit B" alpha and beta subunits, and ...
 157-395 1.15e-160

serine/threonine protein phosphatase 2A regulatory subunit B" alpha and beta subunits, and similar proteins; Heterotrimeric serine/threonine protein phosphatase 2A (PP2A) consists of scaffolding (A), catalytic (C), and variable (B, B', and B") subunits. The variable subunits dictate subcellular localization and substrate specificity of the PP2A holoenzyme. These B-family regulatory subunits play various roles including regulation of cytoskeletal assembly, neuronal differentiation, mitogen-activated protein kinase signaling, and apoptosis. This subfamily includes protein phosphatase 2A regulatory subunit B'' subunits alpha and beta, encoded by PPP2R3A and PPP2R3B. It also includes subunit delta encoded by PPP2R3D in mouse. They contain two-domain elongated structures with two calcium EF-hands which mediate Ca2+-dependent changes in phosphatase activity.


Pssm-ID: 410337  Cd Length: 274  Bit Score: 455.08  E-value: 1.15e-160
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195611 157 QDVVNSHPGLAFLRAAKDFHSRYITTVIQRIFYTVNRSWSGMISREELRRSSFLQAVSQLEVEPDINRMTSFFSYEHFYV 236
Cdd:cd21504    37 QDLLDTHPGLEFLQDTPEFQERYAETVIYRIFYSVNRSWSGRITLRELRRSNLLQALLLLDEEEDINKVLRYFSYEHFYV 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195611 237 IYCKFWELDLDRDLTIDRSDLARHGDGAISSRMIDRIFSGAVTRARLpRKVGKLSYADFVWFLLSEEDKTTPTSTEYWFR 316
Cdd:cd21504   117 IYCKFWELDTDHDLLIDKDDLLRYGDHALSPRIVDRIFSGAVRRFKS-GKEGKMSYEDFVWFILSEEDKTSPTSIEYWFR 195

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907195611 317 CMDLDGDGALSMFELEFFYEEQAQRMAARGVEPLPFHDLARQVLDLVAPRCPGRITLRDLKQCGLAGEFFDAFFNVDKY 395
Cdd:cd21504   196 CMDLDGDGVLSMYEMEYFYEEQLQRMECLGIEPVPFEDILCQMLDMIKPENEGKITLRDLKRCKLAGNFFNTLFNLNKF 274
EF-hand_13 pfam17958
EF-hand domain; This entry represents an EF-hand domain found in one of the regulatory B ...
 157-219 8.63e-28

EF-hand domain; This entry represents an EF-hand domain found in one of the regulatory B subunits of PP2A.


Pssm-ID: 465586 [Multi-domain]  Cd Length: 90  Bit Score: 105.91  E-value: 8.63e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907195611 157 QDVVNSHPGLAFLRAAKDFHSRYITTVIQRIFYTVNRSWSGMISREELRRSSFLQAVSQLEVE 219
Cdd:pfam17958  28 QDVVDTHPGLEFLREAEEFQDKYIQTVIARIFYVVNRSWSGKITLLELRKSDLLKAVRQLDEE 90
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
241-345 6.21e-04

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 39.78  E-value: 6.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195611 241 FWELDLDRDLTIDRSDLArhgdgAISSRMIDRIFSGAVTRArlprkVGKLSYADFVWFLLSEEDKTTPTSTEYWFRCMDL 320
Cdd:COG5126    11 FDLLDADGDGVLERDDFE-----ALFRRLWATLFSEADTDG-----DGRISREEFVAGMESLFEATVEPFARAAFDLLDT 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1907195611 321 DGDGALSMFELEFFY------EEQAQRMAAR 345
Cdd:COG5126    81 DGDGKISADEFRRLLtalgvsEEEADELFAR 111
 
Name Accession Description Interval E-value
PPP2R3A_B-like cd21504
serine/threonine protein phosphatase 2A regulatory subunit B" alpha and beta subunits, and ...
 157-395 1.15e-160

serine/threonine protein phosphatase 2A regulatory subunit B" alpha and beta subunits, and similar proteins; Heterotrimeric serine/threonine protein phosphatase 2A (PP2A) consists of scaffolding (A), catalytic (C), and variable (B, B', and B") subunits. The variable subunits dictate subcellular localization and substrate specificity of the PP2A holoenzyme. These B-family regulatory subunits play various roles including regulation of cytoskeletal assembly, neuronal differentiation, mitogen-activated protein kinase signaling, and apoptosis. This subfamily includes protein phosphatase 2A regulatory subunit B'' subunits alpha and beta, encoded by PPP2R3A and PPP2R3B. It also includes subunit delta encoded by PPP2R3D in mouse. They contain two-domain elongated structures with two calcium EF-hands which mediate Ca2+-dependent changes in phosphatase activity.


Pssm-ID: 410337  Cd Length: 274  Bit Score: 455.08  E-value: 1.15e-160
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195611 157 QDVVNSHPGLAFLRAAKDFHSRYITTVIQRIFYTVNRSWSGMISREELRRSSFLQAVSQLEVEPDINRMTSFFSYEHFYV 236
Cdd:cd21504    37 QDLLDTHPGLEFLQDTPEFQERYAETVIYRIFYSVNRSWSGRITLRELRRSNLLQALLLLDEEEDINKVLRYFSYEHFYV 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195611 237 IYCKFWELDLDRDLTIDRSDLARHGDGAISSRMIDRIFSGAVTRARLpRKVGKLSYADFVWFLLSEEDKTTPTSTEYWFR 316
Cdd:cd21504   117 IYCKFWELDTDHDLLIDKDDLLRYGDHALSPRIVDRIFSGAVRRFKS-GKEGKMSYEDFVWFILSEEDKTSPTSIEYWFR 195

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907195611 317 CMDLDGDGALSMFELEFFYEEQAQRMAARGVEPLPFHDLARQVLDLVAPRCPGRITLRDLKQCGLAGEFFDAFFNVDKY 395
Cdd:cd21504   196 CMDLDGDGVLSMYEMEYFYEEQLQRMECLGIEPVPFEDILCQMLDMIKPENEGKITLRDLKRCKLAGNFFNTLFNLNKF 274
PPP2R3B cd21507
serine/threonine protein phosphatase 2A regulatory subunit B" subunit beta; Heterotrimeric ...
 157-401 2.58e-150

serine/threonine protein phosphatase 2A regulatory subunit B" subunit beta; Heterotrimeric serine/threonine protein phosphatase 2A (PP2A) consists of scaffolding (A), catalytic (C), and variable (B, B', and B") subunits. The variable subunits dictate subcellular localization and substrate specificity of the PP2A holoenzyme. This group contains protein phosphatase subunit PR70 (also known as protein phosphatase 2 regulatory subunit B'' subunit beta, PR48, NYREN8, PPP2R3L, or PPP2R3LY) that is encoded by the PPP2R3B gene. This substrate-recognizing subunit of PP2A has a two-domain elongated structure with two calcium EF-hands, each displaying different affinities to Ca2+. PPP2R3B/PR70 is a gonosomal melanoma tumor suppressor gene; PR70 decreased melanoma growth by negatively interfering with DNA replication and cell cycle progression through its role in stabilizing the cell division cycle 6 (CDC6)-chromatin licensing and DNA replication factor 1 (CDT1) interaction, which delays the firing of origins of DNA replication.


Pssm-ID: 410340  Cd Length: 355  Bit Score: 432.07  E-value: 2.58e-150
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195611 157 QDVVNSHPGLAFLRAAKDFHSRYITTVIQRIFYTVNRSWSGMISREELRRSSFLQAVSQLEVEPDINRMTSFFSYEHFYV 236
Cdd:cd21507   111 QDVVNTHPGLSFLKEASEFHSRYITTVIQRIFYTVNRSWSGRITCTELRRSSFLQNVALLEEEADINQLTEFFSYEHFYV 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195611 237 IYCKFWELDLDRDLTIDRSDLARHGDGAISSRMIDRIFSGAVTRARLPRKVGKLSYADFVWFLLSEEDKTTPTSTEYWFR 316
Cdd:cd21507   191 IYCKFWELDTDHDLYIDQKDLARHNDHAISNRMIERIFSGAVTRGRKAQKEGKISYADFVWFLISEEDKKTPTSIEYWFR 270

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195611 317 CMDLDGDGALSMFELEFFYEEQAQRMAARGVEPLPFHDLARQVLDLVAPRCPGRITLRDLKQCGLAGEFFDAFFNVDKYL 396
Cdd:cd21507   271 CMDLDGDGALSMYELEYFYEEQCQKLDNMAIEPLPFEDCLCQMLDLVKPRTEGKITLHDLKRCKLANVFFDTFFNIEKYL 350


                  ....*
gi 1907195611 397 AREQR 401
Cdd:cd21507   351 DHEQK 355
PPP2R3A cd21506
serine/threonine protein phosphatase 2A regulatory subunit B" subunit alpha; Heterotrimeric ...
 157-402 4.14e-146

serine/threonine protein phosphatase 2A regulatory subunit B" subunit alpha; Heterotrimeric serine/threonine protein phosphatase 2A (PP2A) consists of scaffolding (A), catalytic (C), and variable (B, B', and B") subunits. The variable subunits dictate subcellular localization and substrate specificity of the PP2A holoenzyme. This group contains protein phosphatase subunit PR130 (also known as protein phosphatase 2A regulatory subunit B'' subunit alpha, PR72, or PPP2R3) that is encoded by the PPP2R3A gene. PR130 and PR72 subunits are derived from the same gene through differential splicing; they harbor specific N-terminal domains of different lengths that are encoded by alternatively spliced exons and have identical C-termini. The common C-terminus contains a two-domain elongated structure with two calcium EF-hands which mediate Ca2+-dependent changes in phosphatase activity. The PR130 subunit has been shown to interact with the LIM domain of lipoma-preferred partner (LPP) through a conserved Zn2+-finger-like motif in the N-terminus of PR130.


Pssm-ID: 410339  Cd Length: 284  Bit Score: 418.57  E-value: 4.14e-146
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195611 157 QDVVNSHPGLAFLRAAKDFHSRYITTVIQRIFYTVNRSWSGMISREELRRSSFLQAVSQLEVEPDINRMTSFFSYEHFYV 236
Cdd:cd21506    37 QDIVDTHPGLTFLKDAPEFHSRYITTVIQRIFYTVNRSWSGKITLTELRKSNFLQTLALLEEEDDINQITDYFSYEHFYV 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195611 237 IYCKFWELDLDRDLTIDRSDLARHGDGAISSRMIDRIFSGAVTRARLPRKVGKLSYADFVWFLLSEEDKTTPTSTEYWFR 316
Cdd:cd21506   117 IYCKFWELDTDHDLYIDQKDLARYNDQASSSRIIERIFSGAVTRGNSVQKEGRMSYADFVWFLISEEDKRNPTSIEYWFR 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195611 317 CMDLDGDGALSMFELEFFYEEQAQRMAARGVEPLPFHDLARQVLDLVAPRCPGRITLRDLKQCGLAGEFFDAFFNVDKYL 396
Cdd:cd21506   197 CMDLDGDGVLSMYELEYFYEEQCERMEAMGIEPLPFHDLLCQMLDLVKPEVDGKITLRDLKRCRMAHIFYDTFFNLEKYL 276


                  ....*.
gi 1907195611 397 AREQRE 402
Cdd:cd21506   277 DHEQRD 282
PPP2R3 cd21339
serine/threonine protein phosphatase 2A regulatory subunit B"; Heterotrimeric serine/threonine ...
 157-389 2.86e-121

serine/threonine protein phosphatase 2A regulatory subunit B"; Heterotrimeric serine/threonine protein phosphatase 2A (PP2A) consists of scaffolding (A), catalytic (C), and variable (B, B', and B") subunits. The variable subunits dictate subcellular localization and substrate specificity of the PP2A holoenzyme. This family includes PP2A regulatory B'' subunits alpha, beta and gamma, encoded by PPP2R3A, PPP2R3B and PPP2R3C, respectively. It also includes subunit delta encoded by PPP2R3D in mouse. These B-family regulatory subunits play various roles including regulation of cytoskeletal assembly, neuronal differentiation, mitogen-activated protein kinase signaling, and apoptosis. Subunits alpha and beta contain two-domain elongated structure with two calcium EF-hands which mediate Ca2+-dependent changes in phosphatase activity.


Pssm-ID: 410336  Cd Length: 259  Bit Score: 354.58  E-value: 2.86e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195611 157 QDVVNSHPGLAFLRAAKDFHSRYITTVIQRIFYTVNRSWSGMISREELRRSSFLQAVSQLEVEPDINRMTSFFSYEHFYV 236
Cdd:cd21339    27 QDVVPTHPGLDFLKKAPEFHSRYITTVIQRIFYFVNRSWSGKITIQEIRASSFLQDLALLEEEEDINQETNWFSYEHFYV 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195611 237 IYCKFWELDLDRDLTIDRSDLARHGDGAISSRMIDRIFSGAVTRARLPRKVGKLSYADFVWFLLSEEDKTTPTSTEYWFR 316
Cdd:cd21339   107 IYCKFWELDTDHDLMISKEDLSRYNDAAMSNVFIDRIFSGAVTRGKTIQKEGEMSYADFVWFLISEEDKKEPTSIEYWFR 186

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907195611 317 CMDLDGDGALSMFELEFFYEEQAQRMAARGVEPLPFHDLARQVLDLVAPRCPGRITLRDLKQCGLAGEFFDAF 389
Cdd:cd21339   187 CLDIDGDGYLSVFELEYFYEEQCERMKIHGIEPLPFQDVLCQILDLVKPKDPGKITLQDLKRCNIALNFFDTF 259
PPP2R3C cd21505
serine/threonine protein phosphatase 2A regulatory subunit B" subunit gamma; Heterotrimeric ...
 173-402 4.89e-35

serine/threonine protein phosphatase 2A regulatory subunit B" subunit gamma; Heterotrimeric serine/threonine protein phosphatase 2A (PP2A) consists of scaffolding (A), catalytic (C), and variable (B, B', and B") subunits. The variable subunits dictate subcellular localization and substrate specificity of the PP2A holoenzyme. This subfamily includes protein phosphatase subunit G5PR (also known as serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma, G4-1, G5pr, GDRM, SPGF36, or C14orf10) that is encoded by the PPP2R3C gene. It is involved in the control of the dynamic organization of the cortical cytoskeleton and plays an important role in the organization of interphase microtubule arrays in part through the regulation of nucleation geometry. G5PR is involved in the ontogeny of multiple organs, especially critical for testis development and spermatogenesis. PPP2R3C gene variants cause syndromic 46,XY gonadal dysgenesis and impaired spermatogenesis in humans, and thus is emerging as a potential therapeutic target for male infertility.


Pssm-ID: 410338 [Multi-domain]  Cd Length: 382  Bit Score: 134.24  E-value: 4.89e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195611 173 KDFHSRYITTVIQRIFYTVNRSWSGMISREELRRSSFLQAVSQL--EVEPDINRMTSFFSYEHFYVIYCKFWELDLDRDL 250
Cdd:cd21505   157 ESFYSFYVCTAVRKFFFFLDPLRRGKIRIKDILASPFLDELLELrdEELSEELQESNWFSAPSALRVYGQYLNLDKDHNG 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195611 251 TIDRSDLARHGDGAISSRMIDRIFSGAVTRArlprkvGKLSYADFVWFLLSEEDKTTPTSTEYWFRCMDLDGDGALSMFE 330
Cdd:cd21505   237 MLSKQELSRYGKGTLTSVFIDRVFQECLTYN------GEMDYKTFLDFVLAMENRKEPQALQYFFRILDLKGQGYLTPFT 310

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907195611 331 LEFFYEEQAQRMAARGVEPLPFHDLARQVLDLVAPRCPGRITLRDLKQCGLAGEFFDAFFNVDKYLAREQRE 402
Cdd:cd21505   311 LNYFFRAIQEKMKEHGQEPVSFEDVKDEIFDMVKPKDPLKITLQDLINSGQGDTVVSILIDLNGFWAYENRE 382
EF-hand_13 pfam17958
EF-hand domain; This entry represents an EF-hand domain found in one of the regulatory B ...
 157-219 8.63e-28

EF-hand domain; This entry represents an EF-hand domain found in one of the regulatory B subunits of PP2A.


Pssm-ID: 465586 [Multi-domain]  Cd Length: 90  Bit Score: 105.91  E-value: 8.63e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907195611 157 QDVVNSHPGLAFLRAAKDFHSRYITTVIQRIFYTVNRSWSGMISREELRRSSFLQAVSQLEVE 219
Cdd:pfam17958  28 QDVVDTHPGLEFLREAEEFQDKYIQTVIARIFYVVNRSWSGKITLLELRKSDLLKAVRQLDEE 90
EF-hand_7 pfam13499
EF-hand domain pair;
234-335 9.88e-07

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 46.09  E-value: 9.88e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195611 234 FYVIYCKFWELDLDRDltidrsdlarhgdgaissrmidrifsgavtrarlprkvGKLSYADFVWFL--LSEEDKTTPTST 311
Cdd:pfam13499   1 EEKLKEAFKLLDSDGD--------------------------------------GYLDVEELKKLLrkLEEGEPLSDEEV 42

                          90       100
                  ....*....|....*....|....
gi 1907195611 312 EYWFRCMDLDGDGALSMFELEFFY 335
Cdd:pfam13499  43 EELFKEFDLDKDGRISFEEFLELY 66
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
241-345 6.21e-04

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 39.78  E-value: 6.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195611 241 FWELDLDRDLTIDRSDLArhgdgAISSRMIDRIFSGAVTRArlprkVGKLSYADFVWFLLSEEDKTTPTSTEYWFRCMDL 320
Cdd:COG5126    11 FDLLDADGDGVLERDDFE-----ALFRRLWATLFSEADTDG-----DGRISREEFVAGMESLFEATVEPFARAAFDLLDT 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1907195611 321 DGDGALSMFELEFFY------EEQAQRMAAR 345
Cdd:COG5126    81 DGDGKISADEFRRLLtalgvsEEEADELFAR 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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