RNA N6-adenosine-methyltransferase METTL16 isoform X4 [Mus musculus]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| AdoMet_MTases super family | cl17173 | S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ... |
23-71 | 2.17e-22 | ||
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.). The actual alignment was detected with superfamily member pfam05971: Pssm-ID: 473071 [Multi-domain] Cd Length: 291 Bit Score: 94.89 E-value: 2.17e-22
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| Name | Accession | Description | Interval | E-value | ||
| Methyltransf_10 | pfam05971 | RNA methyltransferase; This family includes ribosomal RNA large subunit methyltransferase F, ... |
23-71 | 2.17e-22 | ||
RNA methyltransferase; This family includes ribosomal RNA large subunit methyltransferase F, and related proteins, including methyltransferase-like protein 16 (METTL16). METTL16 is a conserved RNA methyltransferase which interacts specifically with the MALAT1 triple helix. METTL16 shows nuclear localization. Another functional study indicates that METTL16 regulates expression of human MAT2A, which encodes the SAM synthetase expressed in most cells. Furthermore, results indicate that METTL16 is the long-unknown methyltransferase for the U6 spliceosomal small nuclear RNA (snRNA) and it has evolved an additional function in vertebrates to control SAM homeostasis by post-transcriptionally regulating SAM synthetase gene expression. Pssm-ID: 399160 [Multi-domain] Cd Length: 291 Bit Score: 94.89 E-value: 2.17e-22
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| Name | Accession | Description | Interval | E-value | ||
| Methyltransf_10 | pfam05971 | RNA methyltransferase; This family includes ribosomal RNA large subunit methyltransferase F, ... |
23-71 | 2.17e-22 | ||
RNA methyltransferase; This family includes ribosomal RNA large subunit methyltransferase F, and related proteins, including methyltransferase-like protein 16 (METTL16). METTL16 is a conserved RNA methyltransferase which interacts specifically with the MALAT1 triple helix. METTL16 shows nuclear localization. Another functional study indicates that METTL16 regulates expression of human MAT2A, which encodes the SAM synthetase expressed in most cells. Furthermore, results indicate that METTL16 is the long-unknown methyltransferase for the U6 spliceosomal small nuclear RNA (snRNA) and it has evolved an additional function in vertebrates to control SAM homeostasis by post-transcriptionally regulating SAM synthetase gene expression. Pssm-ID: 399160 [Multi-domain] Cd Length: 291 Bit Score: 94.89 E-value: 2.17e-22
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