|
Name |
Accession |
Description |
Interval |
E-value |
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
34-799 |
0e+00 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 919.40 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 34 SSAAVTEAFVRLYNSGLLYRNRQLVNWSCTLRSAISDIEVESRPLPGRTVLQLPGCPTPVSFGLLASVAFPVDGEPDTEI 113
Cdd:PTZ00419 176 RSKAVKEAFVRLYEDGLIYRDTRLVNWCCYLKTAISDIEVEFEEIEKPTKITIPGYDKKVEVGVLWHFAYPLEDSGQEEI 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 114 VVGTTRPETLPGDVAVAVHPDDPRYTHLHGRQLRHPLT-GQLLPLITDTT-VQPHVGTGAVKVTPAHSPIDAEIGTRHGL 191
Cdd:PTZ00419 256 VVATTRIETMLGDVAVAVHPKDERYKKLHGKELIHPFIpDRKIPIIADDElVDMEFGTGAVKITPAHDPNDYEIAKRHNL 335
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 192 TPLSVIAEDGTMTSLCGDWlQGLHRFVAREKIMCTLREQGLFRGLQEHPMVLPICSRSGDVVEYLLKSQWFVRCQEMGDL 271
Cdd:PTZ00419 336 PFINIFTLDGKINENGGEF-AGMHRFDCRRKIEEELKEMGLLRDKVPNPMRLPRCSRSGDIVEPMLIPQWYVNCKDMAKR 414
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 272 AAKAVESGALELWPSFHQKSWQHWFAHIGDWCVSRQLWWGHQIPAYRVIGENAEDDRK--ECWVVGRSEAEARAVAAKRT 349
Cdd:PTZ00419 415 AVEAVRNGELKIIPSSHENVWYHWLENIQDWCISRQLWWGHRIPAYRVISKGPETDPSdeEPWVVARSEEEALEKAKKKF 494
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 350 GRPEAELTLERDPDVLDTWFSSALFPFSALGWPRETPDLAHFYPLTLLETGSDLLMFWVGRMVMLGTQLTGQLPFSKVLL 429
Cdd:PTZ00419 495 GLSEEDFELEQDEDVLDTWFSSGLFPFSTLGWPDQTDDLQRFFPTSLLETGSDILFFWVARMVMMSLHLTDKLPFKTVFL 574
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 430 HSMVRDRQGRKMSKSLGNVLDPRDIISGQELQVLQAKLRDGNLDPGELAVAAAAQKKDFPYGIPECGTDALRFALCSHGI 509
Cdd:PTZ00419 575 HAMVRDSQGEKMSKSKGNVIDPLEVIEGISLQDLNQKLYEGNLPEKEIKRAIELQKKEFPNGIPECGTDALRFGLLAYTQ 654
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 510 LGGDLHLSVSEVLNYRHFCNKLWNALRFVLRALGDNFVPQPAEEVTPSSP-----MDAWILSRLAFAASECERGFLSREL 584
Cdd:PTZ00419 655 QGRNINLDINRVVGYRHFCNKLWNAVKFALMKLLKDFNLPNSTLFKPNNVeslpwEDKWILHRLNVAIKEVTEGFKEYDF 734
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 585 SLVTHTLYHFWLHNLCDVYLEAVKPVLSSVPRPP---GPPQVLFSCADVGLRLLAPLMPFLAEELWQRLPPRPGGPlaPS 661
Cdd:PTZ00419 735 SEATQATYNFWLYELCDVYLELIKPRLSKQSDGErkqHAQDVLHTVLDIGLRLLHPMMPFITEELYQRLPNYLRKS--ES 812
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 662 ICVAPYPSTRSLefWRQPELERCFSRVQEVVQALRALRATYQLT-KARPQVLLQCSDPGEQGLVQP---FLEPLGILSHC 737
Cdd:PTZ00419 813 ISIAKYPQPNPG--WNNEALDEEMKIIMSIVKSIRSLIATLGIPnKTKPDCYVTAKDAELIELIESaenLISTLAKIGSV 890
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907125978 738 GAVGFLSPGAAAPSGWALTPLGDTMKIYMELQGLVDPQSQLPRLTARRQKLQKQLDDLLNRT 799
Cdd:PTZ00419 891 SVIPPIEEEAEVPKGCGFDVVDNKVIIYLNLDEFIDLKKELAKLEKKLAKLQKSLESYLKKI 952
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
35-831 |
0e+00 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 754.81 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 35 SAAVTEAFVRLYNSGLLYRNRQLVNWSCTLRSAISDIEVESRPLPGRTVLQLPGCPTPVSFGLLASVAFPVDGEPDtEIV 114
Cdd:PLN02381 245 SKAVTEAFVRLYKEGLIYRDIRLVNWDCTLRTAISDVEVDYIDIKERTLLKVPGYDKPVEFGVLTSFAYPLEGGLG-EIV 323
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 115 VGTTRPETLPGDVAVAVHPDDPRYTHLHGRQLRHPLTGQLLPLITDTT-VQPHVGTGAVKVTPAHSPIDAEIGTRHGLTP 193
Cdd:PLN02381 324 VATTRIETMLGDTAIAIHPDDERYKHLHGKFAVHPFNGRKLPIICDAIlVDPNFGTGAVKITPAHDPNDFEVGKRHNLEF 403
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 194 LSVIAEDGTMTSLCGDWLQGLHRFVAREKIMCTLREQGLFRGLQEHPMVLPICSRSGDVVEYLLKSQWFVRCQEMGDLAA 273
Cdd:PLN02381 404 INIFTDDGKINSNGGSEFAGMPRFAAREAVIEALQKKGLYRGAKNNEMRLGLCSRTNDVVEPMIKPQWFVNCSSMAKQAL 483
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 274 KAV---ESGALELWPSFHQKSWQHWFAHIGDWCVSRQLWWGHQIPAYRVIGEnaEDDRKEC------WVVGRSEAEARAV 344
Cdd:PLN02381 484 DAAidgENKKLEFIPKQYLAEWKRWLENIRDWCISRQLWWGHRIPAWYVTLE--DDQLKELgsyndhWVVARNESDALLE 561
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 345 AAKRTgrPEAELTLERDPDVLDTWFSSALFPFSALGWPRETPDLAHFYPLTLLETGSDLLMFWVGRMVMLGTQLTGQLPF 424
Cdd:PLN02381 562 ASQKF--PGKKFELSQDPDVLDTWFSSGLFPLSVLGWPDDTDDLKAFYPTSVLETGHDILFFWVARMVMMGMQLGGDVPF 639
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 425 SKVLLHSMVRDRQGRKMSKSLGNVLDPRDIISGQELQVLQAKLRDGNLDPGELAVAAAAQKKDFPYGIPECGTDALRFAL 504
Cdd:PLN02381 640 RKVYLHPMIRDAHGRKMSKSLGNVIDPLEVINGISLEGLHKRLEEGNLDPKELVVAKEGQKKDFPNGIAECGTDALRFAL 719
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 505 CSHGILGGDLHLSVSEVLNYRHFCNKLWNALRFVLRALGDNFVPQPAEEVTPSSPMDAWILSRLAFAASECERGFLSREL 584
Cdd:PLN02381 720 VSYTAQSDKINLDILRVVGYRQWCNKLWNAVRFAMSKLGDDYTPPATLSVETMPFSCKWILSVLNKAISKTVSSLDAYEF 799
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 585 SLVTHTLYHFWLHNLCDVYLEAVKPVLSS-----VPRPPGPPQVLFSCADVGLRLLAPLMPFLAEELWQRLPPRPGGPLA 659
Cdd:PLN02381 800 SDAASTVYSWWQYQFCDVFIEAIKPYFAGdnpefASERAAAQDTLWICLDTGLRLLHPFMPFVTEELWQRLPQPKDHTRK 879
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 660 PSICVAPYPStrSLEFWRQPELERCFSRVQEVVQALRALRATY---QLTKARPQVLLqCSDPGEQGLVQPFLEPLGILSH 736
Cdd:PLN02381 880 DSIMISEYPS--AVEAWTNEKVEYEMDLVLSTVKCLRSLRAEVlekQKNERLPAFAL-CRNQEIAAIIKSHQLEILTLAN 956
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 737 CGAVGFLSPGA-AAPSGWALTPLGDTMKIYMELQGLVDPQSQLPRLTARRQKLQKQLDDLLNRTMSEGLAERqqriSSLH 815
Cdd:PLN02381 957 LSSLKVLLSENdAPPAGCAFENVNENLKVYLQAQGAVNAEAELEKLRNKMDEIQKQQEKLEKKMNASGYKEK----VPAN 1032
|
810
....*....|....*.
gi 1907125978 816 LELSKLDQAASYLQQL 831
Cdd:PLN02381 1033 IQEEDARKLTKLLQEL 1048
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
33-793 |
0e+00 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 729.93 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 33 GSSAAVTEAFVRLYNSGLLYRNRQLVNWSCTLRSAISDIEVESRPLPGRtvlqlpgcptpvsfglLASVAFPVDGEPDtE 112
Cdd:COG0525 149 GLSKAVREVFVRLYEKGLIYRGKRLVNWDPKLKTALSDLEVEHEEVKGH----------------LWHIRYPLADGSG-Y 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 113 IVVGTTRPETLPGDVAVAVHPDDPRYTHLHGRQLRHPLTGQLLPLITDTTVQPHVGTGAVKVTPAHSPIDAEIGTRHGLT 192
Cdd:COG0525 212 IVVATTRPETMLGDTAVAVHPEDERYKHLIGKTVILPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLP 291
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 193 PLSVIAEDGTMTSLCGDwLQGLHRFVAREKIMCTLREQGLFRGLQEHPMVLPICSRSGDVVEYLLKSQWFVRCQEMGDLA 272
Cdd:COG0525 292 MINILDEDGTINENAGK-YRGLDRFEARKAIVADLEELGLLVKVEPHKHSVGHSDRSGTVIEPYLSDQWFVKMKPLAKPA 370
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 273 AKAVESGALELWPSFHQKSWQHWFAHIGDWCVSRQLWWGHQIPAYrvIGENAEddrkecWVVGRSEAEARAVAAkrtgrp 352
Cdd:COG0525 371 IEAVEDGEIKFVPERWEKTYFHWMENIRDWCISRQLWWGHRIPAW--YCPDGE------VYVARTEPEACAKAG------ 436
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 353 eaELTLERDPDVLDTWFSSALFPFSALGWPRETPDLAHFYPLTLLETGSDLLMFWVGRMVMLGTQLTGQLPFSKVLLHSM 432
Cdd:COG0525 437 --SVNLTQDEDVLDTWFSSALWPFSTLGWPEKTEDLKYFYPTSVLVTGFDIIFFWVARMIMMGLHFTGEVPFKDVYIHGL 514
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 433 VRDRQGRKMSKSLGNVLDPRDIISgqelqvlqaklrdgnldpgelavaaaaqkkdfpygipECGTDALRFALCSHGILGG 512
Cdd:COG0525 515 VRDEQGRKMSKSKGNVIDPLDLID-------------------------------------KYGADALRFTLAALASPGR 557
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 513 DLHLSVSEVLNYRHFCNKLWNALRFVLRaLGDNFVPQPAEEVTPSSPMDAWILSRLAFAASECERGFLSRELSLVTHTLY 592
Cdd:COG0525 558 DIKFDEERVEGYRNFANKLWNASRFVLM-NLEGFDPGLDPDPEELSLADRWILSRLNKTIAEVTEALEKYRFDEAAQALY 636
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 593 HF-WlHNLCDVYLEAVKPVLSSvprpPGPPQ------VLFSCADVGLRLLAPLMPFLAEELWQRLPPRPGGplaPSICVA 665
Cdd:COG0525 637 DFvW-NEFCDWYLELAKPRLYG----GDEAAkretraTLVYVLEQILRLLHPFMPFITEEIWQKLPPRKEG---ESIMLA 708
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 666 PYPSTRslEFWRQPELERCFSRVQEVVQALRALRATYQLT-KARPQVLLQCSDPGEQGLVQPFLEPLGILSHCGAVGFLS 744
Cdd:COG0525 709 PWPEAD--EELIDEEAEAEFEWLKEVISAIRNIRAEMNIPpSKKLPLLLKGADEADRARLEENAAYIKRLARLEEITILV 786
|
730 740 750 760
....*....|....*....|....*....|....*....|....*....
gi 1907125978 745 pgAAAPSGwALTPLGDTMKIYMELQGLVDPQSQLPRLTARRQKLQKQLD 793
Cdd:COG0525 787 --DEKPEG-AASAVVGGAEVFLPLEGLIDVEAERARLEKELAKLEKEIA 832
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
33-793 |
0e+00 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 712.26 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 33 GSSAAVTEAFVRLYNSGLLYRNRQLVNWSCTLRSAISDIEVESRPLPGRtvlqlpgcptpvsfglLASVAFPVDgEPDTE 112
Cdd:PRK05729 150 GLSKAVREVFVRLYEKGLIYRGKRLVNWDPKLQTALSDLEVEYKEVKGK----------------LWHIRYPLA-DGSDY 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 113 IVVGTTRPETLPGDVAVAVHPDDPRYTHLHGRQLRHPLTGQLLPLITDTTVQPHVGTGAVKVTPAHSPIDAEIGTRHGLT 192
Cdd:PRK05729 213 LVVATTRPETMLGDTAVAVNPEDERYKHLIGKTVILPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLP 292
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 193 PLSVIAEDGTMTSLCGDwLQGLHRFVAREKIMCTLREQGLFRGLQEHPMVLPICSRSGDVVEYLLKSQWFVRCQEMGDLA 272
Cdd:PRK05729 293 MINIMDEDGTINENPGE-YQGLDRFEARKAIVADLEELGLLVKIEPHTHSVGHSDRSGVVIEPYLSDQWFVKMKPLAKPA 371
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 273 AKAVESGALELWPSFHQKSWQHWFAHIGDWCVSRQLWWGHQIPAYRvigenaedDRKECWVVGRSEAEARAVAAkrtgrp 352
Cdd:PRK05729 372 LEAVENGEIKFVPERWEKTYFHWMENIQDWCISRQLWWGHRIPAWY--------DEDGEVYVGREEPEAREKAL------ 437
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 353 eaeltLERDPDVLDTWFSSALFPFSALGWPRETPDLAHFYPLTLLETGSDLLMFWVGRMVMLGTQLTGQLPFSKVLLHSM 432
Cdd:PRK05729 438 -----LTQDEDVLDTWFSSALWPFSTLGWPEKTEDLKRFYPTSVLVTGFDIIFFWVARMIMMGLHFTGQVPFKDVYIHGL 512
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 433 VRDRQGRKMSKSLGNVLDPRDIISgqelqvlqaklrdgnldpgelavaaaaqkkdfPYgipecGTDALRFALCSHGILGG 512
Cdd:PRK05729 513 VRDEQGRKMSKSKGNVIDPLDLID--------------------------------KY-----GADALRFTLAALASPGR 555
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 513 DLHLSVSEVLNYRHFCNKLWNALRFVLRALGDNFVPQPAEEvTPSSPMDAWILSRLAFAASECERGFLSRELSLVTHTLY 592
Cdd:PRK05729 556 DIRFDEERVEGYRNFANKLWNASRFVLMNLEGADVGELPDP-EELSLADRWILSRLNRTVAEVTEALDKYRFDEAARALY 634
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 593 HFWLHNLCDVYLEAVKPVLSSvPRPPGPPQVLFSCADVGLRLLAPLMPFLAEELWQRLPPRPGgplAPSICVAPYPSTRS 672
Cdd:PRK05729 635 EFIWNEFCDWYLELAKPVLQE-AAKRATRATLAYVLEQILRLLHPFMPFITEELWQKLAPLGI---EESIMLAPWPEADE 710
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 673 LEFwrqPELERCFSRVQEVVQALRALRATYQLTKARP-QVLLQCSDPGEQGLVQPFLEPLGILSHCGAVGFLSPGAAAPS 751
Cdd:PRK05729 711 AID---EAAEAEFEWLKELITAIRNIRAEMNIPPSKKlPLLLKGADAEDRARLEANEAYIKRLARLESLEILADDEEAPE 787
|
730 740 750 760
....*....|....*....|....*....|....*....|..
gi 1907125978 752 GwALTPLGDTMKIYMELQGLVDPQSQLPRLTARRQKLQKQLD 793
Cdd:PRK05729 788 G-AASAVVGGAELFLPLEGLIDVEAELARLEKELAKLEKEIE 828
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
33-793 |
0e+00 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 630.55 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 33 GSSAAVTEAFVRLYNSGLLYRNRQLVNWSCTLRSAISDIEVESRPLPGrtvlQLPGcptpvsfgllasVAFPVDGEPDTE 112
Cdd:TIGR00422 147 GLSKAVKEAFVRLYEKGLIYRGEYLVNWDPKLNTAISDIEVEYKEVKG----KLYY------------IRYPLANGSKDY 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 113 IVVGTTRPETLPGDVAVAVHPDDPRYTHLHGRQLRHPLTGQLLPLITDTTVQPHVGTGAVKVTPAHSPIDAEIGTRHGLT 192
Cdd:TIGR00422 211 LVVATTRPETMFGDTAVAVHPEDERYKHLIGKKVILPLTGRKIPIIADEYVDMEFGTGAVKVTPAHDFNDYEWGKRHNLE 290
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 193 PLSVIAEDGTMTSLCGDWlQGLHRFVAREKIMCTLREQGLFRGLQEHPMVLPICSRSGDVVEYLLKSQWFVRCQEMGDLA 272
Cdd:TIGR00422 291 FINILDEDGLLNENAGKY-QGLTRFEARKKIVEDLKEEGLLVKIEPHTHNVGTCWRSGTVVEPLLSKQWFVKVEKLADKA 369
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 273 AKAVESGALELWPSFHQKSWQHWFAHIGDWCVSRQLWWGHQIPAYRVigenaeddrKEC--WVVGRSEAEARAVAakrtg 350
Cdd:TIGR00422 370 LEAAEEGEIKFVPKRMEKRYLNWLRNIKDWCISRQLIWGHRIPVWYC---------KECgeVYVAKEEPLPDDKT----- 435
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 351 RPEAELTLERDPDVLDTWFSSALFPFSALGWPRETPDLAHFYPLTLLETGSDLLMFWVGRMVMLGTQLTGQLPFSKVLLH 430
Cdd:TIGR00422 436 NTGPSVELEQDTDVLDTWFSSSLWPFSTLGWPDETKDLKKFYPTDLLVTGYDIIFFWVARMIFRSLALTGQVPFKEVYIH 515
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 431 SMVRDRQGRKMSKSLGNVLDPRDIISgqelqvlqaklrdgnldpgelavaaaaqkkdfpygipECGTDALRFALCSHGIL 510
Cdd:TIGR00422 516 GLVRDEQGRKMSKSLGNVIDPLDVIE-------------------------------------KYGADALRFTLASLVTP 558
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 511 GGDLHLSVSEVLNYRHFCNKLWNALRFVLRALGDNFVPQPAEEvtPSSPMDAWILSRLAFAASECERGFLSRELSLVTHT 590
Cdd:TIGR00422 559 GDDINFDWKRVESARNFLNKLWNASRFVLMNLSDDLELSGGEE--KLSLADRWILSKLNRTIKEVRKALDKYRFAEAAKA 636
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 591 LYHFWLHNLCDVYLEAVKPVL--SSVPRPPGPPQVLFSCADVGLRLLAPLMPFLAEELWQRLPPRpggplAPSICVAPYP 668
Cdd:TIGR00422 637 LYEFIWNDFCDWYIELVKYRLynGNEAEKKAARDTLYYVLDKALRLLHPFMPFITEEIWQHFKEG-----ADSIMLQSYP 711
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 669 STrsLEFWRQPELERCFSRVQEVVQALRALRATYQLTKARP-QVLLQCSDPGEQGLVQPFLEPLGILSHCGAVGFLSpgA 747
Cdd:TIGR00422 712 VV--DAEFVDEEAEKAFELLKEIIVSIRNLKAESNIPPNAPlKVLLIYTEAETAERLKLNAVDIKGAINFSEVEVVI--E 787
|
730 740 750 760
....*....|....*....|....*....|....*....|....*.
gi 1907125978 748 AAPSGWALTPLGDTMKIYMELQGLVDpqsqlprLTARRQKLQKQLD 793
Cdd:TIGR00422 788 KPEVTEAVVELVPGFEIIIPVKGLIN-------KAKELARLQKQLD 826
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
32-798 |
0e+00 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 559.99 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 32 QGSSAAVTEAFVRLYNSGLLYRNRQLVNWSCTLRSAISDIEVESRPLPGrtvlqlpgcptpvsfGLLASVAFPV-DGepD 110
Cdd:PRK14900 162 EGLSRAVREVFVRLHEEGLIYREKKLINWCPDCRTALSDLEVEHEEAHQ---------------GELWSFAYPLaDG--S 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 111 TEIVVGTTRPETLPGDVAVAVHPDDPRYTHLHGRQLRHPLTGQLLPLITDTT-VQPHVGTGAVKVTPAHSPIDAEIGTRH 189
Cdd:PRK14900 225 GEIVVATTRPETMLGDTAVAVHPLDPRYMALHGKKVRHPITGRTFPIVADAIlVDPKFGTGAVKVTPAHDFNDFEVGKRH 304
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 190 GLTPLSVIAEDGTMTSLCGDwLQGLHRFVAREKIMCTLREQGLFRGLQEHPMVLPICSRSGDVVEYLLKSQWFVRCQEMG 269
Cdd:PRK14900 305 GLEMITVIGPDGRMTAEAGP-LAGLDRFEARKEVKRLLAEQGLDRGAKPHVLPLGRCQRSATILEPLLSDQWYVRIEPLA 383
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 270 DLAAKAVESGALELWPSFHQKSWQHWFAHIGDWCVSRQLWWGHQIPAYRVIGENAeddrkecwVVGRSEAEARAVAAKRT 349
Cdd:PRK14900 384 RPAIEAVEQGRTRFIPEQWTNTYMAWMRNIHDWCISRQLWWGHQIPAWYCPDGHV--------TVARETPEACSTCGKAE 455
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 350 grpeaeltLERDPDVLDTWFSSALFPFSALGWPRETPDLAHFYPLTLLETGSDLLMFWVGRMVMLGTQLTGQLPFSKVLL 429
Cdd:PRK14900 456 --------LRQDEDVLDTWFSSGLWPFSTMGWPEQTDTLRTFYPTSVMETGHDIIFFWVARMMMMGLHFMGEVPFRTVYL 527
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 430 HSMVRDRQGRKMSKSLGNVLDPRDIisgqelqvlqaklrdgnldpgelavaaaaqkkdfpygIPECGTDALRFALCSHGI 509
Cdd:PRK14900 528 HPMVRDEKGQKMSKTKGNVIDPLVI-------------------------------------TEQYGADALRFTLAALTA 570
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 510 LGGDLHLSVSEVLNYRHFCNKLWNALRFVLRALGDNFVPQPAEEVTPSSPMDAWILSRLAFAASECERGFLSRELSLVTH 589
Cdd:PRK14900 571 QGRDIKLAKERIEGYRAFANKLWNASRFALMNLSGYQERGEDPARLARTPADRWILARLQRAVNETVEALEAFRFNDAAN 650
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 590 TLYHFWLHNLCDVYLEAVKPVLSSV-PRPPGPPQ-VLFSCADVGLRLLAPLMPFLAEELWQRLPPRPGGPLAP-SICVAP 666
Cdd:PRK14900 651 AVYAFVWHELCDWYIELAKEALASEdPEARRSVQaVLVHCLQTSYRLLHPFMPFITEELWHVLRAQVGASAWAdSVLAAE 730
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 667 YPSTRSLEfwrqPELERCFSRVQEVVQALRALRATYQLT-----KARPQVLLQCSDPGEQGLVQ-PFLEPLGILSHCGAV 740
Cdd:PRK14900 731 YPRKGEAD----EAAEAAFRPVLGIIDAVRNIRGEMGIPwkvklGAQAPVEIAVADPALRDLLQaGELARVHRVAGVEGS 806
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|....*...
gi 1907125978 741 GFLSPGAAAPSGWALTPLGDTMKIYMELQGLVDPQSQLPRLTARRQKLQKQLDDLLNR 798
Cdd:PRK14900 807 RLVVAAATAPAPQSAVGVGPGFEVRVPLAGVIDLAAETARVDKEIGKVDQDLAVLERK 864
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
35-807 |
3.41e-162 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 496.77 E-value: 3.41e-162
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 35 SAAVTEAFVRLYNSGLLYRNRQLVNWSCTLRSAISDIEVESRPLPGRtvlqlpgcptpvsfglLASVAFPVDGEPDTEIV 114
Cdd:PLN02943 204 SRAVVEAFVRLHEKGLIYQGSYMVNWSPNLQTAVSDLEVEYSEEPGT----------------LYYIKYRVAGGSEDFLT 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 115 VGTTRPETLPGDVAVAVHPDDPRYTHLHGRQLRHPLT-GQLLPLITDTTVQPHVGTGAVKVTPAHSPIDAEIGTRHGLTP 193
Cdd:PLN02943 268 IATTRPETLFGDVAIAVNPEDDRYSKYIGKMAIVPMTyGRHVPIIADRYVDKDFGTGVLKISPGHDHNDYLLARKLGLPI 347
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 194 LSVIAEDGTMTSLCGdwlqgLHRFVAREKIMCTLREQGLFRGLQEHPMVLPICSRSGDVVEYLLKSQWFVRCQEMGDLAA 273
Cdd:PLN02943 348 LNVMNKDGTLNEVAG-----LYWFEAREKLWSDLEETGLAVKKEPHTLRVPRSQRGGEVIEPLVSKQWFVTMEPLAEKAL 422
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 274 KAVESGALELWPSFHQKSWQHWFAHIGDWCVSRQLWWGHQIPAYRVIGENAEDDrkecWVVGRSEAEARAVAAKRTGRpe 353
Cdd:PLN02943 423 KAVENGELTIIPERFEKIYNHWLSNIKDWCISRQLWWGHRIPVWYIVGKDCEED----YIVARSAEEALEKAREKYGK-- 496
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 354 aELTLERDPDVLDTWFSSALFPFSALGWPR-ETPDLAHFYPLTLLETGSDLLMFWVGRMVMLGTQLTGQLPFSKVLLHSM 432
Cdd:PLN02943 497 -DVEIYQDPDVLDTWFSSALWPFSTLGWPDvSAEDFKKFYPTTVLETGHDILFFWVARMVMMGIEFTGTVPFSYVYLHGL 575
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 433 VRDRQGRKMSKSLGNVLDPRDIIsgqelqvlqaklrdgnldpgelavaaaaqkKDFpygipecGTDALRFALcSHGILGG 512
Cdd:PLN02943 576 IRDSQGRKMSKTLGNVIDPLDTI------------------------------KEF-------GTDALRFTL-ALGTAGQ 617
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 513 DLHLSVSEVLNYRHFCNKLWNALRFVLRALGDNFVPQP----------AEEVTPSSPM-DAWILSRLAFAASECERGFLS 581
Cdd:PLN02943 618 DLNLSTERLTSNKAFTNKLWNAGKFVLQNLPSQSDTSAwehilackfdKEESLLSLPLpECWVVSKLHELIDSVTTSYDK 697
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 582 RELSLVTHTLYHFWLHNLCDVYLEAVKPVL---SSVPRPPGPPQVLFSCADVGLRLLAPLMPFLAEELWQRLPPRpggpl 658
Cdd:PLN02943 698 YFFGDVGREIYDFFWSDFADWYIEASKTRLyhsGDNSALSRAQAVLLYVFENILKLLHPFMPFVTEELWQALPYR----- 772
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 659 APSICVAPYPsTRSLEfwRQPELERCFSRVQEVVQALRALRATYQLTKARPQVLLQCSDPGEQGLVQPFLEPLGILSHCG 738
Cdd:PLN02943 773 KEALIVSPWP-QTSLP--KDLKSIKRFENLQSLTRAIRNARAEYSVEPAKRISASIVASAEVIEYISKEKEVLALLSRLD 849
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907125978 739 --AVGFLS--PGAAAPSGWALTPLGdtMKIYMELQGLVDPQSQLPRLTARRQKLQKQLDDLLNRTMSEGLAER 807
Cdd:PLN02943 850 lqNVHFTDspPGDANQSVHLVASEG--LEAYLPLADMVDISAEVERLSKRLSKMQTEYDALAARLSSPKFVEK 920
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
35-517 |
9.97e-144 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 437.23 E-value: 9.97e-144
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 35 SAAVTEAFVRLYNSGLLYRNRQLVNWSCTLRSAISDIEVESRPLPGRTVlqlpgcptpvsfgllaSVAFPVDGEPDTEIV 114
Cdd:pfam00133 140 EAAVWEVFVRLHDKGLIYRGKKLVNWSPALNTALSNLEVEYKDVKGPSI----------------HVAFPLADDEGASLV 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 115 VGTTRPETLPGDVAVAVHPD-------------------------------DPRYTHLHGRQLRHPLTGQLLPLITDTTV 163
Cdd:pfam00133 204 IWTTTPWTLPGNTAVAVNPEfdyvitgegyilaeallkslykkgtdkkileDFRGKELEGKEAIHPFVNREIPIITDDYV 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 164 QPHVGTGAVKVTPAHSPIDAEIGTRHGLTPLSVIAEDGTMTSLCGDWlQGLHRFVAREKIMCTLREQGLFRGLQEHPMVL 243
Cdd:pfam00133 284 DMEFGTGAVHIAPAHGENDYEVGQRHNLEVINPVDDDGTFTEEAPDF-QGVYRFDARKKIVELLTEKGLLLKIEPFTHSY 362
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 244 PICSRSGDVVEYLLKSQWFVRCQEMGDLAAKAVESgaLELWPSFHQKSWQHWFAHIGDWCVSRQLWWGHQIPAYRVIGEN 323
Cdd:pfam00133 363 PFCWRSGTPIIPRATPQWFVRMDELADQALEAVEK--VQFVPKSGEKRYFNWLANIQDWCISRQRWWGHPIPAWVSKDTE 440
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 324 AEDDRKEC--WVVGRSEAEARAVA----AKRTGRPEAElTLERDPDVLDTWFSSALFPFSALGWPRE-TPDLAHFYPLTL 396
Cdd:pfam00133 441 EVVCRGELfeLVAGRFEEEGSIKWlhreAKDKLGYGKG-TLEQDEDVLDTWFSSGSWPFSTLGWPFVnTEEFKKFFPADM 519
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 397 LETGSDLLMFWVGRMVMLGTQLTGQLPFSKVLLHSMVRDRQGRKMSKSLGNVLDPRDIISgqelqvlqaklrdgnldpge 476
Cdd:pfam00133 520 LLEGSDQTRGWFYRMIMLSTALTGSVPFKNVLVHGLVRDEQGRKMSKSLGNVIDPLDVID-------------------- 579
|
490 500 510 520
....*....|....*....|....*....|....*....|.
gi 1907125978 477 lavaaaaqkkdfpygipECGTDALRFALCSHGiLGGDLHLS 517
Cdd:pfam00133 580 -----------------KYGADALRLWLANSD-YGRDINLS 602
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
41-696 |
4.41e-105 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 342.17 E-value: 4.41e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 41 AFVRLYNSGLLYRNRQLVNWSCTLRSAISDIEVESRPLPGrtvlqlpgcptpvsfgLLASVAFPVDGepDTEIVVGTTRP 120
Cdd:PRK13208 157 SFLDLYKKGLIYRAEAPVLWCPRCETAIAQAEVEYREREG----------------KLNYIKFPVED--GEEIEIATTRP 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 121 ETLPGDVAVAVHPDDPRYTHLHGRQLRHPLTGQLLPLITDTTVQPHVGTGAVKV------TpahspiDAEIGTRHGLTPL 194
Cdd:PRK13208 219 ELLPACVAVVVHPDDERYKHLVGKTAIVPLFGVEVPILADPLVDPDFGTGAVMIctfgdkT------DVTWWRELNLPTR 292
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 195 SVIAEDGTMTSLCGDwLQGLHRFVAREKIMCTLREQGLFrGLQE---HPmvLPICSRSGDVVEYLLKSQWFVRcqeMGDL 271
Cdd:PRK13208 293 IIIDEDGRMTEAAGK-LAGLTIEEARKKIVEDLKSGGLL-GKQEpikHN--VKFCERCDTPLEILVTRQWFIK---VLDL 365
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 272 AAKAVESGA-LELWPSFHQKSWQHWFAHI-GDWCVSRQ--------LWW----GHQIPAyrvigenaedDRKECWVVGRS 337
Cdd:PRK13208 366 KEELLERGKeINWYPEHMRVRLENWIEGLnWDWCISRQryfgtpipVWYckdcGHPILP----------DEEDLPVDPTK 435
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 338 EAEARAVAAKRTGRPeaeltLERDPDVLDTWFSSALFPFSALGWPRETPDLAHFYPLTLLETGSDLLMFW----VGRMVm 413
Cdd:PRK13208 436 DEPPGYKCPQCGSPG-----FEGETDVMDTWATSSITPLIVTGWERDEDLFEKVFPMDLRPQGHDIIRTWlfytILRAY- 509
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 414 lgtQLTGQLPFSKVLLHSMVRDRQGRKMSKSLGNVLDPRDIisgqelqvlqaklrdgnldpgelavaaaaqkkdfpygIP 493
Cdd:PRK13208 510 ---LLTGKLPWKNIMISGMVLDPDGKKMSKSKGNVVTPEEL-------------------------------------LE 549
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 494 ECGTDALRFALCShGILGGDLHLSVSEVLNYRHFCNKLWNALRFVLrALGDNFVPQPAEEvtpSSPMDAWILSRLAFAAS 573
Cdd:PRK13208 550 KYGADAVRYWAAS-ARLGSDTPFDEKQVKIGRRLLTKLWNASRFVL-HFSADPEPDKAEV---LEPLDRWILAKLAKVVE 624
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 574 ECERGFLSRELSLVTHTLYHFWLHNLCDVYLEAVKPVLSSvpRPPGPPQ-----VLFSCADVGLRLLAPLMPFLAEELWQ 648
Cdd:PRK13208 625 KATEALENYDFAKALEEIESFFWHVFCDDYLELVKSRAYG--EDEEEEQksaryTLYTVLDTLLRLLAPFLPFITEEVWS 702
|
650 660 670 680
....*....|....*....|....*....|....*....|....*...
gi 1907125978 649 RLPPRpggplapSICVAPYPSTRslEFWRQPELERCFSRVQEVVQALR 696
Cdd:PRK13208 703 WLYGG-------SVHRASWPEPD--EELIDEEDEELGELAKEILSAVR 741
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
245-516 |
1.10e-102 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 322.66 E-value: 1.10e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 245 ICSRSGDVVEYLLKSQWFVRCQEMGDLAAKAVESGALELWPSFHQKSWQHWFAHIGDWCVSRQLWWGHQIPAYRVIGENA 324
Cdd:cd00817 155 VCSRSGDVIEPLLKPQWFVKVKDLAKKALEAVKEGDIKFVPERMEKRYENWLENIRDWCISRQLWWGHRIPAWYCKDGGH 234
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 325 eddrkecWVVGRSEAEARAVAAKRTGRPEAELTLERDPDVLDTWFSSALFPFSALGWPRETPDLAHFYPLTLLETGSDLL 404
Cdd:cd00817 235 -------WVVAREEDEAIDKAAPEACVPCGGEELKQDEDVLDTWFSSSLWPFSTLGWPEETKDLKKFYPTSLLVTGHDII 307
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 405 MFWVGRMVMLGTQLTGQLPFSKVLLHSMVRDRQGRKMSKSLGNVLDPRDIISGqelqvlqaklrdgnldpgelavaaaaq 484
Cdd:cd00817 308 FFWVARMIMRGLKLTGKLPFKEVYLHGLVRDEDGRKMSKSLGNVIDPLDVIDG--------------------------- 360
|
250 260 270
....*....|....*....|....*....|..
gi 1907125978 485 kkdfpygipeCGTDALRFALCSHGILGGDLHL 516
Cdd:cd00817 361 ----------YGADALRFTLASAATQGRDINL 382
|
|
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
36-700 |
2.84e-70 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 249.61 E-value: 2.84e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 36 AAVTEAFVRLYNSGLLYRNRQLVNWSCTLRSAISDIEVESRPLPGRTVlqlpgcptpvsfgllaSVAFPVDGEP------ 109
Cdd:COG0060 163 ESIWWALKKLYEKGLLYKGLKPVPWCPRCGTALAEAEVEYKDVTSPSI----------------YVKFPVKDEKalllle 226
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 110 DTEIVVGTTRPETLPGDVAVAVHPD---------DPRY----------------------------THLHGRQLRHPLTG 152
Cdd:COG0060 227 DAYLVIWTTTPWTLPANLAVAVHPDidyvlvevtGGERlilaealveavlkelgiedyevlatfkgAELEGLRYEHPFYY 306
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 153 QLL-----PLITDTtvqpHV----GTGAVKVTPAHSPIDAEIGTRHGLTPLSVIAEDGTMTSLCGDWlQGLHRFVAREKI 223
Cdd:COG0060 307 VVGydrahPVILGD----YVttedGTGIVHTAPGHGEDDFEVGKKYGLPVLNPVDDDGRFTEEAPLF-AGLFVKDANPAI 381
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 224 MCTLREQG--LFRGLQEHPMvlPICSRSGDVVEYLLKSQWFVRcqeMGDLAAKAVEsgALEL--W-PSFHQKSWQHWFAH 298
Cdd:COG0060 382 IEDLKERGalLAREKITHSY--PHCWRCKTPLIYRATPQWFIS---MDKLRDRALE--AIEKvnWiPEWGEGRFGNMLEN 454
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 299 IGDWCVSRQLWWGHQIPAYR------------VIG---ENAEDDRKECWVvgRSEAEARAVAAKRTGRPEAElTLERDPD 363
Cdd:COG0060 455 RPDWCISRQRYWGVPIPIWVcedcgelhrteeVIGsvaELLEEEGADAWF--ELDLHRPFLDETLKCPKCGG-TMRRVPD 531
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 364 VLDTWFSSALFPFSALgwpRETPDL---AHFYpltlLEtGSD--------LLMfwvgrmvmLGTQLTGQLPFSKVLLHSM 432
Cdd:COG0060 532 VLDVWFDSGSMHFAVL---ENREELhfpADFY----LE-GSDqtrgwfysSLL--------TSTALFGRAPYKNVLTHGF 595
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 433 VRDRQGRKMSKSLGNVLDPRDIIsgqelqvlqaklrdgnldpgelavaaaaqKKDfpygipecGTDALRFALCSHGiLGG 512
Cdd:COG0060 596 VLDEDGRKMSKSLGNVVDPQEVI-----------------------------DKY--------GADILRLWVASSD-YWG 637
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 513 DLHLSVSEVLNYRHFCNKLWNALRFVLRALgDNFVPQpAEEVTPSS--PMDAWILSRLAFAASECERGFLSRELSLVTHT 590
Cdd:COG0060 638 DLRFSDEILKEVRDVYRRLRNTYRFLLANL-DDFDPA-EDAVPYEDlpELDRWILSRLNELIKEVTEAYDNYDFHRAYRA 715
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 591 LYHFwlhnlCDV-----YLEAVKPVL-----SSVPRppgppQVLFSCADVGLRLLAPLMPFLAEELWQRLPprpgGPLAP 660
Cdd:COG0060 716 LHNF-----CVEdlsnwYLDISKDRLyteaaDSLDRra-aqTTLYEVLETLVRLLAPILPFTAEEIWQNLP----GEAEE 785
|
730 740 750 760
....*....|....*....|....*....|....*....|....
gi 1907125978 661 SICVAPYPSTrsLEFWRQPELERCFSRVQEVV----QALRALRA 700
Cdd:COG0060 786 SVHLADWPEV--DEELIDEELEAKWDLVREVRsavlKALEAARK 827
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
516-650 |
8.38e-50 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 171.59 E-value: 8.38e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 516 LSVSEVLNYRHFCNKLWNALRFVLRALGDNFVPQPAEEvtPSSPMDAWILSRLAFAASECERGFLSRELSLVTHTLYHFW 595
Cdd:cd07962 1 FDEKRVEGGRNFCNKLWNAARFVLMNLEDDDEPEEDPE--SLSLADRWILSRLNKTVEEVTEALENYRFSEAATALYEFF 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1907125978 596 LHNLCDVYLEAVKPVL--SSVPRPPGPPQVLFSCADVGLRLLAPLMPFLAEELWQRL 650
Cdd:cd07962 79 WNDFCDWYLELVKPRLygEDEEEKKAARATLYYVLETILRLLHPFMPFITEELWQRL 135
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
36-670 |
1.19e-39 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 158.40 E-value: 1.19e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 36 AAVTEAFVRLYNSGLLYRNRQLVNWSCTLRSAISDIEVE------SRPLpgrtVLQLPGCPTPVSFGLLASVAFPvdgep 109
Cdd:PLN02843 147 AAQIEVFGQMFLNGYIYRGRKPVHWSPSSRTALAEAELEypeghvSKSI----YVAFPVVSPSETSPEELEEFLP----- 217
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 110 DTEIVVGTTRPETLPGDVAVAVHPD----------------------DPRYTH--------------------------- 140
Cdd:PLN02843 218 GLSLAIWTTTPWTMPANAAVAVNDKlqysvvevqsfsedestsggnkKKRPGNvlkeqqklflivatdlvpaleakwgvk 297
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 141 -----------LHGRQLRHPLTGQLLPLI-------TDTtvqphvGTGAVKVTPAHSPIDAEIGTRHGLTPLSVIAEDGT 202
Cdd:PLN02843 298 lvvlktfpgsdLEGCRYIHPLYNRESPVViggdyitTES------GTGLVHTAPGHGQEDYITGLKYGLPLLSPVDDAGK 371
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 203 MTSLCGDwLQGLHRFVAREKIMCT-LREQGLFrgLQEHPMV--LPICSRSGDVVEYLLKSQWFVRCQEMGDLAAKAVESg 279
Cdd:PLN02843 372 FTEEAGQ-FSGLSVLGEGNAAVVEaLDEAGSL--LMEEAYGhkYPYDWRTKKPTIFRATEQWFASVEGFRQAALDAIDK- 447
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 280 aLELWPSFHQKSWQHWFAHIGDWCVSRQLWWGHQIPAY-------------------RVIGENAEDdrkeCW----VVGR 336
Cdd:PLN02843 448 -VKWIPAQGENRIRAMVSGRSDWCISRQRTWGVPIPVFyhvetkeplmneetiahvkSIVAQKGSD----AWwymdVEDL 522
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 337 SEAEARAVAAKrtgrpeaeltLERDPDVLDTWFSSALfpfSALGWPRETPDLAhfYPLTLLETGSDLLMFWVGRMVMLGT 416
Cdd:PLN02843 523 LPEKYRDKASD----------YEKGTDTMDVWFDSGS---SWAGVLGSREGLS--YPADLYLEGSDQHRGWFQSSLLTSV 587
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 417 QLTGQLPFSKVLLHSMVRDRQGRKMSKSLGNVLDPRDIISGqelqvlqaklrdGNldpgelavaaaAQKKDfpygiPECG 496
Cdd:PLN02843 588 ATKGKAPYKSVLTHGFVLDEKGFKMSKSLGNVVDPRLVIEG------------GK-----------NQKQE-----PAYG 639
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 497 TDALRFALCSHG-----ILGGDLHLSVSEVlnYRhfcnKLWNALRFVLRALGDnFVPQPAEEVTPSSPMDAWILSRLAFA 571
Cdd:PLN02843 640 ADVLRLWVASVDytgdvLIGPQILKQMSDI--YR----KLRGTLRYLLGNLHD-WKPDNAVPYEDLPSIDKYALFQLENV 712
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 572 ASECERGFLSRELSLVTHTLYHFWLHNLCDVYLEAVKPVLSsVPRPPGPPQ-----VLFSCADVGLRLLAPLMPFLAEEL 646
Cdd:PLN02843 713 VNEIEESYDNYQFFKIFQILQRFTIVDLSNFYLDVAKDRLY-VGGTTSFTRrscqtVLAAHLLSLLRAIAPILPHLAEDA 791
|
730 740
....*....|....*....|....
gi 1907125978 647 WQRLPPRPGGPLAPSICVAPYPST 670
Cdd:PLN02843 792 WQNLPFQEDGSAAESVFEAGWPTP 815
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
260-455 |
1.16e-33 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 131.77 E-value: 1.16e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 260 QWFVRCQEMGDLAAKAVESGALElwPSFHQKSWQHWFAHIGDWCVSRQLWWGHQIPayrvigenaeddrkecwvvgrsea 339
Cdd:cd00668 141 QWFFDMPKFKEKLLKALRRGKIV--PEHVKNRMEAWLESLLDWAISRQRYWGTPLP------------------------ 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 340 earavaakrtgrpeaeltlerdPDVLDTWFSSALFPFSALGWPRETPDLAHFYPLTLLETGSDLLMFWVGRMVMLGTQLT 419
Cdd:cd00668 195 ----------------------EDVFDVWFDSGIGPLGSLGYPEEKEWFKDSYPADWHLIGKDILRGWANFWITMLVALF 252
|
170 180 190
....*....|....*....|....*....|....*.
gi 1907125978 420 GQLPFSKVLLHSMVRDRQGRKMSKSLGNVLDPRDII 455
Cdd:cd00668 253 GEIPPKNLLVHGFVLDEGGQKMSKSKGNVIDPSDVV 288
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
561-709 |
1.23e-33 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 125.98 E-value: 1.23e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 561 DAWILSRLAFAASECERGFLSRELSLVTHTLYHFWLHNLCDVYLEAVKPVLSSVPRPPGPPQVLFSCADVGLRLLAPLMP 640
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFWNDLSDWYLELIKDRLYGEEPDSRAQTTLYEVLETLLRLLAPFMP 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907125978 641 FLAEELWQRLpprpggplapSICVAPYPSTRSLEfwrQPELERCFSRVQEVVQALRALRATYQLTKARP 709
Cdd:pfam08264 81 FITEELWQKE----------SIHLAPWPEDAELE---EAELEEAFELRQEIVQAIRKLRSELKIKKSLP 136
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
260-455 |
9.30e-26 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 109.24 E-value: 9.30e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 260 QWFVRCQEMGDLAAKAVESgaLELWPSFHQKSWQHWFAHIGDWCVSRQLWWGHQIPAYRvigenAEDDrkecwvvgrsea 339
Cdd:cd00818 152 QWFIRVTKIKDRLLEANDK--VNWIPEWVKNRFGNWLENRRDWCISRQRYWGTPIPVWY-----CEDC------------ 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 340 earavaakrtgrpeAELTLERDPDVLDTWFSSALFPFSALGWPRETPDLAHFYPLTLLETGSDLLMFWVGRMVMLGTQLT 419
Cdd:cd00818 213 --------------GEVLVRRVPDVLDVWFDSGSMPYAQLHYPFENEDFEELFPADFILEGSDQTRGWFYSLLLLSTALF 278
|
170 180 190
....*....|....*....|....*....|....*.
gi 1907125978 420 GQLPFSKVLLHSMVRDRQGRKMSKSLGNVLDPRDII 455
Cdd:cd00818 279 GKAPYKNVIVHGFVLDEDGRKMSKSLGNYVDPQEVV 314
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
29-699 |
2.39e-24 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 109.81 E-value: 2.39e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 29 PSFQGSsaaVTEAFVRLYNSGLLYRNRQLVNWSCTLRSAISDIEVEsrpLPGRTVlqlpgcPTPVsfgllASVAFPVDGE 108
Cdd:PLN02882 152 PKFMES---VWWVFKQLFEKGLVYKGFKVMPYSTACKTPLSNFEAG---LNYKDV------SDPA-----VMVSFPIVGD 214
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 109 PD-TEIVVGTTRPETLPGDVAVAVHPD------------------DPRYTHL-----------------HGRQLRHPLTG 152
Cdd:PLN02882 215 PDnASFVAWTTTPWTLPSNLALCVNPNftyvkvrnkytgkvyivaESRLSALptakpkskkgskpenaaEGYEVLAKVPG 294
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 153 QLL------PL--------------ITDTTVQPHVGTGAVKVTPAHSPIDAEIGTRHGLT------PLSVIAeDGTMTSL 206
Cdd:PLN02882 295 SSLvgkkyePLfdyfsefsdtafrvVADDYVTDDSGTGVVHCAPAFGEDDYRVCLANGIIekggnlPVPVDD-DGCFTEK 373
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 207 CGDWlQGLHRFVAREKIMCTLREQGlfRGLQEHPMV--LPICSRSGDVVEYLLKSQWFVRCQEMGDlaaKAVESGALELW 284
Cdd:PLN02882 374 VTDF-SGRYVKDADKDIIAAIKAKG--RLVKSGSIThsYPFCWRSDTPLIYRAVPSWFVKVEEIKD---RLLENNKQTYW 447
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 285 -PSF-HQKSWQHWFAHIGDWCVSRQLWWGHQIPAYrvigenAEDDRKECWVVGrSEAEARAVAAKR-------------- 348
Cdd:PLN02882 448 vPDYvKEKRFHNWLENARDWAVSRSRFWGTPLPIW------ISDDGEEVVVIG-SIAELEKLSGVKvtdlhrhfidhiti 520
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 349 -TGRPEAELTLERDPDVLDTWFSSALFPFSALGWPRETPDLahF---YPLTLLETGSDLLMFWVGRMVMLGTQLTGQLPF 424
Cdd:PLN02882 521 pSSRGPEFGVLRRVDDVFDCWFESGSMPYAYIHYPFENKEL--FeknFPADFVAEGLDQTRGWFYTLMVLSTALFDKPAF 598
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 425 SKVLLHSMVRDRQGRKMSKSLGNVLDPRDIISgqelqvlqaklrdgnldpgelavaaaaqkkdfpygipECGTDALRFAL 504
Cdd:PLN02882 599 KNLICNGLVLAEDGKKMSKSLKNYPDPNEVID-------------------------------------KYGADALRLYL 641
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 505 C-------------SHGILGgdlhlSVSEVL-----NYRHFcnkLWNALRFVLRAlGDNFVPQPAEEVTPSS-PMDAWIL 565
Cdd:PLN02882 642 InspvvraeplrfkEEGVFG-----VVKDVFlpwynAYRFL---VQNAKRLEVEG-GAPFVPLDLAKLQNSAnVLDRWIN 712
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 566 SrlafaASECERGFLSRE-----LSLVTHTLYHFwLHNLCDVYleavkpVLSSVPRPPGPP---------QVLFSCADVG 631
Cdd:PLN02882 713 S-----ATQSLVKFVREEmgayrLYTVVPYLVKF-IDNLTNIY------VRFNRKRLKGRTgeedcrtalSTLYNVLLTS 780
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907125978 632 LRLLAPLMPFLAEELWQRL-PPRPGGPlaPSICVAPYPSTRSLEfwRQPELERCFSRVQEVVQALRALR 699
Cdd:PLN02882 781 CKVMAPFTPFFTEVLYQNLrKVLPGSE--ESIHYCSFPQVDEGE--LDERIEQSVSRMQTVIELARNIR 845
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
136-455 |
4.66e-19 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 92.72 E-value: 4.66e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 136 PRYTHLHGRqlrHPLTGQLLPLITDTTVQPHVGTGAVKVTPAHSPIDAEIGTRHG-LTPLSVIAED-----GTMTSLCgD 209
Cdd:PTZ00427 404 PLFTNFYEK---YNFKERAYKILADDFVTDDAGTGIVHCAPTYGEDDFRVCKKNGvIDPEKNIFIDpldanGYFTNEV-E 479
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 210 WLQGLHRFVAREKIMCTLREQGlfRGLQEHPMV--LPICSRSGDVVEYLLKSQWFVRcqeMGDLAAKAVESGALELWPSF 287
Cdd:PTZ00427 480 EVQNLYIKEADNVIKKKLKNEN--RLLSNNTIVhsYPFCWRSDTPLIYRAIPAWFIR---VSNSTNELVKNNETTYWIPA 554
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 288 H--QKSWQHWFAHIGDWCVSRQLWWGHQIPAYrvigenaEDDRKECWVVGRSEAEARAVAAKRT--------------GR 351
Cdd:PTZ00427 555 HikEKKFHNWIKDAKDWCISRNRYWGTPIPIW-------ADEKMETVICVESIKHLEELSGVKNindlhrhfidhieiKN 627
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 352 PEAEL--TLERDPDVLDTWFSSALFPFSALGWP--RETPDLAHFYPLTLLETGSDLLMFWVGRMVMLGTQLTGQLPFSKV 427
Cdd:PTZ00427 628 PKGKTypKLKRIPEVFDCWFESGSMPYAKVHYPfsTEKEDFHKIFPADFIAEGLDQTRGWFYTLLVISTLLFDKAPFKNL 707
|
330 340
....*....|....*....|....*...
gi 1907125978 428 LLHSMVRDRQGRKMSKSLGNVLDPRDII 455
Cdd:PTZ00427 708 ICNGLVLASDGKKMSKRLKNYPDPLYIL 735
|
|
| Anticodon_Ia_Ile_BEm |
cd07960 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ... |
517-699 |
5.84e-18 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153414 [Multi-domain] Cd Length: 180 Bit Score: 82.19 E-value: 5.84e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 517 SVSEvlNYRhfcnKLWNALRFVLRALGDnfvPQPAEEVTPSSPM---DAWILSRLAFAASECERGFLSRELSLVTHTLYH 593
Cdd:cd07960 8 QVAE--AYR----KIRNTFRFLLGNLND---FDPAKDAVPYEELlelDRYALHRLNELIKEVREAYENYEFHKVYQALNN 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 594 FWLHNLCDVYLEAVKPVL-----SSVPRPPGppQ-VLFSCADVGLRLLAPLMPFLAEELWQRLPPRPGgplAPSICVAPY 667
Cdd:cd07960 79 FCTVDLSAFYLDIIKDRLycdakDSLERRSA--QtVLYHILDALLKLLAPILPFTAEEVWEHLPGEKK---EESVFLEDW 153
|
170 180 190
....*....|....*....|....*....|..
gi 1907125978 668 PSTRslEFWRQPELErcfsrvqEVVQALRALR 699
Cdd:cd07960 154 PELP--EEWKDEELE-------EKWEKLLALR 176
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
518-696 |
2.19e-17 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 80.67 E-value: 2.19e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 518 VSEVLnyRHFCNKLWNALRF-VLRALGDNFVPQPAEEVTPSSP-MDAWILSRLAFAASECERGFLSRELSLVTHTLYHFW 595
Cdd:cd07961 6 VREVV--RKVLLPLWNAYRFfVTYANLDGFDPGKDDDAVASLNvLDRWILSRLNSLIKEVTEEMEAYDLYTAVRALLEFI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 596 LhNLCDVYL------------EAVKpvLSSVprppgppQVLFSCADVGLRLLAPLMPFLAEELWQRLppRPGGPLAP-SI 662
Cdd:cd07961 84 D-ELTNWYIrrnrkrfwgeegDDDK--LAAY-------ATLYEVLLTLSRLMAPFTPFITEEIYQNL--RRELGDAPeSV 151
|
170 180 190
....*....|....*....|....*....|....
gi 1907125978 663 CVAPYPSTRslEFWRQPELERCFSRVQEVVQALR 696
Cdd:cd07961 152 HLLDWPEVD--ESLIDEELEEAMELVREIVELGR 183
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
113-650 |
1.86e-12 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 71.05 E-value: 1.86e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 113 IVVGTTRPETLPGDVAVAVHPD----------------------------------DPRYTHLHGRQLRHPLTGQLLPLI 158
Cdd:PRK12300 172 LPAATLRPETIFGVTNLWVNPDatyvkaevdgekwivskeaaeklsfqdrdveiieEIKGSELIGKKVKNPVTGKEVPIL 251
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 159 TDTTVQPHVGTGAVKVTPAHSPID--------AEIGTRHGLTPLSVI---------AED--------------------- 200
Cdd:PRK12300 252 PADFVDPDNGTGVVMSVPAHAPYDyvalrdlkKNKELLDVIEPIPLIevegygefpAKEvveklgiksqedpeleeatke 331
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 201 --------GTMTSLCGDwLQGLHRFVAREKIMCTLREQGLFRGLQEHpMVLPICSRSG-DVVEYLLKSQWFVRC--QEMG 269
Cdd:PRK12300 332 vyraefhkGVLKENTGE-YAGKPVREAREKITKDLIEKGIADIMYEF-SNRPVYCRCGtECVVKVVKDQWFIDYsdPEWK 409
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 270 DLAAKAVESgaLELWPS-----FHQK-SWqhwfahIGDWCVSRQLWWGHQIP-----------------AY-------RV 319
Cdd:PRK12300 410 ELAHKALDN--MEIIPEeyrkeFENTiDW------LKDRACARRRGLGTRLPwdeewiieslsdstiymAYytiahkiRE 481
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 320 IGENAEDDRKECW---VVGRSEAEAravAAKRTGRPEAELTLERDpdvldtwfssalfpfsalgwpretpDLAHFYPLTL 396
Cdd:PRK12300 482 YGIKPEQLTPEFFdyvFLGKGDPEE---VSKKTGIPKEILEEMRE-------------------------EFLYWYPVDW 533
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 397 LETGSDL----LMF-------------WVGRMVMLGtqltgqlpfskvllhsMVRdRQGRKMSKSLGNVLDPRDIISgqe 459
Cdd:PRK12300 534 RHSGKDLipnhLTFfifnhvaifpeekWPRGIVVNG----------------FVL-LEGKKMSKSKGNVIPLRKAIE--- 593
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 460 lqvlqaklrdgnldpgelavaaaaqkkdfpygipECGTDALRFALCSHGILGGDLHLSVSEVLNYRHFCNKLWNalrFVL 539
Cdd:PRK12300 594 ----------------------------------EYGADVVRLYLTSSAELLQDADWREKEVESVRRQLERFYE---LAK 636
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 540 RALGdnfvpqpAEEVTPSSPMDAWILSRLAFA---ASECERGFLSRELslVTHTLYHfwLHNLCDVYL----EAVKPVLS 612
Cdd:PRK12300 637 ELIE-------IGGEEELRFIDKWLLSRLNRIikeTTEAMESFQTRDA--VQEAFYE--LLNDLRWYLrrvgEANNKVLR 705
|
650 660 670
....*....|....*....|....*....|....*...
gi 1907125978 613 SVprppgppqvlfscADVGLRLLAPLMPFLAEELWQRL 650
Cdd:PRK12300 706 EV-------------LEIWIRLLAPFTPHLAEELWHKL 730
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
42-668 |
3.23e-10 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 63.92 E-value: 3.23e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 42 FVRLYNSGLLYRNRQLVNW--SC-T-L--------RSAISDIEVESRPLPG----------RtvL-----QLPGCPTPV- 93
Cdd:COG0495 140 FLQLYEKGLAYRKEAPVNWcpVDqTvLaneqvidgRCWRCGAPVEKKELPQwflkitdyadE--LlddldKLDGWPEKVk 217
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 94 ---------SFGllASVAFPVDGePDTEIVVGTTRPETLPGD--VAVAV-HP-------DDPR----------------- 137
Cdd:COG0495 218 tmqrnwigrSEG--AEVDFPVEG-SDEKITVFTTRPDTLFGAtfMVLAPeHPlvkelatPEQNaavaafieeakkkseie 294
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 138 -----------YThlhGRQLRHPLTGQLLPL-ITDTtVQPHVGTGAVKVTPAHSPIDAEIGTRHGLTPLSVIA------- 198
Cdd:COG0495 295 rtsetkektgvFT---GLYAINPLTGEKIPIwIADY-VLMDYGTGAVMAVPAHDQRDFEFAKKYGLPIKQVIApedgddp 370
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 199 --------EDGTMT-SlcgDWLQGLHRFVAREKIMCTLREQGLFRGlqehpmvlpicsrsgdVVEYLLKsqwfvrcqemg 269
Cdd:COG0495 371 dileeaytGDGVLInS---GEFDGLDSEEAKEAIIEWLEEKGLGKR----------------KVNYRLR----------- 420
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 270 dlaakavesgalelwpsfhqkswqhwfahigDWCVSRQLWWGHQIP-------------------------AYRVIGENA 324
Cdd:COG0495 421 -------------------------------DWLISRQRYWGEPIPiihcedcgvvpvpedqlpvelpedvDFDPTGGSP 469
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 325 EDDRKEcWVvgrseaearAVAAKRTGRPeAEltleRDPDVLDTWF-SSalfpfsalgW-------PRET-----PDLAHF 391
Cdd:COG0495 470 LARAPE-WV---------NVTCPKCGGP-AR----RETDTMDTFVdSS---------WyylrytdPHNDeapfdPEAANY 525
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 392 Y-PLtlletgsDL-----------LM---FWVgrMVM--LGtQLTGQLPFSKVLLHSMVRD--RQGR------KMSKSLG 446
Cdd:COG0495 526 WlPV-------DQyiggiehailhLLyarFFT--KVLrdLG-LVSFDEPFKRLLTQGMVLEvgKDGVviggieKMSKSKG 595
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 447 NVLDPRDIISgqelqvlqaklrdgnldpgelavaaaaqkkdfpygipECGTDALR----FAlcshgilgGDLHLSVSevl 522
Cdd:COG0495 596 NVVDPDEIIE-------------------------------------KYGADTLRlfemFA--------GPPERDLE--- 627
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 523 nyrhfcnklWN------ALRFVLRA--LGDNFVPQPAEEVTPSSPMDAWI--------------LSRLAF--AASECerg 578
Cdd:COG0495 628 ---------WSdsgvegAYRFLNRVwrLVVDEAEALKLDVADLSEADKELrralhktikkvtedIERLRFntAIAAL--- 695
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 579 flsRELslvTHTLYHFWLHNLCD--VYLEAVKPVlssvprppgppqvlfscadvgLRLLAPLMPFLAEELWQRLpprpGG 656
Cdd:COG0495 696 ---MEL---VNALYKAKDSGEADraVLREALETL---------------------VLLLAPFAPHIAEELWERL----GH 744
|
810
....*....|..
gi 1907125978 657 plAPSICVAPYP 668
Cdd:COG0495 745 --EGSVADAPWP 754
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
438-650 |
1.54e-08 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 58.20 E-value: 1.54e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 438 GRKMSKSLGNVLDPRDIIsgqelqvlqaklrdgnldpgelavaaaaqkKDFpygipecGTDALRFALCSHGILGGDLHLS 517
Cdd:COG0143 325 GEKMSKSRGNVIDPDDLL------------------------------DRY-------GPDALRYYLLREVPFGQDGDFS 367
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 518 VSEVLNyRH---FCNKLWNalrFVLRALG------DNFVPQPAEEvtpsSPMDAWILSRLAFAASECERGFLSRELSLVT 588
Cdd:COG0143 368 WEDFVA-RVnsdLANDLGN---LASRTLSmihkyfDGKVPEPGEL----TEADEELLAEAEAALEEVAEAMEAFEFRKAL 439
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907125978 589 HTLYHFWlhNLCDVYLEAVKP-VLSSVPRPPGPPQVLFSCADVgLR----LLAPLMPFLAEELWQRL 650
Cdd:COG0143 440 EEIMALA--RAANKYIDETAPwKLAKDEDPERLATVLYTLLEA-LRilaiLLKPFLPETAEKILEQL 503
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
42-231 |
6.08e-08 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 56.76 E-value: 6.08e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 42 FVRLYNSGLLYRNRQLVNWSCTLRSAISDIE------------VESRPL----------PGRTVLQLPGCPTPVSFGLL- 98
Cdd:PLN02563 218 FLQLLKRGLAYQAEVPVNWCPALGTVLANEEvvdglsergghpVIRKPMrqwmlkitayADRLLEDLDDLDWPESIKEMq 297
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 99 ---------ASVAFPVDG----EPDTEIVVGTTRPETLPGDVAVAVHPDDP----------------------RYTHLHG 143
Cdd:PLN02563 298 rnwigrsegAELDFSVLDgegkERDEKITVYTTRPDTLFGATYLVVAPEHPllsslttaeqkeaveeyvdaasRKSDLER 377
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 144 RQL-------------RHPLTGQLLPLITDTTVQPHVGTGAVKVTPAHSPIDAEIGTRHGLTPLSVIA------------ 198
Cdd:PLN02563 378 TELqkektgvftgsyaINPATGEAIPIWVADYVLGSYGTGAIMAVPAHDTRDFEFAQKFDLPIKWVVKpadgneddaeka 457
|
250 260 270
....*....|....*....|....*....|....*..
gi 1907125978 199 --EDGTM--TSLCGDWLQGLHRFVAREKIMCTLREQG 231
Cdd:PLN02563 458 ytGEGVIvnSSSSGLDINGLSSKEAAKKVIEWLEETG 494
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
361-650 |
1.62e-07 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 54.89 E-value: 1.62e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 361 DPD-VLDTWFSsALFPF-SALGWP----RETPDLAHFYP--LTLLetGSDLLMF----WVGRMVMLGtqltGQLPfSKVL 428
Cdd:PRK11893 217 DPKhVIYVWFD-ALTNYlTALGYPddeeLLAELFNKYWPadVHLI--GKDILRFhavyWPAFLMAAG----LPLP-KRVF 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 429 LHSMVRdRQGRKMSKSLGNVLDPRDIISgqelqvlqaklrdgnldpgelavaaaaqkkdfpygipECGTDALRFALCSHG 508
Cdd:PRK11893 289 AHGFLT-LDGEKMSKSLGNVIDPFDLVD-------------------------------------EYGVDAVRYFLLREI 330
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 509 ILGGDLHLSVSEVLNYR--HFCNKLWNALRFVLRALGDNF---VPQPAEEvtpsSPMDAWILSRLAFAASECERGFLSRE 583
Cdd:PRK11893 331 PFGQDGDFSREAFINRInaDLANDLGNLAQRTLSMIAKNFdgkVPEPGAL----TEADEALLEAAAALLERVRAAMDNLA 406
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907125978 584 LSLVTHTLYHfwLHNLCDVYLEAVKPVLSSVPRPPGPPQVLFSCADvGLR----LLAPLMPFLAEELWQRL 650
Cdd:PRK11893 407 FDKALEAILA--LVRAANKYIDEQAPWSLAKTDPERLATVLYTLLE-VLRgiavLLQPVMPELAAKILDQL 474
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
257-455 |
1.85e-07 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 53.79 E-value: 1.85e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 257 LKSQWFVR--CQEMGDLAAKAVEsgALELWPSFHQKSWQHWfahIGdwcVSRQLWWGHQIPAYRVIgenaeddrkECWVv 334
Cdd:cd00812 128 LLDQWFLKysETEWKEKLLKDLE--KLDGWPEEVRAMQENW---IG---CSRQRYWGTPIPWTDTM---------ESLS- 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 335 GRSEAEARAVAAKRTGRPEaELTLERDPDVLDTWfssalfpfsalgwpretpdlahfYPLTLLETGSDL----LMFWV-G 409
Cdd:cd00812 190 DSTWYYARYTDAHNLEQPY-EGDLEFDREEFEYW-----------------------YPVDIYIGGKEHapnhLLYSRfN 245
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 1907125978 410 RMVMLGTQLTGQLPFSKVLLHSMVRdRQGRKMSKSLGNVLDPRDII 455
Cdd:cd00812 246 HKALFDEGLVTDEPPKGLIVQGMVL-LEGEKMSKSKGNVVTPDEAI 290
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
552-650 |
1.25e-04 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 42.19 E-value: 1.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 552 EEVTPSSPMDAWILSRLAFAASECERGFLSRELSLVTHTLYhFWLHNLCDVYLEAVKPVLSSvprppgppQVLFSCADVG 631
Cdd:cd07959 28 GELEELTFIDRWLLSRLNRLIKETTEAYENMQFREALKEGL-YELQNDLDWYRERGGAGMNK--------DLLRRFIEVW 98
|
90
....*....|....*....
gi 1907125978 632 LRLLAPLMPFLAEELWQRL 650
Cdd:cd07959 99 TRLLAPFAPHLAEEIWHEL 117
|
|
| Anticodon_Ia_Leu_BEm |
cd07958 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; ... |
632-650 |
2.83e-04 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes bacterial and eukaryotic mitochondrial members, as well as LeuRS from the archaeal Halobacteria. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153412 [Multi-domain] Cd Length: 117 Bit Score: 41.05 E-value: 2.83e-04
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
358-455 |
5.56e-04 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 43.64 E-value: 5.56e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125978 358 LERDPD-VLDTWFSsALFPF-SALGWPRETPDLAH-FYPLTLLETGSDLLMF----WVGRMVMLGtqltgqLPFSKVLL- 429
Cdd:PRK12267 217 VPFDPKhVVYVWID-ALLNYiTALGYGSDDDELFKkFWPADVHLVGKDILRFhaiyWPIMLMALG------LPLPKKVFa 289
|
90 100
....*....|....*....|....*..
gi 1907125978 430 HS-MVRDrqGRKMSKSLGNVLDPRDII 455
Cdd:PRK12267 290 HGwWLMK--DGKMSKSKGNVVDPEELV 314
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
418-455 |
7.45e-04 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 42.78 E-value: 7.45e-04
10 20 30
....*....|....*....|....*....|....*....
gi 1907125978 418 LTGQlPFSKVLLHS-MVRDRqGRKMSKSLGNVLDPRDII 455
Cdd:COG0215 244 ATGK-PFARYWMHNgFLTVN-GEKMSKSLGNFFTVRDLL 280
|
|
| |
