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Conserved domains on  [gi|1907138044|ref|XP_036016680|]
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globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 isoform X2 [Mus musculus]

Protein Classification

glycosyltransferase family 6 protein( domain architecture ID 11142430)

glycosyltransferase family 6 protein similar to Homo sapiens globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 that might have acquired an alternative function in glycosphingolipid metabolism, but it remains to be established

CATH:  3.90.550.10
CAZY:  GT6
EC:  2.4.-.-
Gene Ontology:  GO:0016757|GO:0006486
SCOP:  3000077

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
Glyco_transf_6 pfam03414
Glycosyltransferase family 6;
60-347 0e+00

Glycosyltransferase family 6;


:

Pssm-ID: 427285  Cd Length: 289  Bit Score: 540.51  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138044  60 PVTQLQYPQPKLLEHGPTELLTLTPWLAPIVSEGTFDPELLKSMYQPLNLTIGVTVFAVGKYTCFIQRFLESAEEFFMRG 139
Cdd:pfam03414   2 QLPRWFYPKPKLLEPKRPDVLTVTPWLAPIVWEGTFDPAILEDYYRPQNLTIGLTVFAVGKYVRFLELFLESAEKYFMVG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138044 140 YQVHYYLFTHDPTAVPRVPLGPGRLLSIIPIQGYSRWEEISMRRMETINKHIAKRAHKEVDYLFCVDVDMVFRNPWGPET 219
Cdd:pfam03414  82 HRVIYYVFTDDPAAVPRVPLGPGRQLSVFEIGRYKRWQDISMRRMETISEHIAQRIQHEVDYLFCVDVDMVFRDHFGVET 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138044 220 LGDLVAAIHPGYFAVPRRKFPYERRQVSSAFVADNEGDFYYGGALFGGRVARVYEFTRACHMAILADKANSIMAAWQEES 299
Cdd:pfam03414 162 LGPLVAQLHPWWYAADRQKFTYERRPLSAAYIPFGEGDFYYHGAIFGGTVARVYNLTRACHKAILADKANGIEAAWHDES 241
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1907138044 300 HLNRHFIWHKPSKVLSPEYLWDERKPRPRSLKMIRFSSVKKNANWLRT 347
Cdd:pfam03414 242 HLNKYFLSHKPTKVLSPEYLWDYQIGRPSDLRLVRFAWVPKNYNWVRN 289
 
Name Accession Description Interval E-value
Glyco_transf_6 pfam03414
Glycosyltransferase family 6;
60-347 0e+00

Glycosyltransferase family 6;


Pssm-ID: 427285  Cd Length: 289  Bit Score: 540.51  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138044  60 PVTQLQYPQPKLLEHGPTELLTLTPWLAPIVSEGTFDPELLKSMYQPLNLTIGVTVFAVGKYTCFIQRFLESAEEFFMRG 139
Cdd:pfam03414   2 QLPRWFYPKPKLLEPKRPDVLTVTPWLAPIVWEGTFDPAILEDYYRPQNLTIGLTVFAVGKYVRFLELFLESAEKYFMVG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138044 140 YQVHYYLFTHDPTAVPRVPLGPGRLLSIIPIQGYSRWEEISMRRMETINKHIAKRAHKEVDYLFCVDVDMVFRNPWGPET 219
Cdd:pfam03414  82 HRVIYYVFTDDPAAVPRVPLGPGRQLSVFEIGRYKRWQDISMRRMETISEHIAQRIQHEVDYLFCVDVDMVFRDHFGVET 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138044 220 LGDLVAAIHPGYFAVPRRKFPYERRQVSSAFVADNEGDFYYGGALFGGRVARVYEFTRACHMAILADKANSIMAAWQEES 299
Cdd:pfam03414 162 LGPLVAQLHPWWYAADRQKFTYERRPLSAAYIPFGEGDFYYHGAIFGGTVARVYNLTRACHKAILADKANGIEAAWHDES 241
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1907138044 300 HLNRHFIWHKPSKVLSPEYLWDERKPRPRSLKMIRFSSVKKNANWLRT 347
Cdd:pfam03414 242 HLNKYFLSHKPTKVLSPEYLWDYQIGRPSDLRLVRFAWVPKNYNWVRN 289
Glyco_transf_6 cd02515
Glycosyltransferase family 6 comprises enzymes responsible for the production of the human ABO ...
76-346 2.41e-162

Glycosyltransferase family 6 comprises enzymes responsible for the production of the human ABO blood group antigens; Glycosyltransferase family 6, GT_6, comprises enzymes with three known activities: alpha-1,3-galactosyltransferase, alpha-1,3 N-acetylgalactosaminyltransferase, and alpha-galactosyltransferase. UDP-galactose:beta-galactosyl alpha-1,3-galactosyltransferase (alpha3GT) catalyzes the transfer of galactose from UDP-alpha-d-galactose into an alpha-1,3 linkage with beta-galactosyl groups in glycoconjugates. The enzyme exists in most mammalian species but is absent from humans, apes, and old world monkeys as a result of the mutational inactivation of the gene. The alpha-1,3 N-acetylgalactosaminyltransferase and alpha-galactosyltransferase are responsible for the production of the human ABO blood group antigens. A N-acetylgalactosaminyltransferases use a UDP-GalNAc donor to convert the H-antigen acceptor to the A antigen, whereas a galactosyltransferase uses a UDP-galactose donor to convert the H-antigen acceptor to the B antigen. Alpha-1,3 N-acetylgalactosaminyltransferase and alpha-galactosyltransferase differ only in the identity of four critical amino acid residues.


Pssm-ID: 133008  Cd Length: 271  Bit Score: 454.48  E-value: 2.41e-162
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138044  76 PTELLTLTPWLAPIVSEGTFDPELLKSMYQPLNLTIGVTVFAVGKYTCFIQRFLESAEEFFMRGYQVHYYLFTHDPTAVP 155
Cdd:cd02515     1 RPDVLTVTPWLAPIVWEGTFNPDVLDEYYRKQNITIGLTVFAVGKYTEFLERFLESAEKHFMVGYRVIYYIFTDKPAAVP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138044 156 RVPLGPGRLLSIIPIQGYSRWEEISMRRMETINKHIAKRAHKEVDYLFCVDVDMVFRNPWGPETLGDLVAAIHPGYFAVP 235
Cdd:cd02515    81 EVELGPGRRLTVLKIAEESRWQDISMRRMKTLADHIADRIGHEVDYLFCMDVDMVFQGPFGVETLGDSVAQLHPWWYGKP 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138044 236 RRKFPYERRQVSSAFVADNEGDFYYGGALFGGRVARVYEFTRACHMAILADKANSIMAAWQEESHLNRHFIWHKPSKVLS 315
Cdd:cd02515   161 RKQFPYERRPSSAAYIPEGEGDFYYHGAVFGGSVEEVYRLTRACHEGILADKANGIEARWHDESHLNKYFLLHKPTKVLS 240
                         250       260       270
                  ....*....|....*....|....*....|.
gi 1907138044 316 PEYLWDERKPRPRSLKMIRFSSVKKNANWLR 346
Cdd:cd02515   241 PEYLWDDRIGQAAEIRLPRLSWLPKNYQEVR 271
Gltr_6 NF041524
family 6 glucosyltransferase;
109-333 2.90e-40

family 6 glucosyltransferase;


Pssm-ID: 469409  Cd Length: 226  Bit Score: 141.22  E-value: 2.90e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138044 109 LTIGVTVFAVGKYTCFIQRFLESAEEFFMRGYQVHYYLFThDPTAVPRVPLGPGRLlsiIPIQGYSrWEEISMRRMETIN 188
Cdd:NF041524    1 MKIGILYICTGKYSIFWKDFYLSCEKYFLPGAEKEYFVFT-DPDDLYFKKNNNVHV---IYQENLG-WPLNTLLRFSMFL 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138044 189 KHiaKRAHKEVDYLFCVDVDMVFRNPWGPETLG-----DLVAAIHPGYFAVPRRKFPYERRQVSSAFVADNEGDFYYGGA 263
Cdd:NF041524   76 KI--KEELKEFDYLFFFNANALFVKPISAEILPteeenGLVGVIHPGYYNKPPIEYPYERRKKSTAYIPYGKGGYYFQGG 153
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138044 264 LFGGRVARVYEFTRACHMAILADKANSIMAAWQEESHLNRHFIWHKPsKVLSPEYLWDERKPRPRSLKMI 333
Cdd:NF041524  154 LNGGKTKAYLKLIETCSLNIEKDLKNNIIAIWHDESHLNKYFLDKKP-KILSPAYGYPEGWNLPFEPKII 222
 
Name Accession Description Interval E-value
Glyco_transf_6 pfam03414
Glycosyltransferase family 6;
60-347 0e+00

Glycosyltransferase family 6;


Pssm-ID: 427285  Cd Length: 289  Bit Score: 540.51  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138044  60 PVTQLQYPQPKLLEHGPTELLTLTPWLAPIVSEGTFDPELLKSMYQPLNLTIGVTVFAVGKYTCFIQRFLESAEEFFMRG 139
Cdd:pfam03414   2 QLPRWFYPKPKLLEPKRPDVLTVTPWLAPIVWEGTFDPAILEDYYRPQNLTIGLTVFAVGKYVRFLELFLESAEKYFMVG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138044 140 YQVHYYLFTHDPTAVPRVPLGPGRLLSIIPIQGYSRWEEISMRRMETINKHIAKRAHKEVDYLFCVDVDMVFRNPWGPET 219
Cdd:pfam03414  82 HRVIYYVFTDDPAAVPRVPLGPGRQLSVFEIGRYKRWQDISMRRMETISEHIAQRIQHEVDYLFCVDVDMVFRDHFGVET 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138044 220 LGDLVAAIHPGYFAVPRRKFPYERRQVSSAFVADNEGDFYYGGALFGGRVARVYEFTRACHMAILADKANSIMAAWQEES 299
Cdd:pfam03414 162 LGPLVAQLHPWWYAADRQKFTYERRPLSAAYIPFGEGDFYYHGAIFGGTVARVYNLTRACHKAILADKANGIEAAWHDES 241
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1907138044 300 HLNRHFIWHKPSKVLSPEYLWDERKPRPRSLKMIRFSSVKKNANWLRT 347
Cdd:pfam03414 242 HLNKYFLSHKPTKVLSPEYLWDYQIGRPSDLRLVRFAWVPKNYNWVRN 289
Glyco_transf_6 cd02515
Glycosyltransferase family 6 comprises enzymes responsible for the production of the human ABO ...
76-346 2.41e-162

Glycosyltransferase family 6 comprises enzymes responsible for the production of the human ABO blood group antigens; Glycosyltransferase family 6, GT_6, comprises enzymes with three known activities: alpha-1,3-galactosyltransferase, alpha-1,3 N-acetylgalactosaminyltransferase, and alpha-galactosyltransferase. UDP-galactose:beta-galactosyl alpha-1,3-galactosyltransferase (alpha3GT) catalyzes the transfer of galactose from UDP-alpha-d-galactose into an alpha-1,3 linkage with beta-galactosyl groups in glycoconjugates. The enzyme exists in most mammalian species but is absent from humans, apes, and old world monkeys as a result of the mutational inactivation of the gene. The alpha-1,3 N-acetylgalactosaminyltransferase and alpha-galactosyltransferase are responsible for the production of the human ABO blood group antigens. A N-acetylgalactosaminyltransferases use a UDP-GalNAc donor to convert the H-antigen acceptor to the A antigen, whereas a galactosyltransferase uses a UDP-galactose donor to convert the H-antigen acceptor to the B antigen. Alpha-1,3 N-acetylgalactosaminyltransferase and alpha-galactosyltransferase differ only in the identity of four critical amino acid residues.


Pssm-ID: 133008  Cd Length: 271  Bit Score: 454.48  E-value: 2.41e-162
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138044  76 PTELLTLTPWLAPIVSEGTFDPELLKSMYQPLNLTIGVTVFAVGKYTCFIQRFLESAEEFFMRGYQVHYYLFTHDPTAVP 155
Cdd:cd02515     1 RPDVLTVTPWLAPIVWEGTFNPDVLDEYYRKQNITIGLTVFAVGKYTEFLERFLESAEKHFMVGYRVIYYIFTDKPAAVP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138044 156 RVPLGPGRLLSIIPIQGYSRWEEISMRRMETINKHIAKRAHKEVDYLFCVDVDMVFRNPWGPETLGDLVAAIHPGYFAVP 235
Cdd:cd02515    81 EVELGPGRRLTVLKIAEESRWQDISMRRMKTLADHIADRIGHEVDYLFCMDVDMVFQGPFGVETLGDSVAQLHPWWYGKP 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138044 236 RRKFPYERRQVSSAFVADNEGDFYYGGALFGGRVARVYEFTRACHMAILADKANSIMAAWQEESHLNRHFIWHKPSKVLS 315
Cdd:cd02515   161 RKQFPYERRPSSAAYIPEGEGDFYYHGAVFGGSVEEVYRLTRACHEGILADKANGIEARWHDESHLNKYFLLHKPTKVLS 240
                         250       260       270
                  ....*....|....*....|....*....|.
gi 1907138044 316 PEYLWDERKPRPRSLKMIRFSSVKKNANWLR 346
Cdd:cd02515   241 PEYLWDDRIGQAAEIRLPRLSWLPKNYQEVR 271
Gltr_6 NF041524
family 6 glucosyltransferase;
109-333 2.90e-40

family 6 glucosyltransferase;


Pssm-ID: 469409  Cd Length: 226  Bit Score: 141.22  E-value: 2.90e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138044 109 LTIGVTVFAVGKYTCFIQRFLESAEEFFMRGYQVHYYLFThDPTAVPRVPLGPGRLlsiIPIQGYSrWEEISMRRMETIN 188
Cdd:NF041524    1 MKIGILYICTGKYSIFWKDFYLSCEKYFLPGAEKEYFVFT-DPDDLYFKKNNNVHV---IYQENLG-WPLNTLLRFSMFL 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138044 189 KHiaKRAHKEVDYLFCVDVDMVFRNPWGPETLG-----DLVAAIHPGYFAVPRRKFPYERRQVSSAFVADNEGDFYYGGA 263
Cdd:NF041524   76 KI--KEELKEFDYLFFFNANALFVKPISAEILPteeenGLVGVIHPGYYNKPPIEYPYERRKKSTAYIPYGKGGYYFQGG 153
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138044 264 LFGGRVARVYEFTRACHMAILADKANSIMAAWQEESHLNRHFIWHKPsKVLSPEYLWDERKPRPRSLKMI 333
Cdd:NF041524  154 LNGGKTKAYLKLIETCSLNIEKDLKNNIIAIWHDESHLNKYFLDKKP-KILSPAYGYPEGWNLPFEPKII 222
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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