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Conserved domains on  [gi|1907132285|ref|XP_036017456|]
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guanine nucleotide exchange factor subunit RIC1 isoform X1 [Mus musculus]

Protein Classification

RIC1 family protein( domain architecture ID 10537194)

RIC1 family protein similar to human RAB6A-GEF complex partner protein 1 (RIC1) that interacts with RGP1 to form a complex that acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RIC1 pfam07064
RIC1; RIC1 has been identified in yeast as a Golgi protein involved in retrograde transport to ...
 719-975 2.16e-95

RIC1; RIC1 has been identified in yeast as a Golgi protein involved in retrograde transport to the cis-Golgi network. It forms a heterodimer with Rgp1 and functions as a guanyl-nucleotide exchange factor.


:

Pssm-ID: 462078  Cd Length: 246  Bit Score: 306.83  E-value: 2.16e-95
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132285  719 LLEALWLSCGgAGMKVWLPLFPRDHRKPhSFLSQRIMLPFHINIYPLAVLFEDALVLGAVNDTLlydslyTRSSareqle 798
Cdd:pfam07064    1 LRNSLWLFDG-SDMRVWLPLLDILRASP-GFESLPESVRIPLDFYPLSVLLDKGIILGVESELS------QRRD------ 66

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132285  799 VLFPFCVVERTSQIYLHHILRQLLVRNLGEQALLLAQSCAALPYFPHVLELMLHEVLEEEATSREPIP--DPLLPTVAKF 876
Cdd:pfam07064   67 LSFPFFRFAIRTHLFLHHVLRHLLRRGLGPEALELASHYQHLPYFAHALELLLHTVLEEEADASPPGLprEALLPRVISF 146

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132285  877 ITEFPLFLQTVVHCARKTEYALWNYLFAAVGNPKDLFEECLMAQDLDTAASYLIILQNMEVPAVSRQHATLLFNTALEQG 956
Cdd:pfam07064  147 LDHFPEYLDVVVQCARKTEVARWRTLFDVLGPPKDLFEECLERGRLKTAASYLLVLHNLEQLEVSSQCAVRLLVLALEEG 226

                          250       260
                   ....*....|....*....|
gi 1907132285  957 KWDLCRHMIRFLKAIG-SGE 975
Cdd:pfam07064  227 DWELCKELVRFLAAIDeSGE 246
 
Name Accession Description Interval E-value
RIC1 pfam07064
RIC1; RIC1 has been identified in yeast as a Golgi protein involved in retrograde transport to ...
 719-975 2.16e-95

RIC1; RIC1 has been identified in yeast as a Golgi protein involved in retrograde transport to the cis-Golgi network. It forms a heterodimer with Rgp1 and functions as a guanyl-nucleotide exchange factor.


Pssm-ID: 462078  Cd Length: 246  Bit Score: 306.83  E-value: 2.16e-95
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132285  719 LLEALWLSCGgAGMKVWLPLFPRDHRKPhSFLSQRIMLPFHINIYPLAVLFEDALVLGAVNDTLlydslyTRSSareqle 798
Cdd:pfam07064    1 LRNSLWLFDG-SDMRVWLPLLDILRASP-GFESLPESVRIPLDFYPLSVLLDKGIILGVESELS------QRRD------ 66

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132285  799 VLFPFCVVERTSQIYLHHILRQLLVRNLGEQALLLAQSCAALPYFPHVLELMLHEVLEEEATSREPIP--DPLLPTVAKF 876
Cdd:pfam07064   67 LSFPFFRFAIRTHLFLHHVLRHLLRRGLGPEALELASHYQHLPYFAHALELLLHTVLEEEADASPPGLprEALLPRVISF 146

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132285  877 ITEFPLFLQTVVHCARKTEYALWNYLFAAVGNPKDLFEECLMAQDLDTAASYLIILQNMEVPAVSRQHATLLFNTALEQG 956
Cdd:pfam07064  147 LDHFPEYLDVVVQCARKTEVARWRTLFDVLGPPKDLFEECLERGRLKTAASYLLVLHNLEQLEVSSQCAVRLLVLALEEG 226

                          250       260
                   ....*....|....*....|
gi 1907132285  957 KWDLCRHMIRFLKAIG-SGE 975
Cdd:pfam07064  227 DWELCKELVRFLAAIDeSGE 246
 
Name Accession Description Interval E-value
RIC1 pfam07064
RIC1; RIC1 has been identified in yeast as a Golgi protein involved in retrograde transport to ...
 719-975 2.16e-95

RIC1; RIC1 has been identified in yeast as a Golgi protein involved in retrograde transport to the cis-Golgi network. It forms a heterodimer with Rgp1 and functions as a guanyl-nucleotide exchange factor.


Pssm-ID: 462078  Cd Length: 246  Bit Score: 306.83  E-value: 2.16e-95
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132285  719 LLEALWLSCGgAGMKVWLPLFPRDHRKPhSFLSQRIMLPFHINIYPLAVLFEDALVLGAVNDTLlydslyTRSSareqle 798
Cdd:pfam07064    1 LRNSLWLFDG-SDMRVWLPLLDILRASP-GFESLPESVRIPLDFYPLSVLLDKGIILGVESELS------QRRD------ 66

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132285  799 VLFPFCVVERTSQIYLHHILRQLLVRNLGEQALLLAQSCAALPYFPHVLELMLHEVLEEEATSREPIP--DPLLPTVAKF 876
Cdd:pfam07064   67 LSFPFFRFAIRTHLFLHHVLRHLLRRGLGPEALELASHYQHLPYFAHALELLLHTVLEEEADASPPGLprEALLPRVISF 146

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132285  877 ITEFPLFLQTVVHCARKTEYALWNYLFAAVGNPKDLFEECLMAQDLDTAASYLIILQNMEVPAVSRQHATLLFNTALEQG 956
Cdd:pfam07064  147 LDHFPEYLDVVVQCARKTEVARWRTLFDVLGPPKDLFEECLERGRLKTAASYLLVLHNLEQLEVSSQCAVRLLVLALEEG 226

                          250       260
                   ....*....|....*....|
gi 1907132285  957 KWDLCRHMIRFLKAIG-SGE 975
Cdd:pfam07064  227 DWELCKELVRFLAAIDeSGE 246
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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