|
Name |
Accession |
Description |
Interval |
E-value |
| PUFD_like_1 |
cd14260 |
PCGF Ub-like fold discriminator of BCOR-like 1; The PUFD domain binds the RAWUL (RING finger ... |
1662-1775 |
2.95e-65 |
|
PCGF Ub-like fold discriminator of BCOR-like 1; The PUFD domain binds the RAWUL (RING finger and WD40-associated ubiquitin-like) domain of the polycomb-group RING finger homologs PCGF1 and PCGF3. PUFD was characterized as a domain of the BCL6 corepressor BCOR. It does not appear to bind to PCGF2 and PCGF4. PCGF1 is a component of the Polycomb group (PcG) multi-protein BCOR complex, which is involved in repressing the transcription of BCL6 and CDKN1A. The BCL-6 corepressor-like protein 1 (BCoR-L1) is largely uncharacterized; it contains ankyrin repeats.
Pssm-ID: 271223 Cd Length: 115 Bit Score: 216.25 E-value: 2.95e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 1662 EQDDFMFELSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHLEITTLPKAEFYRQVASSQLLSPAER 1741
Cdd:cd14260 2 EEDDFMFEFSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHFEIATMPKAEFYRQVLSSQLLTPAER 81
|
90 100 110
....*....|....*....|....*....|....
gi 1907204000 1742 PGSLEDRSPPGSSETVELVQYEPELLRLLGSEVE 1775
Cdd:cd14260 82 PGGLDDRSPQGSSETVELVRYEPELLRLLGSAVE 115
|
|
| PUFD |
pfam16553 |
BCORL-PCGF1-binding domain; PUFD is the minimal domain at the C-terminus of BCORL (BCL6 ... |
1664-1780 |
5.95e-62 |
|
BCORL-PCGF1-binding domain; PUFD is the minimal domain at the C-terminus of BCORL (BCL6 corepressor) that is needed for binding and giving specificity to some of the PCGF proteins, polycomb-group RING finger homologs. PUFD binds to the RAWUL (RING finger- and WD40-associated ubiquitin-like) domain of the particular PCGF PCGF1, pfam16207. Polycomb group proteins form repressive complexes (PRC) that mediate epigenetic modifications of histones. In humans there are many different PCGF homologs whose functions all vary, but the direct binding partner of PCGF1 is BCOR. BCOR has emerged as an important player in development and health.
Pssm-ID: 465171 Cd Length: 114 Bit Score: 206.85 E-value: 5.95e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 1664 DDFMFELSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHLEITTLPKAEFYRQVASSQLLSPAERPG 1743
Cdd:pfam16553 2 DVFEFEFSDKPLLPCYNIQVSLSQGPRNWLLLSDVLKRLKMSSRIFRARFPHFEVVTIAEAEFYKQVSLSQLLSPPEDLE 81
|
90 100 110
....*....|....*....|....*....|....*..
gi 1907204000 1744 SledrSPPGSSETVELVQYEPELLRLLGSEVEYQSWS 1780
Cdd:pfam16553 82 A----FNPDSKELVELVEFTPELQTLLGSSVEFLHPS 114
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
1492-1608 |
1.36e-27 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 114.67 E-value: 1.36e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 1492 NAGETLLQRAARLGYKDVVLYCLQKHSeDVNHRDNAGYTALHEACSRGWTDILNILLQHGANVNCSSQDGTRPVHDAVVN 1571
Cdd:COG0666 118 KDGETPLHLAAYNGNLEIVKLLLEAGA-DVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAEN 196
|
90 100 110
....*....|....*....|....*....|....*..
gi 1907204000 1572 DNLETIWLLLSYGADPTLATYSGQTAMKLASSDNMKR 1608
Cdd:COG0666 197 GHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLE 233
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
1498-1589 |
1.04e-16 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 76.69 E-value: 1.04e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 1498 LQRAARLGYKDVVLYCLQKHSeDVNHRDNAGYTALHEACSRGWTDILNILLQHgANVNCSSQDGTrPVHDAVVNDNLETI 1577
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGA-DANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRT-ALHYAARSGHLEIV 77
|
90
....*....|..
gi 1907204000 1578 WLLLSYGADPTL 1589
Cdd:pfam12796 78 KLLLEKGADINV 89
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
182-630 |
2.34e-13 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 76.13 E-value: 2.34e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 182 GVPVEGTLPLVTTNFSQLPAPICPPAPGSASGTPsvPDPfqvPLSVPAPVPHSGLVPVQVATSASAPSPPLAPaapsvPT 261
Cdd:PHA03247 2590 DAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHA--PDP---PPPSPSPAANEPDPHPPPTVPPPERPRDDPA-----PG 2659
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 262 LISDSNPLSVSASvlvPVPVSAPHSVPVPLSAPAPT-PLTVSVSAPPlaliQAPVPPSAPTLVLASVPTPvlapmpastP 340
Cdd:PHA03247 2660 RVSRPRRARRLGR---AAQASSPPQRPRRRAARPTVgSLTSLADPPP----PPPTPEPAPHALVSATPLP---------P 2723
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 341 PAAPAPPSVPMPTPTPSSGPPSTPTLIPAFAPTPVPAPTPAPIFTPAPTPMPAATPAAiPTSAPIPASFSLSRVCFPAAQ 420
Cdd:PHA03247 2724 GPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPR-RLTRPAVASLSESRESLPSPW 2802
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 421 APAMQKVPLSFQPGTVLTPNQPLVYIPPPSCGQPLSVATLPTTLGVSSTLTLPVLPsylqdrclpgvlASPDLRSYPCAF 500
Cdd:PHA03247 2803 DPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAP------------GGDVRRRPPSRS 2870
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 501 SVARPLASDSKLVSlevnRLSCTSPSSSTNSQPAPDGVPGP-----LADTSLTTASAKVLPTSQLLLPAPSGSSVPPHPS 575
Cdd:PHA03247 2871 PAAKPAAPARPPVR----RLARPAVSRSTESFALPPDQPERppqpqAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPT 2946
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 1907204000 576 KMPGGTDQQTEGTSVTFSPLKSPPQLE--REMASPPECSeMPLDLSAKSNRQKLPLP 630
Cdd:PHA03247 2947 TDPAGAGEPSGAVPQPWLGALVPGRVAvpRFRVPQPAPS-REAPASSTPPLTGHSLS 3002
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
1495-1586 |
3.15e-10 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 64.30 E-value: 3.15e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 1495 ETLLQRAARLGYKDVVLYCLqKHSEDVNHRDNAGYTALHEACSRGWTDILNILLQHGANVNCSSQDGTRPVHDAVVNDNL 1574
Cdd:PHA03100 160 KLLIDKGVDINAKNRVNYLL-SYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNK 238
|
90
....*....|..
gi 1907204000 1575 ETIWLLLSYGAD 1586
Cdd:PHA03100 239 EIFKLLLNNGPS 250
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
1528-1556 |
5.88e-06 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 44.50 E-value: 5.88e-06
10 20
....*....|....*....|....*....
gi 1907204000 1528 GYTALHEACSRGWTDILNILLQHGANVNC 1556
Cdd:smart00248 2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
205-658 |
3.93e-04 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 45.53 E-value: 3.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 205 PPAPGSASGTPSVPD-PFQVPLSVPAPVPHSGLVPVQVATSASAPSPPLAPAAPSVPTLISDSNPlsvsasVLVPVPVSA 283
Cdd:pfam03154 171 PPVLQAQSGAASPPSpPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTP------TLHPQRLPS 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 284 PHSVPVPLSAPAPtPLTVSVSAPPLALIQAPVPP------SAPTLVLASVPTpvlapMPASTPPAAPAPPSVPMPTPTPS 357
Cdd:pfam03154 245 PHPPLQPMTQPPP-PSQVSPQPLPQPSLHGQMPPmphslqTGPSHMQHPVPP-----QPFPLTPQSSQSQVPPGPSPAAP 318
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 358 SGPPSTPTLIPAFAPTPVPAPTPAPIFTPAPTPMPAATPaaiPTSAPIPAsfslsrvcFPAAQA---PAMQKVPLSFQPG 434
Cdd:pfam03154 319 GQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKP---PPTTPIPQ--------LPNPQShkhPPHLSGPSPFQMN 387
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 435 TVLtpnqplvyiPPPSCGQPLSvaTLPTTLGVSStlTLPVLPSYLQDRCLPGVLASPdlrsypcafsvarPLASDSKLVS 514
Cdd:pfam03154 388 SNL---------PPPPALKPLS--SLSTHHPPSA--HPPPLQLMPQSQQLPPPPAQP-------------PVLTQSQSLP 441
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 515 LEVNRLSCTSPSSSTNSQP-------APDGVPGPLADTSLTTASAKVLPTSQLLLPAPSGSSVPphpskMPGGTDQQTEG 587
Cdd:pfam03154 442 PPAASHPPTSGLHQVPSQSpfpqhpfVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGP-----VPAAVSCPLPP 516
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907204000 588 TSVTFSPLKSPPQLEremaSPPecsempldlsaksnrqklPLPNQRKTPPMPVLTPVHTSSKALLSTVLSR 658
Cdd:pfam03154 517 VQIKEEALDEAEEPE----SPP------------------PPPRSPSPEPTVVNTPSHASQSARFYKHLDR 565
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
1487-1586 |
8.17e-04 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 44.23 E-value: 8.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 1487 LIVNKNAGETLLQRAARLGYKDVVLYCLQKHSEDVNHRDNAGYTALHEACSRGWTDILNILLQHG---ANVNCSSQ--DG 1561
Cdd:cd22192 10 LLQQKRISESPLLLAAKENDVQAIKKLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAApelVNEPMTSDlyQG 89
|
90 100
....*....|....*....|....*
gi 1907204000 1562 TRPVHDAVVNDNLETIWLLLSYGAD 1586
Cdd:cd22192 90 ETALHIAVVNQNLNLVRELIARGAD 114
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
442-833 |
2.70e-03 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 42.60 E-value: 2.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 442 PLVYIPPPSCGQPLSVA--TLPTTLGVSSTLTlPVLPSyLQDRCLPGVLASPDLRSYPCAFSVARPLASdSKLVSLEVNR 519
Cdd:pfam05109 455 PTNLTAPASTGPTVSTAdvTSPTPAGTTSGAS-PVTPS-PSPRDNGTESKAPDMTSPTSAVTTPTPNAT-SPTPAVTTPT 531
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 520 LSCTSPS------SSTNSQPAPDGV-PGPLADTSLTTAS----AKVLPTSQLLLPAPSGSSVPPHPSKMPGGTDQQTEGT 588
Cdd:pfam05109 532 PNATSPTlgktspTSAVTTPTPNATsPTPAVTTPTPNATiptlGKTSPTSAVTTPTPNATSPTVGETSPQANTTNHTLGG 611
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 589 SVTFSPLKSPPQLEREMASPPE-----CSEMPLDLSAKSNRQKL-PLPNQRKTPPMPVLTPVHTSSkallstvlsrSQRT 662
Cdd:pfam05109 612 TSSTPVVTSPPKNATSAVTTGQhnitsSSTSSMSLRPSSISETLsPSTSDNSTSHMPLLTSAHPTG----------GENI 681
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 663 TQAAGSNVTSCLGSTSSPfvifpeMVRNGDPSTWVKNSTALISTIPGTYVGVANPVPASLLLNKDPNlglnrdprhlPKQ 742
Cdd:pfam05109 682 TQVTPASTSTHHVSTSSP------APRPGTTSQASGPGNSSTSTKPGEVNVTKGTPPKNATSPQAPS----------GQK 745
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 743 EPISIIDQGEPKSTSATCGKKGSQAGAE----------GQPSTVKSRYTPARIAPglpgcqtkelslwkPTGLTNMYPRC 812
Cdd:pfam05109 746 TAVPTVTSTGGKANSTTGGKHTTGHGARtstepttdygGDSTTPRTRYNATTYLP--------------PSTSSKLRPRW 811
|
410 420
....*....|....*....|.
gi 1907204000 813 SINGKPTSTQVLPVGWSPYHQ 833
Cdd:pfam05109 812 TFTSPPVTTAQATVPVPPTSQ 832
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PUFD_like_1 |
cd14260 |
PCGF Ub-like fold discriminator of BCOR-like 1; The PUFD domain binds the RAWUL (RING finger ... |
1662-1775 |
2.95e-65 |
|
PCGF Ub-like fold discriminator of BCOR-like 1; The PUFD domain binds the RAWUL (RING finger and WD40-associated ubiquitin-like) domain of the polycomb-group RING finger homologs PCGF1 and PCGF3. PUFD was characterized as a domain of the BCL6 corepressor BCOR. It does not appear to bind to PCGF2 and PCGF4. PCGF1 is a component of the Polycomb group (PcG) multi-protein BCOR complex, which is involved in repressing the transcription of BCL6 and CDKN1A. The BCL-6 corepressor-like protein 1 (BCoR-L1) is largely uncharacterized; it contains ankyrin repeats.
Pssm-ID: 271223 Cd Length: 115 Bit Score: 216.25 E-value: 2.95e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 1662 EQDDFMFELSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHLEITTLPKAEFYRQVASSQLLSPAER 1741
Cdd:cd14260 2 EEDDFMFEFSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHFEIATMPKAEFYRQVLSSQLLTPAER 81
|
90 100 110
....*....|....*....|....*....|....
gi 1907204000 1742 PGSLEDRSPPGSSETVELVQYEPELLRLLGSEVE 1775
Cdd:cd14260 82 PGGLDDRSPQGSSETVELVRYEPELLRLLGSAVE 115
|
|
| PUFD |
pfam16553 |
BCORL-PCGF1-binding domain; PUFD is the minimal domain at the C-terminus of BCORL (BCL6 ... |
1664-1780 |
5.95e-62 |
|
BCORL-PCGF1-binding domain; PUFD is the minimal domain at the C-terminus of BCORL (BCL6 corepressor) that is needed for binding and giving specificity to some of the PCGF proteins, polycomb-group RING finger homologs. PUFD binds to the RAWUL (RING finger- and WD40-associated ubiquitin-like) domain of the particular PCGF PCGF1, pfam16207. Polycomb group proteins form repressive complexes (PRC) that mediate epigenetic modifications of histones. In humans there are many different PCGF homologs whose functions all vary, but the direct binding partner of PCGF1 is BCOR. BCOR has emerged as an important player in development and health.
Pssm-ID: 465171 Cd Length: 114 Bit Score: 206.85 E-value: 5.95e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 1664 DDFMFELSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHLEITTLPKAEFYRQVASSQLLSPAERPG 1743
Cdd:pfam16553 2 DVFEFEFSDKPLLPCYNIQVSLSQGPRNWLLLSDVLKRLKMSSRIFRARFPHFEVVTIAEAEFYKQVSLSQLLSPPEDLE 81
|
90 100 110
....*....|....*....|....*....|....*..
gi 1907204000 1744 SledrSPPGSSETVELVQYEPELLRLLGSEVEYQSWS 1780
Cdd:pfam16553 82 A----FNPDSKELVELVEFTPELQTLLGSSVEFLHPS 114
|
|
| PUFD_like |
cd14259 |
PCGF Ub-like fold discriminator and related domains; The PUFD domain binds the RAWUL (RING ... |
1664-1775 |
2.12e-42 |
|
PCGF Ub-like fold discriminator and related domains; The PUFD domain binds the RAWUL (RING finger and WD40-associated ubiquitin-like) domain of the polycomb-group RING finger homologs PCGF1 and PCGF3. PUFD was characterized as a domain of the BCL6 corepressor BCOR. It does not appear to bind to PCGF2 and PCGF4. PCGF1 is a component of the Polycomb group (PcG) multi-protein BCOR complex, which is involved in repressing the transcription of BCL6 and CDKN1A. The BCL-6 corepressor (BCOR) is a transcriptional repressor required for germinal center formation and is possibly involved in apoptosis.
Pssm-ID: 271222 Cd Length: 106 Bit Score: 150.54 E-value: 2.12e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 1664 DDFMFELSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHLEITTLPKAEFYRQVASSQLLSPAERPg 1743
Cdd:cd14259 1 DDFEFEFSDEPLPPLYNLRISPNDGPRNWHLLSDVLTRLKLKSRDFLLKQICLELTSIPIEDFLEQASCLQLLCAGEKL- 79
|
90 100 110
....*....|....*....|....*....|..
gi 1907204000 1744 sledrSPPGSSETVELVQYEPELLRLLGSEVE 1775
Cdd:cd14259 80 -----TNNVSSSKVELVEYNDSLRSLLGIEVE 106
|
|
| PUFD |
cd14261 |
PCGF Ub-like fold discriminator of BCOR; The PUFD domain binds the RAWUL (RING finger and ... |
1659-1776 |
4.57e-39 |
|
PCGF Ub-like fold discriminator of BCOR; The PUFD domain binds the RAWUL (RING finger and WD40-associated ubiquitin-like) domain of the polycomb-group RING finger homologs PCGF1 and PCGF3. PUFD was characterized as a domain of the BCL6 corepressor BCOR. It does not appear to bind to PCGF2 and PCGF4. PCGF1 is a component of the Polycomb group (PcG) multi-protein BCOR complex, which is involved in repressing the transcription of BCL6 and CDKN1A. The BCL-6 corepressor (BCOR) is a transcriptional repressor required for germinal center formation and is possibly involved in apoptosis.
Pssm-ID: 271224 Cd Length: 117 Bit Score: 141.52 E-value: 4.57e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 1659 DDSEQDDFMFELSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHLEITTLPKAEFYRQVASSQLLSP 1738
Cdd:cd14261 1 DDAYSDVFEFEFSDRPLLPCYNIQVSLSQGPRNWLLLSDVLKRLKMSSRIFRCNFPNVEVVTIAEAEFYRQVSLSQLFSC 80
|
90 100 110
....*....|....*....|....*....|....*...
gi 1907204000 1739 AErpgSLEDRSPPgSSETVELVQYEPELLRLLGSEVEY 1776
Cdd:cd14261 81 PK---DLEAFNPD-SKELLDLVEFTNELQTLLGSSLEW 114
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
1492-1608 |
1.36e-27 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 114.67 E-value: 1.36e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 1492 NAGETLLQRAARLGYKDVVLYCLQKHSeDVNHRDNAGYTALHEACSRGWTDILNILLQHGANVNCSSQDGTRPVHDAVVN 1571
Cdd:COG0666 118 KDGETPLHLAAYNGNLEIVKLLLEAGA-DVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAEN 196
|
90 100 110
....*....|....*....|....*....|....*..
gi 1907204000 1572 DNLETIWLLLSYGADPTLATYSGQTAMKLASSDNMKR 1608
Cdd:COG0666 197 GHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLE 233
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
1487-1605 |
2.34e-25 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 108.12 E-value: 2.34e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 1487 LIVNKNAGETLLQRAARLGYKDVVLYCLqKHSEDVNHRDNAGYTALHEACSRGWTDILNILLQHGANVNCSSQDGTRPVH 1566
Cdd:COG0666 80 INAKDDGGNTLLHAAARNGDLEIVKLLL-EAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLH 158
|
90 100 110
....*....|....*....|....*....|....*....
gi 1907204000 1567 DAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLASSDN 1605
Cdd:COG0666 159 LAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENG 197
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
1482-1608 |
9.18e-20 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 91.94 E-value: 9.18e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 1482 PEARRLIVNKNA--------GETLLQRAARLGYKDVVLYCLqKHSEDVNHRDNAGYTALHEACSRGWTDILNILLQHGAN 1553
Cdd:COG0666 133 LEIVKLLLEAGAdvnaqdndGNTPLHLAAANGNLEIVKLLL-EAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGAD 211
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1907204000 1554 VNCSSQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLASSDNMKR 1608
Cdd:COG0666 212 VNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAAL 266
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
1487-1605 |
5.83e-17 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 83.46 E-value: 5.83e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 1487 LIVNKNAGETLLQRAARLGYKDVVLYCLQKHSEDVNHRDNAGYTALHEACSRGWTDILNILLQHGANVNCSSQDGTRPVH 1566
Cdd:COG0666 46 ALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLH 125
|
90 100 110
....*....|....*....|....*....|....*....
gi 1907204000 1567 DAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLASSDN 1605
Cdd:COG0666 126 LAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANG 164
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
1498-1589 |
1.04e-16 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 76.69 E-value: 1.04e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 1498 LQRAARLGYKDVVLYCLQKHSeDVNHRDNAGYTALHEACSRGWTDILNILLQHgANVNCSSQDGTrPVHDAVVNDNLETI 1577
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGA-DANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRT-ALHYAARSGHLEIV 77
|
90
....*....|..
gi 1907204000 1578 WLLLSYGADPTL 1589
Cdd:pfam12796 78 KLLLEKGADINV 89
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
182-630 |
2.34e-13 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 76.13 E-value: 2.34e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 182 GVPVEGTLPLVTTNFSQLPAPICPPAPGSASGTPsvPDPfqvPLSVPAPVPHSGLVPVQVATSASAPSPPLAPaapsvPT 261
Cdd:PHA03247 2590 DAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHA--PDP---PPPSPSPAANEPDPHPPPTVPPPERPRDDPA-----PG 2659
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 262 LISDSNPLSVSASvlvPVPVSAPHSVPVPLSAPAPT-PLTVSVSAPPlaliQAPVPPSAPTLVLASVPTPvlapmpastP 340
Cdd:PHA03247 2660 RVSRPRRARRLGR---AAQASSPPQRPRRRAARPTVgSLTSLADPPP----PPPTPEPAPHALVSATPLP---------P 2723
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 341 PAAPAPPSVPMPTPTPSSGPPSTPTLIPAFAPTPVPAPTPAPIFTPAPTPMPAATPAAiPTSAPIPASFSLSRVCFPAAQ 420
Cdd:PHA03247 2724 GPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPR-RLTRPAVASLSESRESLPSPW 2802
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 421 APAMQKVPLSFQPGTVLTPNQPLVYIPPPSCGQPLSVATLPTTLGVSSTLTLPVLPsylqdrclpgvlASPDLRSYPCAF 500
Cdd:PHA03247 2803 DPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAP------------GGDVRRRPPSRS 2870
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 501 SVARPLASDSKLVSlevnRLSCTSPSSSTNSQPAPDGVPGP-----LADTSLTTASAKVLPTSQLLLPAPSGSSVPPHPS 575
Cdd:PHA03247 2871 PAAKPAAPARPPVR----RLARPAVSRSTESFALPPDQPERppqpqAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPT 2946
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 1907204000 576 KMPGGTDQQTEGTSVTFSPLKSPPQLE--REMASPPECSeMPLDLSAKSNRQKLPLP 630
Cdd:PHA03247 2947 TDPAGAGEPSGAVPQPWLGALVPGRVAvpRFRVPQPAPS-REAPASSTPPLTGHSLS 3002
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
1492-1598 |
1.22e-11 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 67.67 E-value: 1.22e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 1492 NAGETLLQRAARLGYKDVVLYcLQKHSEDVNHRDNAGYTALHEACSRGWTDILNILLQHGANVNCSSQDGTRPVHDAVVN 1571
Cdd:COG0666 184 NDGETPLHLAAENGHLEIVKL-LLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAA 262
|
90 100
....*....|....*....|....*..
gi 1907204000 1572 DNLETIWLLLSYGADPTLATYSGQTAM 1598
Cdd:COG0666 263 GAALIVKLLLLALLLLAAALLDLLTLL 289
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
1495-1586 |
3.15e-10 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 64.30 E-value: 3.15e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 1495 ETLLQRAARLGYKDVVLYCLqKHSEDVNHRDNAGYTALHEACSRGWTDILNILLQHGANVNCSSQDGTRPVHDAVVNDNL 1574
Cdd:PHA03100 160 KLLIDKGVDINAKNRVNYLL-SYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNK 238
|
90
....*....|..
gi 1907204000 1575 ETIWLLLSYGAD 1586
Cdd:PHA03100 239 EIFKLLLNNGPS 250
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
91-535 |
5.15e-10 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 64.96 E-value: 5.15e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 91 QSDDPQPKMDYVGNPAeaeGLLVPLSSPGDGLKLPTPDSTEASHSRANCSWTPLSTQMSKQVDCSPAGVKALDSRhgvge 170
Cdd:PHA03247 2594 QSARPRAPVDDRGDPR---GPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPR----- 2665
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 171 KNTFILATLGTGVPVEGTLPlvttnfsqlpaPICPPAPGSASGTPSVPDPFQVPlsVPAPVPHSGLVPVQVATSASAPSP 250
Cdd:PHA03247 2666 RARRLGRAAQASSPPQRPRR-----------RAARPTVGSLTSLADPPPPPPTP--EPAPHALVSATPLPPGPAAARQAS 2732
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 251 plapaapsvPTLISDSNPLSVSASVLVPVPVSAPHSVPVPLSAPAPTPLTVSVSAPPLALIQAPVPPSAPTLVLASVP-- 328
Cdd:PHA03247 2733 ---------PALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPwd 2803
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 329 --------TPVLAPMPASTPPAAPAPPSVPMPTPTPSSGPPSTPTLIPAFAPTPV------PAPTPAPIFTPAPTPMPAA 394
Cdd:PHA03247 2804 padppaavLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPggdvrrRPPSRSPAAKPAAPARPPV 2883
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 395 TPAAIPTSAPIPASFSLSRVCFPAAQAPAMQKVPLSFQPgtvlTPNQPLVYIPPPSCGQPLSVATlPTTLGVSSTLTLPV 474
Cdd:PHA03247 2884 RRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQ----PPPPPQPQPPPPPPPRPQPPLA-PTTDPAGAGEPSGA 2958
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907204000 475 LPSYLQDRCLPGVLASPDLRSYPCAFSVARPLASDSKLVSLEVNRLSCTSPSSSTNSQPAP 535
Cdd:PHA03247 2959 VPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSLALHEETDP 3019
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
1489-1555 |
7.58e-10 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 57.43 E-value: 7.58e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907204000 1489 VNKNAGETLLQRAARLGYKDVVLYCLQKhsEDVNHRDNaGYTALHEACSRGWTDILNILLQHGANVN 1555
Cdd:pfam12796 25 LQDKNGRTALHLAAKNGHLEIVKLLLEH--ADVNLKDN-GRTALHYAARSGHLEIVKLLLEKGADIN 88
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
1532-1617 |
4.79e-09 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 55.12 E-value: 4.79e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 1532 LHEACSRGWTDILNILLQHGANVNCSSQDGTRPVHDAVVNDNLETIWLLLSYGAdpTLATYSGQTAMKLASSDNMK---R 1608
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD--VNLKDNGRTALHYAARSGHLeivK 78
|
....*....
gi 1907204000 1609 FLSDHLSDL 1617
Cdd:pfam12796 79 LLLEKGADI 87
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
1482-1615 |
8.10e-09 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 60.06 E-value: 8.10e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 1482 PEARRLIVNKNA--------GETLLQRAA--RLGYKDVVLYCLQKHSeDVNHRDNAGYTALHEA--CSRGWTDILNILLQ 1549
Cdd:PHA03100 86 KEIVKLLLEYGAnvnapdnnGITPLLYAIskKSNSYSIVEYLLDNGA-NVNIKNSDGENLLHLYleSNKIDLKILKLLID 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 1550 HGANVN-CSSQD---------------GTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLASSDNMKRFLSDH 1613
Cdd:PHA03100 165 KGVDINaKNRVNyllsygvpinikdvyGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLL 244
|
..
gi 1907204000 1614 LS 1615
Cdd:PHA03100 245 LN 246
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
1463-1586 |
6.91e-08 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 57.38 E-value: 6.91e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 1463 YRSAGPEEASESPTARQIPPEARRLIVNKNA----GETLLQRAARLGYKDVVLYCLQKHSEDVNHRDNAGYTALHEACSR 1538
Cdd:PHA02876 272 CKNTPLHHASQAPSLSRLVPKLLERGADVNAknikGETPLYLMAKNGYDTENIRTLIMLGADVNAADRLYITPLHQASTL 351
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1907204000 1539 G-WTDILNILLQHGANVNCSSQDGTRPVHDAVVNDNLETIWLLLSYGAD 1586
Cdd:PHA02876 352 DrNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGAD 400
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
1483-1605 |
2.66e-07 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 54.19 E-value: 2.66e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 1483 EARRLIVNKNAGETLLQRAARLGYKDVVLYCLQKHSEDVNHRDNAGYTALHEACSRGWTDILNILLQHGANVNCSSQDGT 1562
Cdd:COG0666 9 LLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGN 88
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 1907204000 1563 RPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLASSDN 1605
Cdd:COG0666 89 TLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNG 131
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
1528-1580 |
3.62e-07 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 48.42 E-value: 3.62e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 1907204000 1528 GYTALHEACSRGWTDILNILLQHGANVNCSSQDGTRPVHDAVVNDNLETI-WLL 1580
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLkLLL 54
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
1546-1630 |
3.92e-07 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 54.90 E-value: 3.92e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 1546 ILLQHGANVNCSSQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLASSDNMKRFLSDHLSDLQGRAEGDP 1625
Cdd:PTZ00322 100 ILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFELGA 179
|
....*
gi 1907204000 1626 RASWD 1630
Cdd:PTZ00322 180 NAKPD 184
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
1514-1597 |
1.30e-06 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 53.10 E-value: 1.30e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 1514 LQKHSEDVNHRDNAGYTALHeACSRGW---TDILNILLQHGANVNCSSQDGTRPVHDAVVNDN--LETIWLLLSYGADPT 1588
Cdd:PHA03095 103 LIKAGADVNAKDKVGRTPLH-VYLSGFninPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNanVELLRLLIDAGADVY 181
|
....*....
gi 1907204000 1589 LATYSGQTA 1597
Cdd:PHA03095 182 AVDDRFRSL 190
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
1496-1548 |
1.81e-06 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 46.50 E-value: 1.81e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1907204000 1496 TLLQRAARLGYKDVVLYCLQkHSEDVNHRDNAGYTALHEACSRGWTDILNILL 1548
Cdd:pfam13637 3 TALHAAAASGHLELLRLLLE-KGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
215-643 |
2.13e-06 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 53.02 E-value: 2.13e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 215 PSVPDPFQVPLSVPAPVPHSGLVPVQVATSASAPSPPLAPAAPSVPTLISDSNPLSV--SASVLVPVPVSAPHSVP---V 289
Cdd:PHA03247 2489 PFAAGAAPDPGGGGPPDPDAPPAPSRLAPAILPDEPVGEPVHPRMLTWIRGLEELASddAGDPPPPLPPAAPPAAPdrsV 2568
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 290 PLSAPAPTPLTVSV-------SAPPL-ALIQAPV-PPSAPTLVLASVPTPVLAPMPASTPPAAPAPPSVPMPTPTPSSGP 360
Cdd:PHA03247 2569 PPPRPAPRPSEPAVtsrarrpDAPPQsARPRAPVdDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPP 2648
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 361 PSTPTLIPAfaptPVPAPTPAPIFTPAPTPMPAATPAAIPTSAPIPASFSLSRVCFPAAQAPAMQKVPLSFQPGTVLTP- 439
Cdd:PHA03247 2649 PERPRDDPA----PGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPg 2724
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 440 --NQPLVYIPPPSCGQPLSVATLPTTLGVSSTLTLPVLPSYlqdrclPGVLASPDLRSYPCAFSVARPLASdsklvSLEV 517
Cdd:PHA03247 2725 paAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAG------PPAPAPPAAPAAGPPRRLTRPAVA-----SLSE 2793
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 518 NRLSCTSPSSSTnsqPAPDGVPGPLADTSLTTASAKVLPTSQLLLPAPSGSSVPPHPSKMPGGTDQQTEGTSVTFSPLKS 597
Cdd:PHA03247 2794 SRESLPSPWDPA---DPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRS 2870
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 1907204000 598 PPQLEREMASPPECSEMPLDLSAKSNRQKLPlPNQRKTPPMPVLTP 643
Cdd:PHA03247 2871 PAAKPAAPARPPVRRLARPAVSRSTESFALP-PDQPERPPQPQAPP 2915
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
1520-1598 |
3.62e-06 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 51.50 E-value: 3.62e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907204000 1520 DVNHRDNAGYTALHEACSRGWTDILNILLQHGANVNCSSQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAM 1598
Cdd:PHA02874 116 DVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPL 194
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
1506-1601 |
3.87e-06 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 51.42 E-value: 3.87e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 1506 YKDVVLYCLQKHSEDVNHRDNAGYTALHEACSRGWT-DILNILLQHGANVNC-SSQDGTRPVHDAVVNDnlETIWLLLSY 1583
Cdd:PHA02878 212 YNKPIVHILLENGASTDARDKCGNTPLHISVGYCKDyDILKLLLEHGVDVNAkSYILGLTALHSSIKSE--RKLKLLLEY 289
|
90
....*....|....*...
gi 1907204000 1584 GADPTLATYSGQTAMKLA 1601
Cdd:PHA02878 290 GADINSLNSYKLTPLSSA 307
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
1528-1556 |
5.88e-06 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 44.50 E-value: 5.88e-06
10 20
....*....|....*....|....*....
gi 1907204000 1528 GYTALHEACSRGWTDILNILLQHGANVNC 1556
Cdd:smart00248 2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
1494-1610 |
1.43e-05 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 50.25 E-value: 1.43e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 1494 GETLLQRAARLGYKDVVLYCLqKHSEDVNHRDNAGYTALHEACSRGWTDILNILLQHGANVNcsSQDGTRPVHDAVVNDN 1573
Cdd:PLN03192 558 GRTPLHIAASKGYEDCVLVLL-KHACNVHIRDANGNTALWNAISAKHHKIFRILYHFASISD--PHAAGDLLCTAAKRND 634
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 1907204000 1574 LETIWLLLSYGADPTLATYSGQTAMKLASSD---NMKRFL 1610
Cdd:PLN03192 635 LTAMKELLKQGLNVDSEDHQGATALQVAMAEdhvDMVRLL 674
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
1529-1617 |
1.73e-05 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 49.28 E-value: 1.73e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 1529 YTALHEACSRGWTDILNILLQHGANVNCSSQDGTRPVH-----DAVVNDNLETIWLLLSYGADPTLATYSGQT-----AM 1598
Cdd:PHA03100 36 VLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHylsniKYNLTDVKEIVKLLLEYGANVNAPDNNGITpllyaIS 115
|
90
....*....|....*....
gi 1907204000 1599 KLASSDNMKRFLSDHLSDL 1617
Cdd:PHA03100 116 KKSNSYSIVEYLLDNGANV 134
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
1514-1603 |
2.01e-05 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 49.11 E-value: 2.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 1514 LQKHSEDVNHRD-NAGYTALHEACSRGWTDILNILLQHGANVNCSSQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATY 1592
Cdd:PHA02878 153 LLSYGADINMKDrHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDK 232
|
90
....*....|.
gi 1907204000 1593 SGQTAMKLASS 1603
Cdd:PHA02878 233 CGNTPLHISVG 243
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
1520-1586 |
2.02e-05 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 49.25 E-value: 2.02e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907204000 1520 DVNHRDNAGYTALHEACSRGW---TDILNILLQHGANVNCSSQDGTRPVHDAVVNDN-LETIWLLLSYGAD 1586
Cdd:PHA03095 39 DVNFRGEYGKTPLHLYLHYSSekvKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATtLDVIKLLIKAGAD 109
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
1514-1566 |
3.28e-05 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 43.10 E-value: 3.28e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1907204000 1514 LQKHSEDVNHRDNAGYTALHEACSRGWTDILNILLQHGANVNCSSQDGTRPVH 1566
Cdd:pfam13857 2 LEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALD 54
|
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
1528-1556 |
4.11e-05 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 42.28 E-value: 4.11e-05
10 20 30
....*....|....*....|....*....|
gi 1907204000 1528 GYTALHEACSR-GWTDILNILLQHGANVNC 1556
Cdd:pfam00023 2 GNTPLHLAAGRrGNLEIVKLLLSKGADVNA 31
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
201-413 |
5.24e-05 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 48.33 E-value: 5.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 201 APICPPAPGSASGTPSVPDPFQVPLSVPAPVPHSGLVPVQVATSASAPSPPLAPaapsvptlisdsnPLSVSASVLVPVP 280
Cdd:PRK12323 380 APVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEAL-------------AAARQASARGPGG 446
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 281 VSAPHSVPVPLSAPAPTPLTVSVSAPPLALIQAPVPPSAptlvlASVPTPVLAPMPASTPPAAPAPPSVPMPTPTPSSGP 360
Cdd:PRK12323 447 APAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAP-----AAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGW 521
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1907204000 361 PSTPTLIPAFAPTPVPAPTPAPIFTPAPTPMPAATPAaiPTSAPIPASFSLSR 413
Cdd:PRK12323 522 VAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATE--PVVAPRPPRASASG 572
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
1520-1583 |
1.16e-04 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 46.82 E-value: 1.16e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907204000 1520 DVNHRDNAGYTALHEACSRGWTDILNILLQHGANVNCSSQDGTRPVHDAVVNDNLETIWLLLSY 1583
Cdd:PTZ00322 107 DPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRH 170
|
|
| Ank_3 |
pfam13606 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
1528-1556 |
1.45e-04 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.
Pssm-ID: 463933 [Multi-domain] Cd Length: 30 Bit Score: 40.32 E-value: 1.45e-04
10 20
....*....|....*....|....*....
gi 1907204000 1528 GYTALHEACSRGWTDILNILLQHGANVNC 1556
Cdd:pfam13606 2 GNTPLHLAARNGRLEIVKLLLENGADINA 30
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
1514-1577 |
2.93e-04 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 45.82 E-value: 2.93e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907204000 1514 LQKHSEDVNHRDNAGYTALHEACSRGWTDILNILLQHGANVNCSSQDGTRPVHDAVVNDNLETI 1577
Cdd:PHA02876 164 LLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTI 227
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
1488-1555 |
3.31e-04 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 45.04 E-value: 3.31e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907204000 1488 IVNKNA-GETLLQRAARLGYKDVVLYCLQKhSEDVNHRDNAGYTALHEACSRGWTDILNILLQHGANVN 1555
Cdd:PHA03100 185 INIKDVyGFTPLHYAVYNNNPEFVKYLLDL-GANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIK 252
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
205-658 |
3.93e-04 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 45.53 E-value: 3.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 205 PPAPGSASGTPSVPD-PFQVPLSVPAPVPHSGLVPVQVATSASAPSPPLAPAAPSVPTLISDSNPlsvsasVLVPVPVSA 283
Cdd:pfam03154 171 PPVLQAQSGAASPPSpPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTP------TLHPQRLPS 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 284 PHSVPVPLSAPAPtPLTVSVSAPPLALIQAPVPP------SAPTLVLASVPTpvlapMPASTPPAAPAPPSVPMPTPTPS 357
Cdd:pfam03154 245 PHPPLQPMTQPPP-PSQVSPQPLPQPSLHGQMPPmphslqTGPSHMQHPVPP-----QPFPLTPQSSQSQVPPGPSPAAP 318
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 358 SGPPSTPTLIPAFAPTPVPAPTPAPIFTPAPTPMPAATPaaiPTSAPIPAsfslsrvcFPAAQA---PAMQKVPLSFQPG 434
Cdd:pfam03154 319 GQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKP---PPTTPIPQ--------LPNPQShkhPPHLSGPSPFQMN 387
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 435 TVLtpnqplvyiPPPSCGQPLSvaTLPTTLGVSStlTLPVLPSYLQDRCLPGVLASPdlrsypcafsvarPLASDSKLVS 514
Cdd:pfam03154 388 SNL---------PPPPALKPLS--SLSTHHPPSA--HPPPLQLMPQSQQLPPPPAQP-------------PVLTQSQSLP 441
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 515 LEVNRLSCTSPSSSTNSQP-------APDGVPGPLADTSLTTASAKVLPTSQLLLPAPSGSSVPphpskMPGGTDQQTEG 587
Cdd:pfam03154 442 PPAASHPPTSGLHQVPSQSpfpqhpfVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGP-----VPAAVSCPLPP 516
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907204000 588 TSVTFSPLKSPPQLEremaSPPecsempldlsaksnrqklPLPNQRKTPPMPVLTPVHTSSKALLSTVLSR 658
Cdd:pfam03154 517 VQIKEEALDEAEEPE----SPP------------------PPPRSPSPEPTVVNTPSHASQSARFYKHLDR 565
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
1514-1610 |
4.14e-04 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 45.24 E-value: 4.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 1514 LQKHSEDVNHRDNAGYTALHEACSRGWTDILNILLQHGANVNCSSQDGTRPVHDAVVNDNLETIWLLLSYGA--DPTLAT 1591
Cdd:PLN03192 544 LLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILYHFASisDPHAAG 623
|
90
....*....|....*....
gi 1907204000 1592 YSGQTAMKLASSDNMKRFL 1610
Cdd:PLN03192 624 DLLCTAAKRNDLTAMKELL 642
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
1495-1601 |
5.23e-04 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 44.57 E-value: 5.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 1495 ETLLQRAARLGYKDVVlYCLQKHSEDVNHRDNAGYTALHEACSRGWTDILNILLQHGANVNCSSQDGTRPVHDAVVNDNL 1574
Cdd:PHA02874 125 KTFLHYAIKKGDLESI-KMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDY 203
|
90 100
....*....|....*....|....*..
gi 1907204000 1575 ETIWLLLSYGADPTLATYSGQTAMKLA 1601
Cdd:PHA02874 204 ACIKLLIDHGNHIMNKCKNGFTPLHNA 230
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
1506-1588 |
7.24e-04 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 44.25 E-value: 7.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 1506 YKDVVLyCLQKHSEDVNHRDNAGYTALH-EACSRGWTDILNILLQHGANVNCSSQDGTRPVHD--AVVNDNLETIWLLLS 1582
Cdd:PHA03095 62 VKDIVR-LLLEAGADVNAPERCGFTPLHlYLYNATTLDVIKLLIKAGADVNAKDKVGRTPLHVylSGFNINPKVIRLLLR 140
|
....*.
gi 1907204000 1583 YGADPT 1588
Cdd:PHA03095 141 KGADVN 146
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
1514-1615 |
7.96e-04 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 44.25 E-value: 7.96e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 1514 LQKHSEDVNHRDNAGYTALHEA---CSRGWTDILNiLLQHGANVNCSSQDGTRPVHDAVVNDNLETIWLLLSYGADPTLA 1590
Cdd:PHA03095 208 LIRAGCDPAATDMLGNTPLHSMatgSSCKRSLVLP-LLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAV 286
|
90 100
....*....|....*....|....*....
gi 1907204000 1591 TYSGQTAMKLASSDN----MKRFLSDHLS 1615
Cdd:PHA03095 287 SSDGNTPLSLMVRNNngraVRAALAKNPS 315
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
1487-1586 |
8.17e-04 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 44.23 E-value: 8.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 1487 LIVNKNAGETLLQRAARLGYKDVVLYCLQKHSEDVNHRDNAGYTALHEACSRGWTDILNILLQHG---ANVNCSSQ--DG 1561
Cdd:cd22192 10 LLQQKRISESPLLLAAKENDVQAIKKLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAApelVNEPMTSDlyQG 89
|
90 100
....*....|....*....|....*
gi 1907204000 1562 TRPVHDAVVNDNLETIWLLLSYGAD 1586
Cdd:cd22192 90 ETALHIAVVNQNLNLVRELIARGAD 114
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
1514-1591 |
1.09e-03 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 43.44 E-value: 1.09e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907204000 1514 LQKHSEDVNHRDNAGYTALHEACSRGWTDILNILLQHGANVNCSSQDG-TRPVHDAVVNDNLETIWLLLSYGADPTLAT 1591
Cdd:PHA02875 154 LIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGcVAALCYAIENNKIDIVRLFIKRGADCNIMF 232
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
1511-1603 |
1.15e-03 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 43.44 E-value: 1.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 1511 LYCLQKHSEDVNHRDnaGYTALHEACSRGWTDILNILLQHGANVNCSSQDGTRPVHDAVVNDNLETIWLLLSYGADPTLA 1590
Cdd:PHA02875 87 LLDLGKFADDVFYKD--GMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIE 164
|
90
....*....|...
gi 1907204000 1591 TYSGQTAMKLASS 1603
Cdd:PHA02875 165 DCCGCTPLIIAMA 177
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
1488-1560 |
2.18e-03 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 42.93 E-value: 2.18e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907204000 1488 IVNKNAGETLLQRAARLGykDV-VLYCLQKHSEDVNHRDNAGYTALHEACSRGWTDILNILLQHGANVNCSSQD 1560
Cdd:PLN03192 616 ISDPHAAGDLLCTAAKRN--DLtAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKANTD 687
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
442-833 |
2.70e-03 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 42.60 E-value: 2.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 442 PLVYIPPPSCGQPLSVA--TLPTTLGVSSTLTlPVLPSyLQDRCLPGVLASPDLRSYPCAFSVARPLASdSKLVSLEVNR 519
Cdd:pfam05109 455 PTNLTAPASTGPTVSTAdvTSPTPAGTTSGAS-PVTPS-PSPRDNGTESKAPDMTSPTSAVTTPTPNAT-SPTPAVTTPT 531
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 520 LSCTSPS------SSTNSQPAPDGV-PGPLADTSLTTAS----AKVLPTSQLLLPAPSGSSVPPHPSKMPGGTDQQTEGT 588
Cdd:pfam05109 532 PNATSPTlgktspTSAVTTPTPNATsPTPAVTTPTPNATiptlGKTSPTSAVTTPTPNATSPTVGETSPQANTTNHTLGG 611
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 589 SVTFSPLKSPPQLEREMASPPE-----CSEMPLDLSAKSNRQKL-PLPNQRKTPPMPVLTPVHTSSkallstvlsrSQRT 662
Cdd:pfam05109 612 TSSTPVVTSPPKNATSAVTTGQhnitsSSTSSMSLRPSSISETLsPSTSDNSTSHMPLLTSAHPTG----------GENI 681
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 663 TQAAGSNVTSCLGSTSSPfvifpeMVRNGDPSTWVKNSTALISTIPGTYVGVANPVPASLLLNKDPNlglnrdprhlPKQ 742
Cdd:pfam05109 682 TQVTPASTSTHHVSTSSP------APRPGTTSQASGPGNSSTSTKPGEVNVTKGTPPKNATSPQAPS----------GQK 745
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 743 EPISIIDQGEPKSTSATCGKKGSQAGAE----------GQPSTVKSRYTPARIAPglpgcqtkelslwkPTGLTNMYPRC 812
Cdd:pfam05109 746 TAVPTVTSTGGKANSTTGGKHTTGHGARtstepttdygGDSTTPRTRYNATTYLP--------------PSTSSKLRPRW 811
|
410 420
....*....|....*....|.
gi 1907204000 813 SINGKPTSTQVLPVGWSPYHQ 833
Cdd:pfam05109 812 TFTSPPVTTAQATVPVPPTSQ 832
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
1547-1601 |
2.91e-03 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 37.71 E-value: 2.91e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1907204000 1547 LLQHG-ANVNCSSQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLA 1601
Cdd:pfam13857 1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| PHA03269 |
PHA03269 |
envelope glycoprotein C; Provisional |
175-321 |
3.33e-03 |
|
envelope glycoprotein C; Provisional
Pssm-ID: 165527 [Multi-domain] Cd Length: 566 Bit Score: 42.02 E-value: 3.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 175 ILATLGTGVPvegTLPLVTTNFSQLPapicPPAPGSASGTPSVPDPFQVPLSVPAPVPHSGLVPVQVATSASAPSPPLAP 254
Cdd:PHA03269 18 IIANLNTNIP---IPELHTSAATQKP----DPAPAPHQAASRAPDPAVAPTSAASRKPDLAQAPTPAASEKFDPAPAPHQ 90
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907204000 255 AAPSVPtlisDSNPLSVSASVLVPVPVSAPHSVPVPLSAPAPTPL-TVSVSAPPLALIQAPVPPSAPT 321
Cdd:PHA03269 91 AASRAP----DPAVAPQLAAAPKPDAAEAFTSAAQAHEAPADAGTsAASKKPDPAAHTQHSPPPFAYT 154
|
|
| DUF5585 |
pfam17823 |
Family of unknown function (DUF5585); This is a family of unknown function found in chordata. |
270-599 |
3.91e-03 |
|
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
Pssm-ID: 465521 [Multi-domain] Cd Length: 506 Bit Score: 41.87 E-value: 3.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 270 SVSASVLVPVPVSAPHSVPVPLSAPAPTPLTVSVSAPPLALIQAPVPPSAPTLVLASVPTPVLAPMPASTPPAAPAPPSV 349
Cdd:pfam17823 109 GAASRALAAAASSSPSSAAQSLPAAIAALPSEAFSAPRAAACRANASAAPRAAIAAASAPHAASPAPRTAASSTTAASST 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 350 PMPTPTPSSGPPST-PTLIPAFAPTPVPaptpapifTPAPTPMPAATPAAIPTSAPIPASFSLSRVCFPAAQApamqkvp 428
Cdd:pfam17823 189 TAASSAPTTAASSApATLTPARGISTAA--------TATGHPAAGTALAAVGNSSPAAGTVTAAVGTVTPAAL------- 253
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 429 lsfqpGTVLTPNQplvyipppscgqplSVATLPTTLGVSSTLTLPVLPSylqdrclpgvlaspdlRSYPCAFSVARPLAS 508
Cdd:pfam17823 254 -----ATLAAAAG--------------TVASAAGTINMGDPHARRLSPA----------------KHMPSDTMARNPAAP 298
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 509 DSKLVSLEVNRLSCTSPSSSTNSQPAP---DGVPGPLADTSLTTASAKVLPTSQLLLPAPSGSSVP-PHPSKMPggtdqQ 584
Cdd:pfam17823 299 MGAQAQGPIIQVSTDQPVHNTAGEPTPspsNTTLEPNTPKSVASTNLAVVTTTKAQAKEPSASPVPvLHTSMIP-----E 373
|
330
....*....|....*
gi 1907204000 585 TEGTSVTFSPLKSPP 599
Cdd:pfam17823 374 VEATSPTTQPSPLLP 388
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
385-557 |
5.18e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 41.79 E-value: 5.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 385 TPAPTPMPAATPAAIPTSAPIPASFSLSRVCFPAAQAPAMQKVPLSFQPGTVLTPNQPLVYIPPPSCGQPL-SVATLPTT 463
Cdd:PRK12323 396 APAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAAPAAAARPAAaGPRPVAAA 475
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 464 LGVSSTLTLPVLPSYLQDRC------LPGVLASPDLRSYPCAFSVARPLASDSKLVSLEVNRLSCTSPSSSTNSQPAPDG 537
Cdd:PRK12323 476 AAAAPARAAPAAAPAPADDDpppweeLPPEFASPAPAQPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAA 555
|
170 180
....*....|....*....|
gi 1907204000 538 VPGPLADTSLTTASAKVLPT 557
Cdd:PRK12323 556 ATEPVVAPRPPRASASGLPD 575
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
1543-1605 |
8.90e-03 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 40.82 E-value: 8.90e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907204000 1543 ILNILLQHGANVNCSSQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLASSDN 1605
Cdd:PHA02876 160 IAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSK 222
|
|
| PHA02795 |
PHA02795 |
ankyrin-like protein; Provisional |
1519-1561 |
9.38e-03 |
|
ankyrin-like protein; Provisional
Pssm-ID: 165157 [Multi-domain] Cd Length: 437 Bit Score: 40.36 E-value: 9.38e-03
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 1907204000 1519 EDVNHRDNAGYTALHEACSRGWTDILNILLQHGANVNCSSQDG 1561
Cdd:PHA02795 212 EDINQLDAGGRTLLYRAIYAGYIDLVSWLLENGANVNAVMSNG 254
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
305-563 |
9.87e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 40.63 E-value: 9.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 305 APPLALIQAPVPPSAPTLVLASVPTPVLAPMPASTPPAAPAPPSVPMPTPTPSSGPPSTPTLIPAFAPTPVPaptpapif 384
Cdd:PRK12323 372 AGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARG-------- 443
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 385 tPAPTPMPAATPAAIPTSAPIPASFSLSRVCFPAAQAPAMQKVPLSFQPGTVLTPnqPLVYIPPpscgqplsvatlpttl 464
Cdd:PRK12323 444 -PGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPP--PWEELPP---------------- 504
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907204000 465 gvsstlTLPVLPSYLQDRCLPGVLASPDLRSYPCAFSVARPlasdsklvSLEVNRLSCTSPSSSTNSQPAPDGVPGPLAD 544
Cdd:PRK12323 505 ------EFASPAPAQPDAAPAGWVAESIPDPATADPDDAFE--------TLAPAPAAAPAPRAAAATEPVVAPRPPRASA 570
|
250
....*....|....*....
gi 1907204000 545 TSLTTASAKVLPTSQLLLP 563
Cdd:PRK12323 571 SGLPDMFDGDWPALAARLP 589
|
|
| |
