|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
50-361 |
4.04e-28 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 113.47 E-value: 4.04e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907206275 50 DEAVPRVRFANDDRhRLACCSLDGSISLCQLvpAPPTVLHVLRGHTRGVSDFAWSLSNDILVSTSLDATMRIWASEDGRC 129
Cdd:COG2319 120 TGAVRSVAFSPDGK-TLASGSADGTVRLWDL--ATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKL 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907206275 130 IREIPDPDGAeLLCCTFQPvNNNLTVVGNAKHNVHVMNISTGKKVK--GGSsklTGRVLALSFDAPGRLLWAGDDRGSVf 207
Cdd:COG2319 197 LRTLTGHTGA-VRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRtlTGH---SGSVRSVAFSPDGRLLASGSADGTV- 270
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907206275 208 sFLFDMATGKLtkaKRLVVHEGSPVTSISArswvsreARDPSLLINACLNKLLlyRVVDNEGALQLKrsfPIEQSSHPVR 287
Cdd:COG2319 271 -RLWDLATGEL---LRTLTGHSGGVNSVAF-------SPDGKLLASGSDDGTV--RLWDLATGKLLR---TLTGHTGAVR 334
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907206275 288 SI-FCPlmsfrQGACVVTGSEDMCVHFFDVerAAKAAVNKLQGHSAPVLDVSFNCDESLLASSDASGMVIVWRRE 361
Cdd:COG2319 335 SVaFSP-----DGKTLASGSDDGTVRLWDL--ATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
53-359 |
3.42e-18 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 83.54 E-value: 3.42e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907206275 53 VPRVRFaNDDRHRLACCSLDGSISLCQLvpAPPTVLHVLRGHTRGVSDFAWSLSNDILVSTSLDATMRIWASEDGRCIRE 132
Cdd:cd00200 12 VTCVAF-SPDGKLLATGSGDGTIKVWDL--ETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRT 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907206275 133 IPDpDGAELLCCTFQPvNNNLTVVGNAKHNVHVMNISTGKKVKGGSSKlTGRVLALSFDAPGRLLWAGDDRGSVfsFLFD 212
Cdd:cd00200 89 LTG-HTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTTLRGH-TDWVNSVAFSPDGTFVASSSQDGTI--KLWD 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907206275 213 MATGKLTkaKRLVVHEGsPVTSISARSwvsrearDPSLLINACLNKLLlyRVVDNEGALQLKRsfpIEQSSHPVRSI-FC 291
Cdd:cd00200 164 LRTGKCV--ATLTGHTG-EVNSVAFSP-------DGEKLLSSSSDGTI--KLWDLSTGKCLGT---LRGHENGVNSVaFS 228
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907206275 292 PLMSFrqgacVVTGSEDMCVHFFDVEraAKAAVNKLQGHSAPVLDVSFNCDESLLASSDASGMVIVWR 359
Cdd:cd00200 229 PDGYL-----LASGSEDGTIRVWDLR--TGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
84-122 |
6.61e-06 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 42.68 E-value: 6.61e-06
10 20 30
....*....|....*....|....*....|....*....
gi 1907206275 84 PPTVLHVLRGHTRGVSDFAWSLSNDILVSTSLDATMRIW 122
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
86-122 |
1.49e-05 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 41.56 E-value: 1.49e-05
10 20 30
....*....|....*....|....*....|....*..
gi 1907206275 86 TVLHVLRGHTRGVSDFAWSLSNDILVSTSLDATMRIW 122
Cdd:pfam00400 2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
50-361 |
4.04e-28 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 113.47 E-value: 4.04e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907206275 50 DEAVPRVRFANDDRhRLACCSLDGSISLCQLvpAPPTVLHVLRGHTRGVSDFAWSLSNDILVSTSLDATMRIWASEDGRC 129
Cdd:COG2319 120 TGAVRSVAFSPDGK-TLASGSADGTVRLWDL--ATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKL 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907206275 130 IREIPDPDGAeLLCCTFQPvNNNLTVVGNAKHNVHVMNISTGKKVK--GGSsklTGRVLALSFDAPGRLLWAGDDRGSVf 207
Cdd:COG2319 197 LRTLTGHTGA-VRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRtlTGH---SGSVRSVAFSPDGRLLASGSADGTV- 270
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907206275 208 sFLFDMATGKLtkaKRLVVHEGSPVTSISArswvsreARDPSLLINACLNKLLlyRVVDNEGALQLKrsfPIEQSSHPVR 287
Cdd:COG2319 271 -RLWDLATGEL---LRTLTGHSGGVNSVAF-------SPDGKLLASGSDDGTV--RLWDLATGKLLR---TLTGHTGAVR 334
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907206275 288 SI-FCPlmsfrQGACVVTGSEDMCVHFFDVerAAKAAVNKLQGHSAPVLDVSFNCDESLLASSDASGMVIVWRRE 361
Cdd:COG2319 335 SVaFSP-----DGKTLASGSDDGTVRLWDL--ATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
52-361 |
1.39e-22 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 97.67 E-value: 1.39e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907206275 52 AVPRVRFANDDRhRLACCSLDGSISLCQLvpAPPTVLHVLRGHTRGVSDFAWSLSNDILVSTSLDATMRIWASEDGRCIR 131
Cdd:COG2319 80 AVLSVAFSPDGR-LLASASADGTVRLWDL--ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLR 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907206275 132 EIPDPDGAeLLCCTFQPvNNNLTVVGNAKHNVHVMNISTGKKVKggssKLTG---RVLALSFDAPGRLLWAGDDRGSVfs 208
Cdd:COG2319 157 TLTGHSGA-VTSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLR----TLTGhtgAVRSVAFSPDGKLLASGSADGTV-- 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907206275 209 FLFDMATGKLTkakRLVVHEGSPVTSISarswVSreaRDPSLLINACLNKLLlyRVVDNEGALQLKRsfpIEQSSHPVRS 288
Cdd:COG2319 229 RLWDLATGKLL---RTLTGHSGSVRSVA----FS---PDGRLLASGSADGTV--RLWDLATGELLRT---LTGHSGGVNS 293
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907206275 289 I-FCPlmsfrQGACVVTGSEDMCVHFFDVerAAKAAVNKLQGHSAPVLDVSFNCDESLLASSDASGMVIVWRRE 361
Cdd:COG2319 294 VaFSP-----DGKLLASGSDDGTVRLWDL--ATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA 360
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
47-361 |
2.57e-19 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 88.43 E-value: 2.57e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907206275 47 QHVDEAVPRVRFANDDRHRLAccsLDGSISLCQLVPAPPTVLHVLRGHTRGVSDFAWSLSNDILVSTSLDATMRIWASED 126
Cdd:COG2319 33 LGLAAAVASLAASPDGARLAA---GAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907206275 127 GRCIREIPDPDGAeLLCCTFQPvNNNLTVVGNAKHNVHVMNISTGKKVKggssKLTG---RVLALSFDAPGRLLWAGDDR 203
Cdd:COG2319 110 GLLLRTLTGHTGA-VRSVAFSP-DGKTLASGSADGTVRLWDLATGKLLR----TLTGhsgAVTSVAFSPDGKLLASGSDD 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907206275 204 GSVfsFLFDMATGKLTkaKRLVVHEGsPVTSISarswVSreaRDPSLLINACLNKLLlyRVVDNEGALQLKRsfpIEQSS 283
Cdd:COG2319 184 GTV--RLWDLATGKLL--RTLTGHTG-AVRSVA----FS---PDGKLLASGSADGTV--RLWDLATGKLLRT---LTGHS 246
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907206275 284 HPVRSI-FCPlmsfrQGACVVTGSEDMCVHFFDVerAAKAAVNKLQGHSAPVLDVSFNCDESLLASSDASGMVIVWRRE 361
Cdd:COG2319 247 GSVRSVaFSP-----DGRLLASGSADGTVRLWDL--ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA 318
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
53-359 |
3.42e-18 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 83.54 E-value: 3.42e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907206275 53 VPRVRFaNDDRHRLACCSLDGSISLCQLvpAPPTVLHVLRGHTRGVSDFAWSLSNDILVSTSLDATMRIWASEDGRCIRE 132
Cdd:cd00200 12 VTCVAF-SPDGKLLATGSGDGTIKVWDL--ETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRT 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907206275 133 IPDpDGAELLCCTFQPvNNNLTVVGNAKHNVHVMNISTGKKVKGGSSKlTGRVLALSFDAPGRLLWAGDDRGSVfsFLFD 212
Cdd:cd00200 89 LTG-HTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTTLRGH-TDWVNSVAFSPDGTFVASSSQDGTI--KLWD 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907206275 213 MATGKLTkaKRLVVHEGsPVTSISARSwvsrearDPSLLINACLNKLLlyRVVDNEGALQLKRsfpIEQSSHPVRSI-FC 291
Cdd:cd00200 164 LRTGKCV--ATLTGHTG-EVNSVAFSP-------DGEKLLSSSSDGTI--KLWDLSTGKCLGT---LRGHENGVNSVaFS 228
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907206275 292 PLMSFrqgacVVTGSEDMCVHFFDVEraAKAAVNKLQGHSAPVLDVSFNCDESLLASSDASGMVIVWR 359
Cdd:cd00200 229 PDGYL-----LASGSEDGTIRVWDLR--TGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
88-359 |
2.02e-17 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 81.61 E-value: 2.02e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907206275 88 LHVLRGHTRGVSDFAWSLSNDILVSTSLDATMRIWASEDGRCIREIPDPDGaELLCCTFQPVNNNLTVVGNAKhNVHVMN 167
Cdd:cd00200 2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTG-PVRDVAASADGTYLASGSSDK-TIRLWD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907206275 168 ISTGKKVkggsSKLTG---RVLALSFDAPGRLLWAGDDRGSVfsFLFDMATGKLTKAkrLVVHEGsPVTSISARSwvsre 244
Cdd:cd00200 80 LETGECV----RTLTGhtsYVSSVAFSPDGRILSSSSRDKTI--KVWDVETGKCLTT--LRGHTD-WVNSVAFSP----- 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907206275 245 arDPSLLINACLNKLLlyRVVDNEgALQLKRSFPIEQSshPVRSI-FCPlmsfrQGACVVTGSEDMCVHFFDVerAAKAA 323
Cdd:cd00200 146 --DGTFVASSSQDGTI--KLWDLR-TGKCVATLTGHTG--EVNSVaFSP-----DGEKLLSSSSDGTIKLWDL--STGKC 211
|
250 260 270
....*....|....*....|....*....|....*.
gi 1907206275 324 VNKLQGHSAPVLDVSFNCDESLLASSDASGMVIVWR 359
Cdd:cd00200 212 LGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWD 247
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
84-122 |
6.61e-06 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 42.68 E-value: 6.61e-06
10 20 30
....*....|....*....|....*....|....*....
gi 1907206275 84 PPTVLHVLRGHTRGVSDFAWSLSNDILVSTSLDATMRIW 122
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
86-122 |
1.49e-05 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 41.56 E-value: 1.49e-05
10 20 30
....*....|....*....|....*....|....*..
gi 1907206275 86 TVLHVLRGHTRGVSDFAWSLSNDILVSTSLDATMRIW 122
Cdd:pfam00400 2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
324-358 |
4.66e-05 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 39.99 E-value: 4.66e-05
10 20 30
....*....|....*....|....*....|....*
gi 1907206275 324 VNKLQGHSAPVLDVSFNCDESLLASSDASGMVIVW 358
Cdd:smart00320 5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
|
|
| YncE |
COG3391 |
DNA-binding beta-propeller fold protein YncE [General function prediction only]; |
44-220 |
2.38e-04 |
|
DNA-binding beta-propeller fold protein YncE [General function prediction only];
Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 41.99 E-value: 2.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907206275 44 VFDQHVDEAVPRVRFANDDRHRLACCSLDGSISLCQLVPAPPTVLHVLRGHTRGVSDFAWSLSNDIL-VSTSLDATMRIW 122
Cdd:COG3391 16 LALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLyVANSGSGRVSVI 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907206275 123 ASEDGRCIREIPDPDGAELLCctFQPVNNNLTVVGNAKHNVHVMNISTGKKVKggSSKLTGRVLALSFDAPGRLLW---A 199
Cdd:COG3391 96 DLATGKVVATIPVGGGPRGLA--VDPDGGRLYVADSGNGRVSVIDTATGKVVA--TIPVGAGPHGIAVDPDGKRLYvanS 171
|
170 180
....*....|....*....|.
gi 1907206275 200 GDDRGSVFSFLFDMATGKLTK 220
Cdd:COG3391 172 GSNTVSVIVSVIDTATGKVVA 192
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
324-358 |
3.09e-04 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 37.71 E-value: 3.09e-04
10 20 30
....*....|....*....|....*....|....*
gi 1907206275 324 VNKLQGHSAPVLDVSFNCDESLLASSDASGMVIVW 358
Cdd:pfam00400 4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
302-362 |
6.57e-03 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 38.08 E-value: 6.57e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907206275 302 VVTGSEDMCVHFFDVERAAKaaVNKLQGHSAPVLDVSFNCDESLLASSDASGMVIVWRREQ 362
Cdd:cd00200 24 LATGSGDGTIKVWDLETGEL--LRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82
|
|
| |
