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Conserved domains on  [gi|1907142841|ref|XP_036018371|]
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GTPase-activating protein and VPS9 domain-containing protein 1 isoform X13 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
VPS9 pfam02204
Vacuolar sorting protein 9 (VPS9) domain; This domain acts as a GDP-GTP exchange factor (GEF). ...
 551-652 1.22e-37

Vacuolar sorting protein 9 (VPS9) domain; This domain acts as a GDP-GTP exchange factor (GEF). It activates Rab GTPases by stimulating the release of GDP and allowing GTP to bind.


:

Pssm-ID: 460489  Cd Length: 104  Bit Score: 135.42  E-value: 1.22e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907142841 551 WPSAQSEIRTISAYKTPRDKVQCILRMCSTIMNLLSLANEDSVPGADDFVPVLVFVLIKANPPCLLSTVQYISSF-YASC 629
Cdd:pfam02204   1 WEQAQQELKKLNEAKSPREKLKCLLRTCKLITEALSKSNRDESLGADDLLPILIYVLIRANPPNLYSNLQFISEFrDPDL 80

                          90       100
                  ....*....|....*....|...
gi 1907142841 630 LSGEESYWWMQFTAAVEFIKTID 652
Cdd:pfam02204  81 LSGEEGYYLTTLEAALEFIESLD 103
DUF5601 pfam18151
Domain of unknown function (DUF5601); This domain is found in the catalytic core RABEX-5 ...
 440-503 2.30e-17

Domain of unknown function (DUF5601); This domain is found in the catalytic core RABEX-5 present in Homo sapiens. RABEX, also known as Rab GTPase exchange factors, regulate endocytic trafficking through activation of the Rab families RAB5, RAB21 and RAB22. The domain is helical in nature.


:

Pssm-ID: 465668  Cd Length: 65  Bit Score: 76.47  E-value: 2.30e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907142841 440 KKIREFIQDFQKLTA-ADDKTAQVEDFLQFLYGVMAQDVIWQNASEEQLQDAQLAIERSVMNRIF 503
Cdd:pfam18151   1 KQIRSFIERFQNLDStIDEQSELVQDFYQFMADRLLSHPLWKGASDEQLEQLLDGVEKYIMTKLY 65
 
Name Accession Description Interval E-value
VPS9 pfam02204
Vacuolar sorting protein 9 (VPS9) domain; This domain acts as a GDP-GTP exchange factor (GEF). ...
 551-652 1.22e-37

Vacuolar sorting protein 9 (VPS9) domain; This domain acts as a GDP-GTP exchange factor (GEF). It activates Rab GTPases by stimulating the release of GDP and allowing GTP to bind.


Pssm-ID: 460489  Cd Length: 104  Bit Score: 135.42  E-value: 1.22e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907142841 551 WPSAQSEIRTISAYKTPRDKVQCILRMCSTIMNLLSLANEDSVPGADDFVPVLVFVLIKANPPCLLSTVQYISSF-YASC 629
Cdd:pfam02204   1 WEQAQQELKKLNEAKSPREKLKCLLRTCKLITEALSKSNRDESLGADDLLPILIYVLIRANPPNLYSNLQFISEFrDPDL 80

                          90       100
                  ....*....|....*....|...
gi 1907142841 630 LSGEESYWWMQFTAAVEFIKTID 652
Cdd:pfam02204  81 LSGEEGYYLTTLEAALEFIESLD 103
VPS9 smart00167
Domain present in VPS9; Domain present in yeast vacuolar sorting protein 9 and other proteins.
 550-654 5.79e-28

Domain present in VPS9; Domain present in yeast vacuolar sorting protein 9 and other proteins.


Pssm-ID: 128469  Cd Length: 117  Bit Score: 108.70  E-value: 5.79e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907142841  550 PWPSAQSEIRTISAYKTPRDKVQCILRMCSTIMNLLSLaNEDSVPGADDFVPVLVFVLIKANPPCLLSTVQYISSF-YAS 628
Cdd:smart00167   1 FVEIEQIELKFLQLYKSPSDKIKCLLRACKLIYTLLET-QSGEVAGADDFLPVLIYVIIKCDPRDLLLNAEYMEEFlEPS 79

                           90       100
                   ....*....|....*....|....*.
gi 1907142841  629 CLSGEESYWWMQFTAAVEFIKTIDDR 654
Cdd:smart00167  80 LLTGEGGYYLTSLSAALALIKGLTEA 105
DUF5601 pfam18151
Domain of unknown function (DUF5601); This domain is found in the catalytic core RABEX-5 ...
 440-503 2.30e-17

Domain of unknown function (DUF5601); This domain is found in the catalytic core RABEX-5 present in Homo sapiens. RABEX, also known as Rab GTPase exchange factors, regulate endocytic trafficking through activation of the Rab families RAB5, RAB21 and RAB22. The domain is helical in nature.


Pssm-ID: 465668  Cd Length: 65  Bit Score: 76.47  E-value: 2.30e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907142841 440 KKIREFIQDFQKLTA-ADDKTAQVEDFLQFLYGVMAQDVIWQNASEEQLQDAQLAIERSVMNRIF 503
Cdd:pfam18151   1 KQIRSFIERFQNLDStIDEQSELVQDFYQFMADRLLSHPLWKGASDEQLEQLLDGVEKYIMTKLY 65
 
Name Accession Description Interval E-value
VPS9 pfam02204
Vacuolar sorting protein 9 (VPS9) domain; This domain acts as a GDP-GTP exchange factor (GEF). ...
 551-652 1.22e-37

Vacuolar sorting protein 9 (VPS9) domain; This domain acts as a GDP-GTP exchange factor (GEF). It activates Rab GTPases by stimulating the release of GDP and allowing GTP to bind.


Pssm-ID: 460489  Cd Length: 104  Bit Score: 135.42  E-value: 1.22e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907142841 551 WPSAQSEIRTISAYKTPRDKVQCILRMCSTIMNLLSLANEDSVPGADDFVPVLVFVLIKANPPCLLSTVQYISSF-YASC 629
Cdd:pfam02204   1 WEQAQQELKKLNEAKSPREKLKCLLRTCKLITEALSKSNRDESLGADDLLPILIYVLIRANPPNLYSNLQFISEFrDPDL 80

                          90       100
                  ....*....|....*....|...
gi 1907142841 630 LSGEESYWWMQFTAAVEFIKTID 652
Cdd:pfam02204  81 LSGEEGYYLTTLEAALEFIESLD 103
VPS9 smart00167
Domain present in VPS9; Domain present in yeast vacuolar sorting protein 9 and other proteins.
 550-654 5.79e-28

Domain present in VPS9; Domain present in yeast vacuolar sorting protein 9 and other proteins.


Pssm-ID: 128469  Cd Length: 117  Bit Score: 108.70  E-value: 5.79e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907142841  550 PWPSAQSEIRTISAYKTPRDKVQCILRMCSTIMNLLSLaNEDSVPGADDFVPVLVFVLIKANPPCLLSTVQYISSF-YAS 628
Cdd:smart00167   1 FVEIEQIELKFLQLYKSPSDKIKCLLRACKLIYTLLET-QSGEVAGADDFLPVLIYVIIKCDPRDLLLNAEYMEEFlEPS 79

                           90       100
                   ....*....|....*....|....*.
gi 1907142841  629 CLSGEESYWWMQFTAAVEFIKTIDDR 654
Cdd:smart00167  80 LLTGEGGYYLTSLSAALALIKGLTEA 105
DUF5601 pfam18151
Domain of unknown function (DUF5601); This domain is found in the catalytic core RABEX-5 ...
 440-503 2.30e-17

Domain of unknown function (DUF5601); This domain is found in the catalytic core RABEX-5 present in Homo sapiens. RABEX, also known as Rab GTPase exchange factors, regulate endocytic trafficking through activation of the Rab families RAB5, RAB21 and RAB22. The domain is helical in nature.


Pssm-ID: 465668  Cd Length: 65  Bit Score: 76.47  E-value: 2.30e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907142841 440 KKIREFIQDFQKLTA-ADDKTAQVEDFLQFLYGVMAQDVIWQNASEEQLQDAQLAIERSVMNRIF 503
Cdd:pfam18151   1 KQIRSFIERFQNLDStIDEQSELVQDFYQFMADRLLSHPLWKGASDEQLEQLLDGVEKYIMTKLY 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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