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Conserved domains on  [gi|1907152483|ref|XP_036019296|]
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meiotic nuclear division protein 1 homolog isoform X1 [Mus musculus]

Protein Classification

meiotic nuclear division 1 family protein( domain architecture ID 1013224)

meiotic nuclear division 1 (MND1) family protein such as human MND1 homolog that is required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis

Gene Ontology:  GO:0003690|GO:0007131
PubMed:  11940665|25740648
SCOP:  4004373|4007688

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5124 super family cl34914
Protein predicted to be involved in meiotic recombination [Cell division and chromosome ...
 1-189 1.12e-41

Protein predicted to be involved in meiotic recombination [Cell division and chromosome partitioning / General function prediction only];


The actual alignment was detected with superfamily member COG5124:

Pssm-ID: 227453 [Multi-domain]  Cd Length: 209  Bit Score: 139.32  E-value: 1.12e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152483   1 MMEIFFETKDVFQLKDLEKLAPKeKGITAMSVKEVLQSLVDDGMVDCERIGTSNYYWAFPSKALHARKRKLEALNSQLSE 80
Cdd:COG5124    15 LEAIFHDSKDFFQLKEVEKLGSK-KQIVLMTVKDLLQQLVDDGVVSVEKCGTSNIYWSFKSQTLQKLYDSSELLKKKIQE 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152483  81 GSQKHADLQKSIEKARVGRQE--TE-ERAMLAKELSSFRDQRQ-QLKAEVEKYRECDPQVVEEIREANKVAKEAANRWTD 156
Cdd:COG5124    94 VKQDIATYKEEIDKEKATRRKkfTEgQKNYNREALLEKRKKEQdEIKKKLNSLQKIEPIRWDAAKIQEKKKKVHLNKTTD 173

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1907152483 157 NIFAIKSWAKRKFGFEESKIDKNFGIPEDFDYI 189
Cdd:COG5124   174 NIEILIDYLCKKFFLKPEQIRKEFGIPEDLDEF 206
 
Name Accession Description Interval E-value
COG5124 COG5124
Protein predicted to be involved in meiotic recombination [Cell division and chromosome ...
 1-189 1.12e-41

Protein predicted to be involved in meiotic recombination [Cell division and chromosome partitioning / General function prediction only];


Pssm-ID: 227453 [Multi-domain]  Cd Length: 209  Bit Score: 139.32  E-value: 1.12e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152483   1 MMEIFFETKDVFQLKDLEKLAPKeKGITAMSVKEVLQSLVDDGMVDCERIGTSNYYWAFPSKALHARKRKLEALNSQLSE 80
Cdd:COG5124    15 LEAIFHDSKDFFQLKEVEKLGSK-KQIVLMTVKDLLQQLVDDGVVSVEKCGTSNIYWSFKSQTLQKLYDSSELLKKKIQE 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152483  81 GSQKHADLQKSIEKARVGRQE--TE-ERAMLAKELSSFRDQRQ-QLKAEVEKYRECDPQVVEEIREANKVAKEAANRWTD 156
Cdd:COG5124    94 VKQDIATYKEEIDKEKATRRKkfTEgQKNYNREALLEKRKKEQdEIKKKLNSLQKIEPIRWDAAKIQEKKKKVHLNKTTD 173

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1907152483 157 NIFAIKSWAKRKFGFEESKIDKNFGIPEDFDYI 189
Cdd:COG5124   174 NIEILIDYLCKKFFLKPEQIRKEFGIPEDLDEF 206
Mnd1 pfam03962
Mnd1 HTH domain; This family of proteins includes MND1 from S. cerevisiae. The mnd1 protein ...
 1-60 5.32e-34

Mnd1 HTH domain; This family of proteins includes MND1 from S. cerevisiae. The mnd1 protein forms a complex with hop2 to promote homologous chromosome pairing and meiotic double-strand break repair.


Pssm-ID: 461112  Cd Length: 60  Bit Score: 114.91  E-value: 5.32e-34
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152483   1 MMEIFFETKDVFQLKDLEKLAPKEKGITAMSVKEVLQSLVDDGMVDCERIGTSNYYWAFP 60
Cdd:pfam03962   1 ILEIFHETKDFFTLKELEKLAPKEKGIVSQSVKDVLQSLVDDGLVDVEKIGSSNYYWSFP 60
hsdR PRK11448
type I restriction enzyme EcoKI subunit R; Provisional
 60-153 2.86e-03

type I restriction enzyme EcoKI subunit R; Provisional


Pssm-ID: 236912 [Multi-domain]  Cd Length: 1123  Bit Score: 38.01  E-value: 2.86e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152483   60 PSKALHARKRKLEALNSQLSEGSQKHADLQKSIEkarvgrQETEERAMLAKELSSFRDQRQQLKAEVEKYRECDPQV-VE 138
Cdd:PRK11448   140 PENLLHALQQEVLTLKQQLELQAREKAQSQALAE------AQQQELVALEGLAAELEEKQQELEAQLEQLQEKAAETsQE 213

                           90
                   ....*....|....*
gi 1907152483  139 EIREANKVAKEAANR 153
Cdd:PRK11448   214 RKQKRKEITDQAAKR 228
 
Name Accession Description Interval E-value
COG5124 COG5124
Protein predicted to be involved in meiotic recombination [Cell division and chromosome ...
 1-189 1.12e-41

Protein predicted to be involved in meiotic recombination [Cell division and chromosome partitioning / General function prediction only];


Pssm-ID: 227453 [Multi-domain]  Cd Length: 209  Bit Score: 139.32  E-value: 1.12e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152483   1 MMEIFFETKDVFQLKDLEKLAPKeKGITAMSVKEVLQSLVDDGMVDCERIGTSNYYWAFPSKALHARKRKLEALNSQLSE 80
Cdd:COG5124    15 LEAIFHDSKDFFQLKEVEKLGSK-KQIVLMTVKDLLQQLVDDGVVSVEKCGTSNIYWSFKSQTLQKLYDSSELLKKKIQE 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152483  81 GSQKHADLQKSIEKARVGRQE--TE-ERAMLAKELSSFRDQRQ-QLKAEVEKYRECDPQVVEEIREANKVAKEAANRWTD 156
Cdd:COG5124    94 VKQDIATYKEEIDKEKATRRKkfTEgQKNYNREALLEKRKKEQdEIKKKLNSLQKIEPIRWDAAKIQEKKKKVHLNKTTD 173

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1907152483 157 NIFAIKSWAKRKFGFEESKIDKNFGIPEDFDYI 189
Cdd:COG5124   174 NIEILIDYLCKKFFLKPEQIRKEFGIPEDLDEF 206
Mnd1 pfam03962
Mnd1 HTH domain; This family of proteins includes MND1 from S. cerevisiae. The mnd1 protein ...
 1-60 5.32e-34

Mnd1 HTH domain; This family of proteins includes MND1 from S. cerevisiae. The mnd1 protein forms a complex with hop2 to promote homologous chromosome pairing and meiotic double-strand break repair.


Pssm-ID: 461112  Cd Length: 60  Bit Score: 114.91  E-value: 5.32e-34
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152483   1 MMEIFFETKDVFQLKDLEKLAPKEKGITAMSVKEVLQSLVDDGMVDCERIGTSNYYWAFP 60
Cdd:pfam03962   1 ILEIFHETKDFFTLKELEKLAPKEKGIVSQSVKDVLQSLVDDGLVDVEKIGSSNYYWSFP 60
LZ3wCH pfam18517
Leucine zipper with capping helix domain; This domain is found at the C-terminal region of ...
 136-189 7.88e-20

Leucine zipper with capping helix domain; This domain is found at the C-terminal region of Hop2 and Mnd1 proteins. In meiotic DNA recombination, the Hop2-Mnd1 complex promotes Dmc1-mediated single-stranded DNA (ssDNA) invasion into homologous chromosomes to form a synaptic complex. Hop2 (for homologous pairing; also known as TBPIP) is expressed specifically during meiosis, same as Mnd1 (for meiotic nuclear divisions 1). The C-terminal region of both Hop2 and Mnd1, folds into three alpha-helices that are interrupted by two short non-helical regions. These alpha-helices of the two proteins together form a parallel coiled coil that provides the major interface for heterodimer formation. The non-helical regions form substantially kinked junctions between adjacent leucine zippers: the LZ1-LZ2 and LZ2-LZ3 junctions.This domain is the C-terminal segment of Hop2 and Mnd1 which folds back onto the C-terminal leucine zipper (LZ3) to form a helical bundle-like structure, hence designated LZ3wCH (for LZ3 with capping helices). The LZ3wCH region plays a role in interacting with the Dmc1 nucleofilament.


Pssm-ID: 465789  Cd Length: 55  Bit Score: 78.35  E-value: 7.88e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907152483 136 VVEEIREANKVAKEAANRWTDNIFAIKSWAKRKFGFEESKIDKNFGIPEDFDYI 189
Cdd:pfam18517   2 TPEEKKKATKVAKEAANRWTDNIFDIKSWIKEKFPKSKKELNEEFGIETDEDYG 55
hsdR PRK11448
type I restriction enzyme EcoKI subunit R; Provisional
 60-153 2.86e-03

type I restriction enzyme EcoKI subunit R; Provisional


Pssm-ID: 236912 [Multi-domain]  Cd Length: 1123  Bit Score: 38.01  E-value: 2.86e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152483   60 PSKALHARKRKLEALNSQLSEGSQKHADLQKSIEkarvgrQETEERAMLAKELSSFRDQRQQLKAEVEKYRECDPQV-VE 138
Cdd:PRK11448   140 PENLLHALQQEVLTLKQQLELQAREKAQSQALAE------AQQQELVALEGLAAELEEKQQELEAQLEQLQEKAAETsQE 213

                           90
                   ....*....|....*
gi 1907152483  139 EIREANKVAKEAANR 153
Cdd:PRK11448   214 RKQKRKEITDQAAKR 228
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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