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Conserved domains on  [gi|1907166801|ref|XP_036021461|]
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WD repeat domain phosphoinositide-interacting protein 2 isoform X2 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
2-102 5.22e-09

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 56.07  E-value: 5.22e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907166801   2 IPAHDSPLAALAFDASGTKLATASEKGTViRVFSIPEGQKLFEFRRGVKRcvsICSLAFSMDGMFLSASSNTETVHIFKL 81
Cdd:COG2319   284 LTGHSGGVNSVAFSPDGKLLASGSDDGTV-RLWDLATGKLLRTLTGHTGA---VRSVAFSPDGKTLASGSDDGTVRLWDL 359

                          90       100
                  ....*....|....*....|.
gi 1907166801  82 EAvrekpPEEPTTWTGYFGKV 102
Cdd:COG2319   360 AT-----GELLRTLTGHTGAV 375
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
2-102 5.22e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 56.07  E-value: 5.22e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907166801   2 IPAHDSPLAALAFDASGTKLATASEKGTViRVFSIPEGQKLFEFRRGVKRcvsICSLAFSMDGMFLSASSNTETVHIFKL 81
Cdd:COG2319   284 LTGHSGGVNSVAFSPDGKLLASGSDDGTV-RLWDLATGKLLRTLTGHTGA---VRSVAFSPDGKTLASGSDDGTVRLWDL 359

                          90       100
                  ....*....|....*....|.
gi 1907166801  82 EAvrekpPEEPTTWTGYFGKV 102
Cdd:COG2319   360 AT-----GELLRTLTGHTGAV 375
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 5-167 1.45e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 48.49  E-value: 1.45e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907166801   5 HDSPLAALAFDASGTKLATASEKGTvIRVFSIPEGQKLFEFRrGVKRcvSICSLAFSMDGMFLSASSNTETVHIFKLEav 84
Cdd:cd00200    92 HTSYVSSVAFSPDGRILSSSSRDKT-IKVWDVETGKCLTTLR-GHTD--WVNSVAFSPDGTFVASSSQDGTIKLWDLR-- 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907166801  85 rekppeepttwTGYFGKVLMASTSYLPSqvTEMFNQGRAFA------TVRL----------PFCGHKN-ICSLTTIQKiP 147
Cdd:cd00200   166 -----------TGKCVATLTGHTGEVNS--VAFSPDGEKLLssssdgTIKLwdlstgkclgTLRGHENgVNSVAFSPD-G 231

                         170       180
                  ....*....|....*....|.
gi 1907166801 148 RLLVGAS-DGYLYMYNLDPQE 167
Cdd:cd00200   232 YLLASGSeDGTIRVWDLRTGE 252
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
2-102 5.22e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 56.07  E-value: 5.22e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907166801   2 IPAHDSPLAALAFDASGTKLATASEKGTViRVFSIPEGQKLFEFRRGVKRcvsICSLAFSMDGMFLSASSNTETVHIFKL 81
Cdd:COG2319   284 LTGHSGGVNSVAFSPDGKLLASGSDDGTV-RLWDLATGKLLRTLTGHTGA---VRSVAFSPDGKTLASGSDDGTVRLWDL 359

                          90       100
                  ....*....|....*....|.
gi 1907166801  82 EAvrekpPEEPTTWTGYFGKV 102
Cdd:COG2319   360 AT-----GELLRTLTGHTGAV 375
WD40 COG2319
WD40 repeat [General function prediction only];
2-103 5.41e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 56.07  E-value: 5.41e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907166801   2 IPAHDSPLAALAFDASGTKLATASEKGTViRVFSIPEGQKLFEFRRGVKRcvsICSLAFSMDGMFLSASSNTETVHIFKL 81
Cdd:COG2319   158 LTGHSGAVTSVAFSPDGKLLASGSDDGTV-RLWDLATGKLLRTLTGHTGA---VRSVAFSPDGKLLASGSADGTVRLWDL 233

                          90       100
                  ....*....|....*....|..
gi 1907166801  82 EAvrekpPEEPTTWTGYFGKVL 103
Cdd:COG2319   234 AT-----GKLLRTLTGHSGSVR 250
WD40 COG2319
WD40 repeat [General function prediction only];
2-103 2.25e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.15  E-value: 2.25e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907166801   2 IPAHDSPLAALAFDASGTKLATASEKGTViRVFSIPEGQKLFEFRRGVKRcvsICSLAFSMDGMFLSASSNTETVHIFKL 81
Cdd:COG2319   242 LTGHSGSVRSVAFSPDGRLLASGSADGTV-RLWDLATGELLRTLTGHSGG---VNSVAFSPDGKLLASGSDDGTVRLWDL 317

                          90       100
                  ....*....|....*....|..
gi 1907166801  82 EAvrekpPEEPTTWTGYFGKVL 103
Cdd:COG2319   318 AT-----GKLLRTLTGHTGAVR 334
WD40 COG2319
WD40 repeat [General function prediction only];
2-82 6.62e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 52.99  E-value: 6.62e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907166801   2 IPAHDSPLAALAFDASGTKLATASEKGTViRVFSIPEGQKLFEFRRGVKRcvsICSLAFSMDGMFLSASSNTETVHIFKL 81
Cdd:COG2319   326 LTGHTGAVRSVAFSPDGKTLASGSDDGTV-RLWDLATGELLRTLTGHTGA---VTSVAFSPDGRTLASGSADGTVRLWDL 401


                  .
gi 1907166801  82 E 82
Cdd:COG2319   402 A 402
WD40 COG2319
WD40 repeat [General function prediction only];
4-102 8.39e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 52.61  E-value: 8.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907166801   4 AHDSPLAALAFDASGTKLATASEKGTViRVFSIPEGQKLFEFrRGVKRCVSicSLAFSMDGMFLSASSNTETVHIFKLEA 83
Cdd:COG2319   118 GHTGAVRSVAFSPDGKTLASGSADGTV-RLWDLATGKLLRTL-TGHSGAVT--SVAFSPDGKLLASGSDDGTVRLWDLAT 193

                          90
                  ....*....|....*....
gi 1907166801  84 vrekpPEEPTTWTGYFGKV 102
Cdd:COG2319   194 -----GKLLRTLTGHTGAV 207
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 5-167 1.45e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 48.49  E-value: 1.45e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907166801   5 HDSPLAALAFDASGTKLATASEKGTvIRVFSIPEGQKLFEFRrGVKRcvSICSLAFSMDGMFLSASSNTETVHIFKLEav 84
Cdd:cd00200    92 HTSYVSSVAFSPDGRILSSSSRDKT-IKVWDVETGKCLTTLR-GHTD--WVNSVAFSPDGTFVASSSQDGTIKLWDLR-- 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907166801  85 rekppeepttwTGYFGKVLMASTSYLPSqvTEMFNQGRAFA------TVRL----------PFCGHKN-ICSLTTIQKiP 147
Cdd:cd00200   166 -----------TGKCVATLTGHTGEVNS--VAFSPDGEKLLssssdgTIKLwdlstgkclgTLRGHENgVNSVAFSPD-G 231

                         170       180
                  ....*....|....*....|.
gi 1907166801 148 RLLVGAS-DGYLYMYNLDPQE 167
Cdd:cd00200   232 YLLASGSeDGTIRVWDLRTGE 252
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2-87 2.97e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 47.33  E-value: 2.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907166801   2 IPAHDSPLAALAFDASGTKLATASEKGTvIRVFSIPEGQKLFEFRRgvkRCVSICSLAFSMDGMFLSASSNTETVHIFKL 81
Cdd:cd00200   173 LTGHTGEVNSVAFSPDGEKLLSSSSDGT-IKLWDLSTGKCLGTLRG---HENGVNSVAFSPDGYLLASGSEDGTIRVWDL 248


                  ....*.
gi 1907166801  82 EAVREK 87
Cdd:cd00200   249 RTGECV 254
WD40 COG2319
WD40 repeat [General function prediction only];
3-102 7.13e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.83  E-value: 7.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907166801   3 PAHDSPLAALAFDASGTKLATASEKGTViRVFSIPEGQKLFEFRRGVKrcvSICSLAFSMDGMFLSASSNTETVHIFKLE 82
Cdd:COG2319    75 LGHTAAVLSVAFSPDGRLLASASADGTV-RLWDLATGLLLRTLTGHTG---AVRSVAFSPDGKTLASGSADGTVRLWDLA 150

                          90       100
                  ....*....|....*....|
gi 1907166801  83 AvrekpPEEPTTWTGYFGKV 102
Cdd:COG2319   151 T-----GKLLRTLTGHSGAV 165
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2-164 8.67e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 46.17  E-value: 8.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907166801   2 IPAHDSPLAALAFDASGTKLATASEKGTvIRVFSIPEGQKLFEFR---RGVKRCVSICslafsmDGMFLSASSNTETVHI 78
Cdd:cd00200     5 LKGHTGGVTCVAFSPDGKLLATGSGDGT-IKVWDLETGELLRTLKghtGPVRDVAASA------DGTYLASGSSDKTIRL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907166801  79 FKLEAvrekpPEEPTTWTGYFGKVL---------MASTSYLPSQV----TEMFNQGRAFAtvrlpfcGHKNICSLTTIQK 145
Cdd:cd00200    78 WDLET-----GECVRTLTGHTSYVSsvafspdgrILSSSSRDKTIkvwdVETGKCLTTLR-------GHTDWVNSVAFSP 145

                         170       180
                  ....*....|....*....|
gi 1907166801 146 IPRLLVGAS-DGYLYMYNLD 164
Cdd:cd00200   146 DGTFVASSSqDGTIKLWDLR 165
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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