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Conserved domains on  [gi|1952584634|ref|XP_038678309|]
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lymphocyte activation gene 3 protein-like isoform X3 [Scyliorhinus canicula]

Protein Classification

immunoglobulin domain-containing protein( domain architecture ID 11669303)

immunoglobulin (Ig) domain-containing protein adopts a fold comprised of a sandwich of two beta sheets, which is often involved in functions such as cell adhesion, immune recognition, and protein-protein interactions; similar to Homo sapiens V-set and immunoglobulin domain containing 8 (VSIG8) endothelial cell-selective adhesion molecule (ESAM), and Embigin/basigin subgroup, all of which are members of the immunoglobulin superfamily (IgSF)

CATH:  2.60.40.10
PubMed:  9417933|7932691
SCOP:  3000071

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 19-145 2.20e-07

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd05901:

Pssm-ID: 472250  Cd Length: 128  Bit Score: 49.57  E-value: 2.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952584634  19 TERVIAAAGGMASLPC-------LDGDRVGRKAGYRklaLSWS-FERTGMGKVP---LLMMGSDGVVKRGLcETSGRTRV 87
Cdd:cd05901     4 SSRVHGSLSGSVVLPCrfstlptLPPSYNITSEFLR---IKWTkIQVDKNGKDHketTVLVAQNGIIKIGQ-EYMGRVSV 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1952584634  88 SGERTDAGDYSLTARDLRSTDAGVYSCEVRHGsvyleravelhvVQVTTDAVGLPLEG 145
Cdd:cd05901    80 PSHPEDQGDASLTIVKLRASDAGVYRCEVMHG------------IEDTQDTVSLDVSG 125
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 144-220 4.28e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


:

Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 41.72  E-value: 4.28e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1952584634  144 EGSKLNLLCEmAEPLTGARYSWHRGGNMVTPTGQRV-WTGDSGR-KLHFSTLKPEDQGDWECHVTFEMLSVNAHYQLKV 220
Cdd:smart00410   8 EGESVTLSCE-ASGSPPPEVTWYKQGGKLLAESGRFsVSRSGSTsTLTISNVTPEDSGTYTCAATNSSGSASSGTTLTV 85
 
Name Accession Description Interval E-value
Ig_Versican cd05901
Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), ...
 19-145 2.20e-07

Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), versican; The members here are composed of the immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), versican. In CSPGs, the Ig-like domain is followed by hyaluronan (HA)-binding tandem repeats, and a C-terminal region with epidermal growth factor-like, lectin-like, and complement regulatory protein-like domains. Separating these N- and C-terminal regions is a nonhomologous glycosaminoglycan attachment region. In cartilage, the CSPG aggrecan (not included in this group) forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Like aggrecan, versican has a wide distribution in connective tissue and extracellular matrices. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 409482  Cd Length: 128  Bit Score: 49.57  E-value: 2.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952584634  19 TERVIAAAGGMASLPC-------LDGDRVGRKAGYRklaLSWS-FERTGMGKVP---LLMMGSDGVVKRGLcETSGRTRV 87
Cdd:cd05901     4 SSRVHGSLSGSVVLPCrfstlptLPPSYNITSEFLR---IKWTkIQVDKNGKDHketTVLVAQNGIIKIGQ-EYMGRVSV 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1952584634  88 SGERTDAGDYSLTARDLRSTDAGVYSCEVRHGsvyleravelhvVQVTTDAVGLPLEG 145
Cdd:cd05901    80 PSHPEDQGDASLTIVKLRASDAGVYRCEVMHG------------IEDTQDTVSLDVSG 125
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 22-132 7.35e-06

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 44.37  E-value: 7.35e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952584634  22 VIAAAGGMASLPCLDGDRVGRKAGYrklaLSWSFERTGMG-KVPLLMMGSDGVVKRglceTSGRTRVSGErTDAGDYSLT 100
Cdd:pfam07686   6 VTVALGGSVTLPCTYSSSMSEASTS----VYWYRQPPGKGpTFLIAYYSNGSEEGV----KKGRFSGRGD-PSNGDGSLT 76

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1952584634 101 ARDLRSTDAGVYSCEVR-HGSVYLERAVELHVV 132
Cdd:pfam07686  77 IQNLTLSDSGTYTCAVIpSGEGVFGKGTRLTVL 109
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 144-220 4.28e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 41.72  E-value: 4.28e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1952584634  144 EGSKLNLLCEmAEPLTGARYSWHRGGNMVTPTGQRV-WTGDSGR-KLHFSTLKPEDQGDWECHVTFEMLSVNAHYQLKV 220
Cdd:smart00410   8 EGESVTLSCE-ASGSPPPEVTWYKQGGKLLAESGRFsVSRSGSTsTLTISNVTPEDSGTYTCAATNSSGSASSGTTLTV 85
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 143-206 1.54e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 39.86  E-value: 1.54e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1952584634 143 LEGSKLNLLCEmAEPLTGARYSWHRGGNMVTPTGQRVWT-GDSGRKLHFSTLKPEDQGDWECHVT 206
Cdd:pfam13927  14 REGETVTLTCE-ATGSPPPTITWYKNGEPISSGSTRSRSlSGSNSTLTISNVTRSDAGTYTCVAS 77
Ig_Pro_neuregulin cd05750
Immunoglobulin (Ig)-like domain in neuregulins; The members here are composed of the ...
 144-205 7.86e-04

Immunoglobulin (Ig)-like domain in neuregulins; The members here are composed of the immunoglobulin (Ig)-like domain in neuregulins (NRGs). NRGs are signaling molecules which participate in cell-cell interactions in the nervous system, breast, heart, and other organ systems, and are implicated in the pathology of diseases including schizophrenia, multiple sclerosis, and breast cancer. There are four members of the neuregulin gene family (NRG-1, NRG-2, NRG-3, and NRG-4). The NRG-1 protein, binds to and activates the tyrosine kinases receptors ErbB3 and ErbB4, initiating signaling cascades. The other NRGs proteins bind one or the other or both of these ErbBs. NRG-1 has multiple functions: in the brain it regulates various processes such as radial glia formation and neuronal migration, dendritic development, and expression of neurotransmitters receptors, while in the peripheral nervous system NRG-1 regulates processes such as target cell differentiation, and Schwann cell survival. There are many NRG-1 isoforms which arise from the alternative splicing of mRNA. Less is known of the functions of the other NRGs. NRG-2 and NRG-3 are expressed predominantly in the nervous system. NRG-2 is expressed by motor neurons and terminal Schwann cells, and is concentrated near synaptic sites and may be a signal that regulates synaptic differentiation. NRG-4 has been shown to direct pancreatic islet cell development towards the delta-cell lineage.


Pssm-ID: 409408 [Multi-domain]  Cd Length: 92  Bit Score: 38.26  E-value: 7.86e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1952584634 144 EGSKLNLLCEMAEPLTGARYSWHRGGNMVT---PTGQRVWTGDSGRKLHFSTLKPEDQGDWECHV 205
Cdd:cd05750    13 EGSKLVLKCEATSENPSPRYRWFKDGKELNrkrPKNIKIRNKKKNSELQINKAKLEDSGEYTCVV 77
IGv smart00406
Immunoglobulin V-Type;
51-116 8.68e-04

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 37.75  E-value: 8.68e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1952584634   51 LSWSFERTGmgkVPLLMMGSDGVVKRGLCETSGRTRVSGER-TDAGDYSLTARDLRSTDAGVYSCEV 116
Cdd:smart00406  18 VSWVRQPPG---KGLEWLGYIGSNGSSYYQESYKGRFTISKdTSKNDVSLTISNLRVEDTGTYYCAV 81
 
Name Accession Description Interval E-value
Ig_Versican cd05901
Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), ...
 19-145 2.20e-07

Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), versican; The members here are composed of the immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), versican. In CSPGs, the Ig-like domain is followed by hyaluronan (HA)-binding tandem repeats, and a C-terminal region with epidermal growth factor-like, lectin-like, and complement regulatory protein-like domains. Separating these N- and C-terminal regions is a nonhomologous glycosaminoglycan attachment region. In cartilage, the CSPG aggrecan (not included in this group) forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Like aggrecan, versican has a wide distribution in connective tissue and extracellular matrices. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 409482  Cd Length: 128  Bit Score: 49.57  E-value: 2.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952584634  19 TERVIAAAGGMASLPC-------LDGDRVGRKAGYRklaLSWS-FERTGMGKVP---LLMMGSDGVVKRGLcETSGRTRV 87
Cdd:cd05901     4 SSRVHGSLSGSVVLPCrfstlptLPPSYNITSEFLR---IKWTkIQVDKNGKDHketTVLVAQNGIIKIGQ-EYMGRVSV 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1952584634  88 SGERTDAGDYSLTARDLRSTDAGVYSCEVRHGsvyleravelhvVQVTTDAVGLPLEG 145
Cdd:cd05901    80 PSHPEDQGDASLTIVKLRASDAGVYRCEVMHG------------IEDTQDTVSLDVSG 125
Ig_Aggrecan_like cd05878
Immunoglobulin (Ig)-like domain of the aggrecan-like chondroitin sulfate proteoglycan core ...
 22-131 6.83e-07

Immunoglobulin (Ig)-like domain of the aggrecan-like chondroitin sulfate proteoglycan core protein (CSPG); The members here are composed of the immunoglobulin (Ig)-like domain of the aggrecan-like chondroitin sulfate proteoglycan core proteins (CSPGs). Included in this group are the Ig domains of other CSPGs: versican, and neurocan. In CSPGs, this Ig-like domain is followed by hyaluronan (HA)-binding tandem repeats, and a C-terminal region with epidermal growth factor-like, lectin-like, and complement regulatory protein-like domains. Separating these N- and C-terminal regions is a nonhomologous glycosaminoglycan attachment region. In cartilage, aggrecan forms cartilage link protein stabilized aggregates with hyaluronan (HA). These aggregates contribute to the tissue's load bearing properties. Aggrecan and versican have a wide distribution in connective tissue and extracellular matrices. Neurocan is localized almost exclusively in nervous tissue. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 409462  Cd Length: 125  Bit Score: 48.00  E-value: 6.83e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952584634  22 VIAAAGGMASLPCLDGDR---VGRKAGYRKLALSWSFERTGMGK---VPLLMmGSDGVVKRGlCETSGRTRVSGERTDAG 95
Cdd:cd05878     7 VRVLLGTSVTLPCYFIDPphpVTPSTAPLAPRIKWSKVSVDGKKekeVVLLV-ATEGRVRVN-SAYQGRVSLPNYPAIPS 84

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1952584634  96 DYSLTARDLRSTDAGVYSCEVRHGSVYLERAVELHV 131
Cdd:cd05878    85 DATLEVQSLRASDSGLYRCEVMHGIEDSQDTVELVV 120
Ig_CSPGs_LP_like cd05714
Immunoglobulin (Ig)-like domain of chondroitin sulfate proteoglycans (CSPGs), human cartilage ...
 22-145 3.45e-06

Immunoglobulin (Ig)-like domain of chondroitin sulfate proteoglycans (CSPGs), human cartilage link protein (LP), and similar domains; The members here are composed of the immunoglobulin (Ig)-like domain similar to that found in chondroitin sulfate proteoglycans (CSPGs) and human cartilage link protein (LP). Included in this group are the CSPGs aggrecan, versican, and neurocan. In CSPGs, this Ig-like domain is followed by hyaluronan (HA)-binding tandem repeats, and a C-terminal region with epidermal growth factor-like, lectin-like, and complement regulatory protein-like domains. Separating these N- and C-terminal regions is a nonhomologous glycosaminoglycan attachment region. In cartilage, aggrecan forms cartilage link protein stabilized aggregates with hyaluronan (HA). These aggregates contribute to the tissue's load bearing properties. Aggrecan and versican have a wide distribution in connective tissue and extracellular matrices. Neurocan is localized almost exclusively in nervous tissue. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. There is considerable evidence that HA-binding CSPGs are involved in developmental processes in the central nervous system. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 409379  Cd Length: 123  Bit Score: 45.66  E-value: 3.45e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952584634  22 VIAAAGGMASLPCL-DGDRVGRKAGYRKLALSWSFERTGMG---KVPLLMmGSDGVVKRGLcETSGRTRVSGERTDAGDY 97
Cdd:cd05714     7 VFSHLGGNVTLPCKfYRDPTAFGSGIHKIRIKWTKLTSDSGylkEVDVLV-AMGNVVYHKK-TYGGRVSVPLKPGSDSDA 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1952584634  98 SLTARDLRSTDAGVYSCEVRHGsvyleravelhvVQVTTDAVGLPLEG 145
Cdd:cd05714    85 SLVITDLTASDYGLYRCEVIEG------------IEDDQDVVALDVQG 120
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 22-132 7.35e-06

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 44.37  E-value: 7.35e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952584634  22 VIAAAGGMASLPCLDGDRVGRKAGYrklaLSWSFERTGMG-KVPLLMMGSDGVVKRglceTSGRTRVSGErTDAGDYSLT 100
Cdd:pfam07686   6 VTVALGGSVTLPCTYSSSMSEASTS----VYWYRQPPGKGpTFLIAYYSNGSEEGV----KKGRFSGRGD-PSNGDGSLT 76

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1952584634 101 ARDLRSTDAGVYSCEVR-HGSVYLERAVELHVV 132
Cdd:pfam07686  77 IQNLTLSDSGTYTCAVIpSGEGVFGKGTRLTVL 109
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 144-220 4.28e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 41.72  E-value: 4.28e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1952584634  144 EGSKLNLLCEmAEPLTGARYSWHRGGNMVTPTGQRV-WTGDSGR-KLHFSTLKPEDQGDWECHVTFEMLSVNAHYQLKV 220
Cdd:smart00410   8 EGESVTLSCE-ASGSPPPEVTWYKQGGKLLAESGRFsVSRSGSTsTLTISNVTPEDSGTYTCAATNSSGSASSGTTLTV 85
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 143-206 1.54e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 39.86  E-value: 1.54e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1952584634 143 LEGSKLNLLCEmAEPLTGARYSWHRGGNMVTPTGQRVWT-GDSGRKLHFSTLKPEDQGDWECHVT 206
Cdd:pfam13927  14 REGETVTLTCE-ATGSPPPTITWYKNGEPISSGSTRSRSlSGSNSTLTISNVTRSDAGTYTCVAS 77
IgV_1_CD4 cd07690
First immunoglobulin (Ig) domain of Cluster of Differentiation (CD) 4; member of the V-set of ...
 22-131 1.56e-04

First immunoglobulin (Ig) domain of Cluster of Differentiation (CD) 4; member of the V-set of IgSF domains; The members here are composed of the first immunoglobulin (Ig) domain of Cluster of Differentiation (CD) 4. CD4 and CD8 are the two primary co-receptor proteins found on the surface of T cells, and the presence of either CD4 or CD8 determines the function of the T cell. CD4 is found on helper T cells, where it is required for the binding of MHC (major histocompatibility complex) class II molecules, while CD8 is found on cytotoxic T cells, where it is required for the binding of MHC class I molecules. CD4 contains four immunoglobulin domains, with the first three included in this hierarchy. The fourth domain has a general Ig architecture, but has slight topological changes in the arrangement of beta strands relative to the other structures in this family and is not specifically included in the hierarchy.


Pssm-ID: 409487  Cd Length: 97  Bit Score: 40.61  E-value: 1.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952584634  22 VIAAAGGMASLPCldgdrvgrKAGYRK-LALSW--SFERTGMGKVPLLMMgsdgvvkRGLCETSGRTRVSGERTDAGDYS 98
Cdd:cd07690     4 VLGKKGDTAELPC--------TASQKKsIQFHWknSNQIKILGNQGSFLT-------KGPSKLNDRADSRRNLWDQGSFP 68

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1952584634  99 LTARDLRSTDAGVYSCEVRHGsvylERAVELHV 131
Cdd:cd07690    69 LIIKNLKIEDSDTYICEVEDK----KEEVELLV 97
Ig_Aggrecan cd05900
Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), ...
 70-131 2.48e-04

Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), aggrecan; The members here are composed of the immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), aggrecan. In CSPGs, the Ig-like domain is followed by hyaluronan (HA)-binding tandem repeats, and a C-terminal region with epidermal growth factor-like, lectin-like, and complement regulatory protein-like domains. Separating these N- and C-terminal regions is a nonhomologous glycosaminoglycan attachment region. In cartilage, aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggrecan has a wide distribution in connective tissue and extracellular matrices. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 409481  Cd Length: 123  Bit Score: 40.69  E-value: 2.48e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1952584634  70 SDGVVKRGLCETSGRTRVSGERTD----------AGDYSLTARDLRSTDAGVYSCEVRHGSVYLERAVELHV 131
Cdd:cd05900    47 SKEKESVLLVATEGKVRVNTEYLDrvslpnypaiPSDATLEITELRSNDSGTYRCEVMHGIEDNYDTVEVQV 118
Ig_LP_like cd05877
Immunoglobulin (Ig)-like domain of human cartilage link protein (LP), and similar domains; The ...
 20-119 3.39e-04

Immunoglobulin (Ig)-like domain of human cartilage link protein (LP), and similar domains; The members here are composed of the immunoglobulin (Ig)-like domain similar to that found in human cartilage link protein (LP; also called hyaluronan and proteoglycan link protein). In cartilage, chondroitin-keratan sulfate proteoglycan (CSPG), aggrecan, forms cartilage link protein stabilized aggregates with hyaluronan (HA). These aggregates contribute to the tissue's load bearing properties. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 409461  Cd Length: 117  Bit Score: 40.00  E-value: 3.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952584634  20 ERVIAAAGGMASLPC-LDGDRvgRKAGYRKLALSWSFERTGMGK--VPLLMMG----SDGVVKRglcetsgrtRVSGERT 92
Cdd:cd05877     5 AKVFSHRGGNVTLPCrYHYEP--ELSAPRKIRVKWTKLEVDYAKeeDVLVAIGtrhkSYGSYQG---------RVFLRRA 73

                          90       100
                  ....*....|....*....|....*..
gi 1952584634  93 DAGDYSLTARDLRSTDAGVYSCEVRHG 119
Cdd:cd05877    74 DDLDASLVITDLRLEDYGRYRCEVIDG 100
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 143-214 7.76e-04

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 38.33  E-value: 7.76e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1952584634 143 LEGSKLNLLCEMAEPLTGARYSWHRGGNmVTPTGQRVWTGDSGRK---LHFSTLKPEDQGDWECHVTFEMLSVNA 214
Cdd:pfam00047   9 LEGDSATLTCSASTGSPGPDVTWSKEGG-TLIESLKVKHDNGRTTqssLLISNVTKEDAGTYTCVVNNPGGSATL 82
Ig_Pro_neuregulin cd05750
Immunoglobulin (Ig)-like domain in neuregulins; The members here are composed of the ...
 144-205 7.86e-04

Immunoglobulin (Ig)-like domain in neuregulins; The members here are composed of the immunoglobulin (Ig)-like domain in neuregulins (NRGs). NRGs are signaling molecules which participate in cell-cell interactions in the nervous system, breast, heart, and other organ systems, and are implicated in the pathology of diseases including schizophrenia, multiple sclerosis, and breast cancer. There are four members of the neuregulin gene family (NRG-1, NRG-2, NRG-3, and NRG-4). The NRG-1 protein, binds to and activates the tyrosine kinases receptors ErbB3 and ErbB4, initiating signaling cascades. The other NRGs proteins bind one or the other or both of these ErbBs. NRG-1 has multiple functions: in the brain it regulates various processes such as radial glia formation and neuronal migration, dendritic development, and expression of neurotransmitters receptors, while in the peripheral nervous system NRG-1 regulates processes such as target cell differentiation, and Schwann cell survival. There are many NRG-1 isoforms which arise from the alternative splicing of mRNA. Less is known of the functions of the other NRGs. NRG-2 and NRG-3 are expressed predominantly in the nervous system. NRG-2 is expressed by motor neurons and terminal Schwann cells, and is concentrated near synaptic sites and may be a signal that regulates synaptic differentiation. NRG-4 has been shown to direct pancreatic islet cell development towards the delta-cell lineage.


Pssm-ID: 409408 [Multi-domain]  Cd Length: 92  Bit Score: 38.26  E-value: 7.86e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1952584634 144 EGSKLNLLCEMAEPLTGARYSWHRGGNMVT---PTGQRVWTGDSGRKLHFSTLKPEDQGDWECHV 205
Cdd:cd05750    13 EGSKLVLKCEATSENPSPRYRWFKDGKELNrkrPKNIKIRNKKKNSELQINKAKLEDSGEYTCVV 77
IGv smart00406
Immunoglobulin V-Type;
51-116 8.68e-04

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 37.75  E-value: 8.68e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1952584634   51 LSWSFERTGmgkVPLLMMGSDGVVKRGLCETSGRTRVSGER-TDAGDYSLTARDLRSTDAGVYSCEV 116
Cdd:smart00406  18 VSWVRQPPG---KGLEWLGYIGSNGSSYYQESYKGRFTISKdTSKNDVSLTISNLRVEDTGTYYCAV 81
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 20-131 1.51e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 37.48  E-value: 1.51e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952584634   20 ERVIAAAGGMASLPCldgdrvgRKAGYRKLALSWSFErtgmGKVPLLmmgsdgvvkrglceTSGRTRVSGertDAGDYSL 99
Cdd:smart00410   2 PSVTVKEGESVTLSC-------EASGSPPPEVTWYKQ----GGKLLA--------------ESGRFSVSR---SGSTSTL 53

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1952584634  100 TARDLRSTDAGVYSCEVRHGSVYLERAVELHV 131
Cdd:smart00410  54 TISNVTPEDSGTYTCAATNSSGSASSGTTLTV 85
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 148-206 2.92e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 36.15  E-value: 2.92e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952584634 148 LNLLCEmAEPLTGARYSWHRGGNMVTPTGQ-RVWTGDSGRKLHFSTLKPEDQGDWECHVT 206
Cdd:cd00096     1 VTLTCS-ASGNPPPTITWYKNGKPLPPSSRdSRRSELGNGTLTISNVTLEDSGTYTCVAS 59
IgC2_2_CD4 cd07694
Second immunoglobulin (Ig) domain of Cluster of Differentiation (CD) 4; member of the C2-set ...
 165-223 3.00e-03

Second immunoglobulin (Ig) domain of Cluster of Differentiation (CD) 4; member of the C2-set of IgSF domains; The members here are composed of the second immunoglobulin (Ig) Constant 2 (C2)-set domain of Cluster of Differentiation (CD) 4. CD4 and CD8 are the two primary co-receptor proteins found on the surface of T cells, and the presence of either CD4 or CD8 determines the function of the T cell. CD4 is found on helper T cells, where it is required for the binding of MHC (major histocompatibility complex) class II molecules, while CD8 is found on cytotoxic T cells, where it is required for the binding of MHC class I molecules. CD4 contains four immunoglobulin domains, with the first three included in this hierarchy. The fourth domain has a general Ig architecture, but has slight topological changes in the arrangement of beta strands relative to the other structures in this family and is not specifically included in the hierarchy. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group belongs to the C2-set of IgSF domains, having A, B, and E strands in one beta-sheet and A', G, F, C' in the other. Unlike other Ig domain sets, the C2-set lacks the D strand.


Pssm-ID: 409491  Cd Length: 88  Bit Score: 36.51  E-value: 3.00e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952584634 165 WHRGGN-MVTPTGQRVWTgdsgrkLHFSTLKPEDQGDWECHVTFEMLSVNAHYQLKVLGF 223
Cdd:cd07694    35 WRGPGNkSKQILNQDKKT------LNLVQLGPNDSGTWDCIVSVNSSEKTLKLDIKVLAF 88
Ig_Neurocan cd05902
Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), ...
 22-134 3.34e-03

Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), neurocan; The members here are composed of the immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), neurocan. In CSPGs, the Ig-like domain is followed by hyaluronan (HA)-binding tandem repeats, and a C-terminal region with epidermal growth factor-like, lectin-like, and complement regulatory protein-like domains. Separating these N- and C-terminal regions is a nonhomologous glycosaminoglycan attachment region. In cartilage, the CSPG aggrecan (not included in this group) forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Unlike aggrecan which is widely distributed in connective tissue and extracellular matrices, neurocan is localized almost exclusively in nervous tissue. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 409483  Cd Length: 121  Bit Score: 37.12  E-value: 3.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952584634  22 VIAAAGGMASLPCLDGDRVGRKAGYRKLALSWSFERTGMGK--VPLLMmGSDGVVK--RGLcetSGRTRVSGERTDAGDY 97
Cdd:cd05902     7 VRRPLSSSVLLPCVFTLPPSASSPPEGPRIKWTKLSTSGGQqqRPVLV-ARDNVVRvaKAF---QGRVSLPGYPKNRYNA 82

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1952584634  98 SLTARDLRSTDAGVYSCEVRHGSVYLERAVELHVVQV 134
Cdd:cd05902    83 SLVLSRLRYSDSGTYRCEVVLGINDEQDTVPLEVTGV 119
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 22-124 5.88e-03

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 36.16  E-value: 5.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952584634  22 VIAAAGGMASLPCLdgdrvgRKAGYRKLALSWSFERTGMGkvPLLMMGSDGVVKRGLCETSGRtrVSGERTDAGDYSLTA 101
Cdd:cd00099     8 LSVQEGESVTLSCE------VSSSFSSTYIYWYRQKPGQG--PEFLIYLSSSKGKTKGGVPGR--FSGSRDGTSSFSLTI 77

                          90       100
                  ....*....|....*....|...
gi 1952584634 102 RDLRSTDAGVYSCEVRHGSVYLE 124
Cdd:cd00099    78 SNLQPEDSGTYYCAVSESGGTDK 100
IgV_CAR_like cd20960
Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and ...
 94-129 6.43e-03

Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins; The members here are composed of the Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins. CAR, which is encoded by human CXADR gene, is a cell adhesion molecule of the Immunoglobulin (Ig) superfamily. The CAR acts as a type I membrane receptor for group B1-B6 coxsackie viruses and subgroup C adenoviruses. For instance, adenovirus interacts with the coxsackievirus and adenovirus receptor to enter epithelial airway cells. The CAR is also shown to be involved in physiological processes such as neuronal and heart development, epithelial tight junction integrity, and tumor suppression. The CAR is a component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. The CAR is also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. The CAR is composed of one V-set and one C2-set Ig module, a single transmembrane helix, and an intracellular domain. This group belongs to the V-set of IgSF domains, having A, B, E and D strands in one beta-sheet and A', G, F, C, C' and C" in the other


Pssm-ID: 409552  Cd Length: 114  Bit Score: 36.27  E-value: 6.43e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1952584634  94 AGDYSLTARDLRSTDAGVYSCEVRHGSVYLERAVEL 129
Cdd:cd20960    78 SGDASLNISNLKLSDTGTYQCKVKKAPGYAWSKITL 113
IgV_MOG_like cd05713
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); The members here ...
 83-131 8.15e-03

Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); The members here are composed of the immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG). MOG, a minor component of the myelin sheath, is an important CNS-specific autoantigen, linked to the pathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). It is a transmembrane protein having an extracellular Ig domain. MOG is expressed in the CNS on the outermost lamellae of the myelin sheath, and on the surface of oligodendrocytes, and may participate in the completion, compaction, and/or maintenance of myelin. This group also includes butyrophilin (BTN). BTN is the most abundant protein in bovine milk-fat globule membrane (MFGM).


Pssm-ID: 409378  Cd Length: 114  Bit Score: 36.02  E-value: 8.15e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1952584634  83 GRTRVSGERTDAGDYSLTARDLRSTDAGVYSCEVRHGSVYLERAVELHV 131
Cdd:cd05713    65 GRTELLKDAIAEGSVALRIHNVRPSDEGQYTCFFRSGSFYEEATLELKV 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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