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Conserved domains on  [gi|1958794504|ref|XP_038936706|]
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protocadherin Fat 3 isoform X1 [Rattus norvegicus]

Protein Classification

cadherin repeat domain-containing protein( domain architecture ID 10877445)

cadherin repeat domain-containing protein similar to cadherins, which are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1048-1143 1.74e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 126.27  E-value: 1.74e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 1048 VGSVKENSRIGTSVLQVTAHDEDSGRDGEIQYSIRDGSGLGRFNIDDESGVITAADILDRETTASYWLTVYATDRGVVPL 1127
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                           90
                   ....*....|....*.
gi 1958794504 1128 YSTIEVYIEVEDVNDN 1143
Cdd:cd11304     83 SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1151-1249 4.26e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 125.12  E-value: 4.26e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 1151 IYYPVVMENSPKDVSVIQIQAEDPDSGSNEKLTYRITSGNPQNFFAINIKTGLITTTsRKLDREQQAEHFLEVTVTDGGS 1230
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTA-KPLDREEQSSYTLTVTATDGGG 79

                           90
                   ....*....|....*....
gi 1958794504 1231 SPKQSTIWVVVQVLDENDN 1249
Cdd:cd11304     80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3263-3359 6.40e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 124.35  E-value: 6.40e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 3263 YLVTVPEDTSLGTQVLSVFATSKDIGTNAEITYLIRSGNEQGKFRINPKTGGISVLEALDYEMCKRFYLVVEAKDGGTPA 3342
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*..
gi 1958794504 3343 LSTAATVSIDLTDVNDN 3359
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3367-3464 3.67e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 119.34  E-value: 3.67e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 3367 VYSAVISEDALEGDSVILLIAEDVDSKPNGQIRFSIVGGDRDNEFAVDPILGLVKVKKKLDRERVSGYSLLIQAVDSGIP 3446
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1958794504 3447 AMSSTTTVNIDISDVNDN 3464
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3157-3254 1.13e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 118.18  E-value: 1.13e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 3157 HYTACVYENTATKALLTRVQAVDPDVGINRKVVYSL-EDSASGVFSIDSSSGVIVLEQPLDREQQSSYNISVRATDQSpG 3235
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG-G 79

                           90
                   ....*....|....*....
gi 1958794504 3236 QSLSSLTSVTITVLDINDN 3254
Cdd:cd11304     80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2313-2412 1.19e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 118.18  E-value: 1.19e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 2313 TYNTTLSESSLIGTPVLQLVSTDADSGNNNLVHYQIVQDtyNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVTATDNG 2392
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG--NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 1958794504 2393 FPSLSSEVLVQIYISDVNDN 2412
Cdd:cd11304     79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 732-826 6.77e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 113.18  E-value: 6.77e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  732 VAVKENMPVGTNILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYVLNITIYDLGKPQKS 811
Cdd:cd11304      4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                           90
                   ....*....|....*
gi 1958794504  812 SWRLLTVNVEDANDN 826
Cdd:cd11304     84 STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 476-573 1.37e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 112.02  E-value: 1.37e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  476 YETFVNESVPVGTNVLTVSASDKDKGENGYITYSIASLN-LLPFAINQFTGVISTTEELDFESSPEtYRFIVRASDWGSP 554
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNeDGLFSIDPSTGEITTAKPLDREEQSS-YTLTVTATDGGGP 80

                           90
                   ....*....|....*....
gi 1958794504  555 yRHESEVNVTIRVGNVNDN 573
Cdd:cd11304     81 -PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2840-2942 1.14e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 109.71  E-value: 1.14e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 2840 SYETIIMEGMPVGTKLAQVRAIDTDWGANGQVTYSLHSDSHLEKvmeaFNIDSNTGWISTLKDLDHETDPTFSFFVVASD 2919
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGL----FSIDPSTGEITTAKPLDREEQSSYTLTVTATD 76

                           90       100
                   ....*....|....*....|...
gi 1958794504 2920 LGEaFSLSSMALVSVKVTDINDN 2942
Cdd:cd11304     77 GGG-PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3056-3149 1.80e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.94  E-value: 1.80e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 3056 YSASLPEDIPSNKIILKVSAKDADIGSNGDIRYSLYGSGNSDFF-LDPESGELKTLALLDRERVPVYNLIARATDGGG-- 3132
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFsIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGpp 81

                           90
                   ....*....|....*..
gi 1958794504 3133 RFCSSTVLLLLEDVNDN 3149
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 834-930 2.03e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.94  E-value: 2.03e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  834 SYSVSILESSSIGTEIIQVEARDKDLGSNGEVTYSVL--TDTHQFVINSSTGIVYIADQLDRESKANYSLKIEARDKAes 911
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG-- 78

                           90
                   ....*....|....*....
gi 1958794504  912 GQQLFSVVTLKIFLDDVND 930
Cdd:cd11304     79 GPPLSSTATVTITVLDVND 97
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 3887-4016 2.17e-27

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 109.82  E-value: 2.17e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 3887 LRTLQSNGIIMYTRA--NPCMILKIVEGKLWFQLDCGSGPGILGISSRAVNDGSWHSVFLELNRNFTSLSLDDSYVERRR 3964
Cdd:pfam02210    1 FRTRQPNGLLLYAGGggSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSL 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1958794504 3965 APLYFQTLSTDSAIFFGALVQADNIRSLtdtrvtQVLGGFQGCLDSVVLNHN 4016
Cdd:pfam02210   81 PPGESLLLNLNGPLYLGGLPPLLLLPAL------PVRAGFVGCIRDVRVNGE 126
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1795-1901 3.08e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.17  E-value: 3.08e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 1795 QYSGSLSEAAPINSLVrsldnspLVIRATDADSNQNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHEVIAHFHFHVH 1874
Cdd:cd11304      1 SYEVSVPENAPPGTVV-------LTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVT 73

                           90       100
                   ....*....|....*....|....*..
gi 1958794504 1875 VRDSGNPQLTaeSPVEVNIEVTDVNDN 1901
Cdd:cd11304     74 ATDGGGPPLS--STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1486-1584 1.28e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 106.63  E-value: 1.28e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 1486 HYDVTISEDVPPDTEILQIEATDRDEKH--KLSYTIHSSIDAismRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQ 1563
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGEngEVTYSIVSGNED---GLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|.
gi 1958794504 1564 EFPYRRNLARVIVNVEDANDH 1584
Cdd:cd11304     78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1593-1683 5.21e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 104.70  E-value: 5.21e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 1593 YEASVFESAALGSVVLQVTALDKDKGENAELIYSIEAGNTGNTFKIEPVLGIITISKEPDMTAMGQFVLSVKVTDQGSPP 1672
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|.
gi 1958794504 1673 MSATAIVRISI 1683
Cdd:cd11304     82 LSSTATVTITV 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 161-261 5.47e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.01  E-value: 5.47e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  161 TYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFK--NKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRgmk 238
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG--- 77

                           90       100
                   ....*....|....*....|...
gi 1958794504  239 lyGNNGVSSTAKLYVHIERINEH 261
Cdd:cd11304     78 --GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1698-1787 1.11e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 100.85  E-value: 1.11e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 1698 YQAEVNENVDIGTSVILISAISQ-----STLIYEVKDGNINGVFTINPYSGVITTRRALDYEHTSSYQLIIQATNMAG-- 1770
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPdsgenGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGpp 81

                           90
                   ....*....|....*..
gi 1958794504 1771 MASNATVSVQVVDENDN 1787
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2522-2618 1.81e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 100.47  E-value: 1.81e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 2522 TYVAEVRENAASGTKVIHVRATDGDPGTYGQVSYSIINDFAKDRFLIDSN-GQIITTERLDRENPLEgdISIYLRALDGG 2600
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPStGEITTAKPLDREEQSS--YTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 1958794504 2601 G--RTTFCTVRVIVVDENDN 2618
Cdd:cd11304     79 GppLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 939-1022 6.78e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 98.92  E-value: 6.78e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  939 SYSVKVLEDLPVGTVIAWLETQDPDLGLGGQVRYSLV-NDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRP 1017
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80


                   ....*
gi 1958794504 1018 vSLSS 1022
Cdd:cd11304     81 -PLSS 84
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2950-3047 4.83e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.53  E-value: 4.83e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 2950 VYRGNVKESDPPGEVVAVLSTLDKDtSNINRQVSYHITGGNPRGRFALGmvQSEWKVYVKRPLDREEQDIYFLNITASDG 3029
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPD-SGENGEVTYSIVSGNEDGLFSID--PSTGEITTAKPLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|.
gi 1958794504 3030 ---LFVTQAMVEVTVSDVNDN 3047
Cdd:cd11304     78 ggpPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2213-2305 6.86e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.15  E-value: 6.86e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 2213 YTASINEDISINTPILSINAT---SPEGQGIIYLIIDGDPFQQFNIDFDTGVLKVISPLDYEVMSVYKLTVRASDALTGA 2289
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATdpdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*..
gi 1958794504 2290 R-AEVTVDLLVDDVNDN 2305
Cdd:cd11304     82 LsSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2110-2201 6.31e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 87.37  E-value: 6.31e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 2110 PYYAAVQVDAEPGTLIYRVTAIDKDKGANGEVTYVL--QDDYGHFEINPNSGNVILKEAFNSDLSNIdYGVTILAKDGGT 2187
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsGNEDGLFSIDPSTGEITTAKPLDREEQSS-YTLTVTATDGGG 79

                           90
                   ....*....|....
gi 1958794504 2188 PSLSTFVELPITIV 2201
Cdd:cd11304     80 PPLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1257-1347 9.40e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.98  E-value: 9.40e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 1257 VYQIKLPERDrkKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQF---TAGSYdILTIKAVDN 1333
Cdd:cd11304      1 SYEVSVPENA--PPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLdreEQSSY-TLTVTATDG 77

                           90
                   ....*....|....
gi 1958794504 1334 GRPQKSSTARLHIE 1347
Cdd:cd11304     78 GGPPLSSTATVTIT 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2626-2721 1.26e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.90  E-value: 1.26e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 2626 EYRASVRADVGRGHLVTQVQALDPDDGANSRITYSLYSEasvSVADLLEIDPDNGWMVTKGNFNQLRNTVLSFFVKAVDG 2705
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG---NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                           90
                   ....*....|....*.
gi 1958794504 2706 GIPVRHSLIPVYIHVL 2721
Cdd:cd11304     78 GGPPLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2420-2512 1.72e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.52  E-value: 1.72e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 2420 IYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVLTLSSHRKQRMEPLYSLNVSVSDG--- 2496
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGggp 80

                           90
                   ....*....|....*.
gi 1958794504 2497 LFTSTAQVHIRVLGAN 2512
Cdd:cd11304     81 PLSSTATVTITVLDVN 96
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3473-3564 3.90e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.36  E-value: 3.90e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 3473 YTAVIQENKPVGTSILQLVVTDRDSFHNGpPFSFSILSGNEDEEFMLDSH-GILRSAVVFRHMESPEYLLCIQAKDSGKP 3551
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENG-EVTYSIVSGNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|...
gi 1958794504 3552 QQVSHTYIRVRVI 3564
Cdd:cd11304     81 PLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 379-467 1.02e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 72.73  E-value: 1.02e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  379 VYDISISEFSPPGVMVAIVKVN----PEPLDVEYTLLPGKDAEYFKINPRSGLIVTAQPLNTVKKEVYKLEVSDKEGD-- 452
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATdpdsGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGgp 80

                           90
                   ....*....|....*...
gi 1958794504  453 ---AKAQVTIGIEDANDH 467
Cdd:cd11304     81 plsSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2009-2102 2.41e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 71.58  E-value: 2.41e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 2009 YSTSISENSTNITKVAIVNAV--GNRLNEPLKYSIL--NPGNKFKIKSTSGVIQTTGvPFDREEQELYELVVEASrelDH 2084
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATdpDSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAK-PLDREEQSSYTLTVTAT---DG 77

                           90       100
                   ....*....|....*....|.
gi 1958794504 2085 LRVARVVVRV---NIEDVNDN 2102
Cdd:cd11304     78 GGPPLSSTATvtiTVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1920-1999 4.53e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 70.81  E-value: 4.53e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 1920 VGVEVLKVSATDPDSEVPPELTYSLMEGSVD-HFLMDPNTGVLTIKN--NNLSKDHYMLIVRVSDG---KFYSTAMVTIM 1993
Cdd:cd11304     12 PGTVVLTVSATDPDSGENGEVTYSIVSGNEDgLFSIDPSTGEITTAKplDREEQSSYTLTVTATDGggpPLSSTATVTIT 91


                   ....*.
gi 1958794504 1994 VKEAMD 1999
Cdd:cd11304     92 VLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2734-2832 3.34e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 68.11  E-value: 3.34e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 2734 QYSFTIAEDTSIGSTIDTLR-----ILPNQSVRFSTVNGerpenNKENVFIIEQETGAIKLDKRLDHEVSPAFHFKVAAT 2808
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSatdpdSGENGEVTYSIVSG-----NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                           90       100
                   ....*....|....*....|....*.
gi 1958794504 2809 iplDKVDIVF--TVDVDVKVLDLNDN 2832
Cdd:cd11304     76 ---DGGGPPLssTATVTITVLDVNDN 98
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 4120-4155 1.36e-12

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 64.58  E-value: 1.36e-12
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1958794504 4120 DVDECEREE-CENGGSCVNLFGSFFCNCTPGYVGQYC 4155
Cdd:cd00054      1 DIDECASGNpCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1366-1478 5.48e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 61.95  E-value: 5.48e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 1366 YNFTIMESDKVTEIVGVVSVQ----PANTPLWFDIIGGkHAREMFYIlqtacgqncsteggnfDSSFdaekgvGTIVIAK 1441
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATdpdsGENGEVTYSIVSG-NEDGLFSI----------------DPST------GEITTAK 58

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1958794504 1442 PLDAEQRSVYNMSVEVTDGTN---VAVTQVFITVLDNNDN 1478
Cdd:cd11304     59 PLDREEQSSYTLTVTATDGGGpplSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 591-671 1.45e-09

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 58.09  E-value: 1.45e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  591 PVGGHITAISAIDIDELE--LVKYKIISGNELGFFYLNPDSGVLQLKKSLMNSgiKNGNFALRITATDGEN--FADPMAI 666
Cdd:cd11304     11 PPGTVVLTVSATDPDSGEngEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDRE--EQSSYTLTVTATDGGGppLSSTATV 88


                   ....*
gi 1958794504  667 NISVL 671
Cdd:cd11304     89 TITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3583-3660 1.53e-08

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 55.01  E-value: 1.53e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 3583 MEDDFPGGVIGKIHATDQD--MYDVLTFALKSEQ-KSLFKVNSHDGKIIALGGLD---SGKYVLNVSVSDG---RFQVPI 3653
Cdd:cd11304      7 PENAPPGTVVLTVSATDPDsgENGEVTYSIVSGNeDGLFSIDPSTGEITTAKPLDreeQSSYTLTVTATDGggpPLSSTA 86


                   ....*..
gi 1958794504 3654 DVVVHVE 3660
Cdd:cd11304     87 TVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 47-152 3.94e-08

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 53.86  E-value: 3.94e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504   47 YNATVYENSAARTYVnsqsrMGITLIDL----SWDIKYRIVSGDEEGFFkaeeviiadfcflRIRTKGGN---SAILNRE 119
Cdd:cd11304      2 YEVSVPENAPPGTVV-----LTVSATDPdsgeNGEVTYSIVSGNEDGLF-------------SIDPSTGEittAKPLDRE 63

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1958794504  120 IQDNYLLIIKGSVRGED-LEAWTKVNIQVLDMND 152
Cdd:cd11304     64 EQSSYTLTVTATDGGGPpLSSTATVTITVLDVND 97
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 4079-4118 2.04e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.94  E-value: 2.04e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1958794504 4079 CESeitacfPNPCRNGGSCDPIGNTFICSCKAGLTGVTCE 4118
Cdd:cd00054      5 CAS------GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 4045-4080 3.33e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.17  E-value: 3.33e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1958794504 4045 DACQ-RSPCLHGGSCSGLPsGGYQCSCLSQFTGTNCE 4080
Cdd:cd00054      3 DECAsGNPCQNGGTCVNTV-GSYRCSCPPGYTGRNCE 38
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 285-363 5.49e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 44.26  E-value: 5.49e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958794504   285 TVDDLDEGANGEIeSVSIVDGDPLEQFFLAKEGKWmneykVKERRQVDWESFSYgYNLTIQAKDKGSPQKFSELkTVHI 363
Cdd:smart00112    1 SATDADSGENGKV-TYSILSGNDDGLFSIDPETGE-----ITTTKPLDREEQPE-YTLTVEATDGGGPPLSSTA-TVTI 71
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1048-1143 1.74e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 126.27  E-value: 1.74e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 1048 VGSVKENSRIGTSVLQVTAHDEDSGRDGEIQYSIRDGSGLGRFNIDDESGVITAADILDRETTASYWLTVYATDRGVVPL 1127
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                           90
                   ....*....|....*.
gi 1958794504 1128 YSTIEVYIEVEDVNDN 1143
Cdd:cd11304     83 SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1151-1249 4.26e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 125.12  E-value: 4.26e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 1151 IYYPVVMENSPKDVSVIQIQAEDPDSGSNEKLTYRITSGNPQNFFAINIKTGLITTTsRKLDREQQAEHFLEVTVTDGGS 1230
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTA-KPLDREEQSSYTLTVTATDGGG 79

                           90
                   ....*....|....*....
gi 1958794504 1231 SPKQSTIWVVVQVLDENDN 1249
Cdd:cd11304     80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3263-3359 6.40e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 124.35  E-value: 6.40e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 3263 YLVTVPEDTSLGTQVLSVFATSKDIGTNAEITYLIRSGNEQGKFRINPKTGGISVLEALDYEMCKRFYLVVEAKDGGTPA 3342
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*..
gi 1958794504 3343 LSTAATVSIDLTDVNDN 3359
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3367-3464 3.67e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 119.34  E-value: 3.67e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 3367 VYSAVISEDALEGDSVILLIAEDVDSKPNGQIRFSIVGGDRDNEFAVDPILGLVKVKKKLDRERVSGYSLLIQAVDSGIP 3446
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1958794504 3447 AMSSTTTVNIDISDVNDN 3464
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3157-3254 1.13e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 118.18  E-value: 1.13e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 3157 HYTACVYENTATKALLTRVQAVDPDVGINRKVVYSL-EDSASGVFSIDSSSGVIVLEQPLDREQQSSYNISVRATDQSpG 3235
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG-G 79

                           90
                   ....*....|....*....
gi 1958794504 3236 QSLSSLTSVTITVLDINDN 3254
Cdd:cd11304     80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2313-2412 1.19e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 118.18  E-value: 1.19e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 2313 TYNTTLSESSLIGTPVLQLVSTDADSGNNNLVHYQIVQDtyNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVTATDNG 2392
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG--NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 1958794504 2393 FPSLSSEVLVQIYISDVNDN 2412
Cdd:cd11304     79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 732-826 6.77e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 113.18  E-value: 6.77e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  732 VAVKENMPVGTNILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYVLNITIYDLGKPQKS 811
Cdd:cd11304      4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                           90
                   ....*....|....*
gi 1958794504  812 SWRLLTVNVEDANDN 826
Cdd:cd11304     84 STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 476-573 1.37e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 112.02  E-value: 1.37e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  476 YETFVNESVPVGTNVLTVSASDKDKGENGYITYSIASLN-LLPFAINQFTGVISTTEELDFESSPEtYRFIVRASDWGSP 554
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNeDGLFSIDPSTGEITTAKPLDREEQSS-YTLTVTATDGGGP 80

                           90
                   ....*....|....*....
gi 1958794504  555 yRHESEVNVTIRVGNVNDN 573
Cdd:cd11304     81 -PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2840-2942 1.14e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 109.71  E-value: 1.14e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 2840 SYETIIMEGMPVGTKLAQVRAIDTDWGANGQVTYSLHSDSHLEKvmeaFNIDSNTGWISTLKDLDHETDPTFSFFVVASD 2919
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGL----FSIDPSTGEITTAKPLDREEQSSYTLTVTATD 76

                           90       100
                   ....*....|....*....|...
gi 1958794504 2920 LGEaFSLSSMALVSVKVTDINDN 2942
Cdd:cd11304     77 GGG-PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3056-3149 1.80e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.94  E-value: 1.80e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 3056 YSASLPEDIPSNKIILKVSAKDADIGSNGDIRYSLYGSGNSDFF-LDPESGELKTLALLDRERVPVYNLIARATDGGG-- 3132
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFsIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGpp 81

                           90
                   ....*....|....*..
gi 1958794504 3133 RFCSSTVLLLLEDVNDN 3149
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 834-930 2.03e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.94  E-value: 2.03e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  834 SYSVSILESSSIGTEIIQVEARDKDLGSNGEVTYSVL--TDTHQFVINSSTGIVYIADQLDRESKANYSLKIEARDKAes 911
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG-- 78

                           90
                   ....*....|....*....
gi 1958794504  912 GQQLFSVVTLKIFLDDVND 930
Cdd:cd11304     79 GPPLSSTATVTITVLDVND 97
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 3887-4016 2.17e-27

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 109.82  E-value: 2.17e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 3887 LRTLQSNGIIMYTRA--NPCMILKIVEGKLWFQLDCGSGPGILGISSRAVNDGSWHSVFLELNRNFTSLSLDDSYVERRR 3964
Cdd:pfam02210    1 FRTRQPNGLLLYAGGggSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSL 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1958794504 3965 APLYFQTLSTDSAIFFGALVQADNIRSLtdtrvtQVLGGFQGCLDSVVLNHN 4016
Cdd:pfam02210   81 PPGESLLLNLNGPLYLGGLPPLLLLPAL------PVRAGFVGCIRDVRVNGE 126
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1795-1901 3.08e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.17  E-value: 3.08e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 1795 QYSGSLSEAAPINSLVrsldnspLVIRATDADSNQNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHEVIAHFHFHVH 1874
Cdd:cd11304      1 SYEVSVPENAPPGTVV-------LTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVT 73

                           90       100
                   ....*....|....*....|....*..
gi 1958794504 1875 VRDSGNPQLTaeSPVEVNIEVTDVNDN 1901
Cdd:cd11304     74 ATDGGGPPLS--STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1486-1584 1.28e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 106.63  E-value: 1.28e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 1486 HYDVTISEDVPPDTEILQIEATDRDEKH--KLSYTIHSSIDAismRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQ 1563
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGEngEVTYSIVSGNED---GLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|.
gi 1958794504 1564 EFPYRRNLARVIVNVEDANDH 1584
Cdd:cd11304     78 GGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1065-1145 2.70e-26

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 105.12  E-value: 2.70e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  1065 TAHDEDSGRDGEIQYSIRDGSGLGRFNIDDESGVITAADILDRETTASYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNA 1144
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1958794504  1145 P 1145
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1593-1683 5.21e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 104.70  E-value: 5.21e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 1593 YEASVFESAALGSVVLQVTALDKDKGENAELIYSIEAGNTGNTFKIEPVLGIITISKEPDMTAMGQFVLSVKVTDQGSPP 1672
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|.
gi 1958794504 1673 MSATAIVRISI 1683
Cdd:cd11304     82 LSSTATVTITV 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 161-261 5.47e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.01  E-value: 5.47e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  161 TYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFK--NKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRgmk 238
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG--- 77

                           90       100
                   ....*....|....*....|...
gi 1958794504  239 lyGNNGVSSTAKLYVHIERINEH 261
Cdd:cd11304     78 --GGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3176-3256 6.49e-25

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 100.89  E-value: 6.49e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  3176 QAVDPDVGINRKVVYSLED-SASGVFSIDSSSGVIVLEQPLDREQQSSYNISVRATDQSpGQSLSSLTSVTITVLDINDN 3254
Cdd:smart00112    1 SATDADSGENGKVTYSILSgNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGG-GPPLSSTATVTITVLDVNDN 79


                    ..
gi 1958794504  3255 PP 3256
Cdd:smart00112   80 AP 81
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 3859-4014 1.03e-24

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 103.27  E-value: 1.03e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 3859 SLSFAGNSYIKYRLSENSREEdFKLALRLRTLQSNGIIMYT---RANPCMILKIVEGKLWFQLDCGSGPGILGiSSRAVN 3935
Cdd:cd00110      1 GVSFSGSSYVRLPTLPAPRTR-LSISFSFRTTSPNGLLLYAgsqNGGDFLALELEDGRLVLRYDLGSGSLVLS-SKTPLN 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958794504 3936 DGSWHSVFLELNRNFTSLSLDDSYVERRRAPLYFQTLSTDSAIFFGALVQADNIRSLTDTRvtqvlgGFQGCLDSVVLN 4014
Cdd:cd00110     79 DGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSP------GFVGCIRDLKVN 151
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1698-1787 1.11e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 100.85  E-value: 1.11e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 1698 YQAEVNENVDIGTSVILISAISQ-----STLIYEVKDGNINGVFTINPYSGVITTRRALDYEHTSSYQLIIQATNMAG-- 1770
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPdsgenGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGpp 81

                           90
                   ....*....|....*..
gi 1958794504 1771 MASNATVSVQVVDENDN 1787
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1170-1251 1.51e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 100.12  E-value: 1.51e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  1170 QAEDPDSGSNEKLTYRITSGNPQNFFAINIKTGLITTTsRKLDREQQAEHFLEVTVTDGGSSPKQSTIWVVVQVLDENDN 1249
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTT-KPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 1958794504  1250 KP 1251
Cdd:smart00112   80 AP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2522-2618 1.81e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 100.47  E-value: 1.81e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 2522 TYVAEVRENAASGTKVIHVRATDGDPGTYGQVSYSIINDFAKDRFLIDSN-GQIITTERLDRENPLEgdISIYLRALDGG 2600
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPStGEITTAKPLDREEQSS--YTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 1958794504 2601 G--RTTFCTVRVIVVDENDN 2618
Cdd:cd11304     79 GppLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3282-3361 2.39e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 99.35  E-value: 2.39e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  3282 ATSKDIGTNAEITYLIRSGNEQGKFRINPKTGGISVLEALDYEMCKRFYLVVEAKDGGTPALSTAATVSIDLTDVNDNPP 3361
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3387-3466 3.78e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 98.96  E-value: 3.78e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  3387 AEDVDSKPNGQIRFSIVGGDRDNEFAVDPILGLVKVKKKLDRERVSGYSLLIQAVDSGIPAMSSTTTVNIDISDVNDNSP 3466
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 939-1022 6.78e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 98.92  E-value: 6.78e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  939 SYSVKVLEDLPVGTVIAWLETQDPDLGLGGQVRYSLV-NDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRP 1017
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80


                   ....*
gi 1958794504 1018 vSLSS 1022
Cdd:cd11304     81 -PLSS 84
Cadherin pfam00028
Cadherin domain;
3263-3354 2.84e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 96.60  E-value: 2.84e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 3263 YLVTVPEDTSLGTQVLSVFATSKDIGTNAEITYLIRSGNEQGKFRINPKTGGISVLEALDYEMCKRFYLVVEAKDGGTPA 3342
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 1958794504 3343 LSTAATVSIDLT 3354
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
3368-3458 5.04e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 96.22  E-value: 5.04e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 3368 YSAVISEDALEGDSVILLIAEDVDSKPNGQIRFSIVGGDRDNEFAVDPILGLVKVKKKLDRERVSGYSLLIQAVDSGIPA 3447
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 1958794504 3448 MSSTTTVNIDI 3458
Cdd:pfam00028   81 LSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2334-2414 8.01e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 95.11  E-value: 8.01e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  2334 TDADSGNNNLVHYQIVQDtyNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVTATDNGFPSLSSEVLVQIYISDVNDNP 2413
Cdd:smart00112    3 TDADSGENGKVTYSILSG--NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1958794504  2414 P 2414
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
1048-1138 1.96e-22

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 94.29  E-value: 1.96e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 1048 VGSVKENSRIGTSVLQVTAHDEDSGRDGEIQYSIRDGSGLGRFNIDDESGVITAADILDRETTASYWLTVYATDRGVVPL 1127
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPL 81

                           90
                   ....*....|.
gi 1958794504 1128 YSTIEVYIEVE 1138
Cdd:pfam00028   82 SSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1156-1244 2.39e-22

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 94.29  E-value: 2.39e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 1156 VMENSPKDVSVIQIQAEDPDSGSNEKLTYRITSGNPQNFFAINIKTGLITTTSRkLDREQQAEHFLEVTVTDGGSSPKQS 1235
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKP-LDRESIGEYELTVEATDSGGPPLSS 83


                   ....*....
gi 1958794504 1236 TIWVVVQVL 1244
Cdd:pfam00028   84 TATVTITVL 92
LamG smart00282
Laminin G domain;
3882-4016 3.60e-22

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 95.10  E-value: 3.60e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  3882 KLALRLRTLQSNGIIMYTRANP---CMILKIVEGKLWFQLDCGSGPGILGISSRAVNDGSWHSVFLELNRNFTSLSLDDS 3958
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGggdYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958794504  3959 YVERRRAPLYFQTLSTDSAIFFGALVQADNIRSLTDTRvtqvlgGFQGCLDSVVLNHN 4016
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVTP------GFRGCIRNLKVNGK 132
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2950-3047 4.83e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.53  E-value: 4.83e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 2950 VYRGNVKESDPPGEVVAVLSTLDKDtSNINRQVSYHITGGNPRGRFALGmvQSEWKVYVKRPLDREEQDIYFLNITASDG 3029
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPD-SGENGEVTYSIVSGNEDGLFSID--PSTGEITTAKPLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|.
gi 1958794504 3030 ---LFVTQAMVEVTVSDVNDN 3047
Cdd:cd11304     78 ggpPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1821-1903 5.39e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 92.80  E-value: 5.39e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  1821 RATDADSNQNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHEVIAHFHFHVHVRDSGNPQLTaeSPVEVNIEVTDVND 1900
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLS--STATVTITVLDVND 78


                    ...
gi 1958794504  1901 NPP 1903
Cdd:smart00112   79 NAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2213-2305 6.86e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.15  E-value: 6.86e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 2213 YTASINEDISINTPILSINAT---SPEGQGIIYLIIDGDPFQQFNIDFDTGVLKVISPLDYEVMSVYKLTVRASDALTGA 2289
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATdpdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*..
gi 1958794504 2290 R-AEVTVDLLVDDVNDN 2305
Cdd:cd11304     82 LsSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 748-828 1.14e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 91.64  E-value: 1.14e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504   748 KAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYVLNITIYDLGKPQKSSWRLLTVNVEDANDNS 827
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1958794504   828 P 828
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
3158-3249 3.46e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 90.82  E-value: 3.46e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 3158 YTACVYENTATKALLTRVQAVDPDVGINRKVVYS-LEDSASGVFSIDSSSGVIVLEQPLDREQQSSYNISVRATDQSpGQ 3236
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSiLGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG-GP 79

                           90
                   ....*....|...
gi 1958794504 3237 SLSSLTSVTITVL 3249
Cdd:pfam00028   80 PLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2859-2944 1.39e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 88.56  E-value: 1.39e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  2859 RAIDTDWGANGQVTYSLHSDSHLEKvmeaFNIDSNTGWISTLKDLDHETDPTFSFFVVASDLGEAfSLSSMALVSVKVTD 2938
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGL----FSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP-PLSSTATVTITVLD 75


                    ....*.
gi 1958794504  2939 INDNAP 2944
Cdd:smart00112   76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 494-575 1.85e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 88.18  E-value: 1.85e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504   494 SASDKDKGENGYITYSIASLN-LLPFAINQFTGVISTTEELDFESSPEtYRFIVRASDWGSPyRHESEVNVTIRVGNVND 572
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNdDGLFSIDPETGEITTTKPLDREEQPE-YTLTVEATDGGGP-PLSSTATVTITVLDVND 78


                    ...
gi 1958794504   573 NSP 575
Cdd:smart00112   79 NAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3074-3151 3.54e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.41  E-value: 3.54e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  3074 SAKDADIGSNGDIRYSL-YGSGNSDFFLDPESGELKTLALLDRERVPVYNLIARATDGGG--RFCSSTVLLLLEDVNDNP 3150
Cdd:smart00112    1 SATDADSGENGKVTYSIlSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGppLSSTATVTITVLDVNDNA 80


                    .
gi 1958794504  3151 P 3151
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2110-2201 6.31e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 87.37  E-value: 6.31e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 2110 PYYAAVQVDAEPGTLIYRVTAIDKDKGANGEVTYVL--QDDYGHFEINPNSGNVILKEAFNSDLSNIdYGVTILAKDGGT 2187
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsGNEDGLFSIDPSTGEITTAKPLDREEQSS-YTLTVTATDGGG 79

                           90
                   ....*....|....
gi 1958794504 2188 PSLSTFVELPITIV 2201
Cdd:cd11304     80 PPLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1257-1347 9.40e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.98  E-value: 9.40e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 1257 VYQIKLPERDrkKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQF---TAGSYdILTIKAVDN 1333
Cdd:cd11304      1 SYEVSVPENA--PPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLdreEQSSY-TLTVTATDG 77

                           90
                   ....*....|....
gi 1958794504 1334 GRPQKSSTARLHIE 1347
Cdd:cd11304     78 GGPPLSSTATVTIT 91
Cadherin pfam00028
Cadherin domain;
476-567 2.04e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 85.82  E-value: 2.04e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  476 YETFVNESVPVGTNVLTVSASDKDKGENGYITYSIASLNLLP-FAINQFTGVISTTEELDFEsSPETYRFIVRASDWGSP 554
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGnFRIDPDTGDISTTKPLDRE-SIGEYELTVEATDSGGP 79

                           90
                   ....*....|...
gi 1958794504  555 YRhESEVNVTIRV 567
Cdd:pfam00028   80 PL-SSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
1593-1683 3.62e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 85.04  E-value: 3.62e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 1593 YEASVFESAALGSVVLQVTALDKDKGENAELIYSIEAGNTGNTFKIEPVLGIITISKEPDMTAMGQFVLSVKVTDQGSPP 1672
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 1958794504 1673 MSATAIVRISI 1683
Cdd:pfam00028   81 LSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 854-933 4.58e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 84.32  E-value: 4.58e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504   854 ARDKDLGSNGEVTYSVL--TDTHQFVINSSTGIVYIADQLDRESKANYSLKIEARDKAesGQQLFSVVTLKIFLDDVNDC 931
Cdd:smart00112    2 ATDADSGENGKVTYSILsgNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGG--GPPLSSTATVTITVLDVNDN 79


                    ..
gi 1958794504   932 SP 933
Cdd:smart00112   80 AP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2626-2721 1.26e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.90  E-value: 1.26e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 2626 EYRASVRADVGRGHLVTQVQALDPDDGANSRITYSLYSEasvSVADLLEIDPDNGWMVTKGNFNQLRNTVLSFFVKAVDG 2705
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG---NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                           90
                   ....*....|....*.
gi 1958794504 2706 GIPVRHSLIPVYIHVL 2721
Cdd:cd11304     78 GGPPLSSTATVTITVL 93
Cadherin pfam00028
Cadherin domain;
835-923 1.60e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 83.12  E-value: 1.60e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  835 YSVSILESSSIGTEIIQVEARDKDLGSNGEVTYSVLTDT--HQFVINSSTGIVYIADQLDRESKANYSLKIEARDkaESG 912
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGpgGNFRIDPDTGDISTTKPLDRESIGEYELTVEATD--SGG 78

                           90
                   ....*....|.
gi 1958794504  913 QQLFSVVTLKI 923
Cdd:pfam00028   79 PPLSSTATVTI 89
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1721-1789 1.71e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.78  E-value: 1.71e-18
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958794504  1721 STLIYEVKDGNINGVFTINPYSGVITTRRALDYEHTSSYQLIIQATNMAG--MASNATVSVQVVDENDNPP 1789
Cdd:smart00112   11 GKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGppLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2420-2512 1.72e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.52  E-value: 1.72e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 2420 IYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVLTLSSHRKQRMEPLYSLNVSVSDG--- 2496
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGggp 80

                           90
                   ....*....|....*.
gi 1958794504 2497 LFTSTAQVHIRVLGAN 2512
Cdd:cd11304     81 PLSSTATVTITVLDVN 96
Cadherin pfam00028
Cadherin domain;
940-1017 3.14e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 82.35  E-value: 3.14e-18
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958794504  940 YSVKVLEDLPVGTVIAWLETQDPDLGLGGQVRYSLVNDYNGR-FEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRP 1017
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGnFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3473-3564 3.90e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.36  E-value: 3.90e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 3473 YTAVIQENKPVGTSILQLVVTDRDSFHNGpPFSFSILSGNEDEEFMLDSH-GILRSAVVFRHMESPEYLLCIQAKDSGKP 3551
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENG-EVTYSIVSGNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|...
gi 1958794504 3552 QQVSHTYIRVRVI 3564
Cdd:cd11304     81 PLSSTATVTITVL 93
Cadherin pfam00028
Cadherin domain;
2523-2612 4.59e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 81.96  E-value: 4.59e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 2523 YVAEVRENAASGTKVIHVRATDGDPGTYGQVSYSIINDFAKDRFLID-SNGQIITTERLDRENPleGDISIYLRALDGGG 2601
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDpDTGDISTTKPLDRESI--GEYELTVEATDSGG 78

                           90
                   ....*....|.
gi 1958794504 2602 RTTFCTVRVIV 2612
Cdd:pfam00028   79 PPLSSTATVTI 89
Cadherin pfam00028
Cadherin domain;
1796-1894 6.15e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 81.58  E-value: 6.15e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 1796 YSGSLSEAAPINSLVrsldnspLVIRATDADSNQNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHEVIAHFHFHVHV 1875
Cdd:pfam00028    1 YSASVPENAPVGTEV-------LTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEA 73

                           90
                   ....*....|....*....
gi 1958794504 1876 RDSGNPQLTAESPVEVNIE 1894
Cdd:pfam00028   74 TDSGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
3056-3141 1.06e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.81  E-value: 1.06e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 3056 YSASLPEDIPSNKIILKVSAKDADIGSNGDIRYSLYGSGNSDFF-LDPESGELKTLALLDRERVPVYNLIARATDGGGRF 3134
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFrIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80


                   ....*..
gi 1958794504 3135 CSSTVLL 3141
Cdd:pfam00028   81 LSSTATV 87
Cadherin pfam00028
Cadherin domain;
732-821 1.07e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.81  E-value: 1.07e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  732 VAVKENMPVGTNILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYVLNITIYDLGKPQKS 811
Cdd:pfam00028    3 ASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLS 82

                           90
                   ....*....|
gi 1958794504  812 SWRLLTVNVE 821
Cdd:pfam00028   83 STATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1698-1781 2.04e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.04  E-value: 2.04e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 1698 YQAEVNENVDIGTSVILISAIS-----QSTLIYEVKDGNINGVFTINPYSGVITTRRALDYEHTSSYQLIIQATNMA--G 1770
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDpdlgpNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGgpP 80

                           90
                   ....*....|.
gi 1958794504 1771 MASNATVSVQV 1781
Cdd:pfam00028   81 LSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
2213-2298 3.79e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 79.27  E-value: 3.79e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 2213 YTASINEDISINTPILSINAT---SPEGQGIIYLIIDGDPFQQFNIDFDTGVLKVISPLDYEVMSVYKLTVRASDALTGA 2289
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATdpdLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 1958794504 2290 R---AEVTVDLL 2298
Cdd:pfam00028   81 LsstATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1487-1579 6.11e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 78.88  E-value: 6.11e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 1487 YDVTISEDVPPDTEILQIEATDRDEK--HKLSYTIhssIDAISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQE 1564
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGpnGRIFYSI---LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|....*
gi 1958794504 1565 FPYRRNLARVIVNVE 1579
Cdd:pfam00028   78 GPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2234-2307 1.03e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.78  E-value: 1.03e-16
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958794504  2234 SPEGQGIIYLIIDGDPFQQFNIDFDTGVLKVISPLDYEVMSVYKLTVRASDALTGAR-AEVTVDLLVDDVNDNPP 2307
Cdd:smart00112    7 SGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLsSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
2314-2406 1.20e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 77.73  E-value: 1.20e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 2314 YNTTLSESSLIGTPVLQLVSTDADSGNNNLVHYQIVQDtyNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVTATDNGF 2393
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGG--GPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG 78

                           90
                   ....*....|...
gi 1958794504 2394 PSLSSEVLVQIYI 2406
Cdd:pfam00028   79 PPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2541-2620 1.60e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.00  E-value: 1.60e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  2541 RATDGDPGTYGQVSYSIINDFAKDRFLIDSN-GQIITTERLDRENplEGDISIYLRALDGGG--RTTFCTVRVIVVDEND 2617
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPEtGEITTTKPLDREE--QPEYTLTVEATDGGGppLSSTATVTITVLDVND 78


                    ...
gi 1958794504  2618 NAP 2620
Cdd:smart00112   79 NAP 81
Cadherin pfam00028
Cadherin domain;
2841-2937 2.39e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.96  E-value: 2.39e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 2841 YETIIMEGMPVGTKLAQVRAIDTDWGANGQVTYSLHSDShlekVMEAFNIDSNTGWISTLKDLDHETDPTFSFFVVASDL 2920
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGG----PGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                           90
                   ....*....|....*..
gi 1958794504 2921 GEAfSLSSMALVSVKVT 2937
Cdd:pfam00028   77 GGP-PLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1506-1586 4.23e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 75.85  E-value: 4.23e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  1506 ATDRDE--KHKLSYTIHSSIDAismRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDAND 1583
Cdd:smart00112    2 ATDADSgeNGKVTYSILSGNDD---GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                    ...
gi 1958794504  1584 HSP 1586
Cdd:smart00112   79 NAP 81
Cadherin pfam00028
Cadherin domain;
1258-1347 2.07e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 74.26  E-value: 2.07e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 1258 YQIKLPERDRkkRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQF---TAGSYdILTIKAVDNG 1334
Cdd:pfam00028    1 YSASVPENAP--VGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLdreSIGEY-ELTVEATDSG 77

                           90
                   ....*....|...
gi 1958794504 1335 RPQKSSTARLHIE 1347
Cdd:pfam00028   78 GPPLSSTATVTIT 90
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2972-3049 3.21e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.54  E-value: 3.21e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  2972 DKDtSNINRQVSYHITGGNPRGRFALGMVQSEwkVYVKRPLDREEQDIYFLNITASDG---LFVTQAMVEVTVSDVNDNS 3048
Cdd:smart00112    4 DAD-SGENGKVTYSILSGNDDGLFSIDPETGE--ITTTKPLDREEQPEYTLTVEATDGggpPLSSTATVTITVLDVNDNA 80


                    .
gi 1958794504  3049 P 3049
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1611-1689 4.70e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.15  E-value: 4.70e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  1611 TALDKDKGENAELIYSIEAGNTGNTFKIEPVLGIITISKEPDMTAMGQFVLSVKVTDQGSPPMSATAIVRISIS-MSDNS 1689
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLdVNDNA 80
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 180-263 5.82e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.77  E-value: 5.82e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504   180 TATDADIGSNGEFYYYFK--NKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKlygnnGVSSTAKLYVHIER 257
Cdd:smart00112    1 SATDADSGENGKVTYSILsgNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP-----PLSSTATVTITVLD 75


                    ....*.
gi 1958794504   258 INEHAP 263
Cdd:smart00112   76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1279-1347 6.80e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.38  E-value: 6.80e-15
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958794504  1279 AFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQF---TAGSYDiLTIKAVDNGRPQKSSTARLHIE 1347
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLdreEQPEYT-LTVEATDGGGPPLSSTATVTIT 72
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 379-467 1.02e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 72.73  E-value: 1.02e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  379 VYDISISEFSPPGVMVAIVKVN----PEPLDVEYTLLPGKDAEYFKINPRSGLIVTAQPLNTVKKEVYKLEVSDKEGD-- 452
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATdpdsGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGgp 80

                           90
                   ....*....|....*...
gi 1958794504  453 ---AKAQVTIGIEDANDH 467
Cdd:cd11304     81 plsSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
162-256 1.09e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 72.33  E-value: 1.09e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  162 YSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFK--NKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRgmkl 239
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILggGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS---- 76

                           90
                   ....*....|....*..
gi 1958794504  240 yGNNGVSSTAKLYVHIE 256
Cdd:pfam00028   77 -GGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2009-2102 2.41e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 71.58  E-value: 2.41e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 2009 YSTSISENSTNITKVAIVNAV--GNRLNEPLKYSIL--NPGNKFKIKSTSGVIQTTGvPFDREEQELYELVVEASrelDH 2084
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATdpDSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAK-PLDREEQSSYTLTVTAT---DG 77

                           90       100
                   ....*....|....*....|.
gi 1958794504 2085 LRVARVVVRV---NIEDVNDN 2102
Cdd:cd11304     78 GGPPLSSTATvtiTVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1920-1999 4.53e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 70.81  E-value: 4.53e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 1920 VGVEVLKVSATDPDSEVPPELTYSLMEGSVD-HFLMDPNTGVLTIKN--NNLSKDHYMLIVRVSDG---KFYSTAMVTIM 1993
Cdd:cd11304     12 PGTVVLTVSATDPDSGENGEVTYSIVSGNEDgLFSIDPSTGEITTAKplDREEQSSYTLTVTATDGggpPLSSTATVTIT 91


                   ....*.
gi 1958794504 1994 VKEAMD 1999
Cdd:cd11304     92 VLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 961-1022 4.60e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 70.07  E-value: 4.60e-14
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958794504   961 DPDLGLGGQVRYSLV-NDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPvSLSS 1022
Cdd:smart00112    4 DADSGENGKVTYSILsGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP-PLSS 65
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2734-2832 3.34e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 68.11  E-value: 3.34e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 2734 QYSFTIAEDTSIGSTIDTLR-----ILPNQSVRFSTVNGerpenNKENVFIIEQETGAIKLDKRLDHEVSPAFHFKVAAT 2808
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSatdpdSGENGEVTYSIVSG-----NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                           90       100
                   ....*....|....*....|....*.
gi 1958794504 2809 iplDKVDIVF--TVDVDVKVLDLNDN 2832
Cdd:cd11304     76 ---DGGGPPLssTATVTITVLDVNDN 98
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 4120-4155 1.36e-12

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 64.58  E-value: 1.36e-12
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1958794504 4120 DVDECEREE-CENGGSCVNLFGSFFCNCTPGYVGQYC 4155
Cdd:cd00054      1 DIDECASGNpCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
Cadherin pfam00028
Cadherin domain;
2111-2200 4.18e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.01  E-value: 4.18e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 2111 YYAAVQVDAEPGTLIYRVTAIDKDKGANGEVTYVL--QDDYGHFEINPNSGNVILKEAFNSDLSNIdYGVTILAKDGGTP 2188
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIlgGGPGGNFRIDPDTGDISTTKPLDRESIGE-YELTVEATDSGGP 79

                           90
                   ....*....|..
gi 1958794504 2189 SLSTFVELPITI 2200
Cdd:pfam00028   80 PLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
2627-2721 2.28e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 62.70  E-value: 2.28e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 2627 YRASVRADVGRGHLVTQVQALDPDDGANSRITYSLyseASVSVADLLEIDPDNGWMVTKGNFNQLRNTVLSFFVKAVDGG 2706
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI---LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|....*
gi 1958794504 2707 IPVRHSLIPVYIHVL 2721
Cdd:pfam00028   78 GPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1366-1478 5.48e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 61.95  E-value: 5.48e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 1366 YNFTIMESDKVTEIVGVVSVQ----PANTPLWFDIIGGkHAREMFYIlqtacgqncsteggnfDSSFdaekgvGTIVIAK 1441
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATdpdsGENGEVTYSIVSG-NEDGLFSI----------------DPST------GEITTAK 58

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1958794504 1442 PLDAEQRSVYNMSVEVTDGTN---VAVTQVFITVLDNNDN 1478
Cdd:cd11304     59 PLDREEQSSYTLTVTATDGGGpplSSTATVTITVLDVNDN 98
EGF_CA smart00179
Calcium-binding EGF-like domain;
4120-4155 8.85e-11

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 59.57  E-value: 8.85e-11
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1958794504  4120 DVDECERE-ECENGGSCVNLFGSFFCNCTPGYV-GQYC 4155
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2129-2201 4.25e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 58.90  E-value: 4.25e-10
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958794504  2129 TAIDKDKGANGEVTYVL--QDDYGHFEINPNSGNVILKEAFNSDLSNIdYGVTILAKDGGTPSLSTFVELPITIV 2201
Cdd:smart00112    1 SATDADSGENGKVTYSIlsGNDDGLFSIDPETGEITTTKPLDREEQPE-YTLTVEATDGGGPPLSSTATVTITVL 74
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3491-3571 4.33e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 58.90  E-value: 4.33e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  3491 VVTDRDSFHNGPpFSFSILSGNEDEEFMLDSH-GILRSAVVFRHMESPEYLLCIQAKDSGKPQQVSHTYIRVRVIEESTH 3569
Cdd:smart00112    1 SATDADSGENGK-VTYSILSGNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 1958794504  3570 KP 3571
Cdd:smart00112   80 AP 81
Cadherin pfam00028
Cadherin domain;
3473-3564 7.69e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 58.47  E-value: 7.69e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 3473 YTAVIQENKPVGTSILQLVVTDRDSFHNGPPFsFSILSGNEDEEFMLDSH-GILRSAVVFRHMESPEYLLCIQAKDSGKP 3551
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIF-YSILGGGPGGNFRIDPDtGDISTTKPLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|...
gi 1958794504 3552 QQVSHTYIRVRVI 3564
Cdd:pfam00028   80 PLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 405-469 9.10e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 58.13  E-value: 9.10e-10
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504   405 DVEYTLLPGKDAEYFKINPRSGLIVTAQPLNTVKKEVYKLEVSDKEGD-----AKAQVTIGIEDANDHTP 469
Cdd:smart00112   12 KVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGgpplsSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1421-1480 1.36e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 57.36  E-value: 1.36e-09
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958794504  1421 GGNFDSSFDAEKGVGTIVIAKPLDAEQRSVYNMSVEVTDGTN---VAVTQVFITVLDNNDNGP 1480
Cdd:smart00112   19 SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGpplSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 591-671 1.45e-09

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 58.09  E-value: 1.45e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  591 PVGGHITAISAIDIDELE--LVKYKIISGNELGFFYLNPDSGVLQLKKSLMNSgiKNGNFALRITATDGEN--FADPMAI 666
Cdd:cd11304     11 PPGTVVLTVSATDPDSGEngEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDRE--EQSSYTLTVTATDGGGppLSSTATV 88


                   ....*
gi 1958794504  667 NISVL 671
Cdd:cd11304     89 TITVL 93
Cadherin pfam00028
Cadherin domain;
2009-2079 1.48e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 57.70  E-value: 1.48e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958794504 2009 YSTSISENSTNITKVAIVNAV----GnrLNEPLKYSIL--NPGNKFKIKSTSGVIQTTGvPFDREEQELYELVVEAS 2079
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATdpdlG--PNGRIFYSILggGPGGNFRIDPDTGDISTTK-PLDRESIGEYELTVEAT 74
Cadherin pfam00028
Cadherin domain;
2951-3041 1.69e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 57.70  E-value: 1.69e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 2951 YRGNVKESDPPGEVVAVLSTLDKDTSNiNRQVSYHITGGNPRGRFAL----GMVqsewkvYVKRPLDREEQDIYFLNITA 3026
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGP-NGRIFYSILGGGPGGNFRIdpdtGDI------STTKPLDRESIGEYELTVEA 73

                           90
                   ....*....|....*...
gi 1958794504 3027 SDGLF---VTQAMVEVTV 3041
Cdd:pfam00028   74 TDSGGpplSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
2421-2509 2.14e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 57.31  E-value: 2.14e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 2421 YESYVSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVLTLSSH--RKQRmePLYSLNVSVSDGLF 2498
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPldRESI--GEYELTVEATDSGG 78

                           90
                   ....*....|....
gi 1958794504 2499 ---TSTAQVHIRVL 2509
Cdd:pfam00028   79 pplSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2439-2512 2.39e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 56.59  E-value: 2.39e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958794504  2439 QASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVLTLSSH--RKQRmePLYSLNVSVSDG---LFTSTAQVHIRVLGAN 2512
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPldREEQ--PEYTLTVEATDGggpPLSSTATVTITVLDVN 77
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2645-2721 3.24e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 56.20  E-value: 3.24e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958794504  2645 QALDPDDGANSRITYSLyseASVSVADLLEIDPDNGWMVTKGNFNQLRNTVLSFFVKAVDGGIPVRHSLIPVYIHVL 2721
Cdd:smart00112    1 SATDADSGENGKVTYSI---LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2034-2104 5.82e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 55.82  E-value: 5.82e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958794504  2034 NEPLKYSIL--NPGNKFKIKSTSGVIQTTGvPFDREEQELYELVVEASrelDHLRVARVVVRV---NIEDVNDNSP 2104
Cdd:smart00112   10 NGKVTYSILsgNDDGLFSIDPETGEITTTK-PLDREEQPEYTLTVEAT---DGGGPPLSSTATvtiTVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3583-3660 1.53e-08

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 55.01  E-value: 1.53e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 3583 MEDDFPGGVIGKIHATDQD--MYDVLTFALKSEQ-KSLFKVNSHDGKIIALGGLD---SGKYVLNVSVSDG---RFQVPI 3653
Cdd:cd11304      7 PENAPPGTVVLTVSATDPDsgENGEVTYSIVSGNeDGLFSIDPSTGEITTAKPLDreeQSSYTLTVTATDGggpPLSSTA 86


                   ....*..
gi 1958794504 3654 DVVVHVE 3660
Cdd:cd11304     87 TVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 47-152 3.94e-08

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 53.86  E-value: 3.94e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504   47 YNATVYENSAARTYVnsqsrMGITLIDL----SWDIKYRIVSGDEEGFFkaeeviiadfcflRIRTKGGN---SAILNRE 119
Cdd:cd11304      2 YEVSVPENAPPGTVV-----LTVSATDPdsgeNGEVTYSIVSGNEDGLF-------------SIDPSTGEittAKPLDRE 63

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1958794504  120 IQDNYLLIIKGSVRGED-LEAWTKVNIQVLDMND 152
Cdd:cd11304     64 EQSSYTLTVTATDGGGPpLSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2756-2834 6.70e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 52.74  E-value: 6.70e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  2756 PNQSVRFSTVNGerpenNKENVFIIEQETGAIKLDKRLDHEVSPAFHFKVAATiplDKVDIVF--TVDVDVKVLDLNDNK 2833
Cdd:smart00112    9 ENGKVTYSILSG-----NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEAT---DGGGPPLssTATVTITVLDVNDNA 80


                    .
gi 1958794504  2834 P 2834
Cdd:smart00112   81 P 81
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 4079-4118 2.04e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.94  E-value: 2.04e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1958794504 4079 CESeitacfPNPCRNGGSCDPIGNTFICSCKAGLTGVTCE 4118
Cdd:cd00054      5 CAS------GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 4045-4080 3.33e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.17  E-value: 3.33e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1958794504 4045 DACQ-RSPCLHGGSCSGLPsGGYQCSCLSQFTGTNCE 4080
Cdd:cd00054      3 DECAsGNPCQNGGTCVNTV-GSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 4086-4114 7.06e-07

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 48.15  E-value: 7.06e-07
                           10        20
                   ....*....|....*....|....*....
gi 1958794504 4086 CFPNPCRNGGSCDPIGNTFICSCKAGLTG 4114
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1928-1999 7.42e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 49.66  E-value: 7.42e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958794504  1928 SATDPDSEVPPELTYSLMEGSVD-HFLMDPNTGVLTIkNNNL---SKDHYMLIVRVSDG---KFYSTAMVTIMVKEAMD 1999
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDgLFSIDPETGEITT-TKPLdreEQPEYTLTVEATDGggpPLSSTATVTITVLDVND 78
Cadherin pfam00028
Cadherin domain;
1920-1994 2.20e-06

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 48.84  E-value: 2.20e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 1920 VGVEVLKVSATDPDSEVPPELTYSLMEGSVDH-FLMDPNTGVLTIKnNNL---SKDHYMLIVRVSDGKFY---STAMVTI 1992
Cdd:pfam00028   11 VGTEVLTVTATDPDLGPNGRIFYSILGGGPGGnFRIDPDTGDISTT-KPLdreSIGEYELTVEATDSGGPplsSTATVTI 89


                   ..
gi 1958794504 1993 MV 1994
Cdd:pfam00028   90 TV 91
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 4124-4154 2.92e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 46.61  E-value: 2.92e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1958794504 4124 CEREECENGGSCVNLFGSFFCNCTPGYVGQY 4154
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
Cadherin pfam00028
Cadherin domain;
2735-2808 4.07e-06

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 48.07  E-value: 4.07e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958794504 2735 YSFTIAEDTSIGSTIDTLRIL-----PNQSVRFSTVNGERpennkENVFIIEQETGAIKLDKRLDHEVSPAFHFKVAAT 2808
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATdpdlgPNGRIFYSILGGGP-----GGNFRIDPDTGDISTTKPLDRESIGEYELTVEAT 74
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 75-155 5.00e-06

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 47.34  E-value: 5.00e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504    75 SWDIKYRIVSGDEEGFFkaeeviiadfcflRIRTKGGN---SAILNREIQDNYLLIIKGSVRGED-LEAWTKVNIQVLDM 150
Cdd:smart00112   10 NGKVTYSILSGNDDGLF-------------SIDPETGEittTKPLDREEQPEYTLTVEATDGGGPpLSSTATVTITVLDV 76


                    ....*
gi 1958794504   151 NDLRP 155
Cdd:smart00112   77 NDNAP 81
Cadherin pfam00028
Cadherin domain;
591-671 1.68e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 46.14  E-value: 1.68e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  591 PVGGHITAISAIDIDE--LELVKYKIISGNELGFFYLNPDSGVLQLKKSLmnSGIKNGNFALRITATD--GENFADPMAI 666
Cdd:pfam00028   10 PVGTEVLTVTATDPDLgpNGRIFYSILGGGPGGNFRIDPDTGDISTTKPL--DRESIGEYELTVEATDsgGPPLSSTATV 87


                   ....*
gi 1958794504  667 NISVL 671
Cdd:pfam00028   88 TITVL 92
Cadherin pfam00028
Cadherin domain;
1366-1473 1.90e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 46.14  E-value: 1.90e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 1366 YNFTIMESDKVTEIVGVVSVQPANTPLwfdiiggkHAREMFYILqtacgqncsteGGNFDSSFDAEKGVGTIVIAKPLDA 1445
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGP--------NGRIFYSIL-----------GGGPGGNFRIDPDTGDISTTKPLDR 61

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1958794504 1446 EQRSVYNMSVEVTDGTN---VAVTQVFITVL 1473
Cdd:pfam00028   62 ESIGEYELTVEATDSGGpplSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
380-462 3.96e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 44.98  E-value: 3.96e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  380 YDISISEFSPPGVMVAIVKVNPEPLD----VEYTLLPGKDAEYFKINPRSGLIVTAQPLNTVKKEVYKLEV--SDKEGDA 453
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGpngrIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVeaTDSGGPP 80

                           90
                   ....*....|..
gi 1958794504  454 K---AQVTIGIE 462
Cdd:pfam00028   81 LsstATVTITVL 92
EGF_CA smart00179
Calcium-binding EGF-like domain;
4079-4118 5.44e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 5.44e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1958794504  4079 CESeitacfPNPCRNGGSCDPIGNTFICSCKAGLT-GVTCE 4118
Cdd:smart00179    5 CAS------GNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 285-363 5.49e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 44.26  E-value: 5.49e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958794504   285 TVDDLDEGANGEIeSVSIVDGDPLEQFFLAKEGKWmneykVKERRQVDWESFSYgYNLTIQAKDKGSPQKFSELkTVHI 363
Cdd:smart00112    1 SATDADSGENGKV-TYSILSGNDDGLFSIDPETGE-----ITTTKPLDREEQPE-YTLTVEATDGGGPPLSSTA-TVTI 71
EGF_CA smart00179
Calcium-binding EGF-like domain;
4045-4080 8.38e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 8.38e-05
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1958794504  4045 DACQ-RSPCLHGGSCSGLPsGGYQCSCLSQFT-GTNCE 4080
Cdd:smart00179    3 DECAsGNPCQNGGTCVNTV-GSYRCECPPGYTdGRNCE 39
Cadherin pfam00028
Cadherin domain;
282-363 1.83e-04

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 43.06  E-value: 1.83e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  282 AVVTVDDLDEGANGEIeSVSIVDGDPLEQFFLAKEGKWmneykVKERRQVDWESFSYgYNLTIQAKDKGSPQKFSELkTV 361
Cdd:pfam00028   16 LTVTATDPDLGPNGRI-FYSILGGGPGGNFRIDPDTGD-----ISTTKPLDRESIGE-YELTVEATDSGGPPLSSTA-TV 87


                   ..
gi 1958794504  362 HI 363
Cdd:pfam00028   88 TI 89
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 600-657 1.34e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 40.41  E-value: 1.34e-03
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504   600 SAIDIDELE--LVKYKIISGNELGFFYLNPDSGVLQLKKSLMNSgiKNGNFALRITATDG 657
Cdd:smart00112    1 SATDADSGEngKVTYSILSGNDDGLFSIDPETGEITTTKPLDRE--EQPEYTLTVEATDG 58
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 4047-4076 2.43e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.13  E-value: 2.43e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1958794504 4047 CQRSPCLHGGSCSGLPsGGYQCSCLSQFTG 4076
Cdd:pfam00008    1 CAPNPCSNGGTCVDTP-GGYTCICPEGYTG 29
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1048-1143 1.74e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 126.27  E-value: 1.74e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 1048 VGSVKENSRIGTSVLQVTAHDEDSGRDGEIQYSIRDGSGLGRFNIDDESGVITAADILDRETTASYWLTVYATDRGVVPL 1127
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                           90
                   ....*....|....*.
gi 1958794504 1128 YSTIEVYIEVEDVNDN 1143
Cdd:cd11304     83 SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1151-1249 4.26e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 125.12  E-value: 4.26e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 1151 IYYPVVMENSPKDVSVIQIQAEDPDSGSNEKLTYRITSGNPQNFFAINIKTGLITTTsRKLDREQQAEHFLEVTVTDGGS 1230
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTA-KPLDREEQSSYTLTVTATDGGG 79

                           90
                   ....*....|....*....
gi 1958794504 1231 SPKQSTIWVVVQVLDENDN 1249
Cdd:cd11304     80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3263-3359 6.40e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 124.35  E-value: 6.40e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 3263 YLVTVPEDTSLGTQVLSVFATSKDIGTNAEITYLIRSGNEQGKFRINPKTGGISVLEALDYEMCKRFYLVVEAKDGGTPA 3342
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*..
gi 1958794504 3343 LSTAATVSIDLTDVNDN 3359
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3367-3464 3.67e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 119.34  E-value: 3.67e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 3367 VYSAVISEDALEGDSVILLIAEDVDSKPNGQIRFSIVGGDRDNEFAVDPILGLVKVKKKLDRERVSGYSLLIQAVDSGIP 3446
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1958794504 3447 AMSSTTTVNIDISDVNDN 3464
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3157-3254 1.13e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 118.18  E-value: 1.13e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 3157 HYTACVYENTATKALLTRVQAVDPDVGINRKVVYSL-EDSASGVFSIDSSSGVIVLEQPLDREQQSSYNISVRATDQSpG 3235
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG-G 79

                           90
                   ....*....|....*....
gi 1958794504 3236 QSLSSLTSVTITVLDINDN 3254
Cdd:cd11304     80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2313-2412 1.19e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 118.18  E-value: 1.19e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 2313 TYNTTLSESSLIGTPVLQLVSTDADSGNNNLVHYQIVQDtyNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVTATDNG 2392
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG--NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 1958794504 2393 FPSLSSEVLVQIYISDVNDN 2412
Cdd:cd11304     79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 732-826 6.77e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 113.18  E-value: 6.77e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  732 VAVKENMPVGTNILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYVLNITIYDLGKPQKS 811
Cdd:cd11304      4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                           90
                   ....*....|....*
gi 1958794504  812 SWRLLTVNVEDANDN 826
Cdd:cd11304     84 STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 476-573 1.37e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 112.02  E-value: 1.37e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  476 YETFVNESVPVGTNVLTVSASDKDKGENGYITYSIASLN-LLPFAINQFTGVISTTEELDFESSPEtYRFIVRASDWGSP 554
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNeDGLFSIDPSTGEITTAKPLDREEQSS-YTLTVTATDGGGP 80

                           90
                   ....*....|....*....
gi 1958794504  555 yRHESEVNVTIRVGNVNDN 573
Cdd:cd11304     81 -PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2840-2942 1.14e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 109.71  E-value: 1.14e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 2840 SYETIIMEGMPVGTKLAQVRAIDTDWGANGQVTYSLHSDSHLEKvmeaFNIDSNTGWISTLKDLDHETDPTFSFFVVASD 2919
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGL----FSIDPSTGEITTAKPLDREEQSSYTLTVTATD 76

                           90       100
                   ....*....|....*....|...
gi 1958794504 2920 LGEaFSLSSMALVSVKVTDINDN 2942
Cdd:cd11304     77 GGG-PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3056-3149 1.80e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.94  E-value: 1.80e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 3056 YSASLPEDIPSNKIILKVSAKDADIGSNGDIRYSLYGSGNSDFF-LDPESGELKTLALLDRERVPVYNLIARATDGGG-- 3132
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFsIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGpp 81

                           90
                   ....*....|....*..
gi 1958794504 3133 RFCSSTVLLLLEDVNDN 3149
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 834-930 2.03e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.94  E-value: 2.03e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  834 SYSVSILESSSIGTEIIQVEARDKDLGSNGEVTYSVL--TDTHQFVINSSTGIVYIADQLDRESKANYSLKIEARDKAes 911
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG-- 78

                           90
                   ....*....|....*....
gi 1958794504  912 GQQLFSVVTLKIFLDDVND 930
Cdd:cd11304     79 GPPLSSTATVTITVLDVND 97
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 3887-4016 2.17e-27

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 109.82  E-value: 2.17e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 3887 LRTLQSNGIIMYTRA--NPCMILKIVEGKLWFQLDCGSGPGILGISSRAVNDGSWHSVFLELNRNFTSLSLDDSYVERRR 3964
Cdd:pfam02210    1 FRTRQPNGLLLYAGGggSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSL 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1958794504 3965 APLYFQTLSTDSAIFFGALVQADNIRSLtdtrvtQVLGGFQGCLDSVVLNHN 4016
Cdd:pfam02210   81 PPGESLLLNLNGPLYLGGLPPLLLLPAL------PVRAGFVGCIRDVRVNGE 126
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1795-1901 3.08e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.17  E-value: 3.08e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 1795 QYSGSLSEAAPINSLVrsldnspLVIRATDADSNQNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHEVIAHFHFHVH 1874
Cdd:cd11304      1 SYEVSVPENAPPGTVV-------LTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVT 73

                           90       100
                   ....*....|....*....|....*..
gi 1958794504 1875 VRDSGNPQLTaeSPVEVNIEVTDVNDN 1901
Cdd:cd11304     74 ATDGGGPPLS--STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1486-1584 1.28e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 106.63  E-value: 1.28e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 1486 HYDVTISEDVPPDTEILQIEATDRDEKH--KLSYTIHSSIDAismRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQ 1563
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGEngEVTYSIVSGNED---GLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|.
gi 1958794504 1564 EFPYRRNLARVIVNVEDANDH 1584
Cdd:cd11304     78 GGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1065-1145 2.70e-26

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 105.12  E-value: 2.70e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  1065 TAHDEDSGRDGEIQYSIRDGSGLGRFNIDDESGVITAADILDRETTASYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNA 1144
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1958794504  1145 P 1145
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1593-1683 5.21e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 104.70  E-value: 5.21e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 1593 YEASVFESAALGSVVLQVTALDKDKGENAELIYSIEAGNTGNTFKIEPVLGIITISKEPDMTAMGQFVLSVKVTDQGSPP 1672
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|.
gi 1958794504 1673 MSATAIVRISI 1683
Cdd:cd11304     82 LSSTATVTITV 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 161-261 5.47e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.01  E-value: 5.47e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  161 TYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFK--NKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRgmk 238
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG--- 77

                           90       100
                   ....*....|....*....|...
gi 1958794504  239 lyGNNGVSSTAKLYVHIERINEH 261
Cdd:cd11304     78 --GGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3176-3256 6.49e-25

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 100.89  E-value: 6.49e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  3176 QAVDPDVGINRKVVYSLED-SASGVFSIDSSSGVIVLEQPLDREQQSSYNISVRATDQSpGQSLSSLTSVTITVLDINDN 3254
Cdd:smart00112    1 SATDADSGENGKVTYSILSgNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGG-GPPLSSTATVTITVLDVNDN 79


                    ..
gi 1958794504  3255 PP 3256
Cdd:smart00112   80 AP 81
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 3859-4014 1.03e-24

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 103.27  E-value: 1.03e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 3859 SLSFAGNSYIKYRLSENSREEdFKLALRLRTLQSNGIIMYT---RANPCMILKIVEGKLWFQLDCGSGPGILGiSSRAVN 3935
Cdd:cd00110      1 GVSFSGSSYVRLPTLPAPRTR-LSISFSFRTTSPNGLLLYAgsqNGGDFLALELEDGRLVLRYDLGSGSLVLS-SKTPLN 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958794504 3936 DGSWHSVFLELNRNFTSLSLDDSYVERRRAPLYFQTLSTDSAIFFGALVQADNIRSLTDTRvtqvlgGFQGCLDSVVLN 4014
Cdd:cd00110     79 DGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSP------GFVGCIRDLKVN 151
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1698-1787 1.11e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 100.85  E-value: 1.11e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 1698 YQAEVNENVDIGTSVILISAISQ-----STLIYEVKDGNINGVFTINPYSGVITTRRALDYEHTSSYQLIIQATNMAG-- 1770
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPdsgenGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGpp 81

                           90
                   ....*....|....*..
gi 1958794504 1771 MASNATVSVQVVDENDN 1787
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1170-1251 1.51e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 100.12  E-value: 1.51e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  1170 QAEDPDSGSNEKLTYRITSGNPQNFFAINIKTGLITTTsRKLDREQQAEHFLEVTVTDGGSSPKQSTIWVVVQVLDENDN 1249
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTT-KPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 1958794504  1250 KP 1251
Cdd:smart00112   80 AP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2522-2618 1.81e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 100.47  E-value: 1.81e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 2522 TYVAEVRENAASGTKVIHVRATDGDPGTYGQVSYSIINDFAKDRFLIDSN-GQIITTERLDRENPLEgdISIYLRALDGG 2600
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPStGEITTAKPLDREEQSS--YTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 1958794504 2601 G--RTTFCTVRVIVVDENDN 2618
Cdd:cd11304     79 GppLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3282-3361 2.39e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 99.35  E-value: 2.39e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  3282 ATSKDIGTNAEITYLIRSGNEQGKFRINPKTGGISVLEALDYEMCKRFYLVVEAKDGGTPALSTAATVSIDLTDVNDNPP 3361
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3387-3466 3.78e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 98.96  E-value: 3.78e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  3387 AEDVDSKPNGQIRFSIVGGDRDNEFAVDPILGLVKVKKKLDRERVSGYSLLIQAVDSGIPAMSSTTTVNIDISDVNDNSP 3466
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 939-1022 6.78e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 98.92  E-value: 6.78e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  939 SYSVKVLEDLPVGTVIAWLETQDPDLGLGGQVRYSLV-NDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRP 1017
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80


                   ....*
gi 1958794504 1018 vSLSS 1022
Cdd:cd11304     81 -PLSS 84
Cadherin pfam00028
Cadherin domain;
3263-3354 2.84e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 96.60  E-value: 2.84e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 3263 YLVTVPEDTSLGTQVLSVFATSKDIGTNAEITYLIRSGNEQGKFRINPKTGGISVLEALDYEMCKRFYLVVEAKDGGTPA 3342
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 1958794504 3343 LSTAATVSIDLT 3354
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
3368-3458 5.04e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 96.22  E-value: 5.04e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 3368 YSAVISEDALEGDSVILLIAEDVDSKPNGQIRFSIVGGDRDNEFAVDPILGLVKVKKKLDRERVSGYSLLIQAVDSGIPA 3447
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 1958794504 3448 MSSTTTVNIDI 3458
Cdd:pfam00028   81 LSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2334-2414 8.01e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 95.11  E-value: 8.01e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  2334 TDADSGNNNLVHYQIVQDtyNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVTATDNGFPSLSSEVLVQIYISDVNDNP 2413
Cdd:smart00112    3 TDADSGENGKVTYSILSG--NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1958794504  2414 P 2414
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
1048-1138 1.96e-22

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 94.29  E-value: 1.96e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 1048 VGSVKENSRIGTSVLQVTAHDEDSGRDGEIQYSIRDGSGLGRFNIDDESGVITAADILDRETTASYWLTVYATDRGVVPL 1127
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPL 81

                           90
                   ....*....|.
gi 1958794504 1128 YSTIEVYIEVE 1138
Cdd:pfam00028   82 SSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1156-1244 2.39e-22

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 94.29  E-value: 2.39e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 1156 VMENSPKDVSVIQIQAEDPDSGSNEKLTYRITSGNPQNFFAINIKTGLITTTSRkLDREQQAEHFLEVTVTDGGSSPKQS 1235
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKP-LDRESIGEYELTVEATDSGGPPLSS 83


                   ....*....
gi 1958794504 1236 TIWVVVQVL 1244
Cdd:pfam00028   84 TATVTITVL 92
LamG smart00282
Laminin G domain;
3882-4016 3.60e-22

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 95.10  E-value: 3.60e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  3882 KLALRLRTLQSNGIIMYTRANP---CMILKIVEGKLWFQLDCGSGPGILGISSRAVNDGSWHSVFLELNRNFTSLSLDDS 3958
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGggdYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958794504  3959 YVERRRAPLYFQTLSTDSAIFFGALVQADNIRSLTDTRvtqvlgGFQGCLDSVVLNHN 4016
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVTP------GFRGCIRNLKVNGK 132
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2950-3047 4.83e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.53  E-value: 4.83e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 2950 VYRGNVKESDPPGEVVAVLSTLDKDtSNINRQVSYHITGGNPRGRFALGmvQSEWKVYVKRPLDREEQDIYFLNITASDG 3029
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPD-SGENGEVTYSIVSGNEDGLFSID--PSTGEITTAKPLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|.
gi 1958794504 3030 ---LFVTQAMVEVTVSDVNDN 3047
Cdd:cd11304     78 ggpPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1821-1903 5.39e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 92.80  E-value: 5.39e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  1821 RATDADSNQNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHEVIAHFHFHVHVRDSGNPQLTaeSPVEVNIEVTDVND 1900
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLS--STATVTITVLDVND 78


                    ...
gi 1958794504  1901 NPP 1903
Cdd:smart00112   79 NAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2213-2305 6.86e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.15  E-value: 6.86e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 2213 YTASINEDISINTPILSINAT---SPEGQGIIYLIIDGDPFQQFNIDFDTGVLKVISPLDYEVMSVYKLTVRASDALTGA 2289
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATdpdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*..
gi 1958794504 2290 R-AEVTVDLLVDDVNDN 2305
Cdd:cd11304     82 LsSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 748-828 1.14e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 91.64  E-value: 1.14e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504   748 KAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYVLNITIYDLGKPQKSSWRLLTVNVEDANDNS 827
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1958794504   828 P 828
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
3158-3249 3.46e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 90.82  E-value: 3.46e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 3158 YTACVYENTATKALLTRVQAVDPDVGINRKVVYS-LEDSASGVFSIDSSSGVIVLEQPLDREQQSSYNISVRATDQSpGQ 3236
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSiLGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG-GP 79

                           90
                   ....*....|...
gi 1958794504 3237 SLSSLTSVTITVL 3249
Cdd:pfam00028   80 PLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2859-2944 1.39e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 88.56  E-value: 1.39e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  2859 RAIDTDWGANGQVTYSLHSDSHLEKvmeaFNIDSNTGWISTLKDLDHETDPTFSFFVVASDLGEAfSLSSMALVSVKVTD 2938
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGL----FSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP-PLSSTATVTITVLD 75


                    ....*.
gi 1958794504  2939 INDNAP 2944
Cdd:smart00112   76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 494-575 1.85e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 88.18  E-value: 1.85e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504   494 SASDKDKGENGYITYSIASLN-LLPFAINQFTGVISTTEELDFESSPEtYRFIVRASDWGSPyRHESEVNVTIRVGNVND 572
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNdDGLFSIDPETGEITTTKPLDREEQPE-YTLTVEATDGGGP-PLSSTATVTITVLDVND 78


                    ...
gi 1958794504   573 NSP 575
Cdd:smart00112   79 NAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3074-3151 3.54e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.41  E-value: 3.54e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  3074 SAKDADIGSNGDIRYSL-YGSGNSDFFLDPESGELKTLALLDRERVPVYNLIARATDGGG--RFCSSTVLLLLEDVNDNP 3150
Cdd:smart00112    1 SATDADSGENGKVTYSIlSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGppLSSTATVTITVLDVNDNA 80


                    .
gi 1958794504  3151 P 3151
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2110-2201 6.31e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 87.37  E-value: 6.31e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 2110 PYYAAVQVDAEPGTLIYRVTAIDKDKGANGEVTYVL--QDDYGHFEINPNSGNVILKEAFNSDLSNIdYGVTILAKDGGT 2187
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsGNEDGLFSIDPSTGEITTAKPLDREEQSS-YTLTVTATDGGG 79

                           90
                   ....*....|....
gi 1958794504 2188 PSLSTFVELPITIV 2201
Cdd:cd11304     80 PPLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1257-1347 9.40e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.98  E-value: 9.40e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 1257 VYQIKLPERDrkKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQF---TAGSYdILTIKAVDN 1333
Cdd:cd11304      1 SYEVSVPENA--PPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLdreEQSSY-TLTVTATDG 77

                           90
                   ....*....|....
gi 1958794504 1334 GRPQKSSTARLHIE 1347
Cdd:cd11304     78 GGPPLSSTATVTIT 91
Cadherin pfam00028
Cadherin domain;
476-567 2.04e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 85.82  E-value: 2.04e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  476 YETFVNESVPVGTNVLTVSASDKDKGENGYITYSIASLNLLP-FAINQFTGVISTTEELDFEsSPETYRFIVRASDWGSP 554
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGnFRIDPDTGDISTTKPLDRE-SIGEYELTVEATDSGGP 79

                           90
                   ....*....|...
gi 1958794504  555 YRhESEVNVTIRV 567
Cdd:pfam00028   80 PL-SSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
1593-1683 3.62e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 85.04  E-value: 3.62e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 1593 YEASVFESAALGSVVLQVTALDKDKGENAELIYSIEAGNTGNTFKIEPVLGIITISKEPDMTAMGQFVLSVKVTDQGSPP 1672
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 1958794504 1673 MSATAIVRISI 1683
Cdd:pfam00028   81 LSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 854-933 4.58e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 84.32  E-value: 4.58e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504   854 ARDKDLGSNGEVTYSVL--TDTHQFVINSSTGIVYIADQLDRESKANYSLKIEARDKAesGQQLFSVVTLKIFLDDVNDC 931
Cdd:smart00112    2 ATDADSGENGKVTYSILsgNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGG--GPPLSSTATVTITVLDVNDN 79


                    ..
gi 1958794504   932 SP 933
Cdd:smart00112   80 AP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2626-2721 1.26e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.90  E-value: 1.26e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 2626 EYRASVRADVGRGHLVTQVQALDPDDGANSRITYSLYSEasvSVADLLEIDPDNGWMVTKGNFNQLRNTVLSFFVKAVDG 2705
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG---NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                           90
                   ....*....|....*.
gi 1958794504 2706 GIPVRHSLIPVYIHVL 2721
Cdd:cd11304     78 GGPPLSSTATVTITVL 93
Cadherin pfam00028
Cadherin domain;
835-923 1.60e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 83.12  E-value: 1.60e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  835 YSVSILESSSIGTEIIQVEARDKDLGSNGEVTYSVLTDT--HQFVINSSTGIVYIADQLDRESKANYSLKIEARDkaESG 912
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGpgGNFRIDPDTGDISTTKPLDRESIGEYELTVEATD--SGG 78

                           90
                   ....*....|.
gi 1958794504  913 QQLFSVVTLKI 923
Cdd:pfam00028   79 PPLSSTATVTI 89
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1721-1789 1.71e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.78  E-value: 1.71e-18
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958794504  1721 STLIYEVKDGNINGVFTINPYSGVITTRRALDYEHTSSYQLIIQATNMAG--MASNATVSVQVVDENDNPP 1789
Cdd:smart00112   11 GKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGppLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2420-2512 1.72e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.52  E-value: 1.72e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 2420 IYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVLTLSSHRKQRMEPLYSLNVSVSDG--- 2496
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGggp 80

                           90
                   ....*....|....*.
gi 1958794504 2497 LFTSTAQVHIRVLGAN 2512
Cdd:cd11304     81 PLSSTATVTITVLDVN 96
Cadherin pfam00028
Cadherin domain;
940-1017 3.14e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 82.35  E-value: 3.14e-18
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958794504  940 YSVKVLEDLPVGTVIAWLETQDPDLGLGGQVRYSLVNDYNGR-FEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRP 1017
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGnFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3473-3564 3.90e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.36  E-value: 3.90e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 3473 YTAVIQENKPVGTSILQLVVTDRDSFHNGpPFSFSILSGNEDEEFMLDSH-GILRSAVVFRHMESPEYLLCIQAKDSGKP 3551
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENG-EVTYSIVSGNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|...
gi 1958794504 3552 QQVSHTYIRVRVI 3564
Cdd:cd11304     81 PLSSTATVTITVL 93
Cadherin pfam00028
Cadherin domain;
2523-2612 4.59e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 81.96  E-value: 4.59e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 2523 YVAEVRENAASGTKVIHVRATDGDPGTYGQVSYSIINDFAKDRFLID-SNGQIITTERLDRENPleGDISIYLRALDGGG 2601
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDpDTGDISTTKPLDRESI--GEYELTVEATDSGG 78

                           90
                   ....*....|.
gi 1958794504 2602 RTTFCTVRVIV 2612
Cdd:pfam00028   79 PPLSSTATVTI 89
Cadherin pfam00028
Cadherin domain;
1796-1894 6.15e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 81.58  E-value: 6.15e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 1796 YSGSLSEAAPINSLVrsldnspLVIRATDADSNQNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHEVIAHFHFHVHV 1875
Cdd:pfam00028    1 YSASVPENAPVGTEV-------LTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEA 73

                           90
                   ....*....|....*....
gi 1958794504 1876 RDSGNPQLTAESPVEVNIE 1894
Cdd:pfam00028   74 TDSGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
3056-3141 1.06e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.81  E-value: 1.06e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 3056 YSASLPEDIPSNKIILKVSAKDADIGSNGDIRYSLYGSGNSDFF-LDPESGELKTLALLDRERVPVYNLIARATDGGGRF 3134
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFrIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80


                   ....*..
gi 1958794504 3135 CSSTVLL 3141
Cdd:pfam00028   81 LSSTATV 87
Cadherin pfam00028
Cadherin domain;
732-821 1.07e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.81  E-value: 1.07e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  732 VAVKENMPVGTNILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYVLNITIYDLGKPQKS 811
Cdd:pfam00028    3 ASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLS 82

                           90
                   ....*....|
gi 1958794504  812 SWRLLTVNVE 821
Cdd:pfam00028   83 STATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1698-1781 2.04e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.04  E-value: 2.04e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 1698 YQAEVNENVDIGTSVILISAIS-----QSTLIYEVKDGNINGVFTINPYSGVITTRRALDYEHTSSYQLIIQATNMA--G 1770
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDpdlgpNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGgpP 80

                           90
                   ....*....|.
gi 1958794504 1771 MASNATVSVQV 1781
Cdd:pfam00028   81 LSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
2213-2298 3.79e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 79.27  E-value: 3.79e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 2213 YTASINEDISINTPILSINAT---SPEGQGIIYLIIDGDPFQQFNIDFDTGVLKVISPLDYEVMSVYKLTVRASDALTGA 2289
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATdpdLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 1958794504 2290 R---AEVTVDLL 2298
Cdd:pfam00028   81 LsstATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1487-1579 6.11e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 78.88  E-value: 6.11e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 1487 YDVTISEDVPPDTEILQIEATDRDEK--HKLSYTIhssIDAISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQE 1564
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGpnGRIFYSI---LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|....*
gi 1958794504 1565 FPYRRNLARVIVNVE 1579
Cdd:pfam00028   78 GPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2234-2307 1.03e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.78  E-value: 1.03e-16
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958794504  2234 SPEGQGIIYLIIDGDPFQQFNIDFDTGVLKVISPLDYEVMSVYKLTVRASDALTGAR-AEVTVDLLVDDVNDNPP 2307
Cdd:smart00112    7 SGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLsSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
2314-2406 1.20e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 77.73  E-value: 1.20e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 2314 YNTTLSESSLIGTPVLQLVSTDADSGNNNLVHYQIVQDtyNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVTATDNGF 2393
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGG--GPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG 78

                           90
                   ....*....|...
gi 1958794504 2394 PSLSSEVLVQIYI 2406
Cdd:pfam00028   79 PPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2541-2620 1.60e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.00  E-value: 1.60e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  2541 RATDGDPGTYGQVSYSIINDFAKDRFLIDSN-GQIITTERLDRENplEGDISIYLRALDGGG--RTTFCTVRVIVVDEND 2617
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPEtGEITTTKPLDREE--QPEYTLTVEATDGGGppLSSTATVTITVLDVND 78


                    ...
gi 1958794504  2618 NAP 2620
Cdd:smart00112   79 NAP 81
Cadherin pfam00028
Cadherin domain;
2841-2937 2.39e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.96  E-value: 2.39e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 2841 YETIIMEGMPVGTKLAQVRAIDTDWGANGQVTYSLHSDShlekVMEAFNIDSNTGWISTLKDLDHETDPTFSFFVVASDL 2920
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGG----PGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                           90
                   ....*....|....*..
gi 1958794504 2921 GEAfSLSSMALVSVKVT 2937
Cdd:pfam00028   77 GGP-PLSSTATVTITVL 92
Laminin_G_1 pfam00054
Laminin G domain;
3888-4018 4.15e-16

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 77.74  E-value: 4.15e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 3888 RTLQSNGIIMYTRANP---CMILKIVEGKLWFQLDCGSGPGILGISSRaVNDGSWHSVFLELNRNFTSLSLDDSYVERRR 3964
Cdd:pfam00054    2 RTTEPSGLLLYNGTQTerdFLALELRDGRLEVSYDLGSGAAVVRSGDK-LNDGKWHSVELERNGRSGTLSVDGEARPTGE 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958794504 3965 APL-YFQTLSTDSAIFFGAL----VQADNIRSLTdtrvtqvlgGFQGCLDSVVLNHNEL 4018
Cdd:pfam00054   81 SPLgATTDLDVDGPLYVGGLpslgVKKRRLAISP---------SFDGCIRDVIVNGKPL 130
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1506-1586 4.23e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 75.85  E-value: 4.23e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  1506 ATDRDE--KHKLSYTIHSSIDAismRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDAND 1583
Cdd:smart00112    2 ATDADSgeNGKVTYSILSGNDD---GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                    ...
gi 1958794504  1584 HSP 1586
Cdd:smart00112   79 NAP 81
Cadherin pfam00028
Cadherin domain;
1258-1347 2.07e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 74.26  E-value: 2.07e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 1258 YQIKLPERDRkkRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQF---TAGSYdILTIKAVDNG 1334
Cdd:pfam00028    1 YSASVPENAP--VGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLdreSIGEY-ELTVEATDSG 77

                           90
                   ....*....|...
gi 1958794504 1335 RPQKSSTARLHIE 1347
Cdd:pfam00028   78 GPPLSSTATVTIT 90
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2972-3049 3.21e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.54  E-value: 3.21e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  2972 DKDtSNINRQVSYHITGGNPRGRFALGMVQSEwkVYVKRPLDREEQDIYFLNITASDG---LFVTQAMVEVTVSDVNDNS 3048
Cdd:smart00112    4 DAD-SGENGKVTYSILSGNDDGLFSIDPETGE--ITTTKPLDREEQPEYTLTVEATDGggpPLSSTATVTITVLDVNDNA 80


                    .
gi 1958794504  3049 P 3049
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1611-1689 4.70e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.15  E-value: 4.70e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  1611 TALDKDKGENAELIYSIEAGNTGNTFKIEPVLGIITISKEPDMTAMGQFVLSVKVTDQGSPPMSATAIVRISIS-MSDNS 1689
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLdVNDNA 80
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 180-263 5.82e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.77  E-value: 5.82e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504   180 TATDADIGSNGEFYYYFK--NKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKlygnnGVSSTAKLYVHIER 257
Cdd:smart00112    1 SATDADSGENGKVTYSILsgNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP-----PLSSTATVTITVLD 75


                    ....*.
gi 1958794504   258 INEHAP 263
Cdd:smart00112   76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1279-1347 6.80e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.38  E-value: 6.80e-15
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958794504  1279 AFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQF---TAGSYDiLTIKAVDNGRPQKSSTARLHIE 1347
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLdreEQPEYT-LTVEATDGGGPPLSSTATVTIT 72
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 379-467 1.02e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 72.73  E-value: 1.02e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  379 VYDISISEFSPPGVMVAIVKVN----PEPLDVEYTLLPGKDAEYFKINPRSGLIVTAQPLNTVKKEVYKLEVSDKEGD-- 452
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATdpdsGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGgp 80

                           90
                   ....*....|....*...
gi 1958794504  453 ---AKAQVTIGIEDANDH 467
Cdd:cd11304     81 plsSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
162-256 1.09e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 72.33  E-value: 1.09e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  162 YSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFK--NKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRgmkl 239
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILggGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS---- 76

                           90
                   ....*....|....*..
gi 1958794504  240 yGNNGVSSTAKLYVHIE 256
Cdd:pfam00028   77 -GGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2009-2102 2.41e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 71.58  E-value: 2.41e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 2009 YSTSISENSTNITKVAIVNAV--GNRLNEPLKYSIL--NPGNKFKIKSTSGVIQTTGvPFDREEQELYELVVEASrelDH 2084
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATdpDSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAK-PLDREEQSSYTLTVTAT---DG 77

                           90       100
                   ....*....|....*....|.
gi 1958794504 2085 LRVARVVVRV---NIEDVNDN 2102
Cdd:cd11304     78 GGPPLSSTATvtiTVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1920-1999 4.53e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 70.81  E-value: 4.53e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 1920 VGVEVLKVSATDPDSEVPPELTYSLMEGSVD-HFLMDPNTGVLTIKN--NNLSKDHYMLIVRVSDG---KFYSTAMVTIM 1993
Cdd:cd11304     12 PGTVVLTVSATDPDSGENGEVTYSIVSGNEDgLFSIDPSTGEITTAKplDREEQSSYTLTVTATDGggpPLSSTATVTIT 91


                   ....*.
gi 1958794504 1994 VKEAMD 1999
Cdd:cd11304     92 VLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 961-1022 4.60e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 70.07  E-value: 4.60e-14
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958794504   961 DPDLGLGGQVRYSLV-NDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPvSLSS 1022
Cdd:smart00112    4 DADSGENGKVTYSILsGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP-PLSS 65
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2734-2832 3.34e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 68.11  E-value: 3.34e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 2734 QYSFTIAEDTSIGSTIDTLR-----ILPNQSVRFSTVNGerpenNKENVFIIEQETGAIKLDKRLDHEVSPAFHFKVAAT 2808
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSatdpdSGENGEVTYSIVSG-----NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                           90       100
                   ....*....|....*....|....*.
gi 1958794504 2809 iplDKVDIVF--TVDVDVKVLDLNDN 2832
Cdd:cd11304     76 ---DGGGPPLssTATVTITVLDVNDN 98
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 4120-4155 1.36e-12

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 64.58  E-value: 1.36e-12
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1958794504 4120 DVDECEREE-CENGGSCVNLFGSFFCNCTPGYVGQYC 4155
Cdd:cd00054      1 DIDECASGNpCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
Cadherin pfam00028
Cadherin domain;
2111-2200 4.18e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.01  E-value: 4.18e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 2111 YYAAVQVDAEPGTLIYRVTAIDKDKGANGEVTYVL--QDDYGHFEINPNSGNVILKEAFNSDLSNIdYGVTILAKDGGTP 2188
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIlgGGPGGNFRIDPDTGDISTTKPLDRESIGE-YELTVEATDSGGP 79

                           90
                   ....*....|..
gi 1958794504 2189 SLSTFVELPITI 2200
Cdd:pfam00028   80 PLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
2627-2721 2.28e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 62.70  E-value: 2.28e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 2627 YRASVRADVGRGHLVTQVQALDPDDGANSRITYSLyseASVSVADLLEIDPDNGWMVTKGNFNQLRNTVLSFFVKAVDGG 2706
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI---LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|....*
gi 1958794504 2707 IPVRHSLIPVYIHVL 2721
Cdd:pfam00028   78 GPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1366-1478 5.48e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 61.95  E-value: 5.48e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 1366 YNFTIMESDKVTEIVGVVSVQ----PANTPLWFDIIGGkHAREMFYIlqtacgqncsteggnfDSSFdaekgvGTIVIAK 1441
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATdpdsGENGEVTYSIVSG-NEDGLFSI----------------DPST------GEITTAK 58

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1958794504 1442 PLDAEQRSVYNMSVEVTDGTN---VAVTQVFITVLDNNDN 1478
Cdd:cd11304     59 PLDREEQSSYTLTVTATDGGGpplSSTATVTITVLDVNDN 98
EGF_CA smart00179
Calcium-binding EGF-like domain;
4120-4155 8.85e-11

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 59.57  E-value: 8.85e-11
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1958794504  4120 DVDECERE-ECENGGSCVNLFGSFFCNCTPGYV-GQYC 4155
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2129-2201 4.25e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 58.90  E-value: 4.25e-10
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958794504  2129 TAIDKDKGANGEVTYVL--QDDYGHFEINPNSGNVILKEAFNSDLSNIdYGVTILAKDGGTPSLSTFVELPITIV 2201
Cdd:smart00112    1 SATDADSGENGKVTYSIlsGNDDGLFSIDPETGEITTTKPLDREEQPE-YTLTVEATDGGGPPLSSTATVTITVL 74
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3491-3571 4.33e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 58.90  E-value: 4.33e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  3491 VVTDRDSFHNGPpFSFSILSGNEDEEFMLDSH-GILRSAVVFRHMESPEYLLCIQAKDSGKPQQVSHTYIRVRVIEESTH 3569
Cdd:smart00112    1 SATDADSGENGK-VTYSILSGNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 1958794504  3570 KP 3571
Cdd:smart00112   80 AP 81
Cadherin pfam00028
Cadherin domain;
3473-3564 7.69e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 58.47  E-value: 7.69e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 3473 YTAVIQENKPVGTSILQLVVTDRDSFHNGPPFsFSILSGNEDEEFMLDSH-GILRSAVVFRHMESPEYLLCIQAKDSGKP 3551
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIF-YSILGGGPGGNFRIDPDtGDISTTKPLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|...
gi 1958794504 3552 QQVSHTYIRVRVI 3564
Cdd:pfam00028   80 PLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 405-469 9.10e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 58.13  E-value: 9.10e-10
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504   405 DVEYTLLPGKDAEYFKINPRSGLIVTAQPLNTVKKEVYKLEVSDKEGD-----AKAQVTIGIEDANDHTP 469
Cdd:smart00112   12 KVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGgpplsSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1421-1480 1.36e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 57.36  E-value: 1.36e-09
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958794504  1421 GGNFDSSFDAEKGVGTIVIAKPLDAEQRSVYNMSVEVTDGTN---VAVTQVFITVLDNNDNGP 1480
Cdd:smart00112   19 SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGpplSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 591-671 1.45e-09

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 58.09  E-value: 1.45e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  591 PVGGHITAISAIDIDELE--LVKYKIISGNELGFFYLNPDSGVLQLKKSLMNSgiKNGNFALRITATDGEN--FADPMAI 666
Cdd:cd11304     11 PPGTVVLTVSATDPDSGEngEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDRE--EQSSYTLTVTATDGGGppLSSTATV 88


                   ....*
gi 1958794504  667 NISVL 671
Cdd:cd11304     89 TITVL 93
Cadherin pfam00028
Cadherin domain;
2009-2079 1.48e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 57.70  E-value: 1.48e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958794504 2009 YSTSISENSTNITKVAIVNAV----GnrLNEPLKYSIL--NPGNKFKIKSTSGVIQTTGvPFDREEQELYELVVEAS 2079
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATdpdlG--PNGRIFYSILggGPGGNFRIDPDTGDISTTK-PLDRESIGEYELTVEAT 74
Cadherin pfam00028
Cadherin domain;
2951-3041 1.69e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 57.70  E-value: 1.69e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 2951 YRGNVKESDPPGEVVAVLSTLDKDTSNiNRQVSYHITGGNPRGRFAL----GMVqsewkvYVKRPLDREEQDIYFLNITA 3026
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGP-NGRIFYSILGGGPGGNFRIdpdtGDI------STTKPLDRESIGEYELTVEA 73

                           90
                   ....*....|....*...
gi 1958794504 3027 SDGLF---VTQAMVEVTV 3041
Cdd:pfam00028   74 TDSGGpplSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
2421-2509 2.14e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 57.31  E-value: 2.14e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 2421 YESYVSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVLTLSSH--RKQRmePLYSLNVSVSDGLF 2498
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPldRESI--GEYELTVEATDSGG 78

                           90
                   ....*....|....
gi 1958794504 2499 ---TSTAQVHIRVL 2509
Cdd:pfam00028   79 pplSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2439-2512 2.39e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 56.59  E-value: 2.39e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958794504  2439 QASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVLTLSSH--RKQRmePLYSLNVSVSDG---LFTSTAQVHIRVLGAN 2512
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPldREEQ--PEYTLTVEATDGggpPLSSTATVTITVLDVN 77
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2645-2721 3.24e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 56.20  E-value: 3.24e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958794504  2645 QALDPDDGANSRITYSLyseASVSVADLLEIDPDNGWMVTKGNFNQLRNTVLSFFVKAVDGGIPVRHSLIPVYIHVL 2721
Cdd:smart00112    1 SATDADSGENGKVTYSI---LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2034-2104 5.82e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 55.82  E-value: 5.82e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958794504  2034 NEPLKYSIL--NPGNKFKIKSTSGVIQTTGvPFDREEQELYELVVEASrelDHLRVARVVVRV---NIEDVNDNSP 2104
Cdd:smart00112   10 NGKVTYSILsgNDDGLFSIDPETGEITTTK-PLDREEQPEYTLTVEAT---DGGGPPLSSTATvtiTVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3583-3660 1.53e-08

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 55.01  E-value: 1.53e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 3583 MEDDFPGGVIGKIHATDQD--MYDVLTFALKSEQ-KSLFKVNSHDGKIIALGGLD---SGKYVLNVSVSDG---RFQVPI 3653
Cdd:cd11304      7 PENAPPGTVVLTVSATDPDsgENGEVTYSIVSGNeDGLFSIDPSTGEITTAKPLDreeQSSYTLTVTATDGggpPLSSTA 86


                   ....*..
gi 1958794504 3654 DVVVHVE 3660
Cdd:cd11304     87 TVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 47-152 3.94e-08

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 53.86  E-value: 3.94e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504   47 YNATVYENSAARTYVnsqsrMGITLIDL----SWDIKYRIVSGDEEGFFkaeeviiadfcflRIRTKGGN---SAILNRE 119
Cdd:cd11304      2 YEVSVPENAPPGTVV-----LTVSATDPdsgeNGEVTYSIVSGNEDGLF-------------SIDPSTGEittAKPLDRE 63

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1958794504  120 IQDNYLLIIKGSVRGED-LEAWTKVNIQVLDMND 152
Cdd:cd11304     64 EQSSYTLTVTATDGGGPpLSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2756-2834 6.70e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 52.74  E-value: 6.70e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  2756 PNQSVRFSTVNGerpenNKENVFIIEQETGAIKLDKRLDHEVSPAFHFKVAATiplDKVDIVF--TVDVDVKVLDLNDNK 2833
Cdd:smart00112    9 ENGKVTYSILSG-----NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEAT---DGGGPPLssTATVTITVLDVNDNA 80


                    .
gi 1958794504  2834 P 2834
Cdd:smart00112   81 P 81
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 4079-4118 2.04e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.94  E-value: 2.04e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1958794504 4079 CESeitacfPNPCRNGGSCDPIGNTFICSCKAGLTGVTCE 4118
Cdd:cd00054      5 CAS------GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 4045-4080 3.33e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.17  E-value: 3.33e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1958794504 4045 DACQ-RSPCLHGGSCSGLPsGGYQCSCLSQFTGTNCE 4080
Cdd:cd00054      3 DECAsGNPCQNGGTCVNTV-GSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 4086-4114 7.06e-07

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 48.15  E-value: 7.06e-07
                           10        20
                   ....*....|....*....|....*....
gi 1958794504 4086 CFPNPCRNGGSCDPIGNTFICSCKAGLTG 4114
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1928-1999 7.42e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 49.66  E-value: 7.42e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958794504  1928 SATDPDSEVPPELTYSLMEGSVD-HFLMDPNTGVLTIkNNNL---SKDHYMLIVRVSDG---KFYSTAMVTIMVKEAMD 1999
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDgLFSIDPETGEITT-TKPLdreEQPEYTLTVEATDGggpPLSSTATVTITVLDVND 78
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 4123-4155 1.02e-06

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 47.86  E-value: 1.02e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1958794504 4123 ECERE-ECENGGSCVNLFGSFFCNCTPGYVGQ-YC 4155
Cdd:cd00053      1 ECAASnPCSNGGTCVNTPGSYRCVCPPGYTGDrSC 35
Cadherin pfam00028
Cadherin domain;
1920-1994 2.20e-06

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 48.84  E-value: 2.20e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 1920 VGVEVLKVSATDPDSEVPPELTYSLMEGSVDH-FLMDPNTGVLTIKnNNL---SKDHYMLIVRVSDGKFY---STAMVTI 1992
Cdd:pfam00028   11 VGTEVLTVTATDPDLGPNGRIFYSILGGGPGGnFRIDPDTGDISTT-KPLdreSIGEYELTVEATDSGGPplsSTATVTI 89


                   ..
gi 1958794504 1993 MV 1994
Cdd:pfam00028   90 TV 91
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 4124-4154 2.92e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 46.61  E-value: 2.92e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1958794504 4124 CEREECENGGSCVNLFGSFFCNCTPGYVGQY 4154
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
Cadherin pfam00028
Cadherin domain;
2735-2808 4.07e-06

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 48.07  E-value: 4.07e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958794504 2735 YSFTIAEDTSIGSTIDTLRIL-----PNQSVRFSTVNGERpennkENVFIIEQETGAIKLDKRLDHEVSPAFHFKVAAT 2808
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATdpdlgPNGRIFYSILGGGP-----GGNFRIDPDTGDISTTKPLDRESIGEYELTVEAT 74
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 75-155 5.00e-06

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 47.34  E-value: 5.00e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504    75 SWDIKYRIVSGDEEGFFkaeeviiadfcflRIRTKGGN---SAILNREIQDNYLLIIKGSVRGED-LEAWTKVNIQVLDM 150
Cdd:smart00112   10 NGKVTYSILSGNDDGLF-------------SIDPETGEittTKPLDREEQPEYTLTVEATDGGGPpLSSTATVTITVLDV 76


                    ....*
gi 1958794504   151 NDLRP 155
Cdd:smart00112   77 NDNAP 81
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 4129-4150 9.45e-06

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 45.02  E-value: 9.45e-06
                           10        20
                   ....*....|....*....|..
gi 1958794504 4129 CENGGSCVNLFGSFFCNCTPGY 4150
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
Cadherin pfam00028
Cadherin domain;
591-671 1.68e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 46.14  E-value: 1.68e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  591 PVGGHITAISAIDIDE--LELVKYKIISGNELGFFYLNPDSGVLQLKKSLmnSGIKNGNFALRITATD--GENFADPMAI 666
Cdd:pfam00028   10 PVGTEVLTVTATDPDLgpNGRIFYSILGGGPGGNFRIDPDTGDISTTKPL--DRESIGEYELTVEATDsgGPPLSSTATV 87


                   ....*
gi 1958794504  667 NISVL 671
Cdd:pfam00028   88 TITVL 92
Cadherin pfam00028
Cadherin domain;
1366-1473 1.90e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 46.14  E-value: 1.90e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 1366 YNFTIMESDKVTEIVGVVSVQPANTPLwfdiiggkHAREMFYILqtacgqncsteGGNFDSSFDAEKGVGTIVIAKPLDA 1445
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGP--------NGRIFYSIL-----------GGGPGGNFRIDPDTGDISTTKPLDR 61

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1958794504 1446 EQRSVYNMSVEVTDGTN---VAVTQVFITVL 1473
Cdd:pfam00028   62 ESIGEYELTVEATDSGGpplSSTATVTITVL 92
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 4088-4118 2.08e-05

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 44.00  E-value: 2.08e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1958794504 4088 PNPCRNGGSCDPIGNTFICSCKAGLTGV-TCE 4118
Cdd:cd00053      5 SNPCSNGGTCVNTPGSYRCVCPPGYTGDrSCE 36
Cadherin pfam00028
Cadherin domain;
380-462 3.96e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 44.98  E-value: 3.96e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  380 YDISISEFSPPGVMVAIVKVNPEPLD----VEYTLLPGKDAEYFKINPRSGLIVTAQPLNTVKKEVYKLEV--SDKEGDA 453
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGpngrIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVeaTDSGGPP 80

                           90
                   ....*....|..
gi 1958794504  454 K---AQVTIGIE 462
Cdd:pfam00028   81 LsstATVTITVL 92
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3266-3359 5.20e-05

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 45.03  E-value: 5.20e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 3266 TVPEDTSLGTQVLSVfatSKDIGTNAEITYLIRS-GNEQ--GKFRINPKTGGISVLEALDYEMCKRFYLVVEAKDGGTPA 3342
Cdd:cd00031      5 SAVEGRSRGSFRVSI---PTDLIASSGEIIKISAaGKEAlpSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGANV 81

                           90
                   ....*....|....*..
gi 1958794504 3343 LSTAATVSIDLTDVNDN 3359
Cdd:cd00031     82 PQTSSVFSIEVYDENDN 98
EGF_CA smart00179
Calcium-binding EGF-like domain;
4079-4118 5.44e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 5.44e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1958794504  4079 CESeitacfPNPCRNGGSCDPIGNTFICSCKAGLT-GVTCE 4118
Cdd:smart00179    5 CAS------GNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 285-363 5.49e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 44.26  E-value: 5.49e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958794504   285 TVDDLDEGANGEIeSVSIVDGDPLEQFFLAKEGKWmneykVKERRQVDWESFSYgYNLTIQAKDKGSPQKFSELkTVHI 363
Cdd:smart00112    1 SATDADSGENGKV-TYSILSGNDDGLFSIDPETGE-----ITTTKPLDREEQPE-YTLTVEATDGGGPPLSSTA-TVTI 71
EGF_CA pfam07645
Calcium-binding EGF domain;
4120-4149 6.61e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 42.61  E-value: 6.61e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1958794504 4120 DVDEC--EREECENGGSCVNLFGSFFCNCTPG 4149
Cdd:pfam07645    1 DVDECatGTHNCPANTVCVNTIGSFECRCPDG 32
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 4047-4080 8.06e-05

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 42.46  E-value: 8.06e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1958794504 4047 CQRS-PCLHGGSCSGLPsGGYQCSCLSQFTG-TNCE 4080
Cdd:cd00053      2 CAASnPCSNGGTCVNTP-GSYRCVCPPGYTGdRSCE 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
4045-4080 8.38e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 8.38e-05
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1958794504  4045 DACQ-RSPCLHGGSCSGLPsGGYQCSCLSQFT-GTNCE 4080
Cdd:smart00179    3 DECAsGNPCQNGGTCVNTV-GSYRCECPPGYTdGRNCE 39
Cadherin pfam00028
Cadherin domain;
282-363 1.83e-04

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 43.06  E-value: 1.83e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504  282 AVVTVDDLDEGANGEIeSVSIVDGDPLEQFFLAKEGKWmneykVKERRQVDWESFSYgYNLTIQAKDKGSPQKFSELkTV 361
Cdd:pfam00028   16 LTVTATDPDLGPNGRI-FYSILGGGPGGNFRIDPDTGD-----ISTTKPLDRESIGE-YELTVEATDSGGPPLSSTA-TV 87


                   ..
gi 1958794504  362 HI 363
Cdd:pfam00028   88 TI 89
EGF smart00181
Epidermal growth factor-like domain;
4123-4155 3.38e-04

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 40.58  E-value: 3.38e-04
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 1958794504  4123 ECEREE-CENGgSCVNLFGSFFCNCTPGYVGQ-YC 4155
Cdd:smart00181    1 ECASGGpCSNG-TCINTPGSYTCSCPPGYTGDkRC 34
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 600-657 1.34e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 40.41  E-value: 1.34e-03
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504   600 SAIDIDELE--LVKYKIISGNELGFFYLNPDSGVLQLKKSLMNSgiKNGNFALRITATDG 657
Cdd:smart00112    1 SATDADSGEngKVTYSILSGNDDGLFSIDPETGEITTTKPLDRE--EQPEYTLTVEATDG 58
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 4091-4111 1.73e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 38.47  E-value: 1.73e-03
                           10        20
                   ....*....|....*....|.
gi 1958794504 4091 CRNGGSCDPIGNTFICSCKAG 4111
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPG 21
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 4047-4076 2.43e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.13  E-value: 2.43e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1958794504 4047 CQRSPCLHGGSCSGLPsGGYQCSCLSQFTG 4076
Cdd:pfam00008    1 CAPNPCSNGGTCVDTP-GGYTCICPEGYTG 29
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1049-1143 2.72e-03

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 40.02  E-value: 2.72e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 1049 GSVKENSRIGTSVLQV-TAHDEDSGRDGEIQYSIRDgSGLGRFNIDDESGVITAADILDRETTASYWLTVYATDRGVVPL 1127
Cdd:cd00031      4 GSAVEGRSRGSFRVSIpTDLIASSGEIIKISAAGKE-ALPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGANVP 82

                           90
                   ....*....|....*.
gi 1958794504 1128 YSTIEVYIEVEDVNDN 1143
Cdd:cd00031     83 QTSSVFSIEVYDENDN 98
Cadherin_3 pfam16184
Cadherin-like;
1888-1982 5.40e-03

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 39.51  E-value: 5.40e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794504 1888 PVEVNIEVTDVNDNPPVFTQ----AVFE-TVLLLPTyvgvEVLkvSATDPDSevPPE-LTYSLMEG-------------- 1947
Cdd:pfam16184    4 PFTFNITIIPVNDEAPVLTTntglRLWEgSSRPITP----DLL--QAEDPDT--PPEdLTYTVVQGpshghlalkgapgl 75

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1958794504 1948 SVDHF-LMDPNTGVLTIKNNNLSKDHYMLIVRVSDG 1982
Cdd:pfam16184   76 PVTNFtQADIDSGLVVYVHDGSESTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
1130-1193 8.04e-03

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 39.12  E-value: 8.04e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958794504 1130 TIEVYIEVEDVNDNAPL--TSEPIYypvVMENSPKDVSVIQIQAEDPDSgSNEKLTYRITSGnPQN 1193
Cdd:pfam16184    4 PFTFNITIIPVNDEAPVltTNTGLR---LWEGSSRPITPDLLQAEDPDT-PPEDLTYTVVQG-PSH 64
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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