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Conserved domains on  [gi|1958802647|ref|XP_038939598|]
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protein lifeguard 3 isoform X2 [Rattus norvegicus]

Protein Classification

protein lifeguard( domain architecture ID 10179627)

protein lifeguard similar to human protein lifeguard 2, an antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis, and regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LFG_like cd10428
Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; ...
 27-246 6.24e-100

Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; Lifeguard (LFG) inhibits Fas-mediated apoptosis and interacts with the death receptor FasR/CD95/Apo1. LFG has been shown to interact with Bax and is supposed to be integral to cellular membranes such as the ER. A close homolog, PP1201 or RECS1, appears located in the Golgi compartment and also interacts with the Fas receptor CD95/Apo1. PP1201 is expressed in response to shear stress.


:

Pssm-ID: 198410  Cd Length: 217  Bit Score: 290.21  E-value: 6.24e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802647  27 WDDRKVRHTFIQKVYCIISVQLLITVAIIAVFTFVEPVSEYVRSNVAVYYVSYAVFIVTYLILVCCQGPRRRFPWNIILL 106
Cdd:cd10428     2 FDDKTIRRAFIRKVYSILTIQLLVTVAVIALFTFHDPVKKFVRKNPWLYYVSYIVFFITYIALACCEGLRRRFPWNLILL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802647 107 TIFTLALGFMTGAISSMYETKAVIIAMIITAVVSISVTIFCFQTKVDFTSCTGLICVLGIVLAVTGavtsVVLFFEYIYW 186
Cdd:cd10428    82 GIFTLAMSYMLGTIASFYDTKAVLIAVGITAVVCLGLTLFAFQTKYDFTSCGGVLFVLSIVLLIFG----IVAIFFYVKW 157

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802647 187 LHMVYAGLGAICFTLFLAYDTQLVLGNRKHTISPEDYITGALQIYTDIVYIFTFVLQLVG 246
Cdd:cd10428   158 LHIVYASLGALLFSLYLAVDTQLLMGGRKYELSPEEYIFAALNIYVDIVNIFLYILQLIG 217
 
Name Accession Description Interval E-value
LFG_like cd10428
Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; ...
 27-246 6.24e-100

Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; Lifeguard (LFG) inhibits Fas-mediated apoptosis and interacts with the death receptor FasR/CD95/Apo1. LFG has been shown to interact with Bax and is supposed to be integral to cellular membranes such as the ER. A close homolog, PP1201 or RECS1, appears located in the Golgi compartment and also interacts with the Fas receptor CD95/Apo1. PP1201 is expressed in response to shear stress.


Pssm-ID: 198410  Cd Length: 217  Bit Score: 290.21  E-value: 6.24e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802647  27 WDDRKVRHTFIQKVYCIISVQLLITVAIIAVFTFVEPVSEYVRSNVAVYYVSYAVFIVTYLILVCCQGPRRRFPWNIILL 106
Cdd:cd10428     2 FDDKTIRRAFIRKVYSILTIQLLVTVAVIALFTFHDPVKKFVRKNPWLYYVSYIVFFITYIALACCEGLRRRFPWNLILL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802647 107 TIFTLALGFMTGAISSMYETKAVIIAMIITAVVSISVTIFCFQTKVDFTSCTGLICVLGIVLAVTGavtsVVLFFEYIYW 186
Cdd:cd10428    82 GIFTLAMSYMLGTIASFYDTKAVLIAVGITAVVCLGLTLFAFQTKYDFTSCGGVLFVLSIVLLIFG----IVAIFFYVKW 157

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802647 187 LHMVYAGLGAICFTLFLAYDTQLVLGNRKHTISPEDYITGALQIYTDIVYIFTFVLQLVG 246
Cdd:cd10428   158 LHIVYASLGALLFSLYLAVDTQLLMGGRKYELSPEEYIFAALNIYVDIVNIFLYILQLIG 217
Bax1-I pfam01027
Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family ...
 34-244 1.78e-26

Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner. Examination of the crystal structure of a bacterial member of this family shows that these proteins mediate a calcium leak across the membrane that is pH-dependent. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively, and the pore can be opened by intracrystalline transition; together these findings suggest that pH controls the conformational transition.


Pssm-ID: 460029  Cd Length: 207  Bit Score: 101.87  E-value: 1.78e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802647  34 HTFIQKVYCIISVQLLITvAIIAVFTFVEPVSEYVRSNVAVYYVSY-AVFIVTYLILVCCQGPRRRFPWNIILLTIFTLA 112
Cdd:pfam01027   1 RQFLRKVYGLLALGLLLT-AAVAYLVLSSPALLFPSLHPPLFWVLIiAPLGLLFGALLLARKRKYSSNVALLLLLAFTLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802647 113 LGFMTGAISSMYETKAVIIAMIITAVVSISVTIFCFQTKVDFTSCTGLICVLGIVLavtgAVTSVVLFFEYIYWLHMVYA 192
Cdd:pfam01027  80 MGLTLGPLLLVYTGAIIATAFLGTAAIFGGLSLYALTTKRDLSFLGGFLFAGLIGL----IVASLVNIFLPSSALSLAIS 155

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958802647 193 GLGAICFTLFLAYDTQLVLGNRKHTISpEDYITGALQIYTDIVYIFTFVLQL 244
Cdd:pfam01027 156 YLGVLLFSGFILYDTQRIIKRYGEYGD-YDAILAALSLYLDFINLFLSLLRI 206
YbhL COG0670
Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family ...
 32-249 1.61e-19

Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family [Inorganic ion transport and metabolism];


Pssm-ID: 440434  Cd Length: 231  Bit Score: 84.08  E-value: 1.61e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802647  32 VRHTFIQKVYCIISVQLLITVAIIAVFTFVEPVSEYVRSNVAVYYVSYAVFIVTyLILVCCQGPRRRFPWNIILLTIFTL 111
Cdd:COG0670    18 GLRKVLRNTYGLLALGLLLTALVAYLGMALPGLAALLFGSPGLFWVLLIAPLGL-VFLLSKLANRANSAAALALLFAYTA 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802647 112 ALGFMTGAISSMYETKA----VIIAMIITAVVSISVTIFCFQTKVDFTSCTGlICVLGIVLAVtgaVTSVVLFFEYIYWL 187
Cdd:COG0670    97 LMGLTLSPILLVYTGLSgpasIAQAFGGTAATFGGLSLYGYTTKRDLSFLGS-FLFMGLIGLI---IASLVNIFLQSPAL 172

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958802647 188 HMVYAGLGAICFTLFLAYDTQLVlgnRKHTISPEDYITGALQIYTDIVYIFTFVLQLVGNRD 249
Cdd:COG0670   173 SLAISVAGVLLFSGLTLYDTQRI---KHGYETNKQYIMAALSLYLDFINLFLSLLRLLGGRR 231
 
Name Accession Description Interval E-value
LFG_like cd10428
Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; ...
 27-246 6.24e-100

Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; Lifeguard (LFG) inhibits Fas-mediated apoptosis and interacts with the death receptor FasR/CD95/Apo1. LFG has been shown to interact with Bax and is supposed to be integral to cellular membranes such as the ER. A close homolog, PP1201 or RECS1, appears located in the Golgi compartment and also interacts with the Fas receptor CD95/Apo1. PP1201 is expressed in response to shear stress.


Pssm-ID: 198410  Cd Length: 217  Bit Score: 290.21  E-value: 6.24e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802647  27 WDDRKVRHTFIQKVYCIISVQLLITVAIIAVFTFVEPVSEYVRSNVAVYYVSYAVFIVTYLILVCCQGPRRRFPWNIILL 106
Cdd:cd10428     2 FDDKTIRRAFIRKVYSILTIQLLVTVAVIALFTFHDPVKKFVRKNPWLYYVSYIVFFITYIALACCEGLRRRFPWNLILL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802647 107 TIFTLALGFMTGAISSMYETKAVIIAMIITAVVSISVTIFCFQTKVDFTSCTGLICVLGIVLAVTGavtsVVLFFEYIYW 186
Cdd:cd10428    82 GIFTLAMSYMLGTIASFYDTKAVLIAVGITAVVCLGLTLFAFQTKYDFTSCGGVLFVLSIVLLIFG----IVAIFFYVKW 157

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802647 187 LHMVYAGLGAICFTLFLAYDTQLVLGNRKHTISPEDYITGALQIYTDIVYIFTFVLQLVG 246
Cdd:cd10428   158 LHIVYASLGALLFSLYLAVDTQLLMGGRKYELSPEEYIFAALNIYVDIVNIFLYILQLIG 217
GAAP_like cd10429
Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a ...
 6-249 1.81e-43

Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a regulator of apoptosis that is related to the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Human GAAP has been linked to the modulation of intracellular fluxes of Ca(2+), by suppressing influx from the extracellular medium and reducing release from intracellular stores. A viral homolog (vaccinia virus vGAAP) acts similar to its human counterpart in inhibiting apoptosis.


Pssm-ID: 198411  Cd Length: 233  Bit Score: 146.59  E-value: 1.81e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802647   6 YQGHDYSEEERAGSDSFGPgewdDRKVRHTFIQKVYCIISVQLLITVAIIAVFTFVEPVSEYVRSNVAVYYVSyavFIVT 85
Cdd:cd10429     4 YAEADIPDDFKYGTNVASA----EPEIRMAFLRKVYSILSVQLLATTAVSALFYLSPSIKTFVQSHPWLFLIS---LIGS 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802647  86 YLILVCCQGPRRRFPWNIILLTIFTLALGFMTGAISSMYETKAVIIAMIITAVVSISVTIFCFQTKVDFTSCTGLicvLG 165
Cdd:cd10429    77 LILLIALYWKRHSHPVNLILLSLFTLCEAYTVGLVVSFYDGKIVLQALILTLGVFVGLTAYTFQTKRDFSSFGAL---LF 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802647 166 IVLAVTGAVTSVVLFFEYIYWLHMVYAGLGAICFTLFLAYDTQLVLgnrkHTISPEDYITGALQIYTDIVYIFTFVLQLV 245
Cdd:cd10429   154 ILLWALILLALIFQFFPYSPTFELVYAGLGALLFSGYIVYDTQLIM----KRLSPDEYILAAISLYLDIINLFLSILRIL 229


                  ....
gi 1958802647 246 GNRD 249
Cdd:cd10429   230 AAMN 233
BI-1-like cd06181
BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 ...
 32-246 1.47e-37

BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. This superfamily also contains the lifeguard(LFG)-like proteins and other subfamilies which appear to be related by common descent and also function as inhibitors of apoptosis. In plants, BI-1 like proteins play a role in pathogen resistance. A prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198409  Cd Length: 202  Bit Score: 130.61  E-value: 1.47e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802647  32 VRHTFIQKVYCIISVQLLITVAIIAVFTFVEPVSeyvrsnvavYYVSYAVFIVT--YLILVCCQGPRRRFPWNIILLTIF 109
Cdd:cd06181     1 STKDFLRKVYMILALQLLLTAATATAFTVCDPGW---------YWSPALMGLLTsmLALMATAAMIRAKMPVNLILLFGF 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802647 110 TLALGFMTGAISSMYETKAVIIAMIITAVVSISVTIFCFQTKVDFTSCTG-LICVLGIVLavtgaVTSVVLFFEYIYWLH 188
Cdd:cd06181    72 TGLMGYVVGPLLFFYGPTILLRALGGTALVFFGLTVYALQARKDFLFLGGpLMAGLGFLL-----LSFLLNTFFYSPWLH 146

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958802647 189 MVYAGLGAICFTLFLAYDTQLVLGNRKHtiSPEDYITGALQIYTDIVYIFTFVLQLVG 246
Cdd:cd06181   147 LVAAAVGLVLFCGFLLYDTQLIIHKAEV--GPEDYINACISLYLDIINIFIRLLTILA 202
Bax1-I pfam01027
Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family ...
 34-244 1.78e-26

Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner. Examination of the crystal structure of a bacterial member of this family shows that these proteins mediate a calcium leak across the membrane that is pH-dependent. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively, and the pore can be opened by intracrystalline transition; together these findings suggest that pH controls the conformational transition.


Pssm-ID: 460029  Cd Length: 207  Bit Score: 101.87  E-value: 1.78e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802647  34 HTFIQKVYCIISVQLLITvAIIAVFTFVEPVSEYVRSNVAVYYVSY-AVFIVTYLILVCCQGPRRRFPWNIILLTIFTLA 112
Cdd:pfam01027   1 RQFLRKVYGLLALGLLLT-AAVAYLVLSSPALLFPSLHPPLFWVLIiAPLGLLFGALLLARKRKYSSNVALLLLLAFTLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802647 113 LGFMTGAISSMYETKAVIIAMIITAVVSISVTIFCFQTKVDFTSCTGLICVLGIVLavtgAVTSVVLFFEYIYWLHMVYA 192
Cdd:pfam01027  80 MGLTLGPLLLVYTGAIIATAFLGTAAIFGGLSLYALTTKRDLSFLGGFLFAGLIGL----IVASLVNIFLPSSALSLAIS 155

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958802647 193 GLGAICFTLFLAYDTQLVLGNRKHTISpEDYITGALQIYTDIVYIFTFVLQL 244
Cdd:pfam01027 156 YLGVLLFSGFILYDTQRIIKRYGEYGD-YDAILAALSLYLDFINLFLSLLRI 206
YbhL COG0670
Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family ...
 32-249 1.61e-19

Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family [Inorganic ion transport and metabolism];


Pssm-ID: 440434  Cd Length: 231  Bit Score: 84.08  E-value: 1.61e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802647  32 VRHTFIQKVYCIISVQLLITVAIIAVFTFVEPVSEYVRSNVAVYYVSYAVFIVTyLILVCCQGPRRRFPWNIILLTIFTL 111
Cdd:COG0670    18 GLRKVLRNTYGLLALGLLLTALVAYLGMALPGLAALLFGSPGLFWVLLIAPLGL-VFLLSKLANRANSAAALALLFAYTA 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802647 112 ALGFMTGAISSMYETKA----VIIAMIITAVVSISVTIFCFQTKVDFTSCTGlICVLGIVLAVtgaVTSVVLFFEYIYWL 187
Cdd:COG0670    97 LMGLTLSPILLVYTGLSgpasIAQAFGGTAATFGGLSLYGYTTKRDLSFLGS-FLFMGLIGLI---IASLVNIFLQSPAL 172

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958802647 188 HMVYAGLGAICFTLFLAYDTQLVlgnRKHTISPEDYITGALQIYTDIVYIFTFVLQLVGNRD 249
Cdd:COG0670   173 SLAISVAGVLLFSGLTLYDTQRI---KHGYETNKQYIMAALSLYLDFINLFLSLLRLLGGRR 231
BI-1-like_bacterial cd10432
Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial ...
 33-246 7.63e-15

Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial relatives of the mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. In plants, BI-1 like proteins play a role in pathogen resistance. A characterized prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198414  Cd Length: 211  Bit Score: 71.05  E-value: 7.63e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802647  33 RHTFIQKVYCIISVQLLITvAIIAVFTFVEPVSeYVRSNVAVYYVsyaVFIVTYLILVCCQGPRRRFP--WNIILLTIFT 110
Cdd:cd10432     2 LRSFMKKVYGLMAAGLLLT-AVGAYVGASTPAL-LLIAGSPLMWV---LLIAELALVFGLSFRINKMSvaTALPLFFAFA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802647 111 LALGFMTGAISSMYETKAVIIAMIITAVVSISVTIFCFQTKVDFTSCTG--LICVLGIVLAvtgavtSVVLFFEYIYWLH 188
Cdd:cd10432    77 ALTGLTLSPILLVYTGASIAQAFFTTAATFGGLSLYGYTTKKDLSFLGSflFMGLIGLIIA------SLVNIFLQSSALQ 150

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958802647 189 MVYAGLGAICFTLFLAYDTQLVL---GNRKHTISPEDYITGALQIYTDIVYIFTFVLQLVG 246
Cdd:cd10432   151 FAISAIGVLIFSGLIAYDTQRIKrmyEAGGGESGYKDAIMGALSLYLDFINLFLFLLRLFG 211
YccA_like cd10433
YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small ...
 76-246 8.80e-08

YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198415  Cd Length: 205  Bit Score: 51.05  E-value: 8.80e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802647  76 YVSYAVFIVTYLILVCCQGPRRRFPWNIILLTIFTLALGFMTGAISSMYET-----KAVIIAMIITAVVSISVTIFCFQT 150
Cdd:cd10433    35 IMGLLLTLVGAYGLLFLIEKTRNSAWGIVLVFAFTGFMGYTLGPILNMYLAlpnggQIIMTALGGTAAIFFGLSAYALTT 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802647 151 KVDFTSCTGLICVlGIVLAVTGAVTSvvLFFEyIYWLHMVYAGLGAICFTLFLAYDTQLVLgNRKHTispeDYITGALQI 230
Cdd:cd10433   115 KKDFSFLGGFLFV-GAIVLLLAAVAN--IFLQ-IPALSLAISAAFVLFSSGFILYDTSRII-HGGET----NYIMATVSL 185

                         170
                  ....*....|....*.
gi 1958802647 231 YTDIVYIFTFVLQLVG 246
Cdd:cd10433   186 YVSIYNLFVSLLNLLG 201
GHITM cd10431
Growth-hormone inducible transmembrane protein; GHITM appears to be ubiquitiously expressed in ...
 190-247 6.17e-03

Growth-hormone inducible transmembrane protein; GHITM appears to be ubiquitiously expressed in mammalian cells and expression has also been observed in various cancer cell lines. A cytoprotective function has been suggested. It is closely related to the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect.


Pssm-ID: 198413  Cd Length: 264  Bit Score: 36.97  E-value: 6.17e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958802647 190 VYAGLgaICFTLFLAYDTQLVLGNRK----HTISPEDYITGALQIYTDIVYIFTFVLQLVGN 247
Cdd:cd10431   200 LYGGL--VLFGGFLLYDTQKIIKRAEthplYGVRKYDPINASMSIYMDTINIFIRLVTILAG 259
BI-1 cd10430
BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small ...
 173-244 8.33e-03

BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. In plants, BI-1 like proteins play a role in pathogen resistance.


Pssm-ID: 198412  Cd Length: 213  Bit Score: 36.43  E-value: 8.33e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958802647 173 AVTSVVLFFEYIYWLHMVYAGLGAICFTLFLAYDTQLVLGNRKHtiSPEDYITGALQIYTDIVYIFTFVLQL 244
Cdd:cd10430   138 LLVSLANIFGGSKFLFQAELYLGLLVFCGFVLFDTQMIIEKAEN--GDRDYIWHALDLFVDFVALFRRLLII 207
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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