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Conserved domains on  [gi|1958665599|ref|XP_038944312|]
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type 2 lactosamine alpha-2,3-sialyltransferase isoform X1 [Rattus norvegicus]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 114-319 2.73e-139

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467712  Cd Length: 206  Bit Score: 392.57  E-value: 2.73e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 114 PCKRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLFYPESVFSDPSHYDPNTTAVLVVFKPQD 193
Cdd:cd23984     1 SCKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIFSDPSHYDPNTTVVLIPFKPHD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 194 LRWLMEILIGKKINTDGFWKKPALKLIYKQYQIRILDPYIIREAAFQLLRFPRVFPKDQKPKHPTTGIIALTLAFHICSE 273
Cdd:cd23984    81 LRWLLDLLMGKKVSAKGFWKKPALNLIYKPNQIRILNPFILRIAAYELLHFPKRFPKEKKPKHPTTGIIAITLALHICNE 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1958665599 274 VHLAGFKYNFYTPDSPLHYYGNATMSLMKKNAYHNLTAEQLFLKNL 319
Cdd:cd23984   161 VHIAGFKYDFSNLNSTLHYYGNETMSVMTKNEYHNISAEQKFLKDL 206
 
Name Accession Description Interval E-value
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 114-319 2.73e-139

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 392.57  E-value: 2.73e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 114 PCKRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLFYPESVFSDPSHYDPNTTAVLVVFKPQD 193
Cdd:cd23984     1 SCKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIFSDPSHYDPNTTVVLIPFKPHD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 194 LRWLMEILIGKKINTDGFWKKPALKLIYKQYQIRILDPYIIREAAFQLLRFPRVFPKDQKPKHPTTGIIALTLAFHICSE 273
Cdd:cd23984    81 LRWLLDLLMGKKVSAKGFWKKPALNLIYKPNQIRILNPFILRIAAYELLHFPKRFPKEKKPKHPTTGIIAITLALHICNE 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1958665599 274 VHLAGFKYNFYTPDSPLHYYGNATMSLMKKNAYHNLTAEQLFLKNL 319
Cdd:cd23984   161 VHIAGFKYDFSNLNSTLHYYGNETMSVMTKNEYHNISAEQKFLKDL 206
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 109-323 1.39e-73

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 227.49  E-value: 1.39e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 109 EFDTVPCKRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLFYPESVFSD-------PSHYDPN 181
Cdd:pfam00777  37 PFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMNPESAIDSkygnlgfSHPRDPF 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 182 TTAVLVVFKPQDLRWLMEILIGKKINTD----GFWKKPALKLiyKQYQIRILDPYIIREAAFQLLRFPRVfpkdqKPKHP 257
Cdd:pfam00777 117 VEFVLVPFKGRDLLWLPAFLTKGNVSRSlrvlYTLKEVKIPV--DPDKVLFLHPDFLRYVANFWLRSHGL-----KGRRP 189

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958665599 258 TTGIIALTLAFHICSEVHLAGFKYNFYTPDSPLHYYGNATMSLMKKNAYHNLTAEQLFLKNLIKKK 323
Cdd:pfam00777 190 STGLLMLSLALHLCDEVSLYGFGPFLDSRGNSHHYYDNVLMKKGGFYGVHDMPFEFKLLQKLHKEG 255
 
Name Accession Description Interval E-value
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 114-319 2.73e-139

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 392.57  E-value: 2.73e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 114 PCKRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLFYPESVFSDPSHYDPNTTAVLVVFKPQD 193
Cdd:cd23984     1 SCKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIFSDPSHYDPNTTVVLIPFKPHD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 194 LRWLMEILIGKKINTDGFWKKPALKLIYKQYQIRILDPYIIREAAFQLLRFPRVFPKDQKPKHPTTGIIALTLAFHICSE 273
Cdd:cd23984    81 LRWLLDLLMGKKVSAKGFWKKPALNLIYKPNQIRILNPFILRIAAYELLHFPKRFPKEKKPKHPTTGIIAITLALHICNE 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1958665599 274 VHLAGFKYNFYTPDSPLHYYGNATMSLMKKNAYHNLTAEQLFLKNL 319
Cdd:cd23984   161 VHIAGFKYDFSNLNSTLHYYGNETMSVMTKNEYHNISAEQKFLKDL 206
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 114-319 1.23e-110

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 320.01  E-value: 1.23e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 114 PCKRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLFYPESVFSDPSHYDPNTTAVLVVFKPQD 193
Cdd:cd23967     1 SCRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMFYPESAFRDPEEYDSDWLLVLVPFKSMD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 194 LRWLMEILIGKKINT-DGFWKKPALKLIYKQYQIRILDPYIIREAAFQLLRFPrvFPKDQKPKHPTTGIIALTLAFHICS 272
Cdd:cd23967    81 LLWLQAVIKGKKPNGkGGFWKKIATSVPKPPKKIRILNPYILQEAAFDLIGLP--MNGKQGKNVPTTGIIAIVMALHYCD 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1958665599 273 EVHLAGFKYNFYTPDSPLHYYGNATMSLMKKNAYHNLTAEQLFLKNL 319
Cdd:cd23967   159 EVDIAGFGYDPSDPNAPLHYYDSLTMKAIKRSWTHNVTKEKKYLKKL 205
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 114-319 6.75e-83

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 249.58  E-value: 6.75e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 114 PCKRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLFYPESVFSDPS-HYDPNTTAVLVVFKPQ 192
Cdd:cd23982     1 RCRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYPESAQFDPGiENDPDTLLVLVPFKPL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 193 DLRWLMEILIGKKINTDGFWKKPALKLIYKQYQIRILDPYIIREAAFQLLRFPRvfpKDQKPKHPTTGIIALTLAFHICS 272
Cdd:cd23982    81 DFYWLYEILSNEKRVRKGFWKQPPRIWDANPKQIRILNPYYTYVAATKLLQVPG---QRKKKQKPTTGLLAITLALHLCD 157

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1958665599 273 EVHLAGFKY-NFYTPDSPLHYYGNATMSLMkKNAYHNLTAEQLFLKNL 319
Cdd:cd23982   158 EVHIAGFGYpDNGNSNQPIHYYNQITLKSM-ANSGHNLNAEAQAIQRL 204
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 114-319 7.75e-74

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 226.93  E-value: 7.75e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 114 PCKRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLFYPESVFSDPSHYDPNTTAVLVVFKPQD 193
Cdd:cd23983     1 TCRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGAPKSEQEYDPTSLFVAVLFKSVD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 194 LRWLMEILIGKKI---NTDGFWKKPALKLIYKQYQIRILDPYIIREAAFQLLRFP----RVFPKDQkpKHPTTGIIALTL 266
Cdd:cd23983    81 FAWLKAMVKKEPLsfwSRLFFWKEVADSIPLKPSQFRILNPLIIKETALDILQYPepqsRLWGWDK--NVPTLGVTAVVL 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958665599 267 AFHICSEVHLAGFKYNFYTPDSPLHYYGNATMSLMKKNAYHNLTAEQLFLKNL 319
Cdd:cd23983   159 ATHLCDEVSLAGFGYDLSQPHAPLHYYDSVCMAAMNTQTMHNVTKETKFLKKL 211
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 109-323 1.39e-73

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 227.49  E-value: 1.39e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 109 EFDTVPCKRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLFYPESVFSD-------PSHYDPN 181
Cdd:pfam00777  37 PFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMNPESAIDSkygnlgfSHPRDPF 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 182 TTAVLVVFKPQDLRWLMEILIGKKINTD----GFWKKPALKLiyKQYQIRILDPYIIREAAFQLLRFPRVfpkdqKPKHP 257
Cdd:pfam00777 117 VEFVLVPFKGRDLLWLPAFLTKGNVSRSlrvlYTLKEVKIPV--DPDKVLFLHPDFLRYVANFWLRSHGL-----KGRRP 189

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958665599 258 TTGIIALTLAFHICSEVHLAGFKYNFYTPDSPLHYYGNATMSLMKKNAYHNLTAEQLFLKNLIKKK 323
Cdd:pfam00777 190 STGLLMLSLALHLCDEVSLYGFGPFLDSRGNSHHYYDNVLMKKGGFYGVHDMPFEFKLLQKLHKEG 255
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 115-319 2.97e-70

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 217.48  E-value: 2.97e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 115 CKRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLFYPESVFSDPSHYDPNTTAVLVVFKPQDL 194
Cdd:cd23981     2 CRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKPEQYEKDSLFVLAGFKWQDF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 195 RWLMEILIGKKIN-TDGFWKKPALKLIYKQYQIRILDPYIIREAAFQLLRFPRVFPKDQKPKHPTTGIIALTLAFHICSE 273
Cdd:cd23981    82 KWLKYIVYKEKVSaSDGFWKSVATRVPREPHEIRILNPYFIQEAAFSFIGLPFNNGLMGRGNIPTLGSVAITMALHNCDE 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1958665599 274 VHLAGFKYNFYTPDSPLHYYGNATMSLMKKNAYHNLTAEQLFLKNL 319
Cdd:cd23981   162 VAVAGFGYDMNTPNAPLHYYETIKMSAIKESWTHNIQREKEFLRKL 207
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 81-312 1.22e-37

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 135.85  E-value: 1.22e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599  81 FLLPYGVKTFE-SYFRSALSKLQSCDLFGEF----DTVPCKRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEE 155
Cdd:cd23964    43 YKLPFGWGGLNrEVVERLLRNLNLTSSRYMFvlrgGRPRCIRCAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGFEK 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 156 EVGKRTTFRLFYPESVF-SDPSHY--DPNTTAVLVVFKPQDLRWLMEILIGKKINT---DGFWKKPALKLIYKQYQIRIL 229
Cdd:cd23964   123 DVGTKTSFYTFFPESLHnSLLKHVpqDKDTKYLFIPFKIRDYDYLDAVLSGKPVPDgcdKGKRPPPLFGPKLNATNVRLL 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 230 DPYIIREAAFQLLRFPRVFpkdqkpkHPTTGIIALTLAFHICSEVHLAGFKYNfytPDSPLHYYGNATMSLMKKNAYHNL 309
Cdd:cd23964   203 HPDFIRYLFNRWLNSSTSY-------RPTTGALMLLTALHTCDQVSVYGFGYD---PRFSLHYYDKTFVKFTVFYANHDF 272


                  ...
gi 1958665599 310 TAE 312
Cdd:cd23964   273 TNE 275
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 105-323 1.69e-37

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 135.10  E-value: 1.69e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 105 DLFGEFDTVPCKRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLFYPESVfsdpSHYDPNTTA 184
Cdd:cd23966    67 NPYRTRDPNRCRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMYPESA----VDLDPGVHL 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 185 VLVVFKPQDLRWLMEILIGKKINTDGFWKKPALKLIYKqyQIRILDPYIIREAAFQLLrfprvfpkDQKPKHPTTGIIAL 264
Cdd:cd23966   143 VLVPFKVLDLQWLISALTTGEITRTYTPVKRFIKADKD--KVLVINPAFIKYVHDNWT--------EHHGRYPSTGFLAL 212

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958665599 265 TLAFHICSEVHLAGF----KYNFYtpdsplHYY-GNATMSLMKKNAYHNLTAEQLFLKNLIKKK 323
Cdd:cd23966   213 IFALHICDEVSVFGFgadsKGNWH------HYWeKNRSAGAFRKTGVHDADFESDIIKKLAKEG 270
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 118-319 3.00e-37

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 132.10  E-value: 3.00e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 118 CVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRL-------FYPESVFSDPSHYDPNTTAVLVVFK 190
Cdd:cd19952     1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVlnskwagFYLRGPRCGCHPLPLEEEVVLILSR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 191 PQDlrwlmeiligkkinTDGFWKKPALKLIYKQyqirildPYIIREAAFQLL-----RFPRVFPK-DQKPKHPTTGIIAL 264
Cdd:cd19952    81 AAA--------------ADFKRLKRRKKRHDNA-------VLLLTDPAPDLLsyvrkRLEKLGLKsFFGGNAPSSGLLAV 139

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958665599 265 TLAFHICSEVHLAGF-KYNFYTPDSPLHYYGNATMSLMkkNAYHNLTAEQLFLKNL 319
Cdd:cd19952   140 LLALQLCDSVDLYGFgVDSGHAPKVPYHYYDLVEAEEG--TAVHSFDLEAELLRAL 193
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 105-319 9.30e-28

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 109.20  E-value: 9.30e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 105 DLFGEFDTVPCKRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLFYPESVfsdpSHYDPNTTA 184
Cdd:cd23980    71 DPLLEKRLVSCRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYPESF----RELAQNVSM 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 185 VLVVFKPQDLRWLMEILIGKKINTDgFWKKPAlKLIYKQYQIRILDPYIIREAAFQLLRfprvfpkdQKPKHPTTGIIAL 264
Cdd:cd23980   147 ILVPFKTLDLEWVISATTTGTISHT-YVPVPR-KIKVKKEKILIYHPAFIKYVFDRWLQ--------GHGRYPSTGILSV 216

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 265 TLAFHICSEVHLAGF----KYNFYtpdsplHYY-GNATMSLMKKNAYHNLTAEQLFLKNL 319
Cdd:cd23980   217 IFSLHVCDEVDLYGFgadsKGNWH------HYWeNNPSAGAFRKTGVHDGDFESNVTTIL 270
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 116-319 7.16e-26

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 103.89  E-value: 7.16e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 116 KRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLFYPEsVFSDPSHYDPNTT----AVLVVFKP 191
Cdd:cd23968    46 NTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFEKDVGSKTTLRLINSQ-ILSKPEFNFLTDPlyrnVTLLVWDP 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 192 QdlrwlmeiligkKINTDG--FWKKPALKLI--YKQYQIR-------ILDPYIIREAAFQLLRFprvFPKDQKPKHPTTG 260
Cdd:cd23968   125 S------------SYNVNLekWYKKPDFDFFpnYIKYRRRhpeepfyLIDPRFLWRLWDILQEY---TPEKIKPNPPSSG 189

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958665599 261 IIALTLAFHICSEVHLagfkYNFYTP--DSPL-HYYGNATMSLMKKNAYHNLTAEQLFLKNL 319
Cdd:cd23968   190 FIGIVLMLHLCDWVDV----YEYVPSvrQTDRcHYYDVEKDLACTLGAWHPLAAEKLLVRHL 247
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 115-294 2.50e-25

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 101.55  E-value: 2.50e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 115 CKRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLF-YP--ESVFSDPSHYDPNTTA-VLVVFk 190
Cdd:cd23965     1 CDTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVVsHSslPRLLRNAILLLAGTRApTVVVF- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 191 pqdlrWLMEIligkKINTDGFWKKPALKLIYKQYqiRILDPYIIREAafQLLRFPRVFPKDQ-KPKHPT-----TGIIAL 264
Cdd:cd23965    80 -----WGPET----KMNKDGAGKYNLLRSLSKKY--PDVEFYSLTPE--KMDYADELFEKETgKSRIKSgtwlsTGWFTM 146

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1958665599 265 TLAFHICSEVHLAGFKYNFY-----TPDSPLHYYG 294
Cdd:cd23965   147 LLALDVCDEIKVYGMVPENYcrehpNSKVPYHYYE 181
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 116-329 5.26e-25

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 101.57  E-value: 5.26e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 116 KRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLFYPESVfsdpSHYDPNTTavlvvfKPQDLR 195
Cdd:cd23963    64 KTCAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGRKTNLTTLNPSIL----KRRYNSLK------KNRDRD 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 196 WLMEILigKKINTDGFWKKPALKLIYKQYQIRILDPYIIREAAFQLL----RFPRVFPK----DQKPKHPTTGIIALTLA 267
Cdd:cd23963   134 KFLNRL--KEYNGSILWYPKFSFKSSTNLLLKAARALKKNGLNLTVVysnpEHFLAVQKfwkrRGLEKRPSTGLYLVSLA 211

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958665599 268 FHICSEVHLAGFkYNFYTpDS-----PLHYYGNATMSLMKKNayHNLTAEQLFLKNLiKKKMVINLT 329
Cdd:cd23963   212 LTFCDEIHLYGF-WPFPT-DPngrpvPYHYYDDLSPSTKNKV--HNMPEEFKLLREL-HKKGVLKLH 273
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 107-279 3.48e-24

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 99.56  E-value: 3.48e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 107 FGEFDTVPCKRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLFYPESVFSDPshydPNTTAVL 186
Cdd:cd23979    72 YRSWDPSRCRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFMYPESAKNLP----ANVSFVL 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 187 VVFKPQDLRWLMEILIGKKINTDGFWKKPALKLiyKQYQIRILDPyiireaAFqllrFPRVFPK--DQKPKHPTTGIIAL 264
Cdd:cd23979   148 VPFKTLDLLWITSALSTGQIRFTYAPVKQFLRV--DKDKVQIYNP------AF----FKYIHDRwtEHHGRYPSTGMLVL 215

                         170
                  ....*....|....*
gi 1958665599 265 TLAFHICSEVHLAGF 279
Cdd:cd23979   216 FFALHVCDEVNVYGF 230
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 115-303 6.75e-21

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 90.97  E-value: 6.75e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 115 CKRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLFYPESVFSDPSHY----------DPNTTA 184
Cdd:cd23973    83 CIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTSFYVHTAHSITSSLMILqkrgfknipqDKDIKY 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 185 VLVVFKPQDLRWLMEILIGKKINTDGFWKKPALKLIYKQYQIR---ILDPYIIREAAFQLLRFPRVFPKDQKPKHPTTGI 261
Cdd:cd23973   163 ILFPEGPRDYQWLEALLKNKTIPSGAYYGRRPRSYFSGDFTEDkylVLHPDFLRYVKNRFLRSKTLKGKYWAIYRPTTGA 242

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958665599 262 IALTLAFHICSEVHLAGF------KYNFYTPD---SPLHYYGNATMSLMKK 303
Cdd:cd23973   243 FLLLTALHLCDTVSAYGFitedyrKYPDHYYDkkkTKLVFYINHDFRLEKK 293
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 114-322 7.63e-19

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 84.76  E-value: 7.63e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 114 PCKRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLF------YPESVFSDPSHYdpnTTAVLV 187
Cdd:cd23985    44 PLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAGFQQDVGTKTTIRLInsqlvtTEKHKFLKDSLY---NEGILI 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 188 VFKPQDLrwlmeiligkKINTDGFWKKPALKLI--YKQYqiRILDP----YIIR-EAAFQLL-RFPRVFPKDQKPKHPTT 259
Cdd:cd23985   121 VWDPAPY----------HSDIPEWYKNPDYNFFenYKTY--RRLNPnqpfYILHpQMQWELWdIIQENSPEEIQPNPPSS 188

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958665599 260 GIIALTLAFHICSEVHLagfkYNFYTPDSP---LHYYGNATMSLMKKNAYHNLtaeqLFLKNLIKK 322
Cdd:cd23985   189 GMLGIILMMTLCDQVDV----YEFLPSKRKtdvCHYYQKFFDRACTMGAYHPL----LYEKNLVKH 246
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 114-295 1.02e-16

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 79.41  E-value: 1.02e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 114 PCKRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLFYPESVFSDPSHYD-------PNTTAVL 186
Cdd:cd23974    83 PCIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSFYTFSTNTLMNSLRAYAgvgfngpPQSKETR 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 187 VVFKPQDLR--WLMEILIGKKINTDG--FWKKPALKL--IYKQYQIRILDPYIIREAAFQLLRFPRVFPKDQKPKHPTTG 260
Cdd:cd23974   163 YIFLPDHDRdyLLVKAALTHTPIDRGrdKSKRPSKYFgkDVTAEKFKIYHPDFIRYLRNRFLWSPILNTKQRDIYRPSTG 242

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1958665599 261 IIALTLAFHICSEVHlagfKYNFYTPDSPL---HYYGN 295
Cdd:cd23974   243 AVMLLAALHTCDQVS----AYGFMTPDYGKysdHYYDK 276
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 116-321 5.26e-16

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 76.80  E-value: 5.26e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 116 KRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLFYPEsVFSDPSHYDPNTT----AVLVVFKP 191
Cdd:cd23986    50 RSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIINSQ-ILTNPNHHFIDSSlykdVILVAWDP 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 192 QDLrwlmeiligkKINTDGFWKKPALKLI--YKQYQIRILD-PYIIREAAF--QLLRFPRVFPKDQ-KPKHPTTGIIALT 265
Cdd:cd23986   129 APY----------SANLHKWYKKPDYNLFtpYVQYRKRNPNqPFYILHPKFiwQLWDIIQENTQEKiQPNPPSSGFIGIL 198

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958665599 266 LAFHICSEVHLAGFKYNFYTPDSpLHY---YGNATMSLmkkNAYHNLTAEQLFLKNLIK 321
Cdd:cd23986   199 IMMSMCREVHVYEYIPSVRQTDL-CHYherYYDAACTL---GAYHPLLYEKLLIQRMNK 253
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 116-329 5.32e-16

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 77.05  E-value: 5.32e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 116 KRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLFYPesvfSDPSHYDPNttavlvVFKPQDLR 195
Cdd:cd23970    69 NTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLTTFNP----SILEKYYNN------LLTIQDRN 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 196 WLMEILigKKINTDGFWkKPALKLIYKQYQIRILDPYIIreaafQLLRFPRV---FP-------------KDQKPKHPTT 259
Cdd:cd23970   139 NFFLSL--KKLDGAILW-IPAFFFHTSATVTRTLVDFFV-----EHRGQLKVqlaWPgnimqhvnrywktKHLSPKRLST 210

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958665599 260 GIIALTLAFHICSEVHLAGFkYNFYT----PDSPLHYYGN-ATMSLMKKNAYHNLTAEQLFLKNLiKKKMVINLT 329
Cdd:cd23970   211 GILMYTLASAICEEIHLYGF-WPFGFdptgTPLPYHYYDKkGTKFTTKWQESHQLPAEFVLLYKM-HGAGVLKLT 283
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 115-293 5.18e-14

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 70.27  E-value: 5.18e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 115 CKRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLFYPESVFSdpshydpnttavlVVFKPQDL 194
Cdd:cd23978     1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRVVAHSSVYR-------------VLRRPQEF 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 195 --RWLMEILIgkkintdgFW------KKPALKLIYKQYQ-----IRILDPYII---REAAFQLLrFPRVFPKDQKPKHP- 257
Cdd:cd23978    68 lnRTPETTLI--------FWgppnkmQKDGKSNLFRIIQrasmtFPNMSAFVVsprRMRQFDDL-FRGETGRDRKKSHSw 138

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1958665599 258 -TTGIIALTLAFHICSEVHLAGF-KYNFYTPDS-----PLHYY 293
Cdd:cd23978   139 lSTGWFTMVIAVELCDNVHVYGMvPPNYCSKRPtpkkmPYHYY 181
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 115-293 2.15e-13

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 68.42  E-value: 2.15e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 115 CKRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLFYPESV---FSDPSHY--DPNTTaVLVVF 189
Cdd:cd23975     1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTSVpllLKNPDYFfkETNET-IYVIW 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 190 KP-----QDLRWLMEILIGKKINtdgfwkkpalklIYKQYQIrildpYIIREAafQLLRFPRVFPKD------QKPKHPT 258
Cdd:cd23975    80 GPfrnmrKDGKGIVYNMLKKAVE------------SYPQAKI-----YVTTEK--RMSYCDTVFKKEtgkdrvQSGSYLS 140

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1958665599 259 TGIIALTLAFHICSEVHLAGFKYNFYTPDS-----PLHYY 293
Cdd:cd23975   141 TGWFTLILAMDACYGIHVYGMINDTYCKTEgyrkvPYHYY 180
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 116-323 8.70e-13

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 67.44  E-value: 8.70e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 116 KRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLFYPeSVFSDPSHYDPNTTavlvvfkpqDLR 195
Cdd:cd23969    65 RTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNLTTMNP-SVIPHAYGDLVNAT---------DKE 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 196 WLMEILigKKINTDGFWkKPALKLIYKQYQIRILDPYIIREAAFQLLRFP--------RVFPKDQK--PKHPTTGIIALT 265
Cdd:cd23969   135 KFVERL--RQLGDSILW-IPAFVSKGGEEHVQWTNEIILKHKLNVKTAYPplrlnhaiRGYWLTTKfrIKRPSTGLLMYT 211

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958665599 266 LAFHICSEVHLAGFkYNFyTPD---SPL--HYYGNATMSLmkKNAYHNLTAEQLFLKNLIKKK 323
Cdd:cd23969   212 LATRFCDEIHLYGF-YPF-SEDgngRAVkyHYYDNRKYLT--TARPHKMPEEFRALRSLHQRG 270
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 115-326 3.00e-12

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 65.27  E-value: 3.00e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 115 CKRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLFYPESV----FSDPSHYDPNTTAVLVVFK 190
Cdd:cd23977     1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVVSHTSVplllRNQGYFFQQSRDTKYVIWG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 191 PqdLRWLMEILIGKKINTdgfwkKPALKLIYKQYQIrildpYIIREAAFQLLrfPRVFpKDQKPKHP-------TTGIIA 263
Cdd:cd23977    81 P--ERNMDRDGGGKTYRA-----LLTLAKMYPHLQV-----YTLTEEKMAYC--DGVF-QNETGKNRmksgsflSTGWFT 145

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958665599 264 LTLAFHICSEVHLAGFKYNFYT-----PDSPLHYY-----GNATMSLMKKNAY---HNLTAEQLFLKNLIKKKMVI 326
Cdd:cd23977   146 MILALELCEEILVYGMVSDSYCrnknhSSVPYHYYekgrlDECRMYLVHERAPrggHRFITEKAIFSRWAKRKKIR 221
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 49-300 3.23e-12

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 66.00  E-value: 3.23e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599  49 PAFASLLRFPqfYPFLCKADFVKVAATYGTNNFLLPYGVKTF-ESYFRSALSKL---QSCDLFGEFDTVP-CKRCVVVGN 123
Cdd:cd23972    13 PHFRGLFNFD--IPVLLWGQHFTPALWDRLSQRKVPYGWKGLsHQVVASTLSLLndsANAKLFFPRDTPGkCIRCAVVGN 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 124 GGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLF-----------YPESVFsdpsHYDPNTTAVLVVFKPQ 192
Cdd:cd23972    91 GGILNGSRQGRAIDAHDYVFRLNGAVIKGFEEDVGTKTSFYGFtvntmknslisYWNLGF----TRTPQGQDLQYIFIPS 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 193 DLR---WLMEILIGKKI-----NTDGFWKKPALKLIYKQYqiRILDPYIIREAAFQLLRFPRVFPKDQKPKHPTTGIIAL 264
Cdd:cd23972   167 DIRdyvMLRSAILGVPVpegldKGDRPHKYFGPEASAKKF--KLLHPDFISYLTDRFLKSKLLNTHYGHLYMPSTGALML 244

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1958665599 265 TLAFHICSEVHLAGF---KYN-----FYTPDS-PLHYYGNATMSL 300
Cdd:cd23972   245 LTALHTCDQVSAYGFitsNYWkfsdhYYERKKkPLVFYANHDMLL 289
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 116-314 5.71e-12

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 64.98  E-value: 5.71e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 116 KRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLFYPE----------------------SVFS 173
Cdd:cd23988    65 KTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGTKSDFITMNPSvvqrafggfrnesdrekfvhrlSMLN 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 174 DPSHYDPnttAVLVVFKPQDLRWLMEILIGKKINTDGFWkkPALKLIYKQYQIRILDPYIIreaafqllrfprvfpkdqk 253
Cdd:cd23988   145 DSVLWIP---AFMVKGGEKHVEWVNALILKNKLKVRTAY--PSLRLIHAVRGYWLTNKVNI------------------- 200

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958665599 254 pKHPTTGIIALTLAFHICSEVHLAGF------------KYNFYTpDSPLHYYGNAT---MSLMKK--NAYHNLTAEQL 314
Cdd:cd23988   201 -KRPSTGLLMYTLATRFCDEIHLYGFwpfpkdangnpvKYHYYD-DLKYRYFSNAGphrMPLEFKtlNVLHNRGALKL 276
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 116-319 1.30e-11

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 64.19  E-value: 1.30e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 116 KRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLFYPESV---FSDPShydpNTT--------- 183
Cdd:cd23987    65 KTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDLVTMNPSVVqraFEDLV----NETwkekflqrl 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 184 -----------AVLVVFKPQDLRWLMEILIGKKINTDGFWkkPALKLIYKQYQIRILDPYIIreaafqllrfprvfpkdq 252
Cdd:cd23987   141 qslngsilwipAFMAKGGEERVEWVNDLILKHHINVRTAY--PSLRLLHAVRGYWLTNKVHI------------------ 200

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 253 kpKHPTTGIIALTLAFHICSEVHLAGFKYNFYTPD-SPL--HYYGNATMSLMKKNAYHNLTAEQLFLKNL 319
Cdd:cd23987   201 --KRPTTGLLMYTLATRFCNRIHLYGFWPFPRDQNqNPVkyHYYDSLKYGYTSQASPHTMPLEFKALKNL 268
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 110-322 8.88e-11

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 61.50  E-value: 8.88e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 110 FDTVPCKRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPvLGHEEEVGKRTTFrlfypesVFSDPShydpnttavlvvf 189
Cdd:cd23971    59 FSNKPLKTCAVVGNGGILKNSSCGREIDSADFVIRCNLPP-LNDSKDVGSKTNL-------VTANPS------------- 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 190 kpqdlrwlmeILIGKKINTDGfWKKPALKLIyKQYQ------------------IRILdpYIIRE-AAFQLLRF--PR-- 246
Cdd:cd23971   118 ----------ILREKFHNLKK-RRRPFVERM-KVYGnallllpafsytsntepsLRAL--YTLEDfGSPQKVLFfnPEyl 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 247 ----VFPKDQ--KPKHPTTGIIALTLAFHICSEVHLAGF-KYNFYTPDSPL--HYYGNatmsLMKKNAYHNLTAEQLFLK 317
Cdd:cd23971   184 rnlsRYWKSKglKARRLSTGLMLVSAALELCENVHLYGFwPFSTDLDGNPIshHYYDN----VLPKKGVHAMPEEFLRYL 259


                  ....*
gi 1958665599 318 NLIKK 322
Cdd:cd23971   260 KLHSQ 264
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 113-321 1.59e-08

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 54.84  E-value: 1.59e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 113 VPCKRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVL-GHEEEVGKRTTFrlfypesVFSDPSHYDPnttavlvvfKP 191
Cdd:cd23989    61 LPLKKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPLSrEYTDDVGTKTQL-------VTANPSIIDK---------RF 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 192 QDLRW-------LMEILIGKKINTDGFWKKPALKLIYKQYQIrILDPYIIREAAF---QLLRFPRVF--PKDQKPKHPTT 259
Cdd:cd23989   125 QNLLWsrksfveSMKVYGRSYIYMPAFSMKTGTDPSLRVYYT-LADVGANQTVLFanpNFLRNVGKFwkSKGVHAKRLST 203

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958665599 260 GIIALTLAFHICSEVHLAGF-KYNFYTPDSPL--HYYGNatmsLMKKNAYHNLTAEQLFLKNLIK 321
Cdd:cd23989   204 GLFLVSAALGLCEEVTIYGFwPFSVDLDERTIshHYYDN----VLPDSGFHAMPEEFLQLWHLHK 264
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 116-295 3.40e-08

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 53.69  E-value: 3.40e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 116 KRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLG-HEEEVGKRTTFRLFYPESV---FSDPSHYDPNTTAVLVVFKP 191
Cdd:cd23990    65 KKCAVVGNGGILKNSKCGREIDSADFVFRCNLPPISEkYVRDVGVKTDVVTINPSIIterFHKLEKWRRPFYEVLQVYEN 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 192 QDLrwLMEILIGKKiNTD-GFWKKPALKLIYKQYQIRILDP-YIIREAAFQLLRFPRVfpkdqkpKHPTTGIIALTLAFH 269
Cdd:cd23990   145 ASV--VLPAFYNTR-NTDvSIRVKYVLDDFESQQAVYYFHPqYLLNVSRFWLRQGVRA-------KRISSGLMLVTAALE 214

                         170       180       190
                  ....*....|....*....|....*....|
gi 1958665599 270 ICSEVHLAGFkYNFYTPDSPL----HYYGN 295
Cdd:cd23990   215 LCEEVHLYGF-WAFPMNPSGIfithHYYDN 243
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 110-324 4.13e-08

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 53.60  E-value: 4.13e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 110 FDTVPCKRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHE-EEVGKRTTFrlfypesVFSDPShydpnttavlvv 188
Cdd:cd23991    59 FRGYPYKQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGNIsKDVGSKTNL-------VTANPS------------ 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 189 fkpqdlrwlmeiLIGKKINTDGFWKKPALKLIYKQYQIRILDPYIIREA----AFQLLRFPRVFPKDQKPK--HPT---- 258
Cdd:cd23991   120 ------------IISIKYAKLNERRKPFLETVSVYGDAFLLLPAFSYRSntalSFKVYYTLEDFKAKQKVIffHPIylkh 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 259 ----------------TGIIALTLAFHICSEVHLAGF-KYNFYTPDSPL--HYYGNatmsLMKKNAYHNLTAE-----QL 314
Cdd:cd23991   188 laqfwrskgvqvyrlsTGLMITSAALELCEEVKLYGFwPFSKNTEGKPIshHYYDN----QLPKPGFHSMPKEfyqllQL 263

                         250
                  ....*....|
gi 1958665599 315 FLKNLIKKKM 324
Cdd:cd23991   264 HSKGILKLQF 273
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 115-293 7.61e-08

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 52.56  E-value: 7.61e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 115 CKRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLFYPESVfsdpshydpnttavlvvfkPQDL 194
Cdd:cd23976    15 CKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSI-------------------QRIL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665599 195 RWLMEILIGKKINTDGFW------KKPALKLIYKQYQI--RI---LDPYIIREAafQLLRFPRVFP----KDQKPKHP-- 257
Cdd:cd23976    76 RNRNELLNVSQGTVFIFWgpsnymRRDGKGLVYNNLQLmnQIlpkLKVYTITRH--KMLQFDELFKretgKDRKISNTwl 153

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1958665599 258 TTGIIALTLAFHICSEVHLAG-----FKYNFYTPDSPLHYY 293
Cdd:cd23976   154 STGWFTMIIALELCDRINVYGmvppdFCRDPNHPSVPYHYY 194
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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