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Conserved domains on  [gi|1958672678|ref|XP_038946763|]
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kelch domain-containing protein 8A isoform X3 [Rattus norvegicus]

Protein Classification

Kelch repeat-containing protein( domain architecture ID 11459646)

Kelch repeat-containing protein, member of a superfamily of proteins with diverse functions

CATH:  2.120.10.80
Gene Ontology:  GO:0005515
PubMed:  10603472|31442578|24959344
SCOP:  3000448

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
14-203 5.06e-31

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 114.48  E-value: 5.06e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672678  14 YDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGRQSKYAVNAFEVFDIESRSWTKFPNIPCKR-AFSSFVTLDNHLYS 92
Cdd:COG3055    95 YDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRdHLAAAVLPDGKILV 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672678  93 LGGlrqgrlyrqpkflrtmDVFDMEQGGWLKMERsffLKKRRADFVAGGLSGRVIVAGGLGNqptVLETAEAFHPEKNKW 172
Cdd:COG3055   175 IGG----------------RNGSGFSNTWTTLAP---LPTARAGHAAAVLGGKILVFGGESG---FSDEVEAYDPATNTW 232

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1958672678 173 EALPPMPTPRCACSSIVFKNCLLAVGGVSQG 203
Cdd:COG3055   233 TALGELPTPRHGHAAVLTDGKVYVIGGETKP 263
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
14-203 5.06e-31

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 114.48  E-value: 5.06e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672678  14 YDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGRQSKYAVNAFEVFDIESRSWTKFPNIPCKR-AFSSFVTLDNHLYS 92
Cdd:COG3055    95 YDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRdHLAAAVLPDGKILV 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672678  93 LGGlrqgrlyrqpkflrtmDVFDMEQGGWLKMERsffLKKRRADFVAGGLSGRVIVAGGLGNqptVLETAEAFHPEKNKW 172
Cdd:COG3055   175 IGG----------------RNGSGFSNTWTTLAP---LPTARAGHAAAVLGGKILVFGGESG---FSDEVEAYDPATNTW 232

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1958672678 173 EALPPMPTPRCACSSIVFKNCLLAVGGVSQG 203
Cdd:COG3055   233 TALGELPTPRHGHAAVLTDGKVYVIGGETKP 263
PHA03098 PHA03098
kelch-like protein; Provisional
 1-199 1.01e-17

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 80.97  E-value: 1.01e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672678   1 MGLDLRPHNYLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGRQSKYAVNAFEVFDIESRSWTKFPNIPCKRAF 80
Cdd:PHA03098  303 MNKNNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYN 382

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672678  81 SSFVTLDNHLYSLGGlrqgrLYRQPKFLRTMDVFDMEQGGWLKMERsffLKKRRADFVAGGLSGRVIVAGGLG--NQPTV 158
Cdd:PHA03098  383 PCVVNVNNLIYVIGG-----ISKNDELLKTVECFSLNTNKWSKGSP---LPISHYGGCAIYHDGKIYVIGGISyiDNIKV 454

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1958672678 159 LETAEAFHPEKNKWEALPPMPTPRCACSSIVFKNCLLAVGG 199
Cdd:PHA03098  455 YNIVESYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGG 495
Kelch smart00612
Kelch domain;
145-192 2.55e-10

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 54.10  E-value: 2.55e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1958672678  145 RVIVAGGLGNQpTVLETAEAFHPEKNKWEALPPMPTPRCACSSIVFKN 192
Cdd:smart00612   1 KIYVVGGFDGG-QRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 133-179 9.86e-07

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 44.14  E-value: 9.86e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1958672678 133 RRADFVAGGLSGRVIVAGGLGNQpTVLETAEAFHPEKNKWEALPPMP 179
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGN-QSLNSVEVYDPETNTWSKLPSMP 46
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
14-203 5.06e-31

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 114.48  E-value: 5.06e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672678  14 YDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGRQSKYAVNAFEVFDIESRSWTKFPNIPCKR-AFSSFVTLDNHLYS 92
Cdd:COG3055    95 YDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRdHLAAAVLPDGKILV 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672678  93 LGGlrqgrlyrqpkflrtmDVFDMEQGGWLKMERsffLKKRRADFVAGGLSGRVIVAGGLGNqptVLETAEAFHPEKNKW 172
Cdd:COG3055   175 IGG----------------RNGSGFSNTWTTLAP---LPTARAGHAAAVLGGKILVFGGESG---FSDEVEAYDPATNTW 232

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1958672678 173 EALPPMPTPRCACSSIVFKNCLLAVGGVSQG 203
Cdd:COG3055   233 TALGELPTPRHGHAAVLTDGKVYVIGGETKP 263
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
21-211 5.17e-31

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 114.48  E-value: 5.17e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672678  21 WVSLAPMPTPRYAATSFLRGSKIYVLGGRQSKYAVNAFEVFDIESRSWTKFPNIP-CKRAFSSFVTLDNHLYSLGGLRQG 99
Cdd:COG3055     3 WSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPgPPRHHAAAVAQDGKLYVFGGFTGA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672678 100 rlYRQPKFLRTMDVFDMEQGGWLKMERsffLKKRRADFVAGGLSGRVIVAGGLgNQPTVLETAEAFHPEKNKWEALPPMP 179
Cdd:COG3055    83 --NPSSTPLNDVYVYDPATNTWTKLAP---MPTPRGGATALLLDGKIYVVGGW-DDGGNVAWVEVYDPATGTWTQLAPLP 156

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1958672678 180 TPRCACSSIVFKNC-LLAVGGV-SQGLSDAVEAL 211
Cdd:COG3055   157 TPRDHLAAAVLPDGkILVIGGRnGSGFSNTWTTL 190
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
6-211 8.25e-28

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 106.01  E-value: 8.25e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672678   6 RPHNYLQHYDMLKDMWVSLAPMPT-PRYAATSFLRGSKIYVLGGRQSKY----AVNAFEVFDIESRSWTKFPNIPCKRAF 80
Cdd:COG3055    35 SASNSFEVYDPATNTWSELAPLPGpPRHHAAAVAQDGKLYVFGGFTGANpsstPLNDVYVYDPATNTWTKLAPMPTPRGG 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672678  81 SSFVTLDNHLYSLGGlrqgrlYRQPKFLRTMDVFDMEQGGWLKMERsffLKKRRADFVAGGL-SGRVIVAGGlgnqptvl 159
Cdd:COG3055   115 ATALLLDGKIYVVGG------WDDGGNVAWVEVYDPATGTWTQLAP---LPTPRDHLAAAVLpDGKILVIGG-------- 177

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958672678 160 etaEAFHPEKNKWEALPPMPTPRCACSSIVFKNCLLAVGGvSQGLSDAVEAL 211
Cdd:COG3055   178 ---RNGSGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGG-ESGFSDEVEAY 225
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
67-203 2.53e-20

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 86.36  E-value: 2.53e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672678  67 SWTKFPNIPCKRAFSSFVTLDNHLYSLGGLRQGRLyrqpkfLRTMDVFDMEQGGWLKMERsfFLKKRRADFVAGGLSGRV 146
Cdd:COG3055     2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSA------SNSFEVYDPATNTWSELAP--LPGPPRHHAAAVAQDGKL 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672678 147 IVAGGLG---NQPTVLETAEAFHPEKNKWEALPPMPTPRCACSSIVFKNCLLAVGGVSQG 203
Cdd:COG3055    74 YVFGGFTganPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDG 133
PHA03098 PHA03098
kelch-like protein; Provisional
 1-199 1.01e-17

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 80.97  E-value: 1.01e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672678   1 MGLDLRPHNYLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGRQSKYAVNAFEVFDIESRSWTKFPNIPCKRAF 80
Cdd:PHA03098  303 MNKNNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYN 382

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672678  81 SSFVTLDNHLYSLGGlrqgrLYRQPKFLRTMDVFDMEQGGWLKMERsffLKKRRADFVAGGLSGRVIVAGGLG--NQPTV 158
Cdd:PHA03098  383 PCVVNVNNLIYVIGG-----ISKNDELLKTVECFSLNTNKWSKGSP---LPISHYGGCAIYHDGKIYVIGGISyiDNIKV 454

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1958672678 159 LETAEAFHPEKNKWEALPPMPTPRCACSSIVFKNCLLAVGG 199
Cdd:PHA03098  455 YNIVESYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGG 495
PHA03098 PHA03098
kelch-like protein; Provisional
 9-201 4.48e-14

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 70.18  E-value: 4.48e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672678   9 NYLQHYDMLKDMWVSLAPmpTPRYAATSFLRGSKIYVLGGR-QSKYAVNAFEVFDIESRSWTKFPNIPCKRAFSSFVTLD 87
Cdd:PHA03098  265 NYITNYSPLSEINTIIDI--HYVYCFGSVVLNNVIYFIGGMnKNNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFN 342

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672678  88 NHLYSLGGLRQGRLyrqpkfLRTMDVFDMEQGGWlkmERSFFLKKRRADFVAGGLSGRVIVAGGLGNQPTVLETAEAFHP 167
Cdd:PHA03098  343 NRIYVIGGIYNSIS------LNTVESWKPGESKW---REEPPLIFPRYNPCVVNVNNLIYVIGGISKNDELLKTVECFSL 413

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1958672678 168 EKNKWEALPPMPTPRCACSSIVFKNCLLAVGGVS 201
Cdd:PHA03098  414 NTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGIS 447
PLN02153 PLN02153
epithiospecifier protein
 40-199 5.01e-14

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 69.63  E-value: 5.01e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672678  40 GSKIYVLGGRQSKYAVNAFEVFDIESRSWTKFPNI-----PCKRAFSSFVTLDNHLYSLGGLRQGRLYRQPKFLRTMDVF 114
Cdd:PLN02153   85 GTKLYIFGGRDEKREFSDFYSYDTVKNEWTFLTKLdeeggPEARTFHSMASDENHVYVFGGVSKGGLMKTPERFRTIEAY 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672678 115 DMEQGGWLKMER--SFFLKKRRADFVAggLSGRVIVAGGL-------GNQPTVLETAEAFHPEKNKW---EALPPMPTPR 182
Cdd:PLN02153  165 NIADGKWVQLPDpgENFEKRGGAGFAV--VQGKIWVVYGFatsilpgGKSDYESNAVQFFDPASGKWtevETTGAKPSAR 242

                         170
                  ....*....|....*..
gi 1958672678 183 CACSSIVFKNCLLAVGG 199
Cdd:PLN02153  243 SVFAHAVVGKYIIIFGG 259
Kelch smart00612
Kelch domain;
145-192 2.55e-10

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 54.10  E-value: 2.55e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1958672678  145 RVIVAGGLGNQpTVLETAEAFHPEKNKWEALPPMPTPRCACSSIVFKN 192
Cdd:smart00612   1 KIYVVGGFDGG-QRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch smart00612
Kelch domain;
42-88 3.20e-07

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 45.63  E-value: 3.20e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1958672678   42 KIYVLGGRQSKYAVNAFEVFDIESRSWTKFPNIPCKRAFSSFVTLDN 88
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
PHA03098 PHA03098
kelch-like protein; Provisional
 9-75 5.38e-07

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 49.38  E-value: 5.38e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958672678   9 NYLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGRQSKYAVNAFEVFDIESRSWTKFPNIP 75
Cdd:PHA03098  456 NIVESYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWTLFCKFP 522
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 133-179 9.86e-07

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 44.14  E-value: 9.86e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1958672678 133 RRADFVAGGLSGRVIVAGGLGNQpTVLETAEAFHPEKNKWEALPPMP 179
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGN-QSLNSVEVYDPETNTWSKLPSMP 46
Kelch_6 pfam13964
Kelch motif;
144-182 1.42e-06

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 43.86  E-value: 1.42e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1958672678 144 GRVIVAGGLGNQPTVLETAEAFHPEKNKWEALPPMPTPR 182
Cdd:pfam13964  12 GYIYVFGGYTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
Kelch_6 pfam13964
Kelch motif;
30-78 2.48e-06

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 43.09  E-value: 2.48e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958672678  30 PRYAATSFLRGSKIYVLGGR-QSKYAVNAFEVFDIESRSWTKFPNIPCKR 78
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYtNASPALNKLEVYNPLTKSWEELPPLPTPR 50
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
1-62 3.26e-06

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 46.69  E-value: 3.26e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958672678   1 MGLDLRPHNYLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGR----QSKYAVNAFEVFD 62
Cdd:COG3055   212 FGGESGFSDEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGGEtkpgVRTPLVTSAEVYD 277
PLN02193 PLN02193
nitrile-specifier protein
 40-199 3.32e-06

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 46.87  E-value: 3.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672678  40 GSKIYVLGGRQSKYAVNAFEVFDIESRSW---TKFPNIPCKRAFSSFVTLDNHLYSLGGLrqGRLYRqpkfLRTMDVFDM 116
Cdd:PLN02193  228 GSTLYVFGGRDASRQYNGFYSFDTTTNEWkllTPVEEGPTPRSFHSMAADEENVYVFGGV--SATAR----LKTLDSYNI 301

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672678 117 EQGGWlkmersFFLKKRRADFVAGGLSGRVIVAGGL----GNQPTVLETAEAFHPEKNKW---EALPPMPTPRCACSSIV 189
Cdd:PLN02193  302 VDKKW------FHCSTPGDSFSIRGGAGLEVVQGKVwvvyGFNGCEVDDVHYYDPVQDKWtqvETFGVRPSERSVFASAA 375

                         170
                  ....*....|
gi 1958672678 190 FKNCLLAVGG 199
Cdd:PLN02193  376 VGKHIVIFGG 385
PHA02790 PHA02790
Kelch-like protein; Provisional
 8-203 6.47e-06

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 46.19  E-value: 6.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672678   8 HNYLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGRQSKYAVNAFEVFDIesrSWTKFPNIPCKRAFSSFVTLD 87
Cdd:PHA02790  286 HNNAIAVNYISNNWIPIPPMNSPRLYASGVPANNKLYVVGGLPNPTSVERWFHGDA---AWVNMPSLLKPRCNPAVASIN 362

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672678  88 NHLYSLGGLRQGRlyrqpkflRTMDVFDMEQGGWLKMERSFFLKKRRADFVAGglsGRVIVAGglgnqptvlETAEAFHP 167
Cdd:PHA02790  363 NVIYVIGGHSETD--------TTTEYLLPNHDQWQFGPSTYYPHYKSCALVFG---RRLFLVG---------RNAEFYCE 422

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1958672678 168 EKNKWEALPPMPTPRCACSSIVFKNCLLAVGGVSQG 203
Cdd:PHA02790  423 SSNTWTLIDDPIYPRDNPELIIVDNKLLLIGGFYRG 458
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 30-73 2.79e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 40.29  E-value: 2.79e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1958672678  30 PRYAATSFLRGSKIYVLGGRQSKYAVNAFEVFDIESRSWTKFPN 73
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPS 44
PHA02790 PHA02790
Kelch-like protein; Provisional
 32-198 1.27e-04

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 42.34  E-value: 1.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672678  32 YAATSFLRGSKIYVLGGRQSKYAVNAFEVFDIESRSWTKFPNIPCKRAFSSFVTLDNHLYSLGGLrqgrlyrqPKFLRTM 111
Cdd:PHA02790  263 HMCTSTHVGEVVYLIGGWMNNEIHNNAIAVNYISNNWIPIPPMNSPRLYASGVPANNKLYVVGGL--------PNPTSVE 334

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672678 112 DVFDMEQgGWLKMERsffLKKRRADFVAGGLSGRVIVAGGLGNQPTvleTAEAFHPEKNKWEALPPMPTPRCACSSIVFK 191
Cdd:PHA02790  335 RWFHGDA-AWVNMPS---LLKPRCNPAVASINNVIYVIGGHSETDT---TTEYLLPNHDQWQFGPSTYYPHYKSCALVFG 407


                  ....*..
gi 1958672678 192 NCLLAVG 198
Cdd:PHA02790  408 RRLFLVG 414
Kelch_4 pfam13418
Galactose oxidase, central domain;
133-180 2.26e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 34.90  E-value: 2.26e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1958672678 133 RRADFVAGGL-SGRVIVAGGLGNQPTVLETAEAFHPEKNKWEALPPMPT 180
Cdd:pfam13418   1 PRAYHTSTSIpDDTIYLFGGEGEDGTLLSDLWVFDLSTNEWTRLGSLPS 49
Kelch_4 pfam13418
Galactose oxidase, central domain;
30-76 2.73e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 34.90  E-value: 2.73e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1958672678  30 PR-YAATSFLRGSKIYVLGGRQSKYAV-NAFEVFDIESRSWTKFPNIPC 76
Cdd:pfam13418   1 PRaYHTSTSIPDDTIYLFGGEGEDGTLlSDLWVFDLSTNEWTRLGSLPS 49
PRK14131 PRK14131
N-acetylneuraminate epimerase;
21-95 4.87e-03

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 37.30  E-value: 4.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672678  21 WVSLAPMPT-PRYAATSFLRGSKIYVLGGRQ------SKYAVNAFEVFDIESRSWTKFPNI-PCKRAFSSFVTLDN-HLY 91
Cdd:PRK14131   64 WTKIAAFPGgPREQAVAAFIDGKLYVFGGIGktnsegSPQVFDDVYKYDPKTNSWQKLDTRsPVGLAGHVAVSLHNgKAY 143


                  ....
gi 1958672678  92 SLGG 95
Cdd:PRK14131  144 ITGG 147
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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