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Conserved domains on  [gi|1958675207|ref|XP_038947568|]
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homeobox protein OTX1 isoform X1 [Rattus norvegicus]

Protein Classification

homeobox protein( domain architecture ID 11079031)

homeobox protein similar to Otx1 and Otx2 which are vertebrate homologs of the Drosophila gap gene orthodenticle and may play a role in the specification or differentiation of neurons in the deep layers of the cerebral cortex

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
39-95 1.14e-26

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 100.27  E-value: 1.14e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958675207  39 RRERTTFTRSQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQ 95
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
TF_Otx pfam03529
Otx1 transcription factor;
178-274 5.19e-24

Otx1 transcription factor;


:

Pssm-ID: 427350  Cd Length: 91  Bit Score: 94.20  E-value: 5.19e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675207 178 SPASISPgsapasvsVPEPLgAPSNASCMQRSVAAGAATaaaSYPMSYGQGGSYGQGYPAPSSSYFGGVDCSSYLAPMHS 257
Cdd:pfam03529   1 SPASISP--------LPDPL-APSSASCMQRSVSSTASA---SYPMSYGQASAYSQGYPAGSSSYFGGVDCGSYLSPMHS 68

                          90
                  ....*....|....*...
gi 1958675207 258 H-HHPHQLSPMAPSSMAG 274
Cdd:pfam03529  69 QlHHPHQLSPMTASSMGG 86
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
39-95 1.14e-26

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 100.27  E-value: 1.14e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958675207  39 RRERTTFTRSQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQ 95
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 39-97 4.63e-24

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 93.46  E-value: 4.63e-24
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958675207  39 RRERTTFTRSQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQ 97
Cdd:cd00086     1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
TF_Otx pfam03529
Otx1 transcription factor;
178-274 5.19e-24

Otx1 transcription factor;


Pssm-ID: 427350  Cd Length: 91  Bit Score: 94.20  E-value: 5.19e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675207 178 SPASISPgsapasvsVPEPLgAPSNASCMQRSVAAGAATaaaSYPMSYGQGGSYGQGYPAPSSSYFGGVDCSSYLAPMHS 257
Cdd:pfam03529   1 SPASISP--------LPDPL-APSSASCMQRSVSSTASA---SYPMSYGQASAYSQGYPAGSSSYFGGVDCGSYLSPMHS 68

                          90
                  ....*....|....*...
gi 1958675207 258 H-HHPHQLSPMAPSSMAG 274
Cdd:pfam03529  69 QlHHPHQLSPMTASSMGG 86
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 38-94 1.63e-23

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 91.93  E-value: 1.63e-23
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958675207   38 QRRERTTFTRSQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCR 94
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
36-116 8.20e-16

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 74.01  E-value: 8.20e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675207  36 RKQRRERTTFTRSQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQSGN----GTKSRPVKKK 111
Cdd:COG5576    49 SPPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRSGKVeqrpGEEEADLAKI 128


                  ....*
gi 1958675207 112 SSPVR 116
Cdd:COG5576   129 GSLST 133
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
39-95 1.14e-26

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 100.27  E-value: 1.14e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958675207  39 RRERTTFTRSQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQ 95
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 39-97 4.63e-24

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 93.46  E-value: 4.63e-24
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958675207  39 RRERTTFTRSQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQ 97
Cdd:cd00086     1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
TF_Otx pfam03529
Otx1 transcription factor;
178-274 5.19e-24

Otx1 transcription factor;


Pssm-ID: 427350  Cd Length: 91  Bit Score: 94.20  E-value: 5.19e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675207 178 SPASISPgsapasvsVPEPLgAPSNASCMQRSVAAGAATaaaSYPMSYGQGGSYGQGYPAPSSSYFGGVDCSSYLAPMHS 257
Cdd:pfam03529   1 SPASISP--------LPDPL-APSSASCMQRSVSSTASA---SYPMSYGQASAYSQGYPAGSSSYFGGVDCGSYLSPMHS 68

                          90
                  ....*....|....*...
gi 1958675207 258 H-HHPHQLSPMAPSSMAG 274
Cdd:pfam03529  69 QlHHPHQLSPMTASSMGG 86
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 38-94 1.63e-23

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 91.93  E-value: 1.63e-23
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958675207   38 QRRERTTFTRSQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCR 94
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
36-116 8.20e-16

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 74.01  E-value: 8.20e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675207  36 RKQRRERTTFTRSQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQSGN----GTKSRPVKKK 111
Cdd:COG5576    49 SPPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRSGKVeqrpGEEEADLAKI 128


                  ....*
gi 1958675207 112 SSPVR 116
Cdd:COG5576   129 GSLST 133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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