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Conserved domains on  [gi|1958729278|ref|XP_038952165|]
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extracellular matrix protein 2 isoform X1 [Rattus norvegicus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11985686)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
251-580 5.17e-27

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 113.88  E-value: 5.17e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 251 EVTTLELVGNSIISIPNEAFNGLPNLERLDLSRNNitssgigpkAFKLLKKLMHLNMDGNNLVHIPSELPS--TLEELKI 328
Cdd:COG4886    73 LLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE---------ELSNLTNLESLDLSGNQLTDLPEELANltNLKELDL 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 329 NDNNLQAIDEkSLSDLNQLVALELEGNNLSEInvnPLAFKSLKNLSYLRLGKNKFRIIPQGL--PASIEELYLENNQIEE 406
Cdd:COG4886   144 SNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL---PEELGNLTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTD 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 407 ITEicfnhtrkitmivlrynkieesriaPLAwiNHENLESIDLSYNKLYHVP--SYLPKsLLHLVLIGNQIERIPgyVFG 484
Cdd:COG4886   220 LPE-------------------------PLA--NLTNLETLDLSNNQLTDLPelGNLTN-LEELDLSNNQLTDLP--PLA 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 485 HMkPGLEYLYLSFNRLSDDGVDLVSFYGAYHSLRELFLDHNDFKSIPPGIQGMKALHFLRLNNNKIRNILPEQICNAEED 564
Cdd:COG4886   270 NL-TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLA 348

                         330
                  ....*....|....*.
gi 1958729278 565 EDSALEHLHLENNYIT 580
Cdd:COG4886   349 LLTLLLLLNLLSLLLT 364
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 100-154 2.88e-17

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


:

Pssm-ID: 278520  Cd Length: 57  Bit Score: 75.92  E-value: 2.88e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958729278 100 CSVKGMVMYNKAVWSPEPCTTCLCSNGRVLCDETTCPPKTC--PYTVKPEGECCPIC 154
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCpnPRLEIPPGECCPVC 57
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
251-580 5.17e-27

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 113.88  E-value: 5.17e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 251 EVTTLELVGNSIISIPNEAFNGLPNLERLDLSRNNitssgigpkAFKLLKKLMHLNMDGNNLVHIPSELPS--TLEELKI 328
Cdd:COG4886    73 LLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE---------ELSNLTNLESLDLSGNQLTDLPEELANltNLKELDL 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 329 NDNNLQAIDEkSLSDLNQLVALELEGNNLSEInvnPLAFKSLKNLSYLRLGKNKFRIIPQGL--PASIEELYLENNQIEE 406
Cdd:COG4886   144 SNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL---PEELGNLTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTD 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 407 ITEicfnhtrkitmivlrynkieesriaPLAwiNHENLESIDLSYNKLYHVP--SYLPKsLLHLVLIGNQIERIPgyVFG 484
Cdd:COG4886   220 LPE-------------------------PLA--NLTNLETLDLSNNQLTDLPelGNLTN-LEELDLSNNQLTDLP--PLA 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 485 HMkPGLEYLYLSFNRLSDDGVDLVSFYGAYHSLRELFLDHNDFKSIPPGIQGMKALHFLRLNNNKIRNILPEQICNAEED 564
Cdd:COG4886   270 NL-TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLA 348

                         330
                  ....*....|....*.
gi 1958729278 565 EDSALEHLHLENNYIT 580
Cdd:COG4886   349 LLTLLLLLNLLSLLLT 364
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 100-154 2.88e-17

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 75.92  E-value: 2.88e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958729278 100 CSVKGMVMYNKAVWSPEPCTTCLCSNGRVLCDETTCPPKTC--PYTVKPEGECCPIC 154
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCpnPRLEIPPGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
100-154 9.60e-15

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 68.70  E-value: 9.60e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958729278  100 CSVKGMVMYNKAVWSPEPCTTCLCSNGR-VLCDETTCPP-KTC--PYTVKPEGECCPIC 154
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVECPPpPDCpnPERVKPPGECCPRC 59
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
300-540 3.07e-14

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 75.89  E-value: 3.07e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 300 KKLMHLNMDGNNLVHIPSELPSTLEELKINDNNLQAIDEkSLSDLNQLvaLELEGNNLSEINVN-PLAFKSL-------- 370
Cdd:PRK15370  199 EQITTLILDNNELKSLPENLQGNIKTLYANSNQLTSIPA-TLPDTIQE--MELSINRITELPERlPSALQSLdlfhnkis 275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 371 -------KNLSYLRLGKNKFRIIPQGLPASIEELYLENNQIEEITEicfnhTRKITMIVLrynKIEESRIAPLAWINHEN 443
Cdd:PRK15370  276 clpenlpEELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPE-----TLPPGLKTL---EAGENALTSLPASLPPE 347

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 444 LESIDLSYNKLYHVPSYLPKSLLHLVLIGNQIERIPgyvfGHMKPGLEYLYLSFNRLSDDGVDLVSFYGAYHSLRELFLD 523
Cdd:PRK15370  348 LQVLDVSKNQITVLPETLPPTITTLDVSRNALTNLP----ENLPAALQIMQASRNNLVRLPESLPHFRGEGPQPTRIIVE 423

                         250
                  ....*....|....*..
gi 1958729278 524 HNDFKSipPGIQGMKAL 540
Cdd:PRK15370  424 YNPFSE--RTIQNMQRL 438
LRR_8 pfam13855
Leucine rich repeat;
250-312 1.13e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 65.62  E-value: 1.13e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958729278 250 PEVTTLELVGNSIISIPNEAFNGLPNLERLDLSRNNITSsgIGPKAFKLLKKLMHLNMDGNNL 312
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 299-481 6.39e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 68.27  E-value: 6.39e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 299 LKKLMHLNMDGNNLVHIPS-ELPSTLEELKINDNNLQAIDekSLSDLNQLVALELEGNNLSEINVnplaFKSLKNLSYLR 377
Cdd:cd21340     1 LKRITHLYLNDKNITKIDNlSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIEN----LENLVNLKKLY 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 378 LGKNKFRIIpQGL--PASIEELYLENNQIEEITEICFNhTRKITMIV--LRYNKIEESRIAPLAWINH-ENLESIDLSYN 452
Cdd:cd21340    75 LGGNRISVV-EGLenLTNLEELHIENQRLPPGEKLTFD-PRSLAALSnsLRVLNISGNNIDSLEPLAPlRNLEQLDASNN 152

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1958729278 453 KLYHVPSYLP-----KSLLHLVLIGNQIERIPGY 481
Cdd:cd21340   153 QISDLEELLDllsswPSLRELDLTGNPVCKKPKY 186
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
251-580 5.17e-27

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 113.88  E-value: 5.17e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 251 EVTTLELVGNSIISIPNEAFNGLPNLERLDLSRNNitssgigpkAFKLLKKLMHLNMDGNNLVHIPSELPS--TLEELKI 328
Cdd:COG4886    73 LLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE---------ELSNLTNLESLDLSGNQLTDLPEELANltNLKELDL 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 329 NDNNLQAIDEkSLSDLNQLVALELEGNNLSEInvnPLAFKSLKNLSYLRLGKNKFRIIPQGL--PASIEELYLENNQIEE 406
Cdd:COG4886   144 SNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL---PEELGNLTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTD 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 407 ITEicfnhtrkitmivlrynkieesriaPLAwiNHENLESIDLSYNKLYHVP--SYLPKsLLHLVLIGNQIERIPgyVFG 484
Cdd:COG4886   220 LPE-------------------------PLA--NLTNLETLDLSNNQLTDLPelGNLTN-LEELDLSNNQLTDLP--PLA 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 485 HMkPGLEYLYLSFNRLSDDGVDLVSFYGAYHSLRELFLDHNDFKSIPPGIQGMKALHFLRLNNNKIRNILPEQICNAEED 564
Cdd:COG4886   270 NL-TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLA 348

                         330
                  ....*....|....*.
gi 1958729278 565 EDSALEHLHLENNYIT 580
Cdd:COG4886   349 LLTLLLLLNLLSLLLT 364
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
253-581 9.71e-26

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 110.02  E-value: 9.71e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 253 TTLELVGNSIISIPNEAFNGLPNLERLDLSRNNITSSGIGPKAFKLLKKLMHLNMDGNNLVHIPSELPSTLEELKiNDNN 332
Cdd:COG4886    22 TTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLT-NLTE 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 333 LQAIDEKSLSDLNQLVALELEGNNLSEInvnPLAFKSLKNLSYLRLGKNKFRIIPQGLP--ASIEELYLENNQIEEITEI 410
Cdd:COG4886   101 LDLSGNEELSNLTNLESLDLSGNQLTDL---PEELANLTNLKELDLSNNQLTDLPEPLGnlTNLKSLDLSNNQLTDLPEE 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 411 CFNHTrKITMIVLRYNKIEEsriAPLAWINHENLESIDLSYNKLYHVPSYLP--KSLLHLVLIGNQIERIPGyvFGHMkP 488
Cdd:COG4886   178 LGNLT-NLKELDLSNNQITD---LPEPLGNLTNLEELDLSGNQLTDLPEPLAnlTNLETLDLSNNQLTDLPE--LGNL-T 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 489 GLEYLYLSFNRLSDdgvdlVSFYGAYHSLRELFLDHNDFKSIPPGIQGMKALHFLRLNNNKIRNILPEQICNAEEDEDSA 568
Cdd:COG4886   251 NLEELDLSNNQLTD-----LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLL 325

                         330
                  ....*....|...
gi 1958729278 569 LEHLHLENNYITT 581
Cdd:COG4886   326 LLLLLKGLLVTLT 338
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
241-531 1.70e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 103.47  E-value: 1.70e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 241 FTEIPPITA--PEVTTLELVGNSIISIPnEAFNGLPNLERLDLSRNNITSsgIgPKAFKLLKKLMHLNMDGNNLVHIPSE 318
Cdd:COG4886   125 LTDLPEELAnlTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTD--L-PEELGNLTNLKELDLSNNQITDLPEP 200

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 319 L--PSTLEELKINDNNLQAIDEkSLSDLNQLVALELEGNNLSEINvnplAFKSLKNLSYLRLGKNKFRIIPQGLP-ASIE 395
Cdd:COG4886   201 LgnLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLP----ELGNLTNLEELDLSNNQLTDLPPLANlTNLK 275

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 396 ELYLENNQIEEITEICFNHTRKITMIVLRYNKIEESRIAPLAWINHENLESIDLSYNKLYHVPSYLPKSLLHLVLIGNQI 475
Cdd:COG4886   276 TLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLL 355

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958729278 476 ERIPGYVFGHMKPGLEYLYLSFNRLSDDGVDLVSFYGAYHSLRELFLDHNDFKSIP 531
Cdd:COG4886   356 LNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAV 411
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
253-577 2.79e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 102.70  E-value: 2.79e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 253 TTLELVGNSIISIPNEAFNGLPNLERLDLSRNNITSSGIGPKAFKLLKKLMHLNMDGNNLVHIPSELPSTLEELKINDNN 332
Cdd:COG4886     4 LLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 333 LQAIDEKSLSDLNQLVALELEGNNlseinvnplAFKSLKNLSYLRLGKNKFRIIPQGLPA--SIEELYLENNQIEEITEI 410
Cdd:COG4886    84 LLLLGLTDLGDLTNLTELDLSGNE---------ELSNLTNLESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPEP 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 411 CFNHTrKITMIVLRYNKIEEsriAPLAWINHENLESIDLSYNKLYHVPSYL--PKSLLHLVLIGNQIERIPGyVFGHMKp 488
Cdd:COG4886   155 LGNLT-NLKSLDLSNNQLTD---LPEELGNLTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLPE-PLANLT- 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 489 GLEYLYLSFNRLSddgvDLVSFyGAYHSLRELFLDHNDFKSIPPGIQgMKALHFLRLNNNKIRNILPEQICNAEEDEDSA 568
Cdd:COG4886   229 NLETLDLSNNQLT----DLPEL-GNLTNLEELDLSNNQLTDLPPLAN-LTNLKTLDLSNNQLTDLKLKELELLLGLNSLL 302


                  ....*....
gi 1958729278 569 LEHLHLENN 577
Cdd:COG4886   303 LLLLLLNLL 311
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
279-581 4.31e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 96.16  E-value: 4.31e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 279 LDLSRNNITSSGIGPKAFKLLKKLMHLNMDGNNLVHIPSELPSTLEELKINDNNLQAIDEKSLSDLNQLVALELEGNNL- 357
Cdd:COG4886     1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLl 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 358 --SEINVNPLAFKSLKNLSYLRLGKNKfriiPQGLPASIEELYLENNQIEEITEicfnhtrkitmivlrynkieesRIAP 435
Cdd:COG4886    81 llSLLLLGLTDLGDLTNLTELDLSGNE----ELSNLTNLESLDLSGNQLTDLPE----------------------ELAN 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 436 LawinhENLESIDLSYNKLYHVPSYLP--KSLLHLVLIGNQIERIPGyVFGHMkPGLEYLYLSFNRLSDDGVDLvsfyGA 513
Cdd:COG4886   135 L-----TNLKELDLSNNQLTDLPEPLGnlTNLKSLDLSNNQLTDLPE-ELGNL-TNLKELDLSNNQITDLPEPL----GN 203

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958729278 514 YHSLRELFLDHNDFKSIPPGIQGMKALHFLRLNNNKIRNIlpEQICNAeededSALEHLHLENNYITT 581
Cdd:COG4886   204 LTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL--PELGNL-----TNLEELDLSNNQLTD 264
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 100-154 2.88e-17

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 75.92  E-value: 2.88e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958729278 100 CSVKGMVMYNKAVWSPEPCTTCLCSNGRVLCDETTCPPKTC--PYTVKPEGECCPIC 154
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCpnPRLEIPPGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
100-154 9.60e-15

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 68.70  E-value: 9.60e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958729278  100 CSVKGMVMYNKAVWSPEPCTTCLCSNGR-VLCDETTCPP-KTC--PYTVKPEGECCPIC 154
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVECPPpPDCpnPERVKPPGECCPRC 59
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
300-540 3.07e-14

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 75.89  E-value: 3.07e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 300 KKLMHLNMDGNNLVHIPSELPSTLEELKINDNNLQAIDEkSLSDLNQLvaLELEGNNLSEINVN-PLAFKSL-------- 370
Cdd:PRK15370  199 EQITTLILDNNELKSLPENLQGNIKTLYANSNQLTSIPA-TLPDTIQE--MELSINRITELPERlPSALQSLdlfhnkis 275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 371 -------KNLSYLRLGKNKFRIIPQGLPASIEELYLENNQIEEITEicfnhTRKITMIVLrynKIEESRIAPLAWINHEN 443
Cdd:PRK15370  276 clpenlpEELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPE-----TLPPGLKTL---EAGENALTSLPASLPPE 347

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 444 LESIDLSYNKLYHVPSYLPKSLLHLVLIGNQIERIPgyvfGHMKPGLEYLYLSFNRLSDDGVDLVSFYGAYHSLRELFLD 523
Cdd:PRK15370  348 LQVLDVSKNQITVLPETLPPTITTLDVSRNALTNLP----ENLPAALQIMQASRNNLVRLPESLPHFRGEGPQPTRIIVE 423

                         250
                  ....*....|....*..
gi 1958729278 524 HNDFKSipPGIQGMKAL 540
Cdd:PRK15370  424 YNPFSE--RTIQNMQRL 438
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
223-478 4.70e-14

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 75.50  E-value: 4.70e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 223 LPRSCSLSYRTISCIYGDFTEIPPITAPEVTTLELVGNSIISIPNEafngLPN-LERLDLSRNNITSSgigPKafKLLKK 301
Cdd:PRK15370  214 LPENLQGNIKTLYANSNQLTSIPATLPDTIQEMELSINRITELPER----LPSaLQSLDLFHNKISCL---PE--NLPEE 284

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 302 LMHLNMDGNNLVHIPSELPSTLEELKINDNNLQAIDEKSLSDLNQLVALELEGNNLSEiNVNPlafkSLKNLSylrLGKN 381
Cdd:PRK15370  285 LRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPETLPPGLKTLEAGENALTSLPA-SLPP----ELQVLD---VSKN 356

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 382 KFRIIPQGLPASIEELYLENNQIEEITEICfnhtrkitmivlrynkieesriaPLAwinhenLESIDLSYNKLyhvpSYL 461
Cdd:PRK15370  357 QITVLPETLPPTITTLDVSRNALTNLPENL-----------------------PAA------LQIMQASRNNL----VRL 403

                         250
                  ....*....|....*..
gi 1958729278 462 PKSLLHLVLIGNQIERI 478
Cdd:PRK15370  404 PESLPHFRGEGPQPTRI 420
LRR_8 pfam13855
Leucine rich repeat;
250-312 1.13e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 65.62  E-value: 1.13e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958729278 250 PEVTTLELVGNSIISIPNEAFNGLPNLERLDLSRNNITSsgIGPKAFKLLKKLMHLNMDGNNL 312
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 299-481 6.39e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 68.27  E-value: 6.39e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 299 LKKLMHLNMDGNNLVHIPS-ELPSTLEELKINDNNLQAIDekSLSDLNQLVALELEGNNLSEINVnplaFKSLKNLSYLR 377
Cdd:cd21340     1 LKRITHLYLNDKNITKIDNlSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIEN----LENLVNLKKLY 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 378 LGKNKFRIIpQGL--PASIEELYLENNQIEEITEICFNhTRKITMIV--LRYNKIEESRIAPLAWINH-ENLESIDLSYN 452
Cdd:cd21340    75 LGGNRISVV-EGLenLTNLEELHIENQRLPPGEKLTFD-PRSLAALSnsLRVLNISGNNIDSLEPLAPlRNLEQLDASNN 152

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1958729278 453 KLYHVPSYLP-----KSLLHLVLIGNQIERIPGY 481
Cdd:cd21340   153 QISDLEELLDllsswPSLRELDLTGNPVCKKPKY 186
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 252-558 5.94e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 68.72  E-value: 5.94e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 252 VTTLELVGNSIISIPNEAFNGLPNLERLDLSRNNItSSGIGPKAFKLLKKLMHLNMDGNNLV-HIPSELPSTLEELKIND 330
Cdd:PLN00113   71 VVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQL-SGPIPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLDLSN 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 331 NNLQAIDEKSLSDLNQLVALELEGNNLseINVNPLAFKSLKNLSYLRLGKNKFriiPQGLPASIEELylennqieeitei 410
Cdd:PLN00113  150 NMLSGEIPNDIGSFSSLKVLDLGGNVL--VGKIPNSLTNLTSLEFLTLASNQL---VGQIPRELGQM------------- 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 411 cfnhtRKITMIVLRYNKIE---ESRIAPLAWINHenlesIDLSYNKLY-HVPSYLP--KSLLHLVLIGNQIE-RIPGYVF 483
Cdd:PLN00113  212 -----KSLKWIYLGYNNLSgeiPYEIGGLTSLNH-----LDLVYNNLTgPIPSSLGnlKNLQYLFLYQNKLSgPIPPSIF 281

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958729278 484 GHMKpgLEYLYLSFNRLSDDGVDLVSfygAYHSLRELFLDHNDFK-SIPPGIQGMKALHFLRLNNNKIRNILPEQI 558
Cdd:PLN00113  282 SLQK--LISLDLSDNSLSGEIPELVI---QLQNLEILHLFSNNFTgKIPVALTSLPRLQVLQLWSNKFSGEIPKNL 352
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
222-433 2.16e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 63.56  E-value: 2.16e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 222 RLPRSCSLSYRTISCIYGDFTEIPPITAPEVTTLELVGNSIISIPNEafngLPN-LERLDLSRNNITSSgigPKafKLLK 300
Cdd:PRK15370  234 SIPATLPDTIQEMELSINRITELPERLPSALQSLDLFHNKISCLPEN----LPEeLRYLSVYDNSIRTL---PA--HLPS 304

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 301 KLMHLNMDGNNLVHIPSELPSTLEELKINDNNLQAIDEkSLSDlnQLVALELEGNnlsEINVNPLAFKSlkNLSYLRLGK 380
Cdd:PRK15370  305 GITHLNVQSNSLTALPETLPPGLKTLEAGENALTSLPA-SLPP--ELQVLDVSKN---QITVLPETLPP--TITTLDVSR 376

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958729278 381 NKFRIIPQGLPASIEELYLENNQIEEITEiCFNHTR----KITMIVLRYNKIEESRI 433
Cdd:PRK15370  377 NALTNLPENLPAALQIMQASRNNLVRLPE-SLPHFRgegpQPTRIIVEYNPFSERTI 432
LRR_8 pfam13855
Leucine rich repeat;
274-357 2.87e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.99  E-value: 2.87e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 274 PNLERLDLSRNNITSsgIGPKAFKLLKKLMHLNmdgnnlvhipselpstleelkINDNNLQAIDEKSLSDLNQLVALELE 353
Cdd:pfam13855   1 PNLRSLDLSNNRLTS--LDDGAFKGLSNLKVLD---------------------LSNNLLTTLSPGAFSGLPSLRYLDLS 57


                  ....
gi 1958729278 354 GNNL 357
Cdd:pfam13855  58 GNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
246-479 1.41e-09

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 60.95  E-value: 1.41e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 246 PITAPEVTTLELVGNSIISIPNEAfnglPNLERLDLSRNNITSSGIGPKAfkllkkLMHLNMDGNNLVHIPSeLPSTLEE 325
Cdd:PRK15387  238 PALPPELRTLEVSGNQLTSLPVLP----PGLLELSIFSNPLTHLPALPSG------LCKLWIFGNQLTSLPV-LPPGLQE 306

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 326 LKINDNNLqaideKSLSDL-NQLVALELEGNNLSEINVNPlafkslKNLSYLRLGKNKFRIIPQgLPASIEELYLENNQI 404
Cdd:PRK15387  307 LSVSDNQL-----ASLPALpSELCKLWAYNNQLTSLPTLP------SGLQELSVSDNQLASLPT-LPSELYKLWAYNNRL 374

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958729278 405 EEITEIcfnhTRKITMIVLRYNKIEESRIAPlawinhENLESIDLSYNKLYHVPsYLPKSLLHLVLIGNQIERIP 479
Cdd:PRK15387  375 TSLPAL----PSGLKELIVSGNRLTSLPVLP------SELKELMVSGNRLTSLP-MLPSGLLSLSVYRNQLTRLP 438
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
371-558 3.50e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 59.71  E-value: 3.50e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 371 KNLSYLRLGKNKFRIIPQGLPASIEELYLENNQIEEITEicfNHTRKITMIVLRYNKIeeSRI-APLAwinhENLESIDL 449
Cdd:PRK15370  178 NNKTELRLKILGLTTIPACIPEQITTLILDNNELKSLPE---NLQGNIKTLYANSNQL--TSIpATLP----DTIQEMEL 248

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 450 SYNKLYHVPSYLPKSLLHLVLIGNQIERIPgyvfGHMKPGLEYLYLSFNRLSDDGVDLVSfygayhSLRELFLDHNDF-- 527
Cdd:PRK15370  249 SINRITELPERLPSALQSLDLFHNKISCLP----ENLPEELRYLSVYDNSIRTLPAHLPS------GITHLNVQSNSLta 318

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1958729278 528 --KSIPPGIQGMKA---------------LHFLRLNNNKIrNILPEQI 558
Cdd:PRK15370  319 lpETLPPGLKTLEAgenaltslpaslppeLQVLDVSKNQI-TVLPETL 365
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 264-583 3.97e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 59.86  E-value: 3.97e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 264 SIPNEAFnGLPNLERLDLSRNNItsSGIGPKAFKLLKKLMHLNMDGNNLV-HIPSELPS--TLEELKINDNNLQAIDEKS 340
Cdd:PLN00113  275 PIPPSIF-SLQKLISLDLSDNSL--SGEIPELVIQLQNLEILHLFSNNFTgKIPVALTSlpRLQVLQLWSNKFSGEIPKN 351

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 341 LSDLNQLVALELEGNNLS-EInvnPLAFKSLKNLSYLRLGKNKFR-IIPQGLPA--SIEELYLENNQIEEITEICFNHTR 416
Cdd:PLN00113  352 LGKHNNLTVLDLSTNNLTgEI---PEGLCSSGNLFKLILFSNSLEgEIPKSLGAcrSLRRVRLQDNSFSGELPSEFTKLP 428

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 417 KITMIVLRYNKIeESRIAPLAWiNHENLESIDLSYNKLY-HVP-SYLPKSLLHLVLIGNQIERIPGYVFGHMkPGLEYLY 494
Cdd:PLN00113  429 LVYFLDISNNNL-QGRINSRKW-DMPSLQMLSLARNKFFgGLPdSFGSKRLENLDLSRNQFSGAVPRKLGSL-SELMQLK 505

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 495 LSFNRLSDDGVDLVSfygAYHSLRELFLDHNDFK-SIPPGIQGMKALHFLRLNNNKIRNILPEQICNAEEDEDSALEHLH 573
Cdd:PLN00113  506 LSENKLSGEIPDELS---SCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNH 582

                         330
                  ....*....|
gi 1958729278 574 LENNYITTRA 583
Cdd:PLN00113  583 LHGSLPSTGA 592
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 325-585 3.49e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 55.44  E-value: 3.49e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 325 ELKINDNNLQAIDEKSLSD-LNQLVALELEGNNLSEInvnplafkslknlsylrlgknkfriipqGLPASIEELylENNQ 403
Cdd:cd00116     2 QLSLKGELLKTERATELLPkLLCLQVLRLEGNTLGEE----------------------------AAKALASAL--RPQP 51

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 404 IEEITEICFNHTRKITMIVlrynkieesRIAPLAWINHENLESIDLSYNKLYH-----VPSYLPKSLL-HLVL----IGN 473
Cdd:cd00116    52 SLKELCLSLNETGRIPRGL---------QSLLQGLTKGCGLQELDLSDNALGPdgcgvLESLLRSSSLqELKLnnngLGD 122

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 474 QIERIPGYVFGHMKPGLEYLYLSFNRLSDDGV-DLVSFYGAYHSLRELFLDHNDFKsiPPGI----QGMKA---LHFLRL 545
Cdd:cd00116   123 RGLRLLAKGLKDLPPALEKLVLGRNRLEGASCeALAKALRANRDLKELNLANNGIG--DAGIralaEGLKAncnLEVLDL 200

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1958729278 546 NNNKIRNILPEQICNAEEDEdSALEHLHLENNYITTRAMS 585
Cdd:cd00116   201 NNNGLTDEGASALAETLASL-KSLEVLNLGDNNLTDAGAA 239
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 240-580 5.13e-08

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 55.57  E-value: 5.13e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 240 DFTEIPPITaPEVTTLELvGNSIISIPNEAFNGLPNLERldlSRNNITSSGIGPKAFKLLKKLMHLNMDGNNLVHIPSEl 319
Cdd:COG5238    14 ELLSANPAT-TEQSELTK-RATIVNLRSYHLHGGAILLA---RYLQSRSSITQYLRFEGQGDPGLNPVALEKAAEAFPT- 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 320 pstlEELKINDNNLQAIDEKSLSDLNQLVA-----LELEGNNLSEINVNPLA-----------FKSLKNLSYLRLGKNKF 383
Cdd:COG5238    88 ----QLLVVDWEGAEEVSPVALAETATAVAtpppdLRRIMAKTLEDSLILYLalprrinliqvLKDPLGGNAVHLLGLAA 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 384 RI--------IPQGLPASIEELYLENNQIEE--ITEICfNHTRK---ITMIVLRYNKIEESRIAPLAWINHEN--LESID 448
Cdd:COG5238   164 RLgllaaismAKALQNNSVETVYLGCNQIGDegIEELA-EALTQnttVTTLWLKRNPIGDEGAEILAEALKGNksLTTLD 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 449 LSYNK-----LYHVPSYL--PKSLLHLVLIGNQIERiPG--YVFGHMK--PGLEYLYLSFNRLSDDGVdlvsfygayhsl 517
Cdd:COG5238   243 LSNNQigdegVIALAEALknNTTVETLYLSGNQIGA-EGaiALAKALQgnTTLTSLDLSVNRIGDEGA------------ 309

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958729278 518 relfldhndfKSIPPGIQGMKALHFLRLNNNKIRNILPEQICNAEEdEDSALEHLHLENNYIT 580
Cdd:COG5238   310 ----------IALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQ-ENTTLHSLDLSDNQIG 361
VWC_out smart00215
von Willebrand factor (vWF) type C domain;
100-150 7.22e-08

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214565  Cd Length: 67  Bit Score: 49.48  E-value: 7.22e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1958729278  100 CSVKGMVMYNKAVWSpEPCTTCLCSNGRVLCDETTCPPKTCpYTVKPEGEC 150
Cdd:smart00215   1 CWNNGSYYPPGAKWD-DDCNRCTCLNGRVSCTKVWCGPKPC-LLHNLSGEC 49
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
305-584 2.02e-07

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 54.01  E-value: 2.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 305 LNMDGNNLVHIPSELPSTLEELKINDNNLqaideKSLSDL-NQLVALELEGNNLSEINVNPLAFKSL------------- 370
Cdd:PRK15387  206 LNVGESGLTTLPDCLPAHITTLVIPDNNL-----TSLPALpPELRTLEVSGNQLTSLPVLPPGLLELsifsnplthlpal 280

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 371 -KNLSYLRLGKNKFRIIPQgLPASIEELYLENNQIEEITEIcfnhTRKITMIVLRYNKIEESRIAPlawinhENLESIDL 449
Cdd:PRK15387  281 pSGLCKLWIFGNQLTSLPV-LPPGLQELSVSDNQLASLPAL----PSELCKLWAYNNQLTSLPTLP------SGLQELSV 349

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 450 SYNKLYHVPSyLPKSLLHLVLIGNQIERIPGyvfghMKPGLEYLYLSFNRLSDDGVdLVSfygayhSLRELFLDHNDFKS 529
Cdd:PRK15387  350 SDNQLASLPT-LPSELYKLWAYNNRLTSLPA-----LPSGLKELIVSGNRLTSLPV-LPS------ELKELMVSGNRLTS 416

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958729278 530 IPPGIQGMKALHFLRlnNNKIRniLPEQICNAeededSALEHLHLENNYITTRAM 584
Cdd:PRK15387  417 LPMLPSGLLSLSVYR--NQLTR--LPESLIHL-----SSETTVNLEGNPLSERTL 462
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 250-527 2.66e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 52.74  E-value: 2.66e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 250 PEVTTLELVGNSIISIPN------EAFNGLPNLERLDLSRNNITSSGIGPkafklLKKLMHlnmdgnnlvhipselPSTL 323
Cdd:cd00116    51 PSLKELCLSLNETGRIPRglqsllQGLTKGCGLQELDLSDNALGPDGCGV-----LESLLR---------------SSSL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 324 EELKINDNNLQ----AIDEKSLSDLN-QLVALELEGNNLSEINVNPLA--FKSLKNLSYLRLGKNK-----FRIIPQGLP 391
Cdd:cd00116   111 QELKLNNNGLGdrglRLLAKGLKDLPpALEKLVLGRNRLEGASCEALAkaLRANRDLKELNLANNGigdagIRALAEGLK 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 392 AS--IEELYLENNQIEE----ITEICFNHTRKITMIVLRYNKIEESRIAPLAWIN-HEN--LESIDLSYNKLYHVPSylp 462
Cdd:cd00116   191 ANcnLEVLDLNNNGLTDegasALAETLASLKSLEVLNLGDNNLTDAGAAALASALlSPNisLLTLSLSCNDITDDGA--- 267

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958729278 463 KSLlhlvlignqIERIPGyvfghmKPGLEYLYLSFNRLSDDGVDLV--SFYGAYHSLRELFLDHNDF 527
Cdd:cd00116   268 KDL---------AEVLAE------KESLLELDLRGNKFGEEGAQLLaeSLLEPGNELESLWVKDDSF 319
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 253-411 3.93e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 51.33  E-value: 3.93e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 253 TTLELVGNSIISIPNeaFNGLPNLERLDLSRNNITssgigpkafkllkKLMHLnmdgnnlvhipsELPSTLEELKINDNN 332
Cdd:cd21340    49 THLYLQNNQIEKIEN--LENLVNLKKLYLGGNRIS-------------VVEGL------------ENLTNLEELHIENQR 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 333 LQ-----AIDEKSLSDL-NQLVALELEGNNLSeinvnplafkSLKNLSYLRlgknkfriipqglpaSIEELYLENNQIEE 406
Cdd:cd21340   102 LPpgeklTFDPRSLAALsNSLRVLNISGNNID----------SLEPLAPLR---------------NLEQLDASNNQISD 156


                  ....*
gi 1958729278 407 ITEIC 411
Cdd:cd21340   157 LEELL 161
LRR_8 pfam13855
Leucine rich repeat;
443-500 6.07e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.75  E-value: 6.07e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958729278 443 NLESIDLSYNKLYHVPSYLPK---SLLHLVLIGNQIERIPGYVFGHMkPGLEYLYLSFNRL 500
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKglsNLKVLDLSNNLLTTLSPGAFSGL-PSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
321-383 7.24e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 7.24e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958729278 321 STLEELKINDNNLQAIDEKSLSDLNQLVALELEGNNLSEInvNPLAFKSLKNLSYLRLGKNKF 383
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTL--SPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
488-550 3.58e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 3.58e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958729278 488 PGLEYLYLSFNRLSDdgVDLVSFYGAyHSLRELFLDHNDFKSIPPG-IQGMKALHFLRLNNNKI 550
Cdd:pfam13855   1 PNLRSLDLSNNRLTS--LDDGAFKGL-SNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
464-527 9.28e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.28  E-value: 9.28e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958729278 464 SLLHLVLIGNQIERIPGYVFGHMkPGLEYLYLSFNRLSddGVDLVSFYGaYHSLRELFLDHNDF 527
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGL-SNLKVLDLSNNLLT--TLSPGAFSG-LPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
346-404 1.02e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.28  E-value: 1.02e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958729278 346 QLVALELEGNNLSEINvnPLAFKSLKNLSYLRLGKNKFRIIP----QGLPaSIEELYLENNQI 404
Cdd:pfam13855   2 NLRSLDLSNNRLTSLD--DGAFKGLSNLKVLDLSNNLLTTLSpgafSGLP-SLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 241-552 1.15e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 48.25  E-value: 1.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 241 FTEIPPITAPEVTTLELVGNSI------------ISIPNEAFNGLPNLERLDLSRNNITSSGIgpkafKLLKKLMHLNMD 308
Cdd:COG5238   135 LALPRRINLIQVLKDPLGGNAVhllglaarlgllAAISMAKALQNNSVETVYLGCNQIGDEGI-----EELAEALTQNTT 209

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 309 GNNLVhipselpstLEELKINDNNLQAIdEKSLSDLNQLVALELEGNNLSEINVNPLAfKSLKNlsylrlgknkfriipq 388
Cdd:COG5238   210 VTTLW---------LKRNPIGDEGAEIL-AEALKGNKSLTTLDLSNNQIGDEGVIALA-EALKN---------------- 262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 389 glPASIEELYLENNQIEEITEICFNHTRK----ITMIVLRYNKIEESRIAPLAWINHEN--LESIDLSYNKlyhvpsylp 462
Cdd:COG5238   263 --NTTVETLYLSGNQIGAEGAIALAKALQgnttLTSLDLSVNRIGDEGAIALAEGLQGNktLHTLNLAYNG--------- 331

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 463 ksllhlvlIGNQ-IERIpgyvFGHMKPG--LEYLYLSFNRLSDDGVDLVSFYGAYH-SLRELFLDHND-----FKSIPPG 533
Cdd:COG5238   332 --------IGAQgAIAL----AKALQENttLHSLDLSDNQIGDEGAIALAKYLEGNtTLRELNLGKNNigkqgAEALIDA 399

                         330
                  ....*....|....*....
gi 1958729278 534 IQGMKaLHFLRLNNNKIRN 552
Cdd:COG5238   400 LQTNR-LHTLILDGNLIGA 417
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 397-583 1.76e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 46.32  E-value: 1.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 397 LYLENNQIEEITEicFNHTRKITMIVLRYNKIeeSRIaplawinhENLESidlsynklyhvpsyLPKsLLHLVLIGNQIE 476
Cdd:cd21340     7 LYLNDKNITKIDN--LSLCKNLKVLYLYDNKI--TKI--------ENLEF--------------LTN-LTHLYLQNNQIE 59

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 477 RIPGyvFGHMKpGLEYLYLSFNRLSddgvdLVSFYGAYHSLRELFLDHNDfksIPPG----------------------- 533
Cdd:cd21340    60 KIEN--LENLV-NLKKLYLGGNRIS-----VVEGLENLTNLEELHIENQR---LPPGekltfdprslaalsnslrvlnis 128

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958729278 534 ---------IQGMKALHFLRLNNNKIRNIlpEQICNAEEDEDSaLEHLHLENNYITTRA 583
Cdd:cd21340   129 gnnidslepLAPLRNLEQLDASNNQISDL--EELLDLLSSWPS-LRELDLTGNPVCKKP 184
Amnionless pfam14828
Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for ...
 113-154 2.91e-05

Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for vitamin B12 uptake.


Pssm-ID: 464340  Cd Length: 449  Bit Score: 47.00  E-value: 2.91e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958729278 113 WSPEPC---TTCLCSNGRVL---CD--ETTCPPKTCPYTVKPEGECCPIC 154
Cdd:pfam14828 186 VGPEACsdpSGCGCGNDENLeriCAnvLQRCPPPHCLSPLRPEGHCCDVC 235
LRR_8 pfam13855
Leucine rich repeat;
393-454 4.13e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 4.13e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958729278 393 SIEELYLENNQIEEITEICFNHTRKITMIVLRYNKIeeSRIAPLAWINHENLESIDLSYNKL 454
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
516-579 3.01e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.04  E-value: 3.01e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958729278 516 SLRELFLDHNDFKSIPPGI-QGMKALHFLRLNNNKIRNILPEQICNAeededSALEHLHLENNYI 579
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPGAFSGL-----PSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 250-289 6.70e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 37.61  E-value: 6.70e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1958729278 250 PEVTTLELVGNSIISIPNeaFNGLPNLERLDLSRNNITSS 289
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPP--LAKLPNLETLDLSGNNKITD 38
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
232-363 8.81e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.23  E-value: 8.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 232 RTISCIYGDFTEIPPITA-PEVTTLELVGNSIISIPNEAfnGLPNLERLDLSRNNITSSGI-GPKAFKLLKKLMHLNMDG 309
Cdd:COG4886   231 ETLDLSNNQLTDLPELGNlTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLkELELLLGLNSLLLLLLLL 308

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958729278 310 NNLVHIPSELPSTLEELKINDNNLQAIDEKSLSDLNQLVALELEGNNLSEINVN 363
Cdd:COG4886   309 NLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLL 362
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 255-357 1.19e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.14  E-value: 1.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 255 LELVGNSIISIPNEAFNGLPNLERLDLSRNNItsSGIGPKAFKLLKKLMHLNMDGNNLV-HIP---SELPsTLEELKIND 330
Cdd:PLN00113  480 LDLSRNQFSGAVPRKLGSLSELMQLKLSENKL--SGEIPDELSSCKKLVSLDLSHNQLSgQIPasfSEMP-VLSQLDLSQ 556

                          90       100
                  ....*....|....*....|....*..
gi 1958729278 331 NNLQAIDEKSLSDLNQLVALELEGNNL 357
Cdd:PLN00113  557 NQLSGEIPKNLGNVESLVQVNISHNHL 583
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 260-385 4.94e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 37.52  E-value: 4.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958729278 260 NSIISIPNEAFNGLPNLERLDLSrNNITSsgIGPKAFkllkklmhlnmDGNNLVHIpsELPSTLEElkindnnlqaIDEK 339
Cdd:pfam13306  20 SSLTSIGEYAFSNCTSLKSITLP-SSLTS--IGSYAF-----------YNCSLTSI--TIPSSLTS----------IGEY 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1958729278 340 SLSDLNQLVALELEgNNLSEINVNplAFKSLkNLSYLRLGKNKFRI 385
Cdd:pfam13306  74 AFSNCSNLKSITLP-SNLTSIGSY--AFSNC-SLKSITIPSSVTTI 115
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 274-321 8.60e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.53  E-value: 8.60e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1958729278 274 PNLERLDLSRNNITSSGigpkAFKLLKKLMHLNMDGNNLVHIPSELPS 321
Cdd:pfam12799   1 PNLEVLDLSNNQITDIP----PLAKLPNLETLDLSGNNKITDLSDLAN 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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