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Conserved domains on  [gi|1958743521|ref|XP_038952943|]
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alpha-2,8-sialyltransferase 8E isoform X5 [Rattus norvegicus]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
GT29 super family cl45931
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 24-297 0e+00

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


The actual alignment was detected with superfamily member cd23990:

Pssm-ID: 480271  Cd Length: 273  Bit Score: 525.17  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521  24 SEASLFnRSTLSRCCNAPNFLFTTQKNTPVETNLRYEVESSGLYHIDQEIFKMFPKEMPYYRSQFKKCAVVGNGGILKNS 103
Cdd:cd23990     1 TEANAF-KSSLSRCCNAPSFLFTTQKNTPLGTKLKYEVDTSGIYHINSEIFKMFPKDMPYSRSQFKKCAVVGNGGILKNS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521 104 GCGKEINSADFVFRCNLPPISGIYTTDVGEKTDVVTVNPSIIIDRFHKLEKWRRPFFSVLQRYENASVLLPAFYNVRNTL 183
Cdd:cd23990    80 KCGREIDSADFVFRCNLPPISEKYVRDVGVKTDVVTINPSIITERFHKLEKWRRPFYEVLQVYENASVVLPAFYNTRNTD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521 184 VSFRVKYMLDDFQSRQPVYFFHPQYLSSVSRYWLSLGVRARRISTGLILVTAALELCEEVHLFGFWAFPMNPSGFFITHH 263
Cdd:cd23990   160 VSIRVKYVLDDFESQQAVYYFHPQYLLNVSRFWLRQGVRAKRISSGLMLVTAALELCEEVHLYGFWAFPMNPSGIFITHH 239

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1958743521 264 YYDNVKPKPGFHAMPSEIFTFLRMHSRGILRVHT 297
Cdd:cd23990   240 YYDNVKPRPGFHAMPSEIFNFLHMHSRGILRVHT 273
 
Name Accession Description Interval E-value
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 24-297 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 525.17  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521  24 SEASLFnRSTLSRCCNAPNFLFTTQKNTPVETNLRYEVESSGLYHIDQEIFKMFPKEMPYYRSQFKKCAVVGNGGILKNS 103
Cdd:cd23990     1 TEANAF-KSSLSRCCNAPSFLFTTQKNTPLGTKLKYEVDTSGIYHINSEIFKMFPKDMPYSRSQFKKCAVVGNGGILKNS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521 104 GCGKEINSADFVFRCNLPPISGIYTTDVGEKTDVVTVNPSIIIDRFHKLEKWRRPFFSVLQRYENASVLLPAFYNVRNTL 183
Cdd:cd23990    80 KCGREIDSADFVFRCNLPPISEKYVRDVGVKTDVVTINPSIITERFHKLEKWRRPFYEVLQVYENASVVLPAFYNTRNTD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521 184 VSFRVKYMLDDFQSRQPVYFFHPQYLSSVSRYWLSLGVRARRISTGLILVTAALELCEEVHLFGFWAFPMNPSGFFITHH 263
Cdd:cd23990   160 VSIRVKYVLDDFESQQAVYYFHPQYLLNVSRFWLRQGVRAKRISSGLMLVTAALELCEEVHLYGFWAFPMNPSGIFITHH 239

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1958743521 264 YYDNVKPKPGFHAMPSEIFTFLRMHSRGILRVHT 297
Cdd:cd23990   240 YYDNVKPRPGFHAMPSEIFNFLHMHSRGILRVHT 273
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 45-292 2.23e-90

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 269.48  E-value: 2.23e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521  45 FTTQKNTPVETNLRYEvESSGLYHIDQEIFKMFPKEMPYYRSQFKKCAVVGNGGILKNSGCGKEINSADFVFRCNLPPIS 124
Cdd:pfam00777   1 FLTKENFPLGEWIRYS-EWWLPFTVTEELLELLPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521 125 GiYTTDVGEKTDVVTVNP-SIIIDRFHKL--EKWRRPFFSVLQRYE--NASVLLPAFYNVRNTLVSFRVKYMLDDFQSRQ 199
Cdd:pfam00777  80 G-YEKDVGSKTTLRTMNPeSAIDSKYGNLgfSHPRDPFVEFVLVPFkgRDLLWLPAFLTKGNVSRSLRVLYTLKEVKIPV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521 200 P---VYFFHPQYLSSVSRYWL-SLGVRARRISTGLILVTAALELCEEVHLFGFWAFPMNPSgffITHHYYDNVKPKP--- 272
Cdd:pfam00777 159 DpdkVLFLHPDFLRYVANFWLrSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPFLDSRG---NSHHYYDNVLMKKggf 235

                         250       260
                  ....*....|....*....|.
gi 1958743521 273 -GFHAMPSEIFTFLRMHSRGI 292
Cdd:pfam00777 236 yGVHDMPFEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 24-297 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 525.17  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521  24 SEASLFnRSTLSRCCNAPNFLFTTQKNTPVETNLRYEVESSGLYHIDQEIFKMFPKEMPYYRSQFKKCAVVGNGGILKNS 103
Cdd:cd23990     1 TEANAF-KSSLSRCCNAPSFLFTTQKNTPLGTKLKYEVDTSGIYHINSEIFKMFPKDMPYSRSQFKKCAVVGNGGILKNS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521 104 GCGKEINSADFVFRCNLPPISGIYTTDVGEKTDVVTVNPSIIIDRFHKLEKWRRPFFSVLQRYENASVLLPAFYNVRNTL 183
Cdd:cd23990    80 KCGREIDSADFVFRCNLPPISEKYVRDVGVKTDVVTINPSIITERFHKLEKWRRPFYEVLQVYENASVVLPAFYNTRNTD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521 184 VSFRVKYMLDDFQSRQPVYFFHPQYLSSVSRYWLSLGVRARRISTGLILVTAALELCEEVHLFGFWAFPMNPSGFFITHH 263
Cdd:cd23990   160 VSIRVKYVLDDFESQQAVYYFHPQYLLNVSRFWLRQGVRAKRISSGLMLVTAALELCEEVHLYGFWAFPMNPSGIFITHH 239

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1958743521 264 YYDNVKPKPGFHAMPSEIFTFLRMHSRGILRVHT 297
Cdd:cd23990   240 YYDNVKPRPGFHAMPSEIFNFLHMHSRGILRVHT 273
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 30-297 2.80e-162

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 452.10  E-value: 2.80e-162
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521  30 NRSTLSRCCNAPNFLFTTQKNTPVETNLRYEVESSGLYHIDQEIFKMFPKEMPYYRSQFKKCAVVGNGGILKNSGCGKEI 109
Cdd:cd23971     6 FRSELRSCCNASHELVVTQENTPLGSKIHYEGERKKTITVNEKLFSMLPKESPFSNKPLKTCAVVGNGGILKNSSCGREI 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521 110 NSADFVFRCNLPPISgiYTTDVGEKTDVVTVNPSIIIDRFHKLEKWRRPFFSVLQRYENASVLLPAFYNVRNTLVSFRVK 189
Cdd:cd23971    86 DSADFVIRCNLPPLN--DSKDVGSKTNLVTANPSILREKFHNLKKRRRPFVERMKVYGNALLLLPAFSYTSNTEPSLRAL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521 190 YMLDDFQSRQPVYFFHPQYLSSVSRYWLSLGVRARRISTGLILVTAALELCEEVHLFGFWAFPMNPSGFFITHHYYDNVK 269
Cdd:cd23971   164 YTLEDFGSPQKVLFFNPEYLRNLSRYWKSKGLKARRLSTGLMLVSAALELCENVHLYGFWPFSTDLDGNPISHHYYDNVL 243

                         250       260
                  ....*....|....*....|....*...
gi 1958743521 270 PKPGFHAMPSEIFTFLRMHSRGILRVHT 297
Cdd:cd23971   244 PKKGVHAMPEEFLRYLKLHSQGVLRLHL 271
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 25-295 2.42e-125

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 358.68  E-value: 2.42e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521  25 EASLFNRSTLSRCCNAPNFLFTTQKNTPVETNLRYEVESSGLYHIDQEIFKMFPKEMPYYRSQFKKCAVVGNGGILKNSG 104
Cdd:cd23991     1 EEHENFRSELSSCCNAVQNFIVSQNNTPLGTNLTYEVEPKKKILITENIFRMFPKSQPFRGYPYKQCAVVGNGGILKNSS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521 105 CGKEINSADFVFRCNLPPISGIYTTDVGEKTDVVTVNPSIIIDRFHKLEKWRRPFFSVLQRYENASVLLPAFYNVRNTLV 184
Cdd:cd23991    81 CGAEIDQADFVFRCNLPPTGGNISKDVGSKTNLVTANPSIISIKYAKLNERRKPFLETVSVYGDAFLLLPAFSYRSNTAL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521 185 SFRVKYMLDDFQSRQPVYFFHPQYLSSVSRYWLSLGVRARRISTGLILVTAALELCEEVHLFGFWAFPMNPSGFFITHHY 264
Cdd:cd23991   161 SFKVYYTLEDFKAKQKVIFFHPIYLKHLAQFWRSKGVQVYRLSTGLMITSAALELCEEVKLYGFWPFSKNTEGKPISHHY 240

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1958743521 265 YDNVKPKPGFHAMPSEIFTFLRMHSRGILRV 295
Cdd:cd23991   241 YDNQLPKPGFHSMPKEFYQLLQLHSKGILKL 271
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 31-296 4.52e-101

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 297.13  E-value: 4.52e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521  31 RSTLSRCCNAPNFLFTTQKNTPVETNLRYEVESSGLYHIDQEIFKMFPKEMPYYRsQFKKCAVVGNGGILKNSGCGKEIN 110
Cdd:cd23989     7 RKLLEDCCDPKRLFAVTKHNSPLGKNLWFDGEFLHSHTVDNETYSLFPQDTPLQL-PLKKCSVVGNGGILKNSGCGQQID 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521 111 SADFVFRCNLPPISGIYTTDVGEKTDVVTVNPSIIIDRFHKLEKWRRPFFSVLQRYENASVLLPAFYNVRNTLVSFRVKY 190
Cdd:cd23989    86 RADFVMRCNLPPLSREYTDDVGTKTQLVTANPSIIDKRFQNLLWSRKSFVESMKVYGRSYIYMPAFSMKTGTDPSLRVYY 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521 191 MLDDFQSRQPVYFFHPQYLSSVSRYWLSLGVRARRISTGLILVTAALELCEEVHLFGFWAFPMNPSGFFITHHYYDNVKP 270
Cdd:cd23989   166 TLADVGANQTVLFANPNFLRNVGKFWKSKGVHAKRLSTGLFLVSAALGLCEEVTIYGFWPFSVDLDERTISHHYYDNVLP 245

                         250       260
                  ....*....|....*....|....*.
gi 1958743521 271 KPGFHAMPSEIFTFLRMHSRGILRVH 296
Cdd:cd23989   246 DSGFHAMPEEFLQLWHLHKSGVLRMQ 271
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 31-297 1.65e-94

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 280.69  E-value: 1.65e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521  31 RSTLSRCCNAPNFlFTTQKNTPVETNLRYEVESSGLYHIDQEIFKMFPKEMPYYRSQFKKCAVVGNGGILKNSGCGKEIN 110
Cdd:cd23963     7 RKELERLLNTRKL-FLTQKNTPLGDVLYYSYFKKKTFKITKSLYELLPKTSPFSHKRYKTCAVVGNSGILLGSGCGKEID 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521 111 SADFVFRCNLPPISGiYTTDVGEKTDVVTVNPSIIIDRFHKL--EKWRRPFFSVLQRYENASVLLPAFYNVRNTLVSFRV 188
Cdd:cd23963    86 SHDFVIRCNLPPIKG-FEKDVGRKTNLTTLNPSILKRRYNSLkkNRDRDKFLNRLKEYNGSILWYPKFSFKSSTNLLLKA 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521 189 KYMLDDFQSRQPVYFFHPQYLSSVSRYWLSLGVRaRRISTGLILVTAALELCEEVHLFGFWAFPMNPSGFFITHHYYDNV 268
Cdd:cd23963   165 ARALKKNGLNLTVVYSNPEHFLAVQKFWKRRGLE-KRPSTGLYLVSLALTFCDEIHLYGFWPFPTDPNGRPVPYHYYDDL 243

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1958743521 269 KPKP--GFHAMPSEIFTFLRMHSRGILRVHT 297
Cdd:cd23963   244 SPSTknKVHNMPEEFKLLRELHKKGVLKLHT 274
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 45-292 2.23e-90

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 269.48  E-value: 2.23e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521  45 FTTQKNTPVETNLRYEvESSGLYHIDQEIFKMFPKEMPYYRSQFKKCAVVGNGGILKNSGCGKEINSADFVFRCNLPPIS 124
Cdd:pfam00777   1 FLTKENFPLGEWIRYS-EWWLPFTVTEELLELLPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521 125 GiYTTDVGEKTDVVTVNP-SIIIDRFHKL--EKWRRPFFSVLQRYE--NASVLLPAFYNVRNTLVSFRVKYMLDDFQSRQ 199
Cdd:pfam00777  80 G-YEKDVGSKTTLRTMNPeSAIDSKYGNLgfSHPRDPFVEFVLVPFkgRDLLWLPAFLTKGNVSRSLRVLYTLKEVKIPV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521 200 P---VYFFHPQYLSSVSRYWL-SLGVRARRISTGLILVTAALELCEEVHLFGFWAFPMNPSgffITHHYYDNVKPKP--- 272
Cdd:pfam00777 159 DpdkVLFLHPDFLRYVANFWLrSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPFLDSRG---NSHHYYDNVLMKKggf 235

                         250       260
                  ....*....|....*....|.
gi 1958743521 273 -GFHAMPSEIFTFLRMHSRGI 292
Cdd:pfam00777 236 yGVHDMPFEFKLLQKLHKEGV 256
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 69-297 7.15e-64

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 202.62  E-value: 7.15e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521  69 IDQEIFKMFPKEMPYYRSQFKKCAVVGNGGILKNSGCGKEINSADFVFRCNLPPISGiYTTDVGEKTDVVTVNPSIIIDR 148
Cdd:cd23970    49 ISPNLRSLLPEVSPFQNKHYNTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEG-FEKDVGRKTNLTTFNPSILEKY 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521 149 FHKL--EKWRRPFFSVLQRYENASVLLPAFYNVRNTLVSFRVKYMLDDFQSRQPVYFFHP-QYLSSVSRYWLSLGVRARR 225
Cdd:cd23970   128 YNNLltIQDRNNFFLSLKKLDGAILWIPAFFFHTSATVTRTLVDFFVEHRGQLKVQLAWPgNIMQHVNRYWKTKHLSPKR 207

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958743521 226 ISTGLILVTAALELCEEVHLFGFWAFPMNPSGFFITHHYYDNVKPK-----PGFHAMPSEIFTFLRMHSRGILRVHT 297
Cdd:cd23970   208 LSTGILMYTLASAICEEIHLYGFWPFGFDPTGTPLPYHYYDKKGTKfttkwQESHQLPAEFVLLYKMHGAGVLKLTL 284
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 57-297 1.65e-61

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 196.48  E-value: 1.65e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521  57 LRYEVESSGLYHIDQEIFKMFPKEMPYYRSQFKKCAVVGNGGILKNSGCGKEINSADFVFRCNLPPISGiYTTDVGEKTD 136
Cdd:cd23969    33 MHYEIDRHKTVNITQDLYQLLPEVSPLKGKHFRTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEG-YEKDVGTKSN 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521 137 VVTVNPSIIIDRFHKL--EKWRRPFFSVLQRYENASVLLPAFynVRNTLVSfRVKYMLD-DFQSRQPVYFFHP--QYLSS 211
Cdd:cd23969   112 LTTMNPSVIPHAYGDLvnATDKEKFVERLRQLGDSILWIPAF--VSKGGEE-HVQWTNEiILKHKLNVKTAYPplRLNHA 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521 212 VSRYWLSLGVRARRISTGLILVTAALELCEEVHLFGFWAFPMNPSGFFITHHYYDNVK--PKPGFHAMPSEIFTFLRMHS 289
Cdd:cd23969   189 IRGYWLTTKFRIKRPSTGLLMYTLATRFCDEIHLYGFYPFSEDGNGRAVKYHYYDNRKylTTARPHKMPEEFRALRSLHQ 268


                  ....*...
gi 1958743521 290 RGILRVHT 297
Cdd:cd23969   269 RGALRLHT 276
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 68-297 1.72e-55

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 181.29  E-value: 1.72e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521  68 HIDQEIFKMFPKEMPYYRSQFKKCAVVGNGGILKNSGCGKEINSADFVFRCNLPPISGiYTTDVGEKTDVVTVNPSIIID 147
Cdd:cd23987    44 NISQNLYELLPRTSPLKNKHFKTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEE-YAKDVGTKTDLVTMNPSVVQR 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521 148 RFHKL--EKWRRPFFSVLQRYENASVLLPAFYNVRNtlvSFRVKYMLD-DFQSRQPVYFFHP--QYLSSVSRYWLSLGVR 222
Cdd:cd23987   123 AFEDLvnETWKEKFLQRLQSLNGSILWIPAFMAKGG---EERVEWVNDlILKHHINVRTAYPslRLLHAVRGYWLTNKVH 199

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958743521 223 ARRISTGLILVTAALELCEEVHLFGFWAFPMNPSGFFITHHYYDNVK----PKPGFHAMPSEIFTFLRMHSRGILRVHT 297
Cdd:cd23987   200 IKRPTTGLLMYTLATRFCNRIHLYGFWPFPRDQNQNPVKYHYYDSLKygytSQASPHTMPLEFKALKNLHQQGALKLTV 278
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 57-297 2.78e-52

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 172.83  E-value: 2.78e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521  57 LRYEVESSGLYHIDQEIFKMFPKEMPYYRSQFKKCAVVGNGGILKNSGCGKEINSADFVFRCNLPPISGiYTTDVGEKTD 136
Cdd:cd23988    33 IHYVLDRRRTLNISQNLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVE-FAADVGTKSD 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521 137 VVTVNPSIIIDRFHKL--EKWRRPFFSVLQRYENASVLLPAFYnVRNTL--VSFRVKYMLDDFQSRQPVYffhP--QYLS 210
Cdd:cd23988   112 FITMNPSVVQRAFGGFrnESDREKFVHRLSMLNDSVLWIPAFM-VKGGEkhVEWVNALILKNKLKVRTAY---PslRLIH 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521 211 SVSRYWLSLGVRARRISTGLILVTAALELCEEVHLFGFWAFPMNPSGFFITHHYYDNVKPK----PGFHAMPSEIFTFLR 286
Cdd:cd23988   188 AVRGYWLTNKVNIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDANGNPVKYHYYDDLKYRyfsnAGPHRMPLEFKTLNV 267

                         250
                  ....*....|.
gi 1958743521 287 MHSRGILRVHT 297
Cdd:cd23988   268 LHNRGALKLTT 278
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 91-287 5.32e-31

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 114.77  E-value: 5.32e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521  91 CAVVGNGGILKNSGCGKEINSADFVFRCNLPPISGiYTTDVGEKTDVVTVNPSIiidrFHKLEKWRRPFFSVLQ-RYENA 169
Cdd:cd19952     1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKG-FEKDVGSKTTFRVLNSKW----AGFYLRGPRCGCHPLPlEEEVV 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521 170 SVLLPAFYNVRNTLVSFRVKYMlddfqsRQPVYFFH--PQYLSSVSRYWLSLGVRA----RRISTGLILVTAALELCEEV 243
Cdd:cd19952    76 LILSRAAAADFKRLKRRKKRHD------NAVLLLTDpaPDLLSYVRKRLEKLGLKSffggNAPSSGLLAVLLALQLCDSV 149

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1958743521 244 HLFGFWAFPMNPSGFFitHHYYDNVKP--KPGFHAMPSEiFTFLRM 287
Cdd:cd19952   150 DLYGFGVDSGHAPKVP--YHYYDLVEAeeGTAVHSFDLE-AELLRA 192
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 71-296 4.12e-23

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 95.81  E-value: 4.12e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521  71 QEIFKMFPKEMPYYR---SQFKKCAVVGNGGILKNSGCGKEINSADFVFRCNLPPISGiYTTDVGEKT--------DVVT 139
Cdd:cd23966    57 EKLFQVVPGENPYRTrdpNRCRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKG-FEKDVGSKTthhfmypeSAVD 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521 140 VNPSI--IIDRFHKLE-KWrrpffsvlqryenasvLLPAFYNVRNTLVSFRVKYMLDdfQSRQPVYFFHPQYLSSVSRYW 216
Cdd:cd23966   136 LDPGVhlVLVPFKVLDlQW----------------LISALTTGEITRTYTPVKRFIK--ADKDKVLVINPAFIKYVHDNW 197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521 217 LSLgvRARRISTGLILVTAALELCEEVHLFGFWAfpmNPSGFFitHHYYDN-----VKPKPGFHAMPSEIFTFLRMHSRG 291
Cdd:cd23966   198 TEH--HGRYPSTGFLALIFALHICDEVSVFGFGA---DSKGNW--HHYWEKnrsagAFRKTGVHDADFESDIIKKLAKEG 270


                  ....*
gi 1958743521 292 ILRVH 296
Cdd:cd23966   271 KIRVY 275
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 90-297 4.73e-23

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 96.17  E-value: 4.73e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521  90 KCAVVGNGGILKNSGCGKEINSADFVFRCNLPPISGIYtTDVGEKTD--VVTVNPSIIIDRFHklekwrrpffsVLQRYE 167
Cdd:cd23964    84 RCAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGFE-KDVGTKTSfyTFFPESLHNSLLKH-----------VPQDKD 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521 168 NASVLLPAFYN----VRNTLVSFRVKYMLDDFQSRQPVY----------FFHPQYLSSVSRYWLslgvRARRI---STGL 230
Cdd:cd23964   152 TKYLFIPFKIRdydyLDAVLSGKPVPDGCDKGKRPPPLFgpklnatnvrLLHPDFIRYLFNRWL----NSSTSyrpTTGA 227

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958743521 231 ILVTAALELCEEVHLFGF---WAFPMnpsgffithHYYDN----VKPKPGFHAMPSEIFTFLRMHSRGILRVHT 297
Cdd:cd23964   228 LMLLTALHTCDQVSVYGFgydPRFSL---------HYYDKtfvkFTVFYANHDFTNERKLWRKLHEEGIINLYR 292
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 76-297 8.71e-21

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 90.20  E-value: 8.71e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521  76 MFPKEM-PYYRSQFKKCAVVGNGGILKNSGCGKEINSADFVFRCNLPPISGiYTTDVGEKTDVVTVNPSIIidrFHKLEK 154
Cdd:cd23974    71 MFDWWDrPNGRSPCIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKG-FEKDVGRRTSFYTFSTNTL---MNSLRA 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521 155 WRRPFFSVL-QRYENASVLLP----AFYNVRNTLVSFRVKYMLDdfQSRQPV-YF-----------FHPQYLSSV-SRYW 216
Cdd:cd23974   147 YAGVGFNGPpQSKETRYIFLPdhdrDYLLVKAALTHTPIDRGRD--KSKRPSkYFgkdvtaekfkiYHPDFIRYLrNRFL 224

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521 217 LS--LGVRARRI---STGLILVTAALELCEEVHLFGFwafpMNPSGFFITHHYYDNVKPKPGF---HAMPSEIFTFLRMH 288
Cdd:cd23974   225 WSpiLNTKQRDIyrpSTGAVMLLAALHTCDQVSAYGF----MTPDYGKYSDHYYDKTYHKVVFyanHDLRLEMQLWQKLH 300


                  ....*....
gi 1958743521 289 SRGILRVHT 297
Cdd:cd23974   301 KAGLIKLYM 309
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 89-272 1.09e-19

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 85.04  E-value: 1.09e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521  89 KKCAVVGNGGILKNSGCGKEINSADFVFRCNLPPISGiYTTDVGEKTDVVTVNPsiiidrfhklekwRRPFFSVLQRYEN 168
Cdd:cd23967     3 RRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKG-YEKDVGSKTTFRMFYP-------------ESAFRDPEEYDSD 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521 169 ASVLLPAF--------YNV-----RNTLVSF------RVKYMLDDFQsrqpvyFFHPQYLSSVSRYWLSLGVRARRI--- 226
Cdd:cd23967    69 WLLVLVPFksmdllwlQAVikgkkPNGKGGFwkkiatSVPKPPKKIR------ILNPYILQEAAFDLIGLPMNGKQGknv 142

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1958743521 227 -STGLILVTAALELCEEVHLFGFWAFPMNPSgffITHHYYDNVKPKP 272
Cdd:cd23967   143 pTTGIIAIVMALHYCDEVDIAGFGYDPSDPN---APLHYYDSLTMKA 186
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 88-288 4.02e-17

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 79.24  E-value: 4.02e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521  88 FKKCAVVGNGGILKNSGCGKEINSADFVFRCNLPPISGiYTTDVGEKTDVVTVNPSIiidrfhkLEKWRRPFFSvLQRYE 167
Cdd:cd23968    45 YNTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKG-FEKDVGSKTTLRLINSQI-------LSKPEFNFLT-DPLYR 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521 168 NASVLL--PAFYNVRNTLVSFRVKY-MLDDFQSR------QPVYFFHPQYLssvSRYWLSLGVRARRI------STGLIL 232
Cdd:cd23968   116 NVTLLVwdPSSYNVNLEKWYKKPDFdFFPNYIKYrrrhpeEPFYLIDPRFL---WRLWDILQEYTPEKikpnppSSGFIG 192

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958743521 233 VTAALELCEEVHLFGFWafpmnPSgFFITH--HYYDNVKPKP----GFHAMPSEIFTFLRMH 288
Cdd:cd23968   193 IVLMLHLCDWVDVYEYV-----PS-VRQTDrcHYYDVEKDLActlgAWHPLAAEKLLVRHLN 248
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 45-267 3.00e-16

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 77.23  E-value: 3.00e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521  45 FTTQKNTPVETN-------LRYEVESSGLYHIDQEIFKMFPKE---MPYYRS-QFKKCAVVGNGGILKNSGCGKEINSAD 113
Cdd:cd23980    27 LLTAQNAHLEEDtykwwlrLQREKKPKNLNDTIRELFQVVPGNvdpLLEKRLvSCRRCAVVGNSGNLKESYYGPQIDSHD 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521 114 FVFRCNLPPISGiYTTDVGEKTDVVTVNPSIIIDRFHKLEKWRRPFFSVLQRYEnASVLLPAFYNVRNTLVSFRVKYmld 193
Cdd:cd23980   107 FVLRMNKAPTEG-FEADVGSKTTHHFVYPESFRELAQNVSMILVPFKTLDLEWV-ISATTTGTISHTYVPVPRKIKV--- 181

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958743521 194 dfqSRQPVYFFHPQYLSSVSRYWLSlgVRARRISTGLILVTAALELCEEVHLFGFWAfpmNPSGFFitHHYYDN 267
Cdd:cd23980   182 ---KKEKILIYHPAFIKYVFDRWLQ--GHGRYPSTGILSVIFSLHVCDEVDLYGFGA---DSKGNW--HHYWEN 245
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 89-268 4.97e-16

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 75.09  E-value: 4.97e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521  89 KKCAVVGNGGILKNSGCGKEINSADFVFRCNLPPISGiYTTDVGEKTDVvtvnpsiiidrfhklekwrRPFFSvlqryEN 168
Cdd:cd23982     3 RRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRG-FEKDVGSKTTI-------------------RLFYP-----ES 57

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521 169 ASVlLPAFYNVRNTL---VSFR------VKYMLDDfQSRQPVYFF-----------------HPQYLSSVSRYWLSLGVR 222
Cdd:cd23982    58 AQF-DPGIENDPDTLlvlVPFKpldfywLYEILSN-EKRVRKGFWkqppriwdanpkqirilNPYYTYVAATKLLQVPGQ 135

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958743521 223 ---ARRISTGLILVTAALELCEEVHLFGFwAFPMN-PSGFFIthHYYDNV 268
Cdd:cd23982   136 rkkKQKPTTGLLAITLALHLCDEVHIAGF-GYPDNgNSNQPI--HYYNQI 182
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 67-298 8.88e-16

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 76.33  E-value: 8.88e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521  67 YHIDQEIFKMFPK--------EMPYYRSQFKKCAVVGNGGILKNSGCGKEINSADFVFRCNLPPISGiYTTDVGEKTDVV 138
Cdd:cd23973    54 YTLVKEVVELIPKpkeqqllaLSPPGGDGCIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKG-YEEDVGTRTSFY 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521 139 TVNPSIIIDRFHKLEKwrRPFFSVLQRYENASVLLPAF---YN-----VRNTLVS----FRV---KYMLDDFqSRQPVYF 203
Cdd:cd23973   133 VHTAHSITSSLMILQK--RGFKNIPQDKDIKYILFPEGprdYQwlealLKNKTIPsgayYGRrprSYFSGDF-TEDKYLV 209

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521 204 FHPQYLSSV-----------SRYWlslgvRARRISTGLILVTAALELCEEVHLFGFwafpMNPSGFFITHHYYDNVKPKP 272
Cdd:cd23973   210 LHPDFLRYVknrflrsktlkGKYW-----AIYRPTTGAFLLLTALHLCDTVSAYGF----ITEDYRKYPDHYYDKKKTKL 280

                         250       260
                  ....*....|....*....|....*....
gi 1958743521 273 GF---HAMPSEIFTFLRMHSRGILRVHTG 298
Cdd:cd23973   281 VFyinHDFRLEKKLWKRLHDEKIIKLYQR 309
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 89-268 3.22e-15

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 72.86  E-value: 3.22e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521  89 KKCAVVGNGGILKNSGCGKEINSADFVFRCNLPPISGiYTTDVGEKTDVVTVNP-SIIIDRFHklekwrrpffsvlqrYE 167
Cdd:cd23984     3 KKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIG-YENDVGKRTTFRLCYPeSIFSDPSH---------------YD 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521 168 NASVLLpafynvrntLVSFR---VKYMLDDFQS---------RQP----------VYFFHPQYLSSVSRYWLSLGVR--- 222
Cdd:cd23984    67 PNTTVV---------LIPFKphdLRWLLDLLMGkkvsakgfwKKPalnliykpnqIRILNPFILRIAAYELLHFPKRfpk 137

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1958743521 223 ---ARRISTGLILVTAALELCEEVHLFGfwaFPMNPSGFFITHHYYDNV 268
Cdd:cd23984   138 ekkPKHPTTGIIAITLALHICNEVHIAG---FKYDFSNLNSTLHYYGNE 183
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 90-296 1.66e-14

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 72.55  E-value: 1.66e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521  90 KCAVVGNGGILKNSGCGKEINSADFVFRCNLPPISGiYTTDVGEKTD-----VVTVNPSIIidrfhklEKWRRPFFSVLQ 164
Cdd:cd23972    84 RCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKG-FEEDVGTKTSfygftVNTMKNSLI-------SYWNLGFTRTPQ 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521 165 RYENASVLLPA----FYNVRNTLVSFRVKYMLDdfQSRQPVYFF------------HPQYLSSVSRYWLslgvRARRI-- 226
Cdd:cd23972   156 GQDLQYIFIPSdirdYVMLRSAILGVPVPEGLD--KGDRPHKYFgpeasakkfkllHPDFISYLTDRFL----KSKLLnt 229

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521 227 --------STGLILVTAALELCEEVHLFGF-----WAFpmnpsgffiTHHYYDNVKPKPGF---HAMPSEIFTFLRMHSR 290
Cdd:cd23972   230 hyghlympSTGALMLLTALHTCDQVSAYGFitsnyWKF---------SDHYYERKKKPLVFyanHDMLLEAALWRRLHKA 300


                  ....*.
gi 1958743521 291 GILRVH 296
Cdd:cd23972   301 GILQLY 306
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 89-271 3.05e-14

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 70.35  E-value: 3.05e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521  89 KKCAVVGNGGILKNSGCGKEINSADFVFRCNLPPISGiYTTDVGEKTDV-----VTVnPSIIIDRFHKLEKWRRPFFSVL 163
Cdd:cd23965     2 DTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRG-YEKDVGRRTTIrvvshSSL-PRLLRNAILLLAGTRAPTVVVF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521 164 QRYENA--SVLLPAFYNVRNTLVSFR-VK-YMLDDFQSRQPVYFFHPQylSSVSRY----WLslgvrarriSTGLILVTA 235
Cdd:cd23965    80 WGPETKmnKDGAGKYNLLRSLSKKYPdVEfYSLTPEKMDYADELFEKE--TGKSRIksgtWL---------STGWFTMLL 148

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1958743521 236 ALELCEEVHLFGfwafpMNPSGFFITH-------HYYDNVKPK 271
Cdd:cd23965   149 ALDVCDEIKVYG-----MVPENYCREHpnskvpyHYYEPGGLK 186
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 75-248 9.93e-14

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 69.87  E-value: 9.93e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521  75 KMFPKeMP---YYRSQFKKCAVVGNGGILKNSGCGKEINSADFVFRCNLPPISGiYTTDVGEKTDVVTVNPSIIIDRFHK 151
Cdd:cd23986    34 KYVPK-IPlskLHLRGFRSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTRG-YEKDVGNKTTIRIINSQILTNPNHH 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521 152 -----------LEKWRRPFFSV--LQRYENASvllpafYNVRNTLVSFRVKYmlddfqSRQPVYFFHPQY---LSSVSRY 215
Cdd:cd23986   112 fidsslykdviLVAWDPAPYSAnlHKWYKKPD------YNLFTPYVQYRKRN------PNQPFYILHPKFiwqLWDIIQE 179

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1958743521 216 WLSLGVRARRISTGLILVTAALELCEEVHLFGF 248
Cdd:cd23986   180 NTQEKIQPNPPSSGFIGILIMMSMCREVHVYEY 212
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 57-267 1.26e-13

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 69.52  E-value: 1.26e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521  57 LRYEVESSGLYHIDQEIFKMFPKEMPYY---RSQFKKCAVVGNGGILKNSGCGKEINSADFVFRCNLPPISGiYTTDVGE 133
Cdd:cd23979    46 LQPQFKPHNTKEVLSKLFQIIPGENPYRswdPSRCRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVG-FEADVGS 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521 134 KT----------DVVTVNPSIIIDRFHKLE-KWRRPFFSVLQ-RYENASVllPAFYNVrntlvsfrvkymlddfqSRQPV 201
Cdd:cd23979   125 RTthhfmypesaKNLPANVSFVLVPFKTLDlLWITSALSTGQiRFTYAPV--KQFLRV-----------------DKDKV 185

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958743521 202 YFFHPQYLSSVSRYWLSLgvRARRISTGLILVTAALELCEEVHLFGFWAfpmNPSGFFitHHYYDN 267
Cdd:cd23979   186 QIYNPAFFKYIHDRWTEH--HGRYPSTGMLVLFFALHVCDEVNVYGFGA---DSRGNW--HHYWEN 244
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 87-248 5.46e-13

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 67.42  E-value: 5.46e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521  87 QFKKCAVVGNGGILKNSGCGKEINSADFVFRCNLPPISGiYTTDVGEKTDVVTVNPSIIIDRFHKlekwrrpfFSVLQRY 166
Cdd:cd23985    44 PLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAG-FQQDVGTKTTIRLINSQLVTTEKHK--------FLKDSLY 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521 167 eNASVLL---PAFYNV------RNTLVSFrvkymLDDFQS------RQPVYFFHPQYLSSVsryWLSL------GVRARR 225
Cdd:cd23985   115 -NEGILIvwdPAPYHSdipewyKNPDYNF-----FENYKTyrrlnpNQPFYILHPQMQWEL---WDIIqenspeEIQPNP 185

                         170       180
                  ....*....|....*....|...
gi 1958743521 226 ISTGLILVTAALELCEEVHLFGF 248
Cdd:cd23985   186 PSSGMLGIILMMTLCDQVDVYEF 208
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 89-269 6.30e-11

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 60.71  E-value: 6.30e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521  89 KKCAVVGNGGILKNSGCGKEINSADFVFRCNLPPISGiYTTDVGEKTDVVTVNPSIIIDRfhklekwrrpffsvLQRYEN 168
Cdd:cd23981     3 RRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKG-FEKDVGSKTTLRITYPEGAIQK--------------PEQYEK 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521 169 ASVLLPAFYNVRNtlvsFR-VKYML--------DDFQS-------RQP--VYFFHPQYLSSVSRYWLSL----GVRAR-R 225
Cdd:cd23981    68 DSLFVLAGFKWQD----FKwLKYIVykekvsasDGFWKsvatrvpREPheIRILNPYFIQEAAFSFIGLpfnnGLMGRgN 143

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1958743521 226 IST-GLILVTAALELCEEVHLFGFwAFPMN-PSGFFithHYYDNVK 269
Cdd:cd23981   144 IPTlGSVAITMALHNCDEVAVAGF-GYDMNtPNAPL---HYYETIK 185
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 89-268 6.94e-11

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 60.52  E-value: 6.94e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521  89 KKCAVVGNGGILKNSGCGKEINSADFVFRCNLPPISGiYTTDVGEKTDVVTVNP----SIIIDRFHK------------- 151
Cdd:cd23983     3 RRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQG-YSQDVGNKTTIRMTYPegapKSEQEYDPTslfvavlfksvdf 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521 152 -----------LEKWRRPFFsvLQRYENASVLLPAFYNVRNTLVsfrVKYMLDDFQsrqpvyffhpQYLSSVSRYWlslG 220
Cdd:cd23983    82 awlkamvkkepLSFWSRLFF--WKEVADSIPLKPSQFRILNPLI---IKETALDIL----------QYPEPQSRLW---G 143

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958743521 221 VRARRISTGLILVTAALELCEEVHLFGFwafpmnpsGFFITH-----HYYDNV 268
Cdd:cd23983   144 WDKNVPTLGVTAVVLATHLCDEVSLAGF--------GYDLSQphaplHYYDSV 188
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 89-266 5.69e-08

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 52.56  E-value: 5.69e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521  89 KKCAVVGNGGILKNSGCGKEINSADFVFRCNLPPISGiYTTDVGEKTDVVTVN----PSIIIDRFHKLEKWRRPFFSVLQ 164
Cdd:cd23977     2 RRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAG-YEADVGNRSSLRVVShtsvPLLLRNQGYFFQQSRDTKYVIWG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521 165 RYENASVLLPAfynvrntlVSFRVKYMLDDFQSRQPVYFFHPQYLSSVSRYWLSLGVRARR-----ISTGLILVTAALEL 239
Cdd:cd23977    81 PERNMDRDGGG--------KTYRALLTLAKMYPHLQVYTLTEEKMAYCDGVFQNETGKNRMksgsfLSTGWFTMILALEL 152

                         170       180
                  ....*....|....*....|....*....
gi 1958743521 240 CEEVHLFGFW--AFPMNPSGFFITHHYYD 266
Cdd:cd23977   153 CEEILVYGMVsdSYCRNKNHSSVPYHYYE 181
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 89-270 2.04e-06

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 47.94  E-value: 2.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521  89 KKCAVVGNGGILKNSGCGKEINSADFVFRCNLPPISGiYTTDVGEKTDVVTVNPS----IIIDRFHKLEKWRRPFF---- 160
Cdd:cd23976    16 KSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRG-YGKDVGNKTSLRVIAHSsiqrILRNRNELLNVSQGTVFifwg 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521 161 --SVLQR------YENASVL------LPAFYNVRNTLVSFRVKYMLDDFQSRQpvyffhpqylssVSRYWLslgvrarri 226
Cdd:cd23976    95 psNYMRRdgkglvYNNLQLMnqilpkLKVYTITRHKMLQFDELFKRETGKDRK------------ISNTWL--------- 153

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1958743521 227 STGLILVTAALELCEEVHLFGFWA--FPMNPSGFFITHHYYDNVKP 270
Cdd:cd23976   154 STGWFTMIIALELCDRINVYGMVPpdFCRDPNHPSVPYHYYEPSGP 199
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 91-266 9.06e-04

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 39.92  E-value: 9.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521  91 CAVVGNGGILKNSGCGKEINSADFVFRCNLPPISGiYTTDVGEKTDVVTVN----PSIIIDRFHklekwrrpFFSvlQRY 166
Cdd:cd23975     4 CAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKG-YEEDVGKRTTIRVVShtsvPLLLKNPDY--------FFK--ETN 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958743521 167 ENASVLLPAFYNVR---NTLVSFRVKYMLDDFQSRQpVYFFHPQYLSSVSRYWLSLGVRAR-----RISTGLILVTAALE 238
Cdd:cd23975    73 ETIYVIWGPFRNMRkdgKGIVYNMLKKAVESYPQAK-IYVTTEKRMSYCDTVFKKETGKDRvqsgsYLSTGWFTLILAMD 151

                         170       180       190
                  ....*....|....*....|....*....|
gi 1958743521 239 LCEEVHLFGFWAFPMNPSGFF--ITHHYYD 266
Cdd:cd23975   152 ACYGIHVYGMINDTYCKTEGYrkVPYHYYE 181
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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