third BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the third BRCT domain.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052738380 705 GCVFAIADYPEQMADKQLLTtWKKIIQSYGGTVDSSLNNRCTHLLCESQVSSMYVQALREGRRCVTIHWLNTILKKKKMV 784
Cdd:cd17711     1 GCVFFIADYPEQMGDQEIAT-WKKVIEEHGGEVVDEYSPRVTHVICESQDSPEYQQALRDGKRVVTAYWLNDVLKRGKLL 79

                  ..
gi 2052738380 785 PP 786
Cdd:cd17711    80 PP 81

first (N-terminal) BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the first BRCT domain.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2052738380  13 FKDVKFYVVGDIDQKVVQLLKAGKGKEVSYNA-LATHIIAVDGDNPEVSESREVFDLPVVKPSWVILSVRCGDLLP 87
Cdd:cd17714     1 FKDVKYFVVGNLDEKVEQLLKNGGAKEVSYLSdMATHVIVDDNDNPEVGEARDLFELPVVTSSWVILSIKAGKLLP 76

third BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the third BRCT domain.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052738380 705 GCVFAIADYPEQMADKQLLTtWKKIIQSYGGTVDSSLNNRCTHLLCESQVSSMYVQALREGRRCVTIHWLNTILKKKKMV 784
Cdd:cd17711     1 GCVFFIADYPEQMGDQEIAT-WKKVIEEHGGEVVDEYSPRVTHVICESQDSPEYQQALRDGKRVVTAYWLNDVLKRGKLL 79

                  ..
gi 2052738380 785 PP 786
Cdd:cd17711    80 PP 81

first (N-terminal) BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the first BRCT domain.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2052738380  13 FKDVKFYVVGDIDQKVVQLLKAGKGKEVSYNA-LATHIIAVDGDNPEVSESREVFDLPVVKPSWVILSVRCGDLLP 87
Cdd:cd17714     1 FKDVKYFVVGNLDEKVEQLLKNGGAKEVSYLSdMATHVIVDDNDNPEVGEARDLFELPVVTSSWVILSIKAGKLLP 76

twin BRCT domain; This is a BRCT domain that appears in duplicate in most member sequences. BRCT domains are peptide- and phosphopeptide-binding modules. BRCT domains are present in a number of proteins involved in DNA checkpoint controls and DNA repair.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2052738380 807 IISVTGFVDTDRDDLKLMAYLAGARYTGYLCRSNTVLICKEPGGLKYEKAKEWRIPCVNAQW 868
Cdd:pfam12738   2 VICVTGFDGDDREGLQKLIEAMGAEYTKDLTKSVTHLICKSGEGEKYEKAKEWGIPVVSPLW 63

breast cancer carboxy-terminal domain;

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2052738380  801 KPCSQHIISVTG-FVDTDRDDLKLMAYLAGARYTGYLCR-SNTVLICKEPGG--LKYEKAKEWRIPCVNAQWLCDIL 873
Cdd:smart00292   2 KLFKGKTFYITGsFDKEERDELKELIEALGGKVTSSLSSkTTTHVIVGSPEGgkLELLKAIALGIPIVKEEWLLDCL 78

BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage. The BRCT domain of XRCC1 forms a homodimer in the crystal structure. This suggests that pairs of BRCT domains associate as homo- or heterodimers. BRCT domains are often found as tandem-repeat pairs. Structures of the BRCA1 BRCT domains revealed a basis for a widely utilized head-to-tail BRCT-BRCT oligomerization mode. This conserved tandem BRCT architecture facilitates formation of the canonical BRCT phospho-peptide interaction cleft at a groove between the BRCT domains. Disease associated missense and nonsense mutations in the BRCA1 BRCT domains disrupt peptide binding by directly occluding this peptide binding groove, or by disrupting key conserved BRCT core folding determinants.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2052738380 698 PEDGFLVGCVFAIadYPEQMADKQLLttwKKIIQSYGGTVDSSLNNRCTHLLCESqVSSMYVQALREGRRCVTIHWL 774
Cdd:pfam00533   1 PKEKLFSGKTFVI--TGLDGLERDEL---KELIEKLGGKVTDSLSKKTTHVIVEA-RTKKYLKAKELGIPIVTEEWL 71

breast cancer carboxy-terminal domain;

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2052738380  705 GCVFAIADYPEQMADKQLlttwKKIIQSYGGTVDSSLN-NRCTHLLCESQVSSMYV--QALREGRRCVTIHWL 774
Cdd:smart00292   6 GKTFYITGSFDKEERDEL----KELIEALGGKVTSSLSsKTTTHVIVGSPEGGKLEllKAIALGIPIVKEEWL 74

third BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the third BRCT domain.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052738380 705 GCVFAIADYPEQMADKQLLTtWKKIIQSYGGTVDSSLNNRCTHLLCESQVSSMYVQALREGRRCVTIHWLNTILKKKKMV 784
Cdd:cd17711     1 GCVFFIADYPEQMGDQEIAT-WKKVIEEHGGEVVDEYSPRVTHVICESQDSPEYQQALRDGKRVVTAYWLNDVLKRGKLL 79

                  ..
gi 2052738380 785 PP 786
Cdd:cd17711    80 PP 81

first (N-terminal) BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the first BRCT domain.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2052738380  13 FKDVKFYVVGDIDQKVVQLLKAGKGKEVSYNA-LATHIIAVDGDNPEVSESREVFDLPVVKPSWVILSVRCGDLLP 87
Cdd:cd17714     1 FKDVKYFVVGNLDEKVEQLLKNGGAKEVSYLSdMATHVIVDDNDNPEVGEARDLFELPVVTSSWVILSIKAGKLLP 76

twin BRCT domain; This is a BRCT domain that appears in duplicate in most member sequences. BRCT domains are peptide- and phosphopeptide-binding modules. BRCT domains are present in a number of proteins involved in DNA checkpoint controls and DNA repair.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2052738380 807 IISVTGFVDTDRDDLKLMAYLAGARYTGYLCRSNTVLICKEPGGLKYEKAKEWRIPCVNAQW 868
Cdd:pfam12738   2 VICVTGFDGDDREGLQKLIEAMGAEYTKDLTKSVTHLICKSGEGEKYEKAKEWGIPVVSPLW 63

BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage. The BRCT domain of XRCC1 forms a homodimer in the crystal structure. This suggests that pairs of BRCT domains associate as homo- or heterodimers. BRCT domains are often found as tandem-repeat pairs. Structures of the BRCA1 BRCT domains revealed a basis for a widely utilized head-to-tail BRCT-BRCT oligomerization mode. This conserved tandem BRCT architecture facilitates formation of the canonical BRCT phospho-peptide interaction cleft at a groove between the BRCT domains. Disease associated missense and nonsense mutations in the BRCA1 BRCT domains disrupt peptide binding by directly occluding this peptide binding groove, or by disrupting key conserved BRCT core folding determinants.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2052738380 801 KPCSQHIISVTGFVDTDRDDLKLMAYLAGARYTGYLCRSNTVLICkEPGGLKYEKAKEWRIPCVNAQWLCDIL 873
Cdd:pfam00533   4 KLFSGKTFVITGLDGLERDELKELIEKLGGKVTDSLSKKTTHVIV-EARTKKYLKAKELGIPIVTEEWLLDCI 75

C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The BRCT (BRCA1 C-terminus) domain is found within many DNA damage repair and cell cycle checkpoint proteins. BRCT domains interact with each other forming homo/hetero BRCT multimers, but are also involved in BRCT-non-BRCT interactions and interactions within DNA strand breaks. BRCT tandem repeats bind to phosphopeptides; it has been shown that the repeats in human BRCA1 bind specifically to pS-X-X-F motifs, mediating the interaction between BRCA1 and the DNA helicase BACH1, or BRCA1 and CtIP, a transcriptional corepressor. It is assumed that BRCT repeats play similar roles in many signaling pathways associated with the response to DNA damage.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2052738380 102 VTACLPRL-PEDLNTLWALITYHGGDCQLSLNKKCTHLIVPQPKGEKYERALRESGILIVTPEWVVDS 168
Cdd:cd00027     1 LVICFSGLdDEEREELKKLIEALGGKVSESLSSKVTHLIAKSPSGEKYYLAALAWGIPIVSPEWLLDC 68

second BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the second BRCT domain.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2052738380 807 IISVTGFVDTDRDDLKLMAYLAGARYTGYLCRSNTVLICKEPGGLKYEKAKEWR-IPCVNAQWLCD 871
Cdd:cd17731     7 VICVTGFDSEERKEIQQLVEQNGGSYSPDLSKNCTHLIAGSPSGQKYEFARKWNsIHIVTPEWLYD 72

C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The BRCT (BRCA1 C-terminus) domain is found within many DNA damage repair and cell cycle checkpoint proteins. BRCT domains interact with each other forming homo/hetero BRCT multimers, but are also involved in BRCT-non-BRCT interactions and interactions within DNA strand breaks. BRCT tandem repeats bind to phosphopeptides; it has been shown that the repeats in human BRCA1 bind specifically to pS-X-X-F motifs, mediating the interaction between BRCA1 and the DNA helicase BACH1, or BRCA1 and CtIP, a transcriptional corepressor. It is assumed that BRCT repeats play similar roles in many signaling pathways associated with the response to DNA damage.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2052738380 807 IISVTGFVDTDRDDLKLMAYLAGARYTGYLCRSNTVLICKEPGGLKY-EKAKEWRIPCVNAQWL 869
Cdd:cd00027     2 VICFSGLDDEEREELKKLIEALGGKVSESLSSKVTHLIAKSPSGEKYyLAALAWGIPIVSPEWL 65

fourth BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and similar proteins; Rad4, also termed P74, or protein cut5, is an essential component for DNA replication and the checkpoint control system, which couples S and M phases. It may directly or indirectly interact with chromatin proteins to form the complex required for the initiation and/or progression of DNA synthesis. Rad4 contains four BRCT repeats. The family corresponds to the fourth one.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2052738380 808 ISVTGFVDTDRDDLKLMAYLAGARYTGYLCRSNTVLICK--EPGGLKYEKAKEWRIPCVNAQWLCDILM 874
Cdd:cd17723     4 ISLTGFSGVDLLHISKLIKLLGAKYHESLTKDRSLLIVNstEKKSDKINFAKKWGIPVVSVEWLWDCLK 72

second BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar proteins; Schizosaccharomyces pombe BRC1 is required for mitotic fidelity, specifically in the G2 phase of the cell cycle. It plays a role in chromatin organization. The family also includes Cryptococcus neoformans DNA ligase 4 (LIG4, also known as DNA ligase IV or polydeoxyribonucleotide synthase [ATP] 4), which is involved in dsDNA break repair, and plays a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologus end-joining. Members in this family contains six BRCT domains. This family corresponds to the second repeat.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2052738380  99 FFGVTACLPRLPE-DLNTLWALITYHGGDCQLSLNKKCTHLIVPQPKGEKYERALR--ESGILIVTPEWVVDSVK 170
Cdd:cd18436     1 FSGVVITCSDLPSgDKEAIYGGVLALGGQYSDELTRDVTHLIALSPDGDKYKTALKrpELNIKIVLPHWFDDCFK 75

second BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the second BRCT domain.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2052738380 705 GCVFAIADYPEQmaDKQLLttwKKIIQSYGGTVDSSLNNRCTHLLCESQVSSMYVQALREGR-RCVTIHWLNTILKKK 781
Cdd:cd17731     5 GLVICVTGFDSE--ERKEI---QQLVEQNGGSYSPDLSKNCTHLIAGSPSGQKYEFARKWNSiHIVTPEWLYDSIEAG 77

BRCT domain of DNA repair protein Rev1 and similar proteins; REV1, also termed alpha integrin-binding protein 80, or AIBP80, or Rev1-like terminal deoxycytidyl transferase, is a DNA template-dependent dCMP transferase required for mutagenesis induced by UV light.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2052738380 116 LWALITYHGGDCQLSLNK-KCTHLIVPQPKGEKYERALRESGILIVTPEWVVDSVKDKARKDE 177
Cdd:cd17719    20 LKRLILLHGGQYEHYYSRsRVTHIIATNLPGSKIKKLKKARNYKVVRPEWIVDSIKAGRLLPE 82

BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage. The BRCT domain of XRCC1 forms a homodimer in the crystal structure. This suggests that pairs of BRCT domains associate as homo- or heterodimers. BRCT domains are often found as tandem-repeat pairs. Structures of the BRCA1 BRCT domains revealed a basis for a widely utilized head-to-tail BRCT-BRCT oligomerization mode. This conserved tandem BRCT architecture facilitates formation of the canonical BRCT phospho-peptide interaction cleft at a groove between the BRCT domains. Disease associated missense and nonsense mutations in the BRCA1 BRCT domains disrupt peptide binding by directly occluding this peptide binding groove, or by disrupting key conserved BRCT core folding determinants.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2052738380 698 PEDGFLVGCVFAIadYPEQMADKQLLttwKKIIQSYGGTVDSSLNNRCTHLLCESqVSSMYVQALREGRRCVTIHWL 774
Cdd:pfam00533   1 PKEKLFSGKTFVI--TGLDGLERDEL---KELIEKLGGKVTDSLSKKTTHVIVEA-RTKKYLKAKELGIPIVTEEWL 71

second BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the second BRCT domain.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052738380 705 GCVFAIAdypeQMADKQLLTTWKkIIQSYGGTVDSSLNNRCTHLLCESQVSSMYVQALREGR-RCVTIHWLNTILKKKKM 783
Cdd:cd17710     4 GVVVCPS----QISAEDRLKLWA-MVTFHGGKCQLNLDKKCTHLVTGKASGAKYECALKHEGiKIVTPDWVTDCIKAKTL 78

                  ...
gi 2052738380 784 VPP 786
Cdd:cd17710    79 LDE 81

breast cancer carboxy-terminal domain;

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2052738380  705 GCVFAIADYPEQMADKQLlttwKKIIQSYGGTVDSSLN-NRCTHLLCESQVSSMYV--QALREGRRCVTIHWL 774
Cdd:smart00292   6 GKTFYITGSFDKEERDEL----KELIEALGGKVTSSLSsKTTTHVIVGSPEGGKLEllKAIALGIPIVKEEWL 74

breast cancer carboxy-terminal domain;

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2052738380   10 EELFKDVKFYVVGDIDQ----KVVQLLKAGKGKEVSY--NALATHIIAVDGDNPEVSESREVF-DLPVVKPSWVI 77
Cdd:smart00292   1 PKLFKGKTFYITGSFDKeerdELKELIEALGGKVTSSlsSKTTTHVIVGSPEGGKLELLKAIAlGIPIVKEEWLL 75

sixth BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the sixth BRCT domain.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2052738380 101 GVTACLP-RLPEDLNTLWALITYHGGDCQLSLNKKCTHLI--VPQPKGEKYERALRESGILIVTPEWV 165
Cdd:cd17727     3 GVVICVSkKLSKRQGELNKIAASLGAEYRWTYDESCTHFIyqGKANDTNREYKSAKEQGKFIVSPHWL 70

BRCT domain, a BRCA1 C-terminus domain; This BRCT domain, a BRCA1 C-terminus region, is found on many RAP1 proteins, usually at the very N-terminus. The function in human at least of a BRCT is to contribute to the heterogeneity of the telomere DNA length, but that may not be its general function, which remains unknown.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052738380 111 EDLNTLWALITYHGGDCQLSLNKKCTHLIVPQPKGEKyerALRESGILIVTPEWVVDSVK 170
Cdd:pfam16589  18 PSRSKLKRLIEANGGTVVDNINPAVYIVIAPYNKTDK---LAENTKLGVVSPQWIFDCVK 74

BRCT domain of yeast chitin biosynthesis protein CHS5 and similar proteins; CHS5, also termed protein CAL3, is a component of the CHS5/6 complex which mediates export of specific cargo proteins, including chitin synthase CHS3. It is also involved in targeting FUS1 to sites of polarized growth.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2052738380 101 GVTACLPRL--PEDLNTLWALITYHGGDCQLSLNKKCTHLIVPQPKGEKYERALRESgILIVTPEWVV 166
Cdd:cd17742     2 GITVCLGPLdpPESVDELEQCLERIGAKPTDRVAIDTTHFVCTVPSGPEYEKAKEMN-IPIVRPEWLR 68

fifth BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the fifth BRCT domain.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2052738380 135 CTHLIVPQPKGEKYERALReSGILIVTPEWVVDSVKDKARKDE 177
Cdd:cd18434    48 STHLVLKEPEGSKYEAAKK-WNLPAVTKSWLFECARTGKKVPE 89

BRCT domain of DNA repair protein Rev1 and similar proteins; REV1, also termed alpha integrin-binding protein 80, or AIBP80, or Rev1-like terminal deoxycytidyl transferase, is a DNA template-dependent dCMP transferase required for mutagenesis induced by UV light.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052738380  12 LFKDVKFYVVGDIDQKVVQL----LKAGkGKEVSYNA--LATHIIAVDGDNPEVSESREVFDLPVVKPSWVILSVRCGDL 85
Cdd:cd17719     1 IFKGVVIYVNGYTDPSADELkrliLLHG-GQYEHYYSrsRVTHIIATNLPGSKIKKLKKARNYKVVRPEWIVDSIKAGRL 79

                  ....*.
gi 2052738380  86 LPVTGF 91
Cdd:cd17719    80 LPEAPY 85

BRCT domain of poly [ADP-ribose] polymerase 4 (PARP-4) and similar proteins; PARP-4, also termed 193 kDa vault protein, or ADP-ribosyltransferase diphtheria toxin-like 4 (ARTD4), or PARP-related/IalphaI-related H5/proline-rich (PH5P), or vault poly(ADP-ribose) polymerase (VPARP), shows poly(ADP-ribosyl)ation activity that catalyzes the formation of ADP-ribose polymers in response to DNA damage. PARP-4 is a component of the vault ribonucleoprotein particle, at least composed of MVP, PARP4 and one or more vault RNAs (vRNAs). The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is not conserved in this group.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2052738380 114 NTLWALITYHGGDCQLSLNKKCTHLIVPQPKGE-KYE-RALRESGILIVTPEWVVDSVKDK 172
Cdd:cd17726    21 KKLKKKITENGGIISYIINKKCTHVVVNNAKALsSYKcRMAQKYGIPVVSLDYIWKCVEAG 81

First (central) BRCT domain in X-ray repair cross-complementing protein 1 (XRCC1) and similar proteins; XRCC1 is a DNA repair protein that corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. It forms homodimers and interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB), DNA ligase III (LIG3), APTX, APLF, and APEX1. XRCC1 contains an N-terminal XRCC1-specific domain and two BRCT domains. This family corresponds to the first one.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052738380 705 GCVFAIADY--PE--QMADKQLlttwkkiiqSYGGTVDSSLNNRCTHLLCESQVSSMYVQALREGRRCVTIHWLNTILKK 780
Cdd:cd17725     1 GVVFVLSGFqnPFrgELRDKAL---------EMGAKYRPDWTADCTHLICAFANTPKYKQVKGAGGIIVSKEWILDCYKK 71

                  ....*
gi 2052738380 781 KKMVP 785
Cdd:cd17725    72 KKRLP 76

second BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the second BRCT domain.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2052738380 807 IISVTGFVDTDRDDLKLMAYLAGARYTGYLCRSNTVLICKEPGGLKYEKA-KEWRIPCVNAQWLCD 871
Cdd:cd17710     6 VVCPSQISAEDRLKLWAMVTFHGGKCQLNLDKKCTHLVTGKASGAKYECAlKHEGIKIVTPDWVTD 71

first (N-terminal) BRCT domain of microcephalin and similar proteins; Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1. It has been implicated in chromosome condensation and DNA damage induced cellular responses. It may play a role in neurogenesis and regulation of the size of the cerebral cortex. Microcephalin contains three BRCT repeats. This family corresponds to the first repeat.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2052738380 727 KKIIQSYGGTVDSSLNNRCTHLLCESQVSSMYVQALREGRRCVTIHWLNTILKKKKMV 784
Cdd:cd17716    21 RSILEELGAKVVKRLTKTVTHVVFKDGSQSTLEKAKKRNVKLVSPLWVEACKETGKRV 78

twin BRCT domain; This is a BRCT domain that appears in duplicate in most member sequences. BRCT domains are peptide- and phosphopeptide-binding modules. BRCT domains are present in a number of proteins involved in DNA checkpoint controls and DNA repair.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2052738380 727 KKIIQSYGGTVDSSLNNRCTHLLCESQVSSMYVQALREGRRCVTIHW 773
Cdd:pfam12738  17 QKLIEAMGAEYTKDLTKSVTHLICKSGEGEKYEKAKEWGIPVVSPLW 63

fifth BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar proteins; Schizosaccharomyces pombe BRC1 is required for mitotic fidelity, specifically in the G2 phase of the cell cycle. It plays a role in chromatin organization. The family also includes Cryptococcus neoformans DNA ligase 4 (LIG4, also known as DNA ligase IV or polydeoxyribonucleotide synthase [ATP] 4), which is involved in dsDNA break repair, and plays a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologus end-joining. Members in this family contain six BRCT domains. This family corresponds to the fifth one.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2052738380 133 KKCTHLIVPQ-PKGEKYERALrESGILIVTPEWVVDSVKDK 172
Cdd:cd17743    31 DECTHLVAPKiVRTEKFLCAL-AYAPVIVTTDWLEACLKAG 70