1LD8: Co-crystal structure of Human Farnesyltransferase with farnesyldiphosphate and inhibitor compound 49

PDB ID: 1LD8Download
MMDB ID: 19950
PDB Deposition Date: 2002/4/8
Updated in MMDB: 2012/11
Experimental Method:
x-ray diffraction
Resolution: 1.8  Å
Source Organism:
Similar Structures:
Biological Unit for 1LD8: dimeric; determined by author and by software (PISA)
Molecular Components in 1LD8
Label Count Molecule
Proteins (2 molecules)
1
Protein Farnesyltransferase Alpha Subunit
(Gene symbol: FNTA)
Molecule annotation
1
Protein Farnesyltransferase Beta Subunit
(Gene symbol: FNTB)
Molecule annotation
Chemicals and Non-standard biopolymers (7 molecules)
1
1
alpha-D-glucopyranosealpha-D-glucopyranose
2
1
beta-D-fructofuranosebeta-D-fructofuranose
3
2
ACETIC ACIDACETIC ACID
4
1
ZINC IONZINC ION
5
1
FARNESYL DIPHOSPHATEFARNESYL DIPHOSPHATE
6
1
(20S)-19,20,21,22-TETRAHYDRO-19-OXO-5H-18,20-ETHANO-12,14-ETHENO-6,10-METHENO-18H-BENZ[D]IMIDAZO[4,3-K][1,6,9,12]OXATRI AZA-CYCLOOCTADECOSINE-9-CARBONITRILE(20S)-19,20,21,22-TETRAHYDRO-19-OXO-5H-18,20-ETHANO-12,14-ETHENO-6,10-METHENO-18H-BENZ[D]IMIDAZO[4,3-K][1,6,9,12]OXATRI AZA-CYCLOOCTADECOSINE-9-CARBONITRILE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303