1TCO: TERNARY COMPLEX OF A CALCINEURIN A FRAGMENT, CALCINEURIN B, FKBP12 AND THE IMMUNOSUPPRESSANT DRUG FK506 (TACROLIMUS)

PDB ID: 1TCODownload
MMDB ID: 5173
PDB Deposition Date: 1996/8/21
Updated in MMDB: 1998/11
Experimental Method:
x-ray diffraction
Resolution: 2.5  Å
Source Organism:
Similar Structures:
Biological Unit for 1TCO: trimeric; determined by author and by software (PISA)
Molecular Components in 1TCO
Label Count Molecule
Proteins (3 molecules)
1
Serine/threonine Phosphatase B2
(Gene symbol: PPP3CA)
Molecule annotation
1
Serine/threonine Phosphatase B2
(Gene symbol: PPP3R1)
Molecule annotation
1
Fk506-binding Protein
(Gene symbol: FKBP1A)
Molecule annotation
Chemicals and Non-standard biopolymers (9 molecules)
1
1
ZINC IONZINC ION
2
1
FE (III) IONFE (III) ION
3
1
PHOSPHATE IONPHOSPHATE ION
4
4
CALCIUM IONCALCIUM ION
5
1
MYRISTIC ACIDMYRISTIC ACID
6
1
8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303