1U70: Understanding the Role of Leu22 Variants in Methotrexate Resistance: Comparison of Wild-type and Leu22Arg Variant Mouse and Human Dihydrofolate Reductase

PDB ID: 1U70Download
MMDB ID: 31293
PDB Deposition Date: 2004/8/2
Updated in MMDB: 2012/12
Experimental Method:
x-ray diffraction
Resolution: 2.5  Å
Source Organism:
Similar Structures:
Biological Unit for 1U70: monomeric; determined by author
Molecular Components in 1U70
Label Count Molecule
Protein (1 molecule)
1
Dihydrofolate Reductase
(Gene symbol: Dhfr)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
1
METHOTREXATEMETHOTREXATE
2
1
NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATENADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303