2G72: Structure of hPNMT with inhibitor 3-fluoromethyl-7-thiomorpholinosulfonamide-THIQ and AdoMet

PDB ID: 2G72Download
MMDB ID: 44441
PDB Deposition Date: 2006/2/27
Updated in MMDB: 2024/11
Experimental Method:
x-ray diffraction
Resolution: 2  Å
Source Organism:
Similar Structures:
Biological Unit for 2G72: monomeric; determined by author and by software (PQS)
Molecular Components in 2G72
Label Count Molecule
Protein (1 molecule)
1
Phenylethanolamine N-methyltransferase
(Gene symbol: PNMT)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
1
S-ADENOSYLMETHIONINES-ADENOSYLMETHIONINE
2
1
(3R)-3-(FLUOROMETHYL)-7-(THIOMORPHOLIN-4-YLSULFONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE(3R)-3-(FLUOROMETHYL)-7-(THIOMORPHOLIN-4-YLSULFONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303