2HJH: Crystal Structure of the Sir2 deacetylase

PDB ID: 2HJHDownload
MMDB ID: 63573
PDB Deposition Date: 2006/6/30
Updated in MMDB: 2024/11
Experimental Method:
x-ray diffraction
Resolution: 1.85  Å
Source Organism:
Similar Structures:
Biological Unit for 2HJH: dimeric; determined by author
Molecular Components in 2HJH
Label Count Molecule
Proteins (2 molecules)
2
Nad-dependent Histone Deacetylase Sir2
(Gene symbol: SIR2)
Molecule annotation
Chemicals and Non-standard biopolymers (6 molecules)
1
2
ZINC ION (Link to PubChem not yet available)ZINC ION
2
2
(2R,3R,4S,5R)-5-({[(R)-{[(R)-{[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]OXY}METHYL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL ACETATE (Link to PubChem not yet available)(2R,3R,4S,5R)-5-({[(R)-{[(R)-{[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]OXY}METHYL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL ACETATE
3
2
NICOTINAMIDE (Link to PubChem not yet available)NICOTINAMIDE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303