2IEJ: Human Protein Farnesyltransferase Complexed with Inhibitor Compound STN-48 And FPP Analog at 1.8A Resolution

PDB ID: 2IEJDownload
MMDB ID: 43915
PDB Deposition Date: 2006/9/19
Updated in MMDB: 2012/11
Experimental Method:
x-ray diffraction
Resolution: 1.8  Å
Source Organism:
Similar Structures:
Biological Unit for 2IEJ: dimeric; determined by author and by software (PISA)
Molecular Components in 2IEJ
Label Count Molecule
Proteins (2 molecules)
1
Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit
(Gene symbol: FNTA)
Molecule annotation
1
Protein Farnesyltransferase Subunit Beta
(Gene symbol: FNTB)
Molecule annotation
Chemicals and Non-standard biopolymers (10 molecules)
1
1
alpha-D-glucopyranosealpha-D-glucopyranose
2
1
beta-D-fructofuranosebeta-D-fructofuranose
3
5
ACETATE IONACETATE ION
4
1
ZINC IONZINC ION
5
1
METHYL N-{(3S)-1-[(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-6-PHENYL-1,2,3,4-TETRAHYDROQUINOLIN-3-YL}-N-[(1-METHYL-1H-IMIDAZOL-4-YL)SULFONYL]GLYCINATEMETHYL N-{(3S)-1-[(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-6-PHENYL-1,2,3,4-TETRAHYDROQUINOLIN-3-YL}-N-[(1-METHYL-1H-IMIDAZOL-4-YL)SULFONYL]GLYCINATE
6
1
[(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID[(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303