3H3C: Crystal structure of PYK2 in complex with Sulfoximine-substituted trifluoromethylpyrimidine analog

PDB ID: 3H3CDownload
MMDB ID: 72936
PDB Deposition Date: 2009/4/16
Updated in MMDB: 2009/07
Experimental Method:
x-ray diffraction
Resolution: 2  Å
Source Organism:
Similar Structures:
Biological Unit for 3H3C: monomeric; determined by author and by software (PISA)
Molecular Components in 3H3C
Label Count Molecule
Protein (1 molecule)
1
Protein Tyrosine Kinase 2 Beta
(Gene symbol: PTK2B)
Molecule annotation
Chemicals and Non-standard biopolymers (6 molecules)
1
5
SULFATE IONSULFATE ION
2
1
4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-N-methylbenzenesulfonamide4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-N-methylbenzenesulfonamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303