3H4G: Structure of aldehyde reductase holoenzyme in complex with potent aldose reductase inhibitor Fidarestat: Implications for inhibitor binding and selectivity

PDB ID: 3H4GDownload
MMDB ID: 72515
PDB Deposition Date: 2009/4/20
Updated in MMDB: 2023/11
Experimental Method:
x-ray diffraction
Resolution: 1.85  Å
Source Organism:
Similar Structures:
Biological Unit for 3H4G: monomeric; determined by author and by software (PISA)
Molecular Components in 3H4G
Label Count Molecule
Protein (1 molecule)
1
Alcohol Dehydrogenase [nadp+]
(Gene symbol: AKR1A1)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
1
SULFATE IONSULFATE ION
2
1
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATENADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
3
1
(2S,4S)-2-AMINOFORMYL-6-FLUORO-SPIRO[CHROMAN-4,4'-IMIDAZOLIDINE]-2',5'-DIONE(2S,4S)-2-AMINOFORMYL-6-FLUORO-SPIRO[CHROMAN-4,4'-IMIDAZOLIDINE]-2',5'-DIONE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303