3KJN: Caspase 8 bound to a covalent inhibitor

PDB ID: 3KJNDownload
MMDB ID: 83996
PDB Deposition Date: 2009/11/3
Updated in MMDB: 2024/11
Experimental Method:
x-ray diffraction
Resolution: 1.8  Å
Source Organism:
Similar Structures:
Biological Unit for 3KJN: tetrameric; determined by author and by software (PISA)
Molecular Components in 3KJN
Label Count Molecule
Proteins (4 molecules)
2
Caspase-8
(Gene symbol: CASP8)
Molecule annotation
2
Caspase-8
(Gene symbol: CASP8)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
2
2,3-DIHYDROXY-1,4-DITHIOBUTANE (Link to PubChem not yet available)2,3-DIHYDROXY-1,4-DITHIOBUTANE
2
2
(3S)-3-({[(5S)-2-{2-[(1H-benzimidazol-5-ylcarbonyl)amino]ethyl}-7-(cyclohexylmethyl)-1,3-dioxo-2,3,5,8-tetrahydro-1H-[1,2,4]triazolo[1,2-a]pyridazin-5-yl]carbonyl}amino)-4-oxopentanoic acid (Link to PubChem not yet available)(3S)-3-({[(5S)-2-{2-[(1H-benzimidazol-5-ylcarbonyl)amino]ethyl}-7-(cyclohexylmethyl)-1,3-dioxo-2,3,5,8-tetrahydro-1H-[1,2,4]triazolo[1,2-a]pyridazin-5-yl]carbonyl}amino)-4-oxopentanoic acid
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303