3NW2: Novel nanomolar Imidazopyridines as selective Nitric Oxide Synthase (iNOS) inhibitors: SAR and structural insights

PDB ID: 3NW2Download
MMDB ID: 91822
PDB Deposition Date: 2010/7/9
Updated in MMDB: 2011/12
Experimental Method:
x-ray diffraction
Resolution: 2.8  Å
Source Organism:
Similar Structures:
Biological Unit for 3NW2: dimeric; determined by author and by software (PISA)
Molecular Components in 3NW2
Label Count Molecule
Proteins (2 molecules)
2
Nitric Oxide Synthase, Inducible
(Gene symbol: Nos2)
Molecule annotation
Chemicals and Non-standard biopolymers (8 molecules)
1
2
PROTOPORPHYRIN IX CONTAINING FEPROTOPORPHYRIN IX CONTAINING FE
2
2
5,6,7,8-TETRAHYDROBIOPTERIN5,6,7,8-TETRAHYDROBIOPTERIN
3
2
SULFATE IONSULFATE ION
4
2
2-[2-(4-methoxypyridin-2-yl)ethyl]-3H-imidazo[4,5-b]pyridine2-[2-(4-methoxypyridin-2-yl)ethyl]-3H-imidazo[4,5-b]pyridine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303