3ROC: Crystal structure of human p38 alpha complexed with a pyrimidinone compound

PDB ID: 3ROCDownload
MMDB ID: 91955
PDB Deposition Date: 2011/4/25
Updated in MMDB: 2011/07
Experimental Method:
x-ray diffraction
Resolution: 1.7  Å
Source Organism:
Similar Structures:
Biological Unit for 3ROC: monomeric; determined by author and by software (PISA)
Molecular Components in 3ROC
Label Count Molecule
Protein (1 molecule)
1
Mitogen-activated Protein Kinase 14
(Gene symbol: MAPK14)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
1
3-{5-chloro-4-[(2,4-difluorobenzyl)oxy]-6-oxopyrimidin-1(6H)-yl}-N-(2-hydroxyethyl)-4-methylbenzamide3-{5-chloro-4-[(2,4-difluorobenzyl)oxy]-6-oxopyrimidin-1(6H)-yl}-N-(2-hydroxyethyl)-4-methylbenzamide
2
1
4-[4-(4-fluorophenyl)-1H-pyrazol-3-yl]pyridine4-[4-(4-fluorophenyl)-1H-pyrazol-3-yl]pyridine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303