4BVG: CRYSTAL STRUCTURE OF HUMAN SIRT3 IN COMPLEX WITH NATIVE ALKYLIMIDATE FORMED FROM ACETYL-LYSINE ACS2-PEPTIDE CRYSTALLIZED IN PRESENCE OF THE INHIBITOR EX-527

PDB ID: 4BVGDownload
MMDB ID: 111800
PDB Deposition Date: 2013/6/25
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 2.5  Å
Source Organism:
Similar Structures:
Biological Unit for 4BVG: dimeric; determined by author and by software (PISA)
Molecular Components in 4BVG
Label Count Molecule
Proteins (2 molecules)
1
Nad-dependent Protein Deacetylase Sirtuin-3, Mitochondrial
(Gene symbol: SIRT3)
Molecule annotation
1
Acetyl-coenzyme a Synthetase 2-like, Mitochondrial
(Gene symbol: ACSS1)
Molecule annotation
Chemicals and Non-standard biopolymers (15 molecules)
1
7
1,2-ETHANEDIOL1,2-ETHANEDIOL
2
3
GLYCEROLGLYCEROL
3
2
SULFATE IONSULFATE ION
4
1
DI(HYDROXYETHYL)ETHERDI(HYDROXYETHYL)ETHER
5
1
ZINC IONZINC ION
6
1
(2R,3R,4S,5R)-5-({[(R)-{[(R)-{[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]OXY}METHYL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL ACETATE(2R,3R,4S,5R)-5-({[(R)-{[(R)-{[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]OXY}METHYL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL ACETATE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303