4G8A: Crystal structure of human TLR4 polymorphic variant D299G and T399I in complex with MD-2 and LPS

PDB ID: 4G8ADownload
MMDB ID: 104088
PDB Deposition Date: 2012/7/23
Updated in MMDB: 2024/12
Experimental Method:
x-ray diffraction
Resolution: 2.4  Å
Source Organism:
Similar Structures:
Biological Unit for 4G8A: tetrameric; determined by author and by software (PISA)
Molecular Components in 4G8A
Label Count Molecule
Proteins (4 molecules)
2
Toll-like Receptor 4
(Gene symbol: TLR4)
Molecule annotation
2
Lymphocyte Antigen 96
(Gene symbol: LY96)
Molecule annotation
Chemicals and Non-standard biopolymers (22 molecules)
1
12
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
2
2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-{[(3R)-3-hydroxytetradecanoyl]amino}-4-O-phosphono-beta-D-glucopyranose2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-{[(3R)-3-hydroxytetradecanoyl]amino}-4-O-phosphono-beta-D-glucopyranose
3
2
(R)-((2R,3S,4R,5R,6R)-3-HYDROXY-2-(HYDROXYMETHYL)-5-((R)-3-HYDROXYTETRADECANAMIDO)-6-(PHOSPHONOOXY)TETRAHYDRO-2H-PYRAN-4-YL) 3-HYDROXYTETRADECANOATE(R)-((2R,3S,4R,5R,6R)-3-HYDROXY-2-(HYDROXYMETHYL)-5-((R)-3-HYDROXYTETRADECANAMIDO)-6-(PHOSPHONOOXY)TETRAHYDRO-2H-PYRAN-4-YL) 3-HYDROXYTETRADECANOATE
4
2
LAURIC ACIDLAURIC ACID
5
2
MYRISTIC ACIDMYRISTIC ACID
6
2
3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303