4GS9: Crystal structure of the high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains in complex with an inactive benzoxadiazole antagonist

PDB ID: 4GS9Download
MMDB ID: 108848
PDB Deposition Date: 2012/8/27
Updated in MMDB: 2023/09
Experimental Method:
x-ray diffraction
Resolution: 1.72  Å
Source Organism:
Similar Structures:
Biological Unit for 4GS9: trimeric; determined by author and by software (PISA)
Molecular Components in 4GS9
Label Count Molecule
Proteins (3 molecules)
1
Endothelial PAS Domain-containing Protein 1
(Gene symbol: EPAS1)
Molecule annotation
2
Aryl Hydrocarbon Receptor Nuclear Translocator
(Gene symbol: ARNT)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
1
N-(3-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amineN-(3-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine
2
1
3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303