5CPR: The novel SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity

PDB ID: 5CPRDownload
MMDB ID: 146691
PDB Deposition Date: 2015/7/21
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 2.22  Å
Source Organism:
Similar Structures:
Biological Unit for 5CPR: monomeric; determined by author
Molecular Components in 5CPR
Label Count Molecule
Protein (1 molecule)
1
Histone-lysine N-methyltransferase Suv420h1
(Gene symbol: KMT5B)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
1
ZINC IONZINC ION
2
1
S-ADENOSYLMETHIONINES-ADENOSYLMETHIONINE
3
1
6,7-dichloro-N-cyclopentyl-4-(pyridin-4-yl)phthalazin-1-amine6,7-dichloro-N-cyclopentyl-4-(pyridin-4-yl)phthalazin-1-amine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303