5E1S: The Crystal structure of INSR Tyrosine Kinase in complex with the Inhibitor BI 885578

PDB ID: 5E1SDownload
MMDB ID: 133403
PDB Deposition Date: 2015/9/30
Updated in MMDB: 2015/12
Experimental Method:
x-ray diffraction
Resolution: 2.264  Å
Source Organism:
Similar Structures:
Biological Unit for 5E1S: monomeric; determined by software (PISA)
Molecular Components in 5E1S
Label Count Molecule
Protein (1 molecule)
1
Insulin Receptor
(Gene symbol: INSR)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
(5R)-N-(1-{2-[4-(2-methoxyethyl)piperazin-1-yl]ethyl}-1H-pyrazol-3-yl)-5,8-dimethyl-9-phenyl-6,8-dihydro-5H-pyrazolo[3,4-h]quinazolin-2-amine(5R)-N-(1-{2-[4-(2-methoxyethyl)piperazin-1-yl]ethyl}-1H-pyrazol-3-yl)-5,8-dimethyl-9-phenyl-6,8-dihydro-5H-pyrazolo[3,4-h]quinazolin-2-amine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303