5JFR: Potent, Reversible Metap2 Inhibitors Via Fragment Based Drug Discovery

PDB ID: 5JFRDownload
MMDB ID: 139629
PDB Deposition Date: 2016/4/19
Updated in MMDB: 2016/06
Experimental Method:
x-ray diffraction
Resolution: 1.6  Å
Source Organism:
Similar Structures:
Biological Unit for 5JFR: monomeric; determined by author and by software (PISA)
Molecular Components in 5JFR
Label Count Molecule
Protein (1 molecule)
1
Methionine Aminopeptidase 2
(Gene symbol: METAP2)
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
2
Manganese (Ii) IonManganese (Ii) Ion
2
1
Dimethyl SulfoxideDimethyl Sulfoxide
3
1
1,2-Ethanediol1,2-Ethanediol
4
1
7-Fluoro-4-(5-Methyl-3h-Imidazo[4,5-B]pyridin-6-Yl)-2,4-Dihydropyrazolo[4,3-B]indole7-Fluoro-4-(5-Methyl-3h-Imidazo[4,5-B]pyridin-6-Yl)-2,4-Dihydropyrazolo[4,3-B]indole
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303