5JHU: Potent, Reversible MetAP2 Inhibitors via FBDD

PDB ID: 5JHUDownload
MMDB ID: 139631
PDB Deposition Date: 2016/4/21
Updated in MMDB: 2017/12
Experimental Method:
x-ray diffraction
Resolution: 1.8  Å
Source Organism:
Similar Structures:
Biological Unit for 5JHU: monomeric; determined by author and by software (PISA)
Molecular Components in 5JHU
Label Count Molecule
Protein (1 molecule)
1
Methionine Aminopeptidase 2
(Gene symbol: METAP2)
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
2
MANGANESE (II) IONMANGANESE (II) ION
2
1
GLYCEROLGLYCEROL
3
1
DIMETHYL SULFOXIDEDIMETHYL SULFOXIDE
4
1
[(2R)-1-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)pyrrolidin-2-yl]methyl 2-methoxybenzoate[(2R)-1-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)pyrrolidin-2-yl]methyl 2-methoxybenzoate
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303