5JI6: Potent, Reversible MetAP2 Inhibitors via FBDD

PDB ID: 5JI6Download
MMDB ID: 139632
PDB Deposition Date: 2016/4/21
Updated in MMDB: 2017/12
Experimental Method:
x-ray diffraction
Resolution: 2.15  Å
Source Organism:
Similar Structures:
Biological Unit for 5JI6: monomeric; determined by author and by software (PISA)
Molecular Components in 5JI6
Label Count Molecule
Protein (1 molecule)
1
Methionine Aminopeptidase 2
(Gene symbol: METAP2)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
2
MANGANESE (II) IONMANGANESE (II) ION
2
1
SULFATE IONSULFATE ION
3
1
4-(3-methylpyridin-4-yl)-6-(trifluoromethyl)-1H-indazole4-(3-methylpyridin-4-yl)-6-(trifluoromethyl)-1H-indazole
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303