5KOQ: Discovery of TAK-272: A Novel, Potent and Orally Active Renin In-hibitor

PDB ID: 5KOQDownload
MMDB ID: 144564
PDB Deposition Date: 2016/7/1
Updated in MMDB: 2016/11
Experimental Method:
x-ray diffraction
Resolution: 2.7  Å
Source Organism:
Similar Structures:
Biological Unit for 5KOQ: monomeric; determined by author
Molecular Components in 5KOQ
Label Count Molecule
Protein (1 molecule)
1
Renin
(Gene symbol: REN)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
1
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
1
2-~{tert}-butyl-4-(furan-2-ylmethylamino)-~{N}-(2-methylpropyl)-~{N}-[(3~{S})-piperidin-3-yl]pyrimidine-5-carboxamide2-~{tert}-butyl-4-(furan-2-ylmethylamino)-~{N}-(2-methylpropyl)-~{N}-[(3~{S})-piperidin-3-yl]pyrimidine-5-carboxamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303