5LEZ: Human 20S proteasome complex with Oprozomib in Mg-Acetate at 2.2 Angstrom

PDB ID: 5LEZDownload
MMDB ID: 142523
PDB Deposition Date: 2016/6/30
Updated in MMDB: 2023/11
Experimental Method:
x-ray diffraction
Resolution: 2.19  Å
Source Organism:
Similar Structures:
Biological Unit for 5LEZ: 32-meric; determined by software (PISA)
Molecular Components in 5LEZ
Label Count Molecule
Proteins (28 molecules)
2
Proteasome Subunit Alpha Type-2
(Gene symbol: PSMA2)
Molecule annotation
2
Proteasome Subunit Alpha Type-4
(Gene symbol: PSMA4)
Molecule annotation
2
Proteasome Subunit Alpha Type-7
(Gene symbol: PSMA7)
Molecule annotation
2
Proteasome Subunit Alpha Type-5
(Gene symbol: PSMA5)
Molecule annotation
2
Proteasome Subunit Alpha Type-1
(Gene symbol: PSMA1)
Molecule annotation
2
Proteasome Subunit Alpha Type-3
(Gene symbol: PSMA3)
Molecule annotation
2
Proteasome Subunit Alpha Type-6
(Gene symbol: PSMA6)
Molecule annotation
2
Proteasome Subunit Beta Type-7
(Gene symbol: PSMB7)
Molecule annotation
2
Proteasome Subunit Beta Type-3
(Gene symbol: PSMB3)
Molecule annotation
2
Proteasome Subunit Beta Type-2
(Gene symbol: PSMB2)
Molecule annotation
2
Proteasome Subunit Beta Type-5
(Gene symbol: PSMB5)
Molecule annotation
2
Proteasome Subunit Beta Type-1
(Gene symbol: PSMB1)
Molecule annotation
2
Proteasome Subunit Beta Type-4
(Gene symbol: PSMB4)
Molecule annotation
2
Proteasome Subunit Beta Type-6
(Gene symbol: PSMB6)
Molecule annotation
Chemicals and Non-standard biopolymers (31 molecules)
cdef
4
bound Oprozomib
1
6
POTASSIUM IONPOTASSIUM ION
2
8
MAGNESIUM IONMAGNESIUM ION
3
9
PENTAETHYLENE GLYCOLPENTAETHYLENE GLYCOL
4
4
ACETATE IONACETATE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303